Jason I. E. Bruce

Pharmacological evaluation of the role of cytochrome P450 in intracellular calcium signalling in rat pancreatic acinar cells

Bruce, Jason I E, Elliott, Austin C

We have investigated whether the cytochrome P450 system is involved in Ca2+ signalling in rat pancreatic acinar cells. Intracellular free [Ca2+] ([Ca2+]i) was measured in collagenase-isolated cells...

Cytosolic Ca2+ and Ca2+-activated Cl− current dynamics: insights from two functionally distinct mouse exocrine cells

Giovannucci, David R, Bruce, Jason I. E, Straub, Stephen V, Arreola, Jorge, Sneyd, James, Shuttleworth, Trevor J, ...

The dynamics of Ca2+ release and Ca2+-activated Cl− currents in two related, but functionally distinct exocrine cells, were studied to gain insight into how the molecular specialization of Ca2+...

Oxidant-induced inhibition of the plasma membrane Ca2+-ATPase in pancreatic acinar cells: role of the mitochondria

Baggaley, Erin M., Elliott, Austin C., Bruce, Jason I. E.

Impairment of the normal spatiotemporal pattern of intracellular Ca2+ ([Ca2+]i) signaling, and in particular, the transition to an irreversible “Ca2+ overload” response, has been implicated in...