A stress signaling pathway in adipose tissue regulates hepatic insulin resistance (2008)
Sabio, Guadalupe, Das, Madhumita, Mora, Alfonso, Zhang, Zhiyou, Jun, John Y., Ko, Hwi Jin, ...
A high-fat diet causes activation of the regulatory protein c-Jun NH2-terminal kinase 1 (JNK1) and triggers development of insulin resistance. JNK1 is therefore a potential target for therapeutic...
Fernández, Ana M., Kim, Jason K., Yakar, Shoshana, Dupont, Joëlle, Hernandez-Sanchez, Catalina, Castle, Arthur L., ...
Zabolotny, Janice M., Kim, Young-Bum, Peroni, Odile D., Kim, Jason K., Pani, Michael A., Boss, Olivier, ...
Previous reports indicate that the expression and/or activity of the protein-tyrosine phosphatase (PTP) LAR are increased in insulin-responsive tissues of obese, insulin-resistant humans and rodents,...
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
Kim, Jason K., Fillmore, Jonathan J., Chen, Yan, Yu, Chunli, Moore, Irene K., Pypaert, Marc, ...
Insulin resistance in skeletal muscle and liver may play a primary role in the development of type 2 diabetes mellitus, and the mechanism by which insulin resistance occurs may be related to...
Klaman, Lori D., Boss, Olivier, Peroni, Odile D., Kim, Jason K., Martino, Jennifer L., Zabolotny, Janice M., ...
Protein-tyrosine phosphatase 1B (PTP-1B) is a major protein-tyrosine phosphatase that has been implicated in the regulation of insulin action, as well as in other signal transduction pathways. To...
Rui, Liangyou, Aguirre, Vincent, Kim, Jason K., Shulman, Gerald I., Lee, Anna, Corbould, Anne, ...
Serine/threonine phosphorylation of IRS-1 might inhibit insulin signaling, but the relevant phosphorylation sites are difficult to identify in cultured cells and to validate in isolated tissues....
Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance
Yang, Chunmei, Coker, Kenneth J., Kim, Jason K., Mora, Silvia, Thurmond, Debbie C., Davis, Ann C., ...
To investigate the physiological function of syntaxin 4 in the regulation of GLUT4 vesicle trafficking, we used homologous recombination to generate syntaxin 4–knockout mice. Homozygotic disruption...
Prevention of fat-induced insulin resistance by salicylate
Kim, Jason K., Kim, Yoon-Jung, Fillmore, Jonathan J., Chen, Yan, Moore, Irene, Lee, Jongsoon, ...
Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and may involve fat-induced activation of a serine kinase cascade involving IKK-β. To test this hypothesis, we first...
Kim, Jason K., Gimeno, Ruth E., Higashimori, Takamasa, Kim, Hyo-Jeong, Choi, Hyejeong, Punreddy, Sandhya, ...
Insulin resistance in skeletal muscle plays a major role in the development of type 2 diabetes and may be causally associated with increases in intramuscular fatty acid metabolites. Fatty acid...
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4
Kim, Jason K., Zisman, Ariel, Fillmore, Jonathan J., Peroni, Odile D., Kotani, Ko, Perret, Pascale, ...
Using cre/loxP gene targeting, transgenic mice with muscle-specific inactivation of the GLUT4 gene (muscle GLUT4 KO) were generated and shown to develop a diabetes phenotype. To determine the...
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
Gavrilova, Oksana, Marcus-Samuels, Bernice, Graham, David, Kim, Jason K., Shulman, Gerald I., Castle, Arthur L., ...
In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and hyperglycemia. This is in striking contrast to the usual association of diabetes with obesity. To understand the...
Kim, Jason K., Michael, M. Dodson, Previs, Stephen F., Peroni, Odile D., Mauvais-Jarvis, Franck, Neschen, Susanne, ...
Obesity and insulin resistance in skeletal muscle are two major factors in the pathogenesis of type 2 diabetes. Mice with muscle-specific inactivation of the insulin receptor gene (MIRKO) are...
Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARγ
Tsai, Yau-Sheng, Kim, Hyo-Jeong, Takahashi, Nobuyuki, Kim, Hyung-Suk, Hagaman, John R., Kim, Jason K., ...
Peroxisome proliferator–activated receptor γ (PPARγ), the molecular target of a class of insulin sensitizers, regulates adipocyte differentiation and lipid metabolism. A dominant negative P467L...
PKC-θ knockout mice are protected from fat-induced insulin resistance
Kim, Jason K., Fillmore, Jonathan J., Sunshine, Mary Jean, Albrecht, Bjoern, Higashimori, Takamasa, Kim, Dong-Wook, ...
Insulin resistance plays a primary role in the development of type 2 diabetes and may be related to alterations in fat metabolism. Recent studies have suggested that local accumulation of fat...
Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes
Fernández, Ana M., Kim, Jason K., Yakar, Shoshana, Dupont, Joëlle, Hernandez-Sanchez, Catalina, Castle, Arthur L., ...
Peripheral insulin resistance and impaired insulin action are the primary characteristics of type 2 diabetes. The first observable defect in this major disorder occurs in muscle, where glucose...
Zabolotny, Janice M., Kim, Young-Bum, Peroni, Odile D., Kim, Jason K., Pani, Michael A., Boss, Olivier, ...
Previous reports indicate that the expression and/or activity of the protein-tyrosine phosphatase (PTP) LAR are increased in insulin-responsive tissues of obese, insulin-resistant humans and rodents,...
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
Kim, Jason K., Fillmore, Jonathan J., Chen, Yan, Yu, Chunli, Moore, Irene K., Pypaert, Marc, ...
Insulin resistance in skeletal muscle and liver may play a primary role in the development of type 2 diabetes mellitus, and the mechanism by which insulin resistance occurs may be related to...
Klaman, Lori D., Boss, Olivier, Peroni, Odile D., Kim, Jason K., Martino, Jennifer L., Zabolotny, Janice M., ...
Protein-tyrosine phosphatase 1B (PTP-1B) is a major protein-tyrosine phosphatase that has been implicated in the regulation of insulin action, as well as in other signal transduction pathways. To...
Rui, Liangyou, Aguirre, Vincent, Kim, Jason K., Shulman, Gerald I., Lee, Anna, Corbould, Anne, ...
Serine/threonine phosphorylation of IRS-1 might inhibit insulin signaling, but the relevant phosphorylation sites are difficult to identify in cultured cells and to validate in isolated tissues....
Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance
Yang, Chunmei, Coker, Kenneth J., Kim, Jason K., Mora, Silvia, Thurmond, Debbie C., Davis, Ann C., ...
To investigate the physiological function of syntaxin 4 in the regulation of GLUT4 vesicle trafficking, we used homologous recombination to generate syntaxin 4–knockout mice. Homozygotic disruption...
Prevention of fat-induced insulin resistance by salicylate
Kim, Jason K., Kim, Yoon-Jung, Fillmore, Jonathan J., Chen, Yan, Moore, Irene, Lee, Jongsoon, ...
Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and may involve fat-induced activation of a serine kinase cascade involving IKK-β. To test this hypothesis, we first...
Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes
Fernández, Ana M., Kim, Jason K., Yakar, Shoshana, Dupont, Joëlle, Hernandez-Sanchez, Catalina, Castle, Arthur L., ...
Peripheral insulin resistance and impaired insulin action are the primary characteristics of type 2 diabetes. The first observable defect in this major disorder occurs in muscle, where glucose...
Kim, Jason K., Gimeno, Ruth E., Higashimori, Takamasa, Kim, Hyo-Jeong, Choi, Hyejeong, Punreddy, Sandhya, ...
Insulin resistance in skeletal muscle plays a major role in the development of type 2 diabetes and may be causally associated with increases in intramuscular fatty acid metabolites. Fatty acid...
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4
Kim, Jason K., Zisman, Ariel, Fillmore, Jonathan J., Peroni, Odile D., Kotani, Ko, Perret, Pascale, ...
