Unsung Hero Robert C. Gallo (2009)
Abbadessa, Giovanni, Accolla, Roberto, Aiuti, Fernando, Albini, Adriana, Aldovini, Anna, Alfano, Massimo, ...
Awarding the Nobel prize in physiology or medicine to Francoise Barré-Sinoussi and Luc Montagnier for the discovery of HIV-1, the causative agent of AIDS, is timely given the harm that the virus...
Estimation of low frequency antigen-presenting cells with a novel RELISPOT assay (2008)
Dzutsev, Amiran K., Belyakov, Igor M., Isakov, Dmitry V., Gagnon, Susan J., Margulies, David H., Berzofsky, Jay A.
Adequate presentation of self and foreign antigens is a key factor for efficient T-cell immunosurveillance against pathogens and tumors. Cells presenting foreign antigens usually comprise a rare...
Avidity of CD8 T cells sharpens immunodominance (2007)
Dzutsev, Amiran H., Belyakov, Igor M., Isakov, Dmitry V., Margulies, David H., Berzofsky, Jay A.
In the course of viral infection, the immune system exploits only a fraction of the available CTL repertoire and focuses on a few of a myriad of potentially antigenic peptides. This phenomenon, known...
Avidity of CD8 T cells sharpens immunodominance (2007)
Dzutsev, Amiran H., Belyakov, Igor M., Isakov, Dmitry V., Margulies, David H., Berzofsky, Jay A.
In the course of viral infection, the immune system exploits only a fraction of the available CTL repertoire and focuses on a few of a myriad of potentially antigenic peptides. This phenomenon, known...
Avidity of CD8 T cells sharpens immunodominance (2007)
Dzutsev, Amiran H., Belyakov, Igor M., Isakov, Dmitry V., Margulies, David H., Berzofsky, Jay A.
In the course of viral infection, the immune system exploits only a fraction of the available CTL repertoire and focuses on a few of a myriad of potentially antigenic peptides. This phenomenon, known...
Overcoming CD4 deficiency to induce long-lived memory CD8+CTL (2006)
Oh, SangKon, Perera, Liyanage P, Waldmann, Thomas A, Berzofsky, Jay A
No abstract available.
Can Vaccine-induced Mucosal High Avidity CD8+ CTL Delay AIDS-viral Dissemination from Mucosa? (2005)
Belyakov, Igor M, Kuznetsov, Vladimir A, Kelsall, Brian, Klinman, Dennis, Moniuszko, Marcin, Lemon, Michael, ...
No abstract available.
HPV-16 L1 VLP vaccine elicits a broad-spectrum of cytokine responses in whole blood (2005)
Pinto, Ligia A., Castle, Philip E., Roden, Richard B., Harro, Clayton D., Lowy, Douglas R., Schiller, John T., ...
Here, we evaluated innate and adaptive immune system cytokine responses induced by HPV-16 L1 VLP in whole blood (WB) cultures from individuals receiving the vaccine (n = 20) or placebo (n = 4) before...
HPV-16 L1 VLP vaccine elicits a broad-spectrum of cytokine responses in whole blood (2005)
Pinto, Ligia A., Castle, Philip E., Roden, Richard B., Harro, Clayton D., Lowy, Douglas R., Schiller, John T., ...
Here, we evaluated innate and adaptive immune system cytokine responses induced by HPV-16 L1 VLP in whole blood (WB) cultures from individuals receiving the vaccine (n = 20) or placebo (n = 4) before...
Whether the immune protective mechanisms against AIDS involve antibodies or cytotoxic T lymphocytes (CTL) or both, helper T cells will be necessary to induce either type of response. Also, it is...
Ahlers, Jeffrey D., Belyakov, Igor M., Matsui, So, Berzofsky, Jay A.
Regulation of the IL-12 receptor (IL-12R) β2 chain has been suggested to function as a molecular switch in determining T cell phenotype. However, because most studies have been carried out under...
Takahashi, Megumi, Nakagawa, Yohko, Berzofsky, Jay A., Takahashi, Hidemi
We have reported previously that the cytolytic activity of murine CD8+ cytotoxic T lymphocytes (CTL) specific for HIV-1 gp160 envelope glycoprotein was markedly inhibited by brief exposure to...
Mechanisms of cytokine synergy essential for vaccine protection against viral challenge (2001)
Ahlers, Jeffrey D., Belyakov, Igor M., Matsui, So, Berzofsky, Jay A.
The ability of cytokines to steer CD4+ Th cell responses toward a Th1 or Th2 phenotype and enhance the magnitude of both CD8+ cytotoxic T lymphocytes (CTL) and antibody responses has...
Derby, Michael A., Wang, Jian, Margulies, David H., Berzofsky, Jay A.
The efficacy of cytotoxic T lymphocytes (CTL) has been shown to be highly dependent upon their functional avidity (the sensitivity of their cellular response to MHC–peptide complexes). To examine...
Molecular Alterations in Pediatric Sarcomas: Potential Targets for Immunotherapy (1998)
Theresa J. Goletz, Crystal L. Mackall, Jay A. Berzofsky, Lee J. Helman
Purpose/results/discussion. Recurrent chromosomal translocations are common features of many human malignancies. While such translocations often serve as diagnostic markers, molecular analysis of...
Alexander-Miller, Martha A., Parker, Kenneth C., Tsukui, Taku, Pendleton, C. David, Coligan, John E., Berzofsky, Jay A.
P18IIIB is a highly immunogenic peptide from the V3 loop of the HIV-1 gp160 envelope protein that is presented promiscuously by multiple class I MHC molecules. Understanding the molecular basis for...
Takahashi, Hidemi, Nakagawa, Yohko, Yokomuro, Kozo, Berzofsky, Jay A., Wigzell, H.
Based on the evidence that CD8+; cytotoxic T cells (CTL) precursors do not appear to distinguish between virus-infected cells and viral peptide-puised syngeneic cells, we have developed methods...
Takeshita, Toshiyuki, Kozlowski, Steven, England, Richard D., Brower, Richard, Schneck, Jonathan, Takahashi, Hidemi, ...
To analyze the molecular interactions involved in CD8+ cytotoxic T lymphocyte (CTL) recognition quantitatively, we developed a cell-free antigen presenting system. Genetically engineered soluble...
Kovac, Zdenko, Schwartz, Ronald H., Berzofsky, Jay A.
[B10.A(4R) × B10.PL]F1 mice are low responders to pigeon cytochrome c, while [B10.A(2R) × B10.PL]F1 and B10.A mice are high responders. The in vivo site at which the different aliomorphs of the Ea...
Belyakov, Igor M., Moss, Bernard, Strober, Warren, Berzofsky, Jay A.
Overcoming preexisting immunity to vaccinia virus in the adult population is a key requirement for development of otherwise potent recombinant vaccinia vaccines. Based on our observation that s.c....
Belyakov, Igor M., Derby, Michael A., Ahlers, Jeffrey D., Kelsall, Brian L., Earl, Patricia, Moss, Bernard, ...
Mucosal tissues are major sites of HIV entry and initial infection. Thus, the induction of a mucosal cytotoxic T lymphocyte (CTL) response is an important feature for an effective HIV vaccine....
Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence
Ahlers, Jeffrey D., Takeshita, Toshiyuki, Pendleton, C. David, Berzofsky, Jay A.
Viral proteins are not naturally selected for high affinity major histocompatibility complex (MHC) binding sequences; indeed, if there is any selection, it is likely to be negative in nature. Thus,...
Goletz, Theresa J., Klimpel, Kurt R., Arora, Naveen, Leppla, Stephen H., Keith, Jerry M., Berzofsky, Jay A.
