Javier M. Di Noia

Active nuclear import and cytoplasmic retention of activation-induced deaminase (2009)

Patenaude, Anne-Marie, Orthwein, Alexandre, Hu, Yi, Campo, Vanina A., Kavli, Bodil, Buschiazzo, Alejandro, ...

The enzyme activation-induced deaminase (AID) triggers antibody diversification in B cells by catalyzing deamination and consequently mutation of immunoglobulin genes. To minimize off-target...

Trypanosoma cruzi surface mucin TcMuc-e2 expressed on higher eukaryotic cells induces human T cell anergy, which is reversible (2002)

Argibay, Pablo F., Di Noia, Javier M., Hidalgo, Alejandra, Mocetti, Esteban, Barbich, Mariana, Lorenti, Alicia S., ...

Chagas’ disease is a chronic, debilitating, multisystemic disorder that affects millions of people in Latin America. The protozoan parasite Trypanosoma cruzi, the etiological agent of Chagas’...

Gene Discovery in the Freshwater Fish Parasite Trypanosoma carassii: Identification of trans-Sialidase-Like and Mucin-Like Genes

Agüero, Fernán, Campo, Vanina, Cremona, Laura, Jäger, Adriana, Di Noia, Javier M., Overath, Peter, ...

A total of 1,921 expressed sequence tags (ESTs) were obtained from bloodstream trypomastigotes of Trypanosoma carassii, a parasite of economic importance due to its high prevalence in fish farms....

Gene Discovery in the Freshwater Fish Parasite Trypanosoma carassii: Identification of trans-Sialidase-Like and Mucin-Like Genes

Agüero, Fernán, Campo, Vanina, Cremona, Laura, Jäger, Adriana, Di Noia, Javier M., Overath, Peter, ...

A total of 1,921 expressed sequence tags (ESTs) were obtained from bloodstream trypomastigotes of Trypanosoma carassii, a parasite of economic importance due to its high prevalence in fish farms....

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair

Di Noia, Javier M, Rada, Cristina, Neuberger, Michael S

Mammals harbour multiple enzymes capable of excising uracil from DNA, although their distinct physiological roles remain uncertain. One of them (UNG) plays a critical role in antibody gene...

A Trypanosoma cruzi Small Surface Molecule Provides the First Immunological Evidence that Chagas' Disease Is Due to a Single Parasite Lineage

Di Noia, Javier M., Buscaglia, Carlos A., De Marchi, Claudia R., Almeida, Igor C., Frasch, Alberto C.C.

Chagas' disease is a major health and economic problem caused by the protozoan Trypanosoma cruzi. Multiple independently evolving clones define a complex parasite population that can be arranged into...

Dependence of antibody gene diversification on uracil excision

Di Noia, Javier M., Williams, Gareth T., Chan, Denice T.Y., Buerstedde, Jean-Marie, Baldwin, Geoff S., Neuberger, Michael S.

Activation-induced deaminase (AID) catalyses deamination of deoxycytidine to deoxyuridine within immunoglobulin loci, triggering pathways of antibody diversification that are largely dependent on...