Jason Nigel John Peart

Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts. (2008)

Peart, Jason Nigel John, Gross, Eric R., Reichelt, Melissa Elizabeth, Hsu, Anna, Headrick, John Patrick, Gross, Garrett J.

The temporal properties of kappa-opioid receptor (κ-OR) mediated cardioprotection are less well characterised than delta-opioid receptor (δ-OR) responses. This study was aimed at delineating the...

Sustained cardioprotection: Exploring unconventional modalities. (2008)

Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts. (2008)

Yes

Peart, Jason Nigel John, Gross, Eric R., Reichelt, Melissa Elizabeth, Hsu, Anna, Headrick, John Patrick, Gross, Garrett J.

The temporal properties of kappa-opioid receptor (κ-OR) mediated cardioprotection are less well characterised than delta-opioid receptor (δ-OR) responses. This study was aimed at delineating the...

Sustained cardioprotection: Exploring unconventional modalities. (2008)

Cardiac and coronary function in the Langendorff-perfused mouse heart model (2008)

Reichelt, Melissa Elizabeth, Willems, Laura, Hack, Benjamin A., Peart, Jason Nigel John, Headrick, John Patrick

The Langendorff mouse heart model is widely employed in studies of myocardial function and responses to injury (e.g. ischaemia). Nonetheless, marked variability exists in its preparation and...

P2 purinoceptor-mediated cardioprotection in ischemic-reperfused mouse heart (2007)

Wee, Shirley, Peart, Jason Nigel John, Headrick, John Patrick

Yes

Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection (2007)

Peart, Jason Nigel John, Gross, Eric R., Headrick, John Patrick, Gross, Garretta J.

Yes

Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine (2007)

Reichelt, Melissa Elizabeth, Willems, Laura, Peart, Jason Nigel John, Ashton, Kevin John, Matherne, G. Paul, Blackburn, Michael R., ...

Yes

Adenosinergic cardioprotection: multiple receptors, multiple pathways (2007)

Genetic modulation of adenosine receptor function and adenosine handling in murine hearts: insights and issues (2007)

Yes

Ashton, Kevin John, Peart, Jason Nigel John, Morrison, R. Ray, Matherne, G. Paul, Blackburn, Michael R., Headrick, John Patrick

Yes

Opioids and myocardial reperfusion injury. (2007)

Gross, G.J., Peart, Jason Nigel John

Yes

P2 purinoceptor-mediated cardioprotection in ischemic-reperfused mouse heart (2007)

Wee, Shirley, Peart, Jason Nigel John, Headrick, John Patrick

Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection (2007)

Peart, Jason Nigel John, Gross, Eric R., Headrick, John Patrick, Gross, Garretta J.

Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine (2007)

Reichelt, Melissa Elizabeth, Willems, Laura, Peart, Jason Nigel John, Ashton, Kevin John, Matherne, G. Paul, Blackburn, Michael R., ...

Adenosinergic cardioprotection: multiple receptors, multiple pathways (2007)

Genetic modulation of adenosine receptor function and adenosine handling in murine hearts: insights and issues (2007)

Ashton, Kevin John, Peart, Jason Nigel John, Morrison, R. Ray, Matherne, G. Paul, Blackburn, Michael R., Headrick, John Patrick

Opioids and myocardial reperfusion injury. (2007)

Gross, G.J., Peart, Jason Nigel John

P2 purinoceptor-mediated cardioprotection in ischemic-reperfused mouse heart (2007)

Wee, Shirley, Peart, Jason Nigel John, Headrick, John Patrick

Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection (2007)

Peart, Jason Nigel John, Gross, Eric R., Headrick, John Patrick, Gross, Garretta J.

Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine (2007)

Reichelt, Melissa Elizabeth, Willems, Laura, Peart, Jason Nigel John, Ashton, Kevin John, Matherne, G. Paul, Blackburn, Michael R., ...

