Endocrine Perturbation Increases Susceptibility of Mice to Anthrax Lethal Toxin
Moayeri, Mahtab, Webster, Jeanette I., Wiggins, Jason F., Leppla, Stephen H., Sternberg, Esther M.
Bacillus anthracis lethal toxin (LT) causes vascular collapse and high lethality in BALB/cJ mice, intermediate lethality in C57BL/6J mice, and no lethality in DBA/2J mice. We found that...
Anthrax Lethal Toxin Induces Ketotifen-Sensitive Intradermal Vascular Leakage in Certain Inbred Mice
Gozes, Yehoshua, Moayeri, Mahtab, Wiggins, Jason F., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) is a bipartite toxin composed of protective antigen (PA) and lethal factor (LF). Injection of LT produces clinical signs characteristic of anthrax infection,...
Dph3, a Small Protein Required for Diphthamide Biosynthesis, Is Essential in Mouse Development
Liu, Shihui, Wiggins, Jason F., Sreenath, Taduru, Kulkarni, Ashok B., Ward, Jerrold M., Leppla, Stephen H.
The translation elongation factor 2 in eukaryotes (eEF-2) contains a unique posttranslationally modified histidine residue, termed diphthamide, which serves as the only target for diphtheria toxin...
Oxidized ATP Protection against Anthrax Lethal Toxin
Moayeri, Mahtab, Wickliffe, Katherine E., Wiggins, Jason F., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) induces rapid lysis (
Cisplatin Inhibition of Anthrax Lethal Toxin
Moayeri, Mahtab, Wiggins, Jason F., Lindeman, Robin E., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component,...
Endocrine Perturbation Increases Susceptibility of Mice to Anthrax Lethal Toxin
Moayeri, Mahtab, Webster, Jeanette I., Wiggins, Jason F., Leppla, Stephen H., Sternberg, Esther M.
Bacillus anthracis lethal toxin (LT) causes vascular collapse and high lethality in BALB/cJ mice, intermediate lethality in C57BL/6J mice, and no lethality in DBA/2J mice. We found that...
Anthrax Lethal Toxin Induces Ketotifen-Sensitive Intradermal Vascular Leakage in Certain Inbred Mice
Gozes, Yehoshua, Moayeri, Mahtab, Wiggins, Jason F., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) is a bipartite toxin composed of protective antigen (PA) and lethal factor (LF). Injection of LT produces clinical signs characteristic of anthrax infection,...
Dph3, a Small Protein Required for Diphthamide Biosynthesis, Is Essential in Mouse Development
Liu, Shihui, Wiggins, Jason F., Sreenath, Taduru, Kulkarni, Ashok B., Ward, Jerrold M., Leppla, Stephen H.
The translation elongation factor 2 in eukaryotes (eEF-2) contains a unique posttranslationally modified histidine residue, termed diphthamide, which serves as the only target for diphtheria toxin...
Oxidized ATP Protection against Anthrax Lethal Toxin
Moayeri, Mahtab, Wickliffe, Katherine E., Wiggins, Jason F., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) induces rapid lysis (
Cisplatin Inhibition of Anthrax Lethal Toxin
Moayeri, Mahtab, Wiggins, Jason F., Lindeman, Robin E., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component,...
Bacillus anthracis Edema Toxin Causes Extensive Tissue Lesions and Rapid Lethality in Mice
Firoved, Aaron M., Miller, Georgina F., Moayeri, Mahtab, Kakkar, Rahul, Shen, Yuequan, Wiggins, Jason F., ...
Bacillus anthracis edema toxin (ET), an adenylyl cyclase, is an important virulence factor that contributes to anthrax disease. The role of ET in anthrax pathogenesis is, however, poorly understood....
Anthrax Edema Toxin Sensitizes DBA/2J Mice to Lethal Toxin▿
Firoved, Aaron M., Moayeri, Mahtab, Wiggins, Jason F., Shen, Yuequan, Tang, Wei-Jen, Leppla, Stephen H.
Anthrax toxin is made up of three separate protein components: the receptor-binding protective antigen (PA), the adenylyl cyclase edema factor (EF), and the metalloproteinase lethal factor (LF). EF...
Anthrax Protective Antigen Cleavage and Clearance from the Blood of Mice and Rats▿
Moayeri, Mahtab, Wiggins, Jason F., Leppla, Stephen H.
Bacillus anthracis protective antigen (PA) is an 83-kDa (PA83) protein that is cleaved to the 63-kDa protein (PA63) as an essential step in binding and internalizing lethal factor (LF). To assess in...