Using cre/loxP gene targeting, transgenic mice with muscle-specific inactivation of the GLUT4 gene (muscle GLUT4 KO) were generated and shown to develop a diabetes phenotype. To determine the...
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
Gavrilova, Oksana, Marcus-Samuels, Bernice, Graham, David, Kim, Jason K., Shulman, Gerald I., Castle, Arthur L., ...
In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and hyperglycemia. This is in striking contrast to the usual association of diabetes with obesity. To understand the...
Kim, Jason K., Michael, M. Dodson, Previs, Stephen F., Peroni, Odile D., Mauvais-Jarvis, Franck, Neschen, Susanne, ...
Obesity and insulin resistance in skeletal muscle are two major factors in the pathogenesis of type 2 diabetes. Mice with muscle-specific inactivation of the insulin receptor gene (MIRKO) are...
Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARγ
Tsai, Yau-Sheng, Kim, Hyo-Jeong, Takahashi, Nobuyuki, Kim, Hyung-Suk, Hagaman, John R., Kim, Jason K., ...
Peroxisome proliferator–activated receptor γ (PPARγ), the molecular target of a class of insulin sensitizers, regulates adipocyte differentiation and lipid metabolism. A dominant negative P467L...
PKC-θ knockout mice are protected from fat-induced insulin resistance
Kim, Jason K., Fillmore, Jonathan J., Sunshine, Mary Jean, Albrecht, Bjoern, Higashimori, Takamasa, Kim, Dong-Wook, ...
Insulin resistance plays a primary role in the development of type 2 diabetes and may be related to alterations in fat metabolism. Recent studies have suggested that local accumulation of fat...
Choi, Cheol Soo, Fillmore, Jonathan J., Kim, Jason K., Liu, Zhen-Xiang, Kim, Sheene, Collier, Emily F., ...
Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and is strongly associated with obesity. Increased concentrations of intracellular fatty acid metabolites have been...
Hurov, Jonathan B., Huang, Mei, White, Lynn S., Lennerz, Jochen, Choi, Cheol Soo, Cho, You-Ree, ...
Obesity is a major factor central to the development of insulin resistance and type 2 diabetes. The identification and characterization of genes involved in regulation of adiposity, insulin...
Delibegovic, Mirela, Bence, Kendra K., Mody, Nimesh, Hong, Eun-Gyoung, Ko, Hwi Jin, Kim, Jason K., ...
Obesity and type 2 diabetes are characterized by insulin resistance. Mice lacking the protein-tyrosine phosphatase PTP1B in all tissues are hypersensitive to insulin but also have diminished fat...
Txnip balances metabolic and growth signaling via PTEN disulfide reduction
Hui, Simon T. Y., Andres, Allen M., Miller, Amber K., Spann, Nathanael J., Potter, Douglas W., Post, Noah M., ...
Thioredoxin-interacting protein (Txnip) inhibits thioredoxin NADPH-dependent reduction of protein disulfides. Total Txnip knockout (TKO) mice adapted inappropriately to prolonged fasting by shifting...
Hinoi, Eiichi, Gao, Nan, Jung, Dae Young, Yadav, Vijay, Yoshizawa, Tatsuya, Myers, Martin G., ...
The osteoblast-secreted molecule osteocalcin favors insulin secretion, but how this function is regulated in vivo by extracellular signals is for now unknown. In this study, we show that leptin,...
DeAngelis, Anthony M., Heinrich, Garrett, Dai, Tong, Bowman, Thomas A., Patel, Payal R., Lee, Sang Jun, ...
OBJECTIVE—Liver-specific inactivation of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) by a dominant-negative transgene (l-SACC1 mice) impaired insulin clearance, caused...
Yoshizawa, Tatsuya, Hinoi, Eiichi, Jung, Dae Young, Kajimura, Daisuke, Ferron, Mathieu, Seo, Jin, ...
The recent demonstration that osteoblasts have a role in controlling energy metabolism suggests that they express cell-specific regulatory genes involved in this process. Activating transcription...