Adenosinergic cardioprotection: multiple receptors, multiple pathways (2007)

Genetic modulation of adenosine receptor function and adenosine handling in murine hearts: insights and issues (2007)

Ashton, Kevin John, Peart, Jason Nigel John, Morrison, R. Ray, Matherne, G. Paul, Blackburn, Michael R., Headrick, John Patrick

Opioids and myocardial reperfusion injury. (2007)

Gross, G.J., Peart, Jason Nigel John

Trigger and mediation phase of chronic opioid preconditioning are mediated via divergent pathways (2006)

Peart, Jason Nigel John, Headrick, John Patrick, Gross, Garrett J.

Chronic opioid preconditioning confers a pronounced and prolonged cardioprotective phenotype, existing at least 24 hours beyond opioid drug withdrawal. This study aims to delineate both the trigger...

Trigger and mediation phase of chronic opioid preconditioning are mediated via divergent pathways (2006)

Peart, Jason Nigel John, Headrick, John Patrick, Gross, Garrett J.

Chronic opioid preconditioning confers a pronounced and prolonged cardioprotective phenotype, existing at least 24 hours beyond opioid drug withdrawal. This study aims to delineate both the trigger...

Cardioprotective effects of acute and chronic opioid treatment are mediated via different signaling pathways (2006)

Cardioprotective effects of acute and chronic opioid treatment are mediated via different signaling pathways (2006)

A 5-day exposure to morphine exerts a profound cardioprotective phenotype in murine hearts. In the present study, we examined mechanisms by which morphine generates this effect, exploring the roles...

A3 adenosine receptor-mediated protection of the ischemic heart (2005)

A 5-day exposure to morphine exerts a profound cardioprotective phenotype in murine hearts. In the present study, we examined mechanisms by which morphine generates this effect, exploring the roles...

A3 adenosine receptor-mediated protection of the ischemic heart (2005)

The A3 adenosine receptor (A3AR) is attributed with multiple beneficial actions in ischemic reperfused myocardium, including modulation of oncotic and apoptotic cell death and enhancement of...

A3 adenosine receptor-mediated protection of the ischemic heart (2005)

The A3 adenosine receptor (A3AR) is attributed with multiple beneficial actions in ischemic reperfused myocardium, including modulation of oncotic and apoptotic cell death and enhancement of...

A3 adenosine receptor-mediated protection of the ischemic heart (2005)

The A3 adenosine receptor (A3AR) is attributed with multiple beneficial actions in ischemic reperfused myocardium, including modulation of oncotic and apoptotic cell death and enhancement of...

Opioid-induced preconditioning: recent advances and future perspectives (2005)

The A3 adenosine receptor (A3AR) is attributed with multiple beneficial actions in ischemic–reperfused myocardium, including modulation of oncotic and apoptotic cell death and enhancement of...

Peart, Jason Nigel John, Gross, Eric R., Gross, Garrett J.

Opioids, named by Acheson [Martin, W.R., 1967. Opioid antagonists.Pharmacol Rev. 19, 463–521] for compounds with morphine-like actions despite chemically distinct structures, have received much...

Cardioprotection following adenosine kinase inhibition in rat hearts (2005)

Sarcolemmal KATP channel triggers delayed ischemic preconditioning in rats (2005)

Adenosine kinase phosphorylates adenosine to AMP, the primary pathway for adenosine metabolism under basal conditions. Inhibition of adenosine kinase results in a site–specific increase in...

Patel, Hemal H., Gross, Eric R., Peart, Jason Nigel John, Hsu, Anna K., Gross, Garrett J.

Previous work from our laboratory has shown that the sarcolemmal KATP channel (sKATP) is required as a trigger for delayed cardioprotection upon exogenous opioid administration. We also established...

Extending the cardioprotective window using a novel δ-opioid agonist fentanyl isothiocyanate via the PI3-kinase pathway (2005)

Gross, Eric R., Peart, Jason Nigel John, Hsu, Anna K., Auchampach, John A., Gross, Garrett J.

Selective δ-opioid agonists produce delayed cardioprotection that lasts for 24–48 h in rats; however, the maximum length of the cardioprotective window is unclear. In this study, we attempted to...

Opioid-induced preconditioning: recent advances and future perspectives (2005)

Peart, Jason Nigel John, Gross, Eric R., Gross, Garrett J.

Opioids, named by Acheson [Martin, W.R., 1967. Opioid antagonists.Pharmacol Rev. 19, 463–521] for compounds with morphine-like actions despite chemically distinct structures, have received much...

Cardioprotection following adenosine kinase inhibition in rat hearts (2005)

Sarcolemmal KATP channel triggers delayed ischemic preconditioning in rats (2005)

Adenosine kinase phosphorylates adenosine to AMP, the primary pathway for adenosine metabolism under basal conditions. Inhibition of adenosine kinase results in a site–specific increase in...

Patel, Hemal H., Gross, Eric R., Peart, Jason Nigel John, Hsu, Anna K., Gross, Garrett J.

Previous work from our laboratory has shown that the sarcolemmal KATP channel (sKATP) is required as a trigger for delayed cardioprotection upon exogenous opioid administration. We also established...

Extending the cardioprotective window using a novel δ-opioid agonist fentanyl isothiocyanate via the PI3-kinase pathway (2005)

Gross, Eric R., Peart, Jason Nigel John, Hsu, Anna K., Auchampach, John A., Gross, Garrett J.

Selective δ-opioid agonists produce delayed cardioprotection that lasts for 24–48 h in rats; however, the maximum length of the cardioprotective window is unclear. In this study, we attempted to...

Cytochrome P450 ω-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel (2004)

Gross, Eric R., Nithipatikom, Kasem, Hsu, Anna K., Peart, Jason Nigel John, Falck, John R., Campbell, William B., ...

Inhibition of 20-hydroxyeicosatrienoic acid (20-HETE), by pretreatment with pharmacological inhibitors of cytochrome P450 (CYP) ω-hydroxylase, has been shown to reduce infarct size in canines when...

Cytochrome P450 ω-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel (2004)

Gross, Eric R., Nithipatikom, Kasem, Hsu, Anna K., Peart, Jason Nigel John, Falck, John R., Campbell, William B., ...

Inhibition of 20-hydroxyeicosatrienoic acid (20-HETE), by pretreatment with pharmacological inhibitors of cytochrome P450 (CYP) ω-hydroxylase, has been shown to reduce infarct size in canines when...

Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)

Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Lankford, Amy R., Matherne, G. Paul, Grimmond, Sean, ...

Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A1 adenosine receptors (A1ARs). Methods: cDNA...

Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine (2003)

Peart, Jason Nigel John, Willems, Laura, Headrick, John Patrick

Yes

Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression (2003)

Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul

The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...

Evidence of transcriptional and translational components in anti-ischemic effects of adenosine (2003)

Headrick, John Patrick, Peart, Jason Nigel John, Holmgren, Kirsty, Ashton, Kevin John

Yes

Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects (2003)

Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)

Objective: ±1-Adrenergic receptors (ARs) are known mediators of a positive inotropy in the heart, which may play even more important roles in heart disease. Due to a lack of sufficiently selective...

Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Lankford, Amy R., Matherne, G. Paul, Grimmond, Sean, ...

Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A1 adenosine receptors (A1ARs). Methods: cDNA...

Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine (2003)

Peart, Jason Nigel John, Willems, Laura, Headrick, John Patrick

Yes

Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression (2003)

Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul

The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...

Evidence of transcriptional and translational components in anti-ischemic effects of adenosine (2003)

Headrick, John Patrick, Peart, Jason Nigel John, Holmgren, Kirsty, Ashton, Kevin John

Yes

Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects (2003)

KATP channels and myocardial preconditioning: an update. (2003)

Objective: ±1-Adrenergic receptors (ARs) are known mediators of a positive inotropy in the heart, which may play even more important roles in heart disease. Due to a lack of sufficiently selective...

Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors. (2003)

Yes

KATP channels and myocardial preconditioning: an update. (2003)

Yes

Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors. (2003)

Yes

Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)

Yes

Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Lankford, Amy R., Matherne, G. Paul, Grimmond, Sean, ...

Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A1 adenosine receptors (A1ARs). Methods: cDNA...

Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine (2003)

Peart, Jason Nigel John, Willems, Laura, Headrick, John Patrick

Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression (2003)

Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul

The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...

Evidence of transcriptional and translational components in anti-ischemic effects of adenosine (2003)

Headrick, John Patrick, Peart, Jason Nigel John, Holmgren, Kirsty, Ashton, Kevin John

Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects (2003)

KATP channels and myocardial preconditioning: an update. (2003)

Objective: ±1-Adrenergic receptors (ARs) are known mediators of a positive inotropy in the heart, which may play even more important roles in heart disease. Due to a lack of sufficiently selective...

Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors. (2003)

Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)

Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Lankford, Amy R., Matherne, G. Paul, Grimmond, Sean, ...

Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A1 adenosine receptors (A1ARs). Methods: cDNA...

Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine (2003)

Peart, Jason Nigel John, Willems, Laura, Headrick, John Patrick

Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression (2003)

Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul

The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...

Evidence of transcriptional and translational components in anti-ischemic effects of adenosine (2003)

Headrick, John Patrick, Peart, Jason Nigel John, Holmgren, Kirsty, Ashton, Kevin John

Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects (2003)

KATP channels and myocardial preconditioning: an update. (2003)

Objective: ±1-Adrenergic receptors (ARs) are known mediators of a positive inotropy in the heart, which may play even more important roles in heart disease. Due to a lack of sufficiently selective...

Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors. (2003)

Adenosine mediated cardioprotection in ischemic reperfused mouse heart. (2002)

Peart, Jason Nigel John, Zatta, Amanda Jane, Linden, Joel, Matherne, G. Paul, Headrick, John Patrick

Yes

Effects of A3 adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart (2002)

Harrison, Glenn, Cerniway, Rachael J, Peart, Jason Nigel John, Berr, Stuart S, Ashton, Kevin John, Regan, Sara, ...

Objectives: To characterize effects of A3 adenosine receptor (A3AR) activation and gene knock-out on responses to ischemia-reperfusion in mouse heart. Methods: Perfused hearts from wild-type and A3AR...

Adenosine mediated cardioprotection in ischemic reperfused mouse heart. (2002)

Peart, Jason Nigel John, Zatta, Amanda Jane, Linden, Joel, Matherne, G. Paul, Headrick, John Patrick

Yes

Effects of A3 adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart (2002)

Harrison, Glenn, Cerniway, Rachael J, Peart, Jason Nigel John, Berr, Stuart S, Ashton, Kevin John, Regan, Sara, ...

Objectives: To characterize effects of A3 adenosine receptor (A3AR) activation and gene knock-out on responses to ischemia-reperfusion in mouse heart. Methods: Perfused hearts from wild-type and A3AR...

Adenosine mediated cardioprotection in ischemic reperfused mouse heart. (2002)

Peart, Jason Nigel John, Zatta, Amanda Jane, Linden, Joel, Matherne, G. Paul, Headrick, John Patrick

Effects of A3 adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart (2002)

Harrison, Glenn, Cerniway, Rachael J, Peart, Jason Nigel John, Berr, Stuart S, Ashton, Kevin John, Regan, Sara, ...

Objectives: To characterize effects of A3 adenosine receptor (A3AR) activation and gene knock-out on responses to ischemia-reperfusion in mouse heart. Methods: Perfused hearts from wild-type and A3AR...