A challenge for subunit vaccines whose goal is to elicit CD8+ cytotoxic T lymphocytes (CTLs) is to deliver the antigen to the cytosol of the living cell, where it can be processed for presentation by...
Arichi, Tatsumi, Saito, Takafumi, Major, Marian E., Belyakov, Igor M., Shirai, Mutsunori, Engelhard, Victor H., ...
DNA vaccines express antigens intracellularly and effectively induce cellular immune responses. Because only chimpanzees can be used to model human hepatitis C virus (HCV) infections, we developed a...
Arichi, Tatsumi, Saito, Takafumi, Major, Marian E., Belyakov, Igor M., Shirai, Mutsunori, Engelhard, Victor H., ...
Parra, Marcela, Hui, George, Johnson, Armead H., Berzofsky, Jay A., Roberts, Theodore, Quakyi, Isabella A., ...
Vaccines for P. falciparum will need to contain both T- and B-cell epitopes. Conserved epitopes are the most desirable, but they are often poorly immunogenic. The major merozoite surface protein 1...
Belyakov, Igor M., Wyatt, Linda S., Ahlers, Jeffrey D., Earl, Patricia, Pendleton, C. David, Kelsall, Brian L., ...
To improve the safety of recombinant vaccinia virus vaccines, modified vaccinia virus Ankara (MVA) has been employed, because it has a replication defect in most mammalian cells. Here we apply MVA to...
McGettigan, James P., Foley, Heather D., Belyakov, Igor M., Berzofsky, Jay A., Pomerantz, Roger J., Schnell, Matthias J.
Novel viral vectors that are able to induce both strong and long-lasting immune responses may be required as effective vaccines for human immunodeficiency virus type 1 (HIV-1) infection. Our previous...
Hel, Zdenek, Nacsa, Janos, Kelsall, Brian, Tsai, Wen-Po, Letvin, Norman, Parks, Robyn Washington, ...
The identification of several simian immunodeficiency virus mac251 (SIVmac251) cytotoxic T-lymphocyte epitopes recognized by CD8+ T cells of infected rhesus macaques carrying the Mamu-A*01 molecule...
Bukreyev, Alexander, Belyakov, Igor M., Berzofsky, Jay A., Murphy, Brian R., Collins, Peter L.
An obstacle to developing a vaccine against human respiratory syncytial virus (RSV) is that natural infection typically does not confer solid immunity to reinfection. To investigate methods to...
Ahlers, Jeffrey D., Belyakov, Igor M., Terabe, Masaki, Koka, Rima, Donaldson, Debra D., Thomas, Elaine K., ...
Although a role for CD4+ helper cells in CD8+ cytotoxic T lymphocyte (CTL) induction by vaccines is widely recognized, much less is known about a counterbalancing role of CD4+ T cells in...
Allen, Todd M., Jing, Peicheng, Calore, Briana, Horton, Helen, O'Connor, David H., Hanke, Tomas, ...
Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency...
Oh, SangKon, Berzofsky, Jay A., Burke, Donald S., Waldmann, Thomas A., Perera, Liyanage P.
Vaccine efficacy is determined largely by cellular and humoral immunity as well as long-lasting immunological memory. IL-2 and IL-15 were evaluated in vaccinia vectors expressing HIV gp160 for the...
Belyakov, Igor M., Earl, Patricia, Dzutsev, Amiran, Kuznetsov, Vladimir A., Lemon, Michael, Wyatt, Linda S., ...
The concern about bioterrorism with smallpox has raised the possibility of widespread vaccination, but the greater prevalence of immunocompromised individuals today requires a safer vaccine, and the...
Ahlers, Jeffrey D., Belyakov, Igor M., Thomas, Elaine K., Berzofsky, Jay A.
Natural viral proteins do not always make optimal vaccines. We have found that sequence modification to increase epitope affinity for class II MHC molecules (epitope enhancement) can improve...
Belyakov, Igor M., Hammond, Scott A., Ahlers, Jeffrey D., Glenn, Gregory M., Berzofsky, Jay A.
Transcutaneous immunization (TCI), the application of vaccines on the skin, induces robust systemic and mucosal antibodies in animal models and in humans. The means by which mucosal immune responses...
Berzofsky, Jay A., Richman, Lee K., Killion, Douglas J.
The murine antibody and T lymphocyte proliferative responses to sperm whale myoglobin (Mb) were found to be under control of two distinct H-2-linked immune response (Ir) genes (Ir-Mb-1, mapping in...
Progress on new vaccine strategies for the immunotherapy and prevention of cancer
Berzofsky, Jay A., Terabe, Masaki, Oh, SangKon, Belyakov, Igor M., Ahlers, Jeffrey D., Janik, John E., ...
In recent years, great strides in understanding and regulating the immune system have led to new hope for harnessing its exquisite specificity to destroy cancer cells without affecting normal...
Snyder, James T., Belyakov, Igor M., Dzutsev, Amiran, Lemonnier, François, Berzofsky, Jay A.
CD8+ T lymphocytes have been shown to be involved in controlling poxvirus infection, but no protective cytotoxic T-lymphocyte (CTL) epitopes are defined for variola virus, the causative agent of...
Progress on new vaccine strategies against chronic viral infections
Berzofsky, Jay A., Ahlers, Jeffrey D., Janik, John, Morris, John, Oh, SangKon, Terabe, Masaki, ...
Among the most cost-effective strategies for preventing viral infections, vaccines have proven effective primarily against viruses causing acute, self-limited infections. For these it has been...
IL-15/IL-15Rα-mediated avidity maturation of memory CD8+ T cells
Oh, SangKon, Perera, Liyanage P., Burke, Donald S., Waldmann, Thomas A., Berzofsky, Jay A.
T cell avidity is critical to viral clearance, but mechanisms of CD8+ T cell avidity maturation are poorly understood. Here, we find that IL-15 mediates two mechanisms of avidity maturation. (i) By...
Bukreyev, Alexander, Belyakov, Igor M., Prince, Gregory A., Yim, Kevin C., Harris, Katie K., Berzofsky, Jay A., ...
The outcome of a viral infection or of immunization with a vaccine can be influenced by the local cytokine environment. In studies of experimental vaccines against respiratory syncytial virus (RSV),...
Pal, Ranajit, Venzon, David, Santra, Sampa, Kalyanaraman, Vaniambadi S., Montefiori, David C., Hocker, Lindsey, ...
Transmission of human immunodeficiency virus type 1 (HIV-1) occurs primarily via the mucosal route, suggesting that HIV-1 vaccines may need to elicit mucosal immune responses. Here, we investigated...
Kotelkin, Alexander, Belyakov, Igor M., Yang, Lijuan, Berzofsky, Jay A., Collins, Peter L., Bukreyev, Alexander
The NS1 and NS2 proteins of human respiratory syncytial virus (HRSV) have been shown to antagonize the type I interferon (IFN) response, an effect subject to host range constraints. We have now found...
Belyakov, Igor M., Moss, Bernard, Strober, Warren, Berzofsky, Jay A.
Overcoming preexisting immunity to vaccinia virus in the adult population is a key requirement for development of otherwise potent recombinant vaccinia vaccines. Based on our observation that s.c....
Belyakov, Igor M., Derby, Michael A., Ahlers, Jeffrey D., Kelsall, Brian L., Earl, Patricia, Moss, Bernard, ...
Mucosal tissues are major sites of HIV entry and initial infection. Thus, the induction of a mucosal cytotoxic T lymphocyte (CTL) response is an important feature for an effective HIV vaccine....
Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence
Ahlers, Jeffrey D., Takeshita, Toshiyuki, Pendleton, C. David, Berzofsky, Jay A.
Viral proteins are not naturally selected for high affinity major histocompatibility complex (MHC) binding sequences; indeed, if there is any selection, it is likely to be negative in nature. Thus,...
Goletz, Theresa J., Klimpel, Kurt R., Arora, Naveen, Leppla, Stephen H., Keith, Jerry M., Berzofsky, Jay A.
A challenge for subunit vaccines whose goal is to elicit CD8+ cytotoxic T lymphocytes (CTLs) is to deliver the antigen to the cytosol of the living cell, where it can be processed for presentation by...
Arichi, Tatsumi, Saito, Takafumi, Major, Marian E., Belyakov, Igor M., Shirai, Mutsunori, Engelhard, Victor H., ...
DNA vaccines express antigens intracellularly and effectively induce cellular immune responses. Because only chimpanzees can be used to model human hepatitis C virus (HCV) infections, we developed a...
Arichi, Tatsumi, Saito, Takafumi, Major, Marian E., Belyakov, Igor M., Shirai, Mutsunori, Engelhard, Victor H., ...
Parra, Marcela, Hui, George, Johnson, Armead H., Berzofsky, Jay A., Roberts, Theodore, Quakyi, Isabella A., ...
Vaccines for P. falciparum will need to contain both T- and B-cell epitopes. Conserved epitopes are the most desirable, but they are often poorly immunogenic. The major merozoite surface protein 1...
Belyakov, Igor M., Wyatt, Linda S., Ahlers, Jeffrey D., Earl, Patricia, Pendleton, C. David, Kelsall, Brian L., ...
To improve the safety of recombinant vaccinia virus vaccines, modified vaccinia virus Ankara (MVA) has been employed, because it has a replication defect in most mammalian cells. Here we apply MVA to...
McGettigan, James P., Foley, Heather D., Belyakov, Igor M., Berzofsky, Jay A., Pomerantz, Roger J., Schnell, Matthias J.
Novel viral vectors that are able to induce both strong and long-lasting immune responses may be required as effective vaccines for human immunodeficiency virus type 1 (HIV-1) infection. Our previous...
Hel, Zdenek, Nacsa, Janos, Kelsall, Brian, Tsai, Wen-Po, Letvin, Norman, Parks, Robyn Washington, ...
The identification of several simian immunodeficiency virus mac251 (SIVmac251) cytotoxic T-lymphocyte epitopes recognized by CD8+ T cells of infected rhesus macaques carrying the Mamu-A*01 molecule...
Bukreyev, Alexander, Belyakov, Igor M., Berzofsky, Jay A., Murphy, Brian R., Collins, Peter L.
An obstacle to developing a vaccine against human respiratory syncytial virus (RSV) is that natural infection typically does not confer solid immunity to reinfection. To investigate methods to...
Ahlers, Jeffrey D., Belyakov, Igor M., Terabe, Masaki, Koka, Rima, Donaldson, Debra D., Thomas, Elaine K., ...
Although a role for CD4+ helper cells in CD8+ cytotoxic T lymphocyte (CTL) induction by vaccines is widely recognized, much less is known about a counterbalancing role of CD4+ T cells in...
Allen, Todd M., Jing, Peicheng, Calore, Briana, Horton, Helen, O'Connor, David H., Hanke, Tomas, ...
Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency...
Oh, SangKon, Berzofsky, Jay A., Burke, Donald S., Waldmann, Thomas A., Perera, Liyanage P.
Vaccine efficacy is determined largely by cellular and humoral immunity as well as long-lasting immunological memory. IL-2 and IL-15 were evaluated in vaccinia vectors expressing HIV gp160 for the...
Belyakov, Igor M., Earl, Patricia, Dzutsev, Amiran, Kuznetsov, Vladimir A., Lemon, Michael, Wyatt, Linda S., ...
The concern about bioterrorism with smallpox has raised the possibility of widespread vaccination, but the greater prevalence of immunocompromised individuals today requires a safer vaccine, and the...
Ahlers, Jeffrey D., Belyakov, Igor M., Thomas, Elaine K., Berzofsky, Jay A.
Natural viral proteins do not always make optimal vaccines. We have found that sequence modification to increase epitope affinity for class II MHC molecules (epitope enhancement) can improve...
Belyakov, Igor M., Hammond, Scott A., Ahlers, Jeffrey D., Glenn, Gregory M., Berzofsky, Jay A.
Transcutaneous immunization (TCI), the application of vaccines on the skin, induces robust systemic and mucosal antibodies in animal models and in humans. The means by which mucosal immune responses...
Berzofsky, Jay A., Richman, Lee K., Killion, Douglas J.
The murine antibody and T lymphocyte proliferative responses to sperm whale myoglobin (Mb) were found to be under control of two distinct H-2-linked immune response (Ir) genes (Ir-Mb-1, mapping in...
Progress on new vaccine strategies for the immunotherapy and prevention of cancer
Berzofsky, Jay A., Terabe, Masaki, Oh, SangKon, Belyakov, Igor M., Ahlers, Jeffrey D., Janik, John E., ...
In recent years, great strides in understanding and regulating the immune system have led to new hope for harnessing its exquisite specificity to destroy cancer cells without affecting normal...
Snyder, James T., Belyakov, Igor M., Dzutsev, Amiran, Lemonnier, François, Berzofsky, Jay A.
CD8+ T lymphocytes have been shown to be involved in controlling poxvirus infection, but no protective cytotoxic T-lymphocyte (CTL) epitopes are defined for variola virus, the causative agent of...
Progress on new vaccine strategies against chronic viral infections
Berzofsky, Jay A., Ahlers, Jeffrey D., Janik, John, Morris, John, Oh, SangKon, Terabe, Masaki, ...
Among the most cost-effective strategies for preventing viral infections, vaccines have proven effective primarily against viruses causing acute, self-limited infections. For these it has been...
IL-15/IL-15Rα-mediated avidity maturation of memory CD8+ T cells
Oh, SangKon, Perera, Liyanage P., Burke, Donald S., Waldmann, Thomas A., Berzofsky, Jay A.
T cell avidity is critical to viral clearance, but mechanisms of CD8+ T cell avidity maturation are poorly understood. Here, we find that IL-15 mediates two mechanisms of avidity maturation. (i) By...
Bukreyev, Alexander, Belyakov, Igor M., Prince, Gregory A., Yim, Kevin C., Harris, Katie K., Berzofsky, Jay A., ...
The outcome of a viral infection or of immunization with a vaccine can be influenced by the local cytokine environment. In studies of experimental vaccines against respiratory syncytial virus (RSV),...
Pal, Ranajit, Venzon, David, Santra, Sampa, Kalyanaraman, Vaniambadi S., Montefiori, David C., Hocker, Lindsey, ...
Transmission of human immunodeficiency virus type 1 (HIV-1) occurs primarily via the mucosal route, suggesting that HIV-1 vaccines may need to elicit mucosal immune responses. Here, we investigated...
Kotelkin, Alexander, Belyakov, Igor M., Yang, Lijuan, Berzofsky, Jay A., Collins, Peter L., Bukreyev, Alexander
The NS1 and NS2 proteins of human respiratory syncytial virus (HRSV) have been shown to antagonize the type I interferon (IFN) response, an effect subject to host range constraints. We have now found...
Overcoming CD4 deficiency to induce long-lived memory CD8+ CTL
Oh, SangKon, Perera, Liyanage P, Waldmann, Thomas A, Berzofsky, Jay A
Kotelkin, Alexander, Belyakov, Igor M., Yang, Lijuan, Berzofsky, Jay A., Collins, Peter L., Bukreyev, Alexander
Okazaki, Takahiro, Terabe, Masaki, Catanzaro, Andrew T., Pendleton, C. David, Yarchoan, Robert, Berzofsky, Jay A.
Mutation of human immunodeficiency virus (HIV) leading to escape from anti-HIV drugs is the greatest challenge to the treatment of HIV infection. High-grade resistance to the nucleoside reverse...
Belyakov, Igor M., Kuznetsov, Vladimir A., Kelsall, Brian, Klinman, Dennis, Moniuszko, Marcin, Lemon, Michael, ...
Natural HIV transmission occurs through mucosa, but it is debated whether mucosal cytotoxic T lymphocytes (CTLs) can prevent or reduce dissemination from the initial mucosal site to the systemic...
Perera, Liyanage P., Waldmann, Thomas A., Mosca, Joseph D., Baldwin, Nicole, Berzofsky, Jay A., Oh, Sang-Kon
The potential use of variola virus, the etiological agent of smallpox, as a bioterror agent has heightened the interest in the reinitiation of smallpox vaccination. However, the currently licensed...
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
Zeng, Rong, Spolski, Rosanne, Finkelstein, Steven E., Oh, SangKon, Kovanen, Panu E., Hinrichs, Christian S., ...
Interleukin (IL)-21 is the most recently recognized of the cytokines that share the common cytokine receptor γ chain (γc), which is mutated in humans with X-linked severe combined immunodeficiency....
Terabe, Masaki, Swann, Jeremy, Ambrosino, Elena, Sinha, Pratima, Takaku, Shun, Hayakawa, Yoshihiro, ...
The importance of immunoregulatory T cells has become increasingly apparent. Both CD4+CD25+ T cells and CD1d-restricted NKT cells have been reported to down-regulate tumor immunity in mouse tumor...
Terabe, Masaki, Matsui, So, Park, Jong-Myun, Mamura, Mizuko, Noben-Trauth, Nancy, Donaldson, Debra D., ...
Our previous work demonstrated that cytotoxic T lymphocyte (CTL)-mediated tumor immunosurveillance of the 15-12RM tumor could be suppressed by a CD1d-restricted lymphocyte, most likely a natural...
Alexander-Miller, Martha A., Derby, Michael A., Sarin, Apurva, Henkart, Pierre A., Berzofsky, Jay A.
Cytotoxic T lymphocytes (CTLs) are primary mediators of viral clearance, but high viral burden can result in deletion of antigen-specific CTLs. We previously reported a potential mechanism for this...
Molecular Alterations in Pediatric Sarcomas: Potential Targets for Immunotherapy
Goletz, Theresa J., Mackall, Crystal L., Berzofsky, Jay A., Helman, Lee J.
Purpose/results/discussion. Recurrent chromosomal translocations are common features of many human malignancies. While such translocations often serve as diagnostic markers, molecular analysis of...
IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis
Oh, SangKon, Perera, Liyanage P., Terabe, Masaki, Ni, Ling, Waldmann, Thomas A., Berzofsky, Jay A.
CD4+ helper T cells contribute to the induction and maintenance of antigen-specific CD8+ T cells. Their absence results in short-lived antigen-specific CD8+ T cells and defective secondary CD8+ T...
Zhu, Qing, Egelston, Colt, Vivekanandhan, Aravindhan, Uematsu, Satoshi, Akira, Shizuo, Klinman, Dennis M., ...
Toll-like receptors (TLRs) may need to cooperate with each other to be effective in detecting imminent infection and trigger immune responses. Understanding is still limited about the intracellular...
Pathogenic Roles of CD14, Galectin-3, and OX40 during Experimental Cerebral Malaria in Mice
Oakley, Miranda S., Majam, Victoria, Mahajan, Babita, Gerald, Noel, Anantharaman, Vivek, Ward, Jerrold M., ...
An in-depth knowledge of the host molecules and biological pathways that contribute towards the pathogenesis of cerebral malaria would help guide the development of novel prognostics and...