Jason Pyrdol

Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic protein

Gauthier, Laurent, Smith, Kathrine J., Pyrdol, Jason, Kalandadze, Avtandil, Strominger, Jack L., Wiley, Don C., ...

HLA-DR2 is associated with susceptibility to multiple sclerosis (MS). A peptide from human myelin basic protein (MBP, residues 85–99) was previously found to bind to purified HLA-DR2 (DRA,...

Stoichiometry of the T-cell receptor–CD3 complex and key intermediates assembled in the endoplasmic reticulum

Call, Matthew E, Pyrdol, Jason, Wucherpfennig, Kai W

The T-cell receptor (TCR)–CD3 complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. Models of different stoichiometry and valency...

Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis

Reddy, Jayagopala, Illes, Zsolt, Zhang, Xingmin, Encinas, Jeffrey, Pyrdol, Jason, Nicholson, Lindsay, ...

SJL mice are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) peptide 139-151, whereas H-2 congenic B10.S mice are resistant....

Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic protein

Gauthier, Laurent, Smith, Kathrine J., Pyrdol, Jason, Kalandadze, Avtandil, Strominger, Jack L., Wiley, Don C., ...

HLA-DR2 is associated with susceptibility to multiple sclerosis (MS). A peptide from human myelin basic protein (MBP, residues 85–99) was previously found to bind to purified HLA-DR2 (DRA,...

Stoichiometry of the T-cell receptor–CD3 complex and key intermediates assembled in the endoplasmic reticulum

Call, Matthew E, Pyrdol, Jason, Wucherpfennig, Kai W

The T-cell receptor (TCR)–CD3 complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. Models of different stoichiometry and valency...

Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis

Reddy, Jayagopala, Illes, Zsolt, Zhang, Xingmin, Encinas, Jeffrey, Pyrdol, Jason, Nicholson, Lindsay, ...

SJL mice are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) peptide 139-151, whereas H-2 congenic B10.S mice are resistant....

Visualization of Myelin Basic Protein (Mbp) T Cell Epitopes in Multiple Sclerosis Lesions Using a Monoclonal Antibody Specific for the Human Histocompatibility Leukocyte Antigen (Hla)-Dr2–Mbp 85–99 Complex

Krogsgaard, Michelle, Wucherpfennig, Kai W., Canella, Barbara, Hansen, Bjarke E., Svejgaard, Arne, Pyrdol, Jason, ...

Susceptibility to multiple sclerosis (MS) is associated with the human histocompatibility leukocyte antigen (HLA)-DR2 haplotype, suggesting that major histocompatibility complex class II–restricted...

Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein

Smith, Kathrine J., Pyrdol, Jason, Gauthier, Laurent, Wiley, Don C., Wucherpfennig, Kai W.

Susceptibility to multiple sclerosis is associated with the human histocompatibility leukocyte antigen (HLA)-DR2 (DRB1*1501) haplotype. The structure of HLA-DR2 was determined with a bound peptide...