Adenosine mediated cardioprotection in ischemic reperfused mouse heart. (2002)

Peart, Jason Nigel John, Zatta, Amanda Jane, Linden, Joel, Matherne, G. Paul, Headrick, John Patrick

Effects of A3 adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart (2002)

Harrison, Glenn, Cerniway, Rachael J, Peart, Jason Nigel John, Berr, Stuart S, Ashton, Kevin John, Regan, Sara, ...

Objectives: To characterize effects of A3 adenosine receptor (A3AR) activation and gene knock-out on responses to ischemia-reperfusion in mouse heart. Methods: Perfused hearts from wild-type and A3AR...

Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart (2001)

Peart, Jason Nigel John, Matherne, Paul, Cerniway, Rachel, Headrick, John Patrick

Objectives: To characterize the anti-ischemic' effects of adenosine metabolism inhibition in ischemic reperfused myocardium. Methods: Perfused C57/B16 mouse hearts were subjected to 20 min ischemia...

5'-Adenosine monophosphate and adenosine metabolism, and adenosine responses in mouse, rat and guinea pig heart (2001)

Headrick, John Patrick, Peart, Jason Nigel John, Hack, Benjamin Daniel Noel, Garnham, Bronwyn Gaye, Matherne, G Paul

We examined myocardial 52-adenosine monophosphate (52-AMP) catabolism, adenosine salvage and adenosine responses in perfused guinea pig, rat and mouse heart. MV2 increased from 71±8 ¼l O2/min per g...

Functional properties and responses to ischemia reperfusion in Langendorff perfused mouse hearts (2001)

Headrick, John Patrick, Peart, Jason Nigel John, Hack, Benjamin Daniel Noel, Zatta, Amanda Jane, Matherne, G Paul

Yes

Acute but not chronic caffeine impairs functional responses to ischaemia-reperfusion in rat isolated perfused heart. (2001)

Rose'Meyer, Roselyn, Headrick, John Patrick, Peart, Jason Nigel John, Harrison, Glenn, Garnham, Bronwyn Gaye, Willis, Roger, ...

1. The effect of acute (50 ¼mol/L) and chronic (0.06% in drinking water for 14 days) caffeine on the response to ischaemia reperfusion was studied in Wistar rat isolated perfused hearts.2. Neither...

Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart (2001)

Peart, Jason Nigel John, Matherne, Paul, Cerniway, Rachel, Headrick, John Patrick

Objectives: To characterize the anti-ischemic' effects of adenosine metabolism inhibition in ischemic reperfused myocardium. Methods: Perfused C57/B16 mouse hearts were subjected to 20 min ischemia...

5'-Adenosine monophosphate and adenosine metabolism, and adenosine responses in mouse, rat and guinea pig heart (2001)

Headrick, John Patrick, Peart, Jason Nigel John, Hack, Benjamin Daniel Noel, Garnham, Bronwyn Gaye, Matherne, G Paul

We examined myocardial 52-adenosine monophosphate (52-AMP) catabolism, adenosine salvage and adenosine responses in perfused guinea pig, rat and mouse heart. MV2 increased from 71±8 ¼l O2/min per g...

Functional properties and responses to ischemia reperfusion in Langendorff perfused mouse hearts (2001)

Headrick, John Patrick, Peart, Jason Nigel John, Hack, Benjamin Daniel Noel, Zatta, Amanda Jane, Matherne, G Paul

Yes

Acute but not chronic caffeine impairs functional responses to ischaemia-reperfusion in rat isolated perfused heart. (2001)

Rose'Meyer, Roselyn, Headrick, John Patrick, Peart, Jason Nigel John, Harrison, Glenn, Garnham, Bronwyn Gaye, Willis, Roger

1. The effect of acute (50 ¼mol/L) and chronic (0.06% in drinking water for 14 days) caffeine on the response to ischaemia reperfusion was studied in Wistar rat isolated perfused hearts. 2. Neither...

Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart (2001)

Peart, Jason Nigel John, Matherne, Paul, Cerniway, Rachel, Headrick, John Patrick

Objectives: To characterize the anti-ischemic' effects of adenosine metabolism inhibition in ischemic reperfused myocardium. Methods: Perfused C57/B16 mouse hearts were subjected to 20 min ischemia...

5'-Adenosine monophosphate and adenosine metabolism, and adenosine responses in mouse, rat and guinea pig heart (2001)

Headrick, John Patrick, Peart, Jason Nigel John, Hack, Benjamin Daniel Noel, Garnham, Bronwyn Gaye, Matherne, G Paul

We examined myocardial 52-adenosine monophosphate (52-AMP) catabolism, adenosine salvage and adenosine responses in perfused guinea pig, rat and mouse heart. MV2 increased from 71±8 ¼l O2/min per g...

Functional properties and responses to ischemia reperfusion in Langendorff perfused mouse hearts (2001)

Headrick, John Patrick, Peart, Jason Nigel John, Hack, Benjamin Daniel Noel, Zatta, Amanda Jane, Matherne, G Paul

Acute but not chronic caffeine impairs functional responses to ischaemia-reperfusion in rat isolated perfused heart. (2001)

Rose'Meyer, Roselyn, Headrick, John Patrick, Peart, Jason Nigel John, Harrison, Glenn, Garnham, Bronwyn Gaye, Willis, Roger

1. The effect of acute (50 ¼mol/L) and chronic (0.06% in drinking water for 14 days) caffeine on the response to ischaemia reperfusion was studied in Wistar rat isolated perfused hearts. 2. Neither...

Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart (2001)

Peart, Jason Nigel John, Matherne, Paul, Cerniway, Rachel, Headrick, John Patrick

Objectives: To characterize the anti-ischemic' effects of adenosine metabolism inhibition in ischemic reperfused myocardium. Methods: Perfused C57/B16 mouse hearts were subjected to 20 min ischemia...

5'-Adenosine monophosphate and adenosine metabolism, and adenosine responses in mouse, rat and guinea pig heart (2001)

Headrick, John Patrick, Peart, Jason Nigel John, Hack, Benjamin Daniel Noel, Garnham, Bronwyn Gaye, Matherne, G Paul

We examined myocardial 52-adenosine monophosphate (52-AMP) catabolism, adenosine salvage and adenosine responses in perfused guinea pig, rat and mouse heart. MV2 increased from 71±8 ¼l O2/min per g...

Functional properties and responses to ischemia reperfusion in Langendorff perfused mouse hearts (2001)

Headrick, John Patrick, Peart, Jason Nigel John, Hack, Benjamin Daniel Noel, Zatta, Amanda Jane, Matherne, G Paul

Acute but not chronic caffeine impairs functional responses to ischaemia-reperfusion in rat isolated perfused heart. (2001)

Rose'Meyer, Roselyn, Headrick, John Patrick, Peart, Jason Nigel John, Harrison, Glenn, Garnham, Bronwyn Gaye, Willis, Roger

1. The effect of acute (50 ¼mol/L) and chronic (0.06% in drinking water for 14 days) caffeine on the response to ischaemia reperfusion was studied in Wistar rat isolated perfused hearts. 2. Neither...

Transgenic overexpression of cardiac A1 adenosine receptors mimics ischemic preconditioning (2000)

Peart, Jason Nigel John, Headrick, John Patrick, Morrison, RR, Jones, R, Byford, AM, Stell, AR.

Yes

Intrinsic activation of A1 adenosine receptors during ischemia and repurfusion improves ischemic tolerance (2000)

Transgenic overexpression of cardiac A1 adenosine receptors mimics ischemic preconditioning (2000)

Yes

Peart, Jason Nigel John, Headrick, John Patrick, Morrison, RR, Jones, R, Byford, AM, Stell, AR.

Yes

Intrinsic activation of A1 adenosine receptors during ischemia and repurfusion improves ischemic tolerance (2000)