Scientific Commons: Jay C. D. Hinton

Recent advances in high-throughput pyrosequencing (HTPS) technology now allow a thorough analysis of RNA bound to cellular proteins, and, therefore, of post-transcriptional regulons. We used HTPS to...

Systematic deletion of Salmonella small RNA genes identifies CyaR, a conserved CRP-dependent riboregulator of OmpX synthesis (2008)

Papenfort, Kai, Pfeiffer, Verena, Lucchini, Sacha, Sonawane, Avinash, Hinton, Jay C. D., Vogel, Jörg

MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands (2007)

Ou, Hong-Yu, He, Xinyi, Harrison, Ewan M., Kulasekara, Bridget R., Thani, Ali Bin, Kadioglu, Aras, ...

MobilomeFINDER (http://mml.sjtu.edu.cn/MobilomeFINDER) is an interactive online tool that facilitates bacterial genomic island or ‘mobile genome’ (mobilome) discovery; it integrates the ArrayOme...

Sigma(E)-dependent small RNAs of Salmonella respond to membrane stress by accelerating global omp mRNA decay (2006)

Papenfort, Kai, Pfeiffer, Verena, Mika, Franziska, Lucchini, Sacha, Hinton, Jay C. D., Vogel, Jörg

Transcriptional Profiling of Colicin-Induced Cell Death of Escherichia coli MG1655 Identifies Potential Mechanisms by Which Bacteriocins Promote Bacterial Diversity (2004)

Walker, Daniel, Rolfe, Matthew, Thompson, Arthur, Moore, Geoffrey R., James, Richard, Hinton, Jay C. D., ...

We report the transcriptional response of Escherichia coli MG1655 to damage induced by colicins E3 and E9, bacteriocins that kill cells through inactivation of the ribosome and degradation of...

Transcriptional Profiling of Colicin-Induced Cell Death of Escherichia coli MG1655 Identifies Potential Mechanisms by Which Bacteriocins Promote Bacterial Diversity (2004)

Walker, Daniel, Rolfe, Matthew, Thompson, Arthur, Moore, Geoffrey R., James, Richard, Hinton, Jay C. D., ...

We report the transcriptional response of Escherichia coli MG1655 to damage induced by colicins E3 and E9, bacteriocins that kill cells through inactivation of the ribosome and degradation of...

Transcriptional Profiling of Colicin-Induced Cell Death of Escherichia coli MG1655 Identifies Potential Mechanisms by Which Bacteriocins Promote Bacterial Diversity (2004)

Walker, Daniel, Rolfe, Matthew, Thompson, Arthur, Moore, Geoffrey R., James, Richard, Hinton, Jay C. D., ...

We report the transcriptional response of Escherichia coli MG1655 to damage induced by colicins E3 and E9, bacteriocins that kill cells through inactivation of the ribosome and degradation of...

Structural characterization of the N-terminal oligomerization domain of the bacterial chromatin-structuring protein, H-NS1 (2001)

Renzoni, D., Esposito, D., Pfuhl, M., Hinton, Jay C.D., Higgins, C.F., Driscoll, P.C., ...

Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica

Clements, Mark O., Eriksson, Sofia, Thompson, Arthur, Lucchini, Sacha, Hinton, Jay C. D., Normark, Staffan, ...

For many pathogens, the ability to regulate their replication in host cells is a key element in establishing persistency. Here, we identified a single point mutation in the gene for polynucleotide...

Comparative Genomic Indexing Reveals the Phylogenomics of Escherichia coli Pathogens

Anjum, Muna F., Lucchini, Sacha, Thompson, Arthur, Hinton, Jay C. D., Woodward, Martin J.

The Escherichia coli O26 serogroup includes important food-borne pathogens associated with human and animal diarrheal disease. Current typing methods have revealed great genetic heterogeneity within...

Single-Copy Green Fluorescent Protein Gene Fusions Allow Accurate Measurement of Salmonella Gene Expression In Vitro and during Infection of Mammalian Cells

Hautefort, Isabelle, Proença, Maria José, Hinton, Jay C. D.

We developed a reliable and flexible green fluorescent protein (GFP)-based system for measuring gene expression in individual bacterial cells. Until now, most systems have relied upon plasmid-borne...

Transcriptional Profiling of Colicin-Induced Cell Death of Escherichia coli MG1655 Identifies Potential Mechanisms by Which Bacteriocins Promote Bacterial Diversity

Walker, Daniel, Rolfe, Matthew, Thompson, Arthur, Moore, Geoffrey R., James, Richard, Hinton, Jay C. D., ...

We report the transcriptional response of Escherichia coli MG1655 to damage induced by colicins E3 and E9, bacteriocins that kill cells through inactivation of the ribosome and degradation of...

Transcriptional Adaptation of Shigella flexneri during Infection of Macrophages and Epithelial Cells: Insights into the Strategies of a Cytosolic Bacterial Pathogen

Lucchini, Sacha, Liu, Hong, Jin, Qi, Hinton, Jay C. D., Yu, Jun

Shigella flexneri, the etiologic agent of bacillary dysentery, invades epithelial cells as well as macrophages and dendritic cells and escapes into the cytosol soon after invasion. Dissection of the...

Polynucleotide Phosphorylase Negatively Controls spv Virulence Gene Expression in Salmonella enterica †

Ygberg, Sofia Eriksson, Clements, Mark O., Rytkönen, Anne, Thompson, Arthur, Holden, David W., Hinton, Jay C. D., ...

Mutational inactivation of the cold-shock-associated exoribonuclease polynucleotide phosphorylase (PNPase; encoded by the pnp gene) in Salmonella enterica serovar Typhimurium was previously shown to...

H-NS Mediates the Silencing of Laterally Acquired Genes in Bacteria

Lucchini, Sacha, Rowley, Gary, Goldberg, Martin D, Hurd, Douglas, Harrison, Marcus, Hinton, Jay C. D

Histone-like nucleoid structuring protein (H-NS) is a modular protein that is associated with the bacterial nucleoid. We used chromatin immunoprecipitation to determine the binding sites of H-NS and...

Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica

Clements, Mark O., Eriksson, Sofia, Thompson, Arthur, Lucchini, Sacha, Hinton, Jay C. D., Normark, Staffan, ...

For many pathogens, the ability to regulate their replication in host cells is a key element in establishing persistency. Here, we identified a single point mutation in the gene for polynucleotide...

Comparative Genomic Indexing Reveals the Phylogenomics of Escherichia coli Pathogens

Anjum, Muna F., Lucchini, Sacha, Thompson, Arthur, Hinton, Jay C. D., Woodward, Martin J.

The Escherichia coli O26 serogroup includes important food-borne pathogens associated with human and animal diarrheal disease. Current typing methods have revealed great genetic heterogeneity within...

Single-Copy Green Fluorescent Protