Jaunius Urbonavičius

Improvement of reading frame maintenance is a common function for several tRNA modifications

Urbonavičius, Jaunius, Qian, Qiang, Durand, Jérôme M.B., Hagervall, Tord G., Björk, Glenn R.

Transfer RNAs from all organisms contain many modified nucleosides. Their vastly different chemical structures, their presence in different tRNAs, their occurrence in different locations in tRNA and...

Three Modifications in the D and T Arms of tRNA Influence Translation in Escherichia coli and Expression of Virulence Genes in Shigella flexneri

Urbonavičius, Jaunius, Durand, Jérôme M. B., Björk, Glenn R.

The modified nucleosides 2′-O-methylguanosine, present at position 18 (Gm18), 5-methyluridine, present at position 54 (m5U54), and pseudouridine, present at position 55 (Ψ55), are located in the D...

Identification of a novel gene encoding a flavin-dependent tRNA:m5U methyltransferase in bacteria—evolutionary implications

Urbonavičius, Jaunius, Skouloubris, Stéphane, Myllykallio, Hannu, Grosjean, Henri

Formation of 5-methyluridine (ribothymidine) at position 54 of the T-psi loop of tRNA is catalyzed by site-specific tRNA methyltransferases (tRNA:m5U-54 MTase). In all Eukarya and many Gram-negative...

Improvement of reading frame maintenance is a common function for several tRNA modifications

Urbonavičius, Jaunius, Qian, Qiang, Durand, Jérôme M.B., Hagervall, Tord G., Björk, Glenn R.

Transfer RNAs from all organisms contain many modified nucleosides. Their vastly different chemical structures, their presence in different tRNAs, their occurrence in different locations in tRNA and...

Three Modifications in the D and T Arms of tRNA Influence Translation in Escherichia coli and Expression of Virulence Genes in Shigella flexneri

Urbonavičius, Jaunius, Durand, Jérôme M. B., Björk, Glenn R.

The modified nucleosides 2′-O-methylguanosine, present at position 18 (Gm18), 5-methyluridine, present at position 54 (m5U54), and pseudouridine, present at position 55 (Ψ55), are located in the D...

Identification of a novel gene encoding a flavin-dependent tRNA:m5U methyltransferase in bacteria—evolutionary implications

Urbonavičius, Jaunius, Skouloubris, Stéphane, Myllykallio, Hannu, Grosjean, Henri

Formation of 5-methyluridine (ribothymidine) at position 54 of the T-psi loop of tRNA is catalyzed by site-specific tRNA methyltransferases (tRNA:m5U-54 MTase). In all Eukarya and many Gram-negative...

Amino acid residues of the Escherichia coli tRNA(m5U54)methyltransferase (TrmA) critical for stability, covalent binding of tRNA and enzymatic activity

Urbonavičius, Jaunius, Jäger, Gunilla, Björk, Glenn R.

The Escherichia coli trmA gene encodes the tRNA(m5U54)methyltransferase, which catalyses the formation of m5U54 in tRNA. During the synthesis of m5U54, a covalent 62-kDa TrmA-tRNA intermediate is...