Selective Ligand Recognition by a Diversity-Generating Retroelement Variable Protein (2008)
Jason L. Miller, Johanne Le Coq, Asher Hodes, Roman Barbalat, Jeff F. Miller, Partho Ghosh
Diversity-generating retroelements (DGRs) recognize novel ligands through massive protein sequence variation, a property shared uniquely with the adaptive immune response. Little is known about how...
Only a few protein folds are known to tolerate massive sequence variation for the sake of binding diversity. The immunoglobulin (Ig)-fold found in the structural design of antibodies and T-cell...
Thesis (Ph. D.)--University of California, San Diego, 2006.
Typescript.
Selective Ligand Recognition by a Diversity-Generating Retroelement Variable Protein
Miller, Jason L, Coq, Johanne Le, Hodes, Asher, Barbalat, Roman, Miller, Jeff F, Ghosh, Partho
Diversity-generating retroelements (DGRs) recognize novel ligands through massive protein sequence variation, a property shared uniquely with the adaptive immune response. Little is known about how...