Jason I. Herschkowitz

The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas (2008)

Herschkowitz, Jason I, He, Xiaping, Fan, Cheng, Perou, Charles M

Abstract Introduction Breast cancers can be classified using whole genome expression into distinct subtypes that show differences in prognosis. One of these groups, the basal-like subtype, is poorly...

Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1 (2008)

Wright, Mollie H, Robles, Ana I, Herschkowitz, Jason I, Hollingshead, Melinda G, Anver, Miriam R, Perou, Charles M, ...

Abstract Background Development of therapies for patients with BRCA1 mutations has been hampered by lack of readily available in vitro and in vivo models. We recently showed that transplantation of...

Clustering microarray-derived gene lists through implicit literature relationships (2007)

Burkart, Mark F., Wren, Jonathan D., Herschkowitz, Jason I., Perou, Charles M., Garner, Harold R.

Motivation: Microarrays rapidly generate large quantities of gene expression information, but interpreting such data within a biological context is still relatively complex and laborious. New methods...

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors (2007)

Herschkowitz, Jason I, Simin, Karl, Weigman, Victor J, Mikaelian, Igor, Usary, Jerry, Hu, Zhiyuan, ...

Abstract Background Although numerous mouse models of breast carcinomas have been developed, we do not know the extent to which any faithfully represent clinically significant human phenotypes. To...

Gene expression patterns associated with p53 status in breast cancer (2006)

Troester, Melissa A, Herschkowitz, Jason I, Oh, Daniel S, He, Xiaping, Hoadley, Katherine A, Barbier, Claire S, ...

Abstract Background Breast cancer subtypes identified in genomic studies have different underlying genetic defects. Mutations in the tumor suppressor p53 occur more frequently in estrogen receptor...

BIOINFORMATICS ORIGINAL PAPER doi:10.1093/bioinformatics/btm261 Data and text mining (2006)

Mark F. Burkart, Jonathan D. Wren, Jason I. Herschkowitz, Charles M. Perou, Harold R. Garner

Clustering microarray-derived gene lists through implicit literature relationships

Gene expression patterns associated with p53 status in breast cancer

Troester, Melissa A, Herschkowitz, Jason I, Oh, Daniel S, He, Xiaping, Hoadley, Katherine A, Barbier, Claire S, ...

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors

Herschkowitz, Jason I, Simin, Karl, Weigman, Victor J, Mikaelian, Igor, Usary, Jerry, Hu, Zhiyuan, ...

Comparison of mammary tumor gene-expression profiles from thirteen murine models using microarrays and with that of human breast tumors showed that many of the defining characteristics of human...

Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1

Wright, Mollie H, Robles, Ana I, Herschkowitz, Jason I, Hollingshead, Melinda G, Anver, Miriam R, Perou, Charles M, ...

The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas

Herschkowitz, Jason I, He, Xiaping, Fan, Cheng, Perou, Charles M

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

Creighton, Chad J., Li, Xiaoxian, Landis, Melissa, Dixon, J. Michael, Neumeister, Veronique M., Sjolund, Ashley, ...

Some breast cancers have been shown to contain a small fraction of cells characterized by CD44+/CD24−/low cell-surface antigen profile that have high tumor-initiating potential. In addition, breast...