Jason E. Hill

PCR-based subtractive hybridization and differences in gene content among strains of Helicobacter pylori

Akopyants, Natalia S., Fradkov, Arkady, Diatchenko, Luda, Hill, Jason E., Siebert, Paul D., Lukyanov, Sergey A., ...

Genes that are characteristic of only certain strains of a bacterial species can be of great biologic interest. Here we describe a PCR-based subtractive hybridization method for efficiently detecting...

Down-Regulation of p53 by Double-Stranded RNA Modulates the Antiviral Response

Marques, Joao T., Rebouillat, Dominique, Ramana, Chilakamarti V., Murakami, Junko, Hill, Jason E., Gudkov, Andrei, ...

p53 has been well characterized as a tumor suppressor gene, but its role in antiviral defense remains unclear. A recent report has demonstrated that p53 can be induced by interferons and is activated...

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors

Gurova, Katerina V., Hill, Jason E., Guo, Canhui, Prokvolit, Anatoly, Burdelya, Lyudmila G., Samoylova, Eugenia, ...

Renal cell carcinomas (RCC) commonly retain wild-type but functionally inactive p53, which is repressed by an unknown dominant mechanism. To help reveal this mechanism, we screened a diverse chemical...

PCR-based subtractive hybridization and differences in gene content among strains of Helicobacter pylori

Akopyants, Natalia S., Fradkov, Arkady, Diatchenko, Luda, Hill, Jason E., Siebert, Paul D., Lukyanov, Sergey A., ...

Genes that are characteristic of only certain strains of a bacterial species can be of great biologic interest. Here we describe a PCR-based subtractive hybridization method for efficiently detecting...

Down-Regulation of p53 by Double-Stranded RNA Modulates the Antiviral Response

Marques, Joao T., Rebouillat, Dominique, Ramana, Chilakamarti V., Murakami, Junko, Hill, Jason E., Gudkov, Andrei, ...

p53 has been well characterized as a tumor suppressor gene, but its role in antiviral defense remains unclear. A recent report has demonstrated that p53 can be induced by interferons and is activated...

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors

Gurova, Katerina V., Hill, Jason E., Guo, Canhui, Prokvolit, Anatoly, Burdelya, Lyudmila G., Samoylova, Eugenia, ...

Renal cell carcinomas (RCC) commonly retain wild-type but functionally inactive p53, which is repressed by an unknown dominant mechanism. To help reveal this mechanism, we screened a diverse chemical...

Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells

Spector, Neil L., Yarden, Yosef, Smith, Bradley, Lyass, Ljuba, Trusk, Patricia, Pry, Karen, ...

The human EGF receptor (HER) 2 receptor tyrosine kinase is a survival factor for human cardiomyocytes, and its inhibition may explain the increased incidence of cardiomyopathy associated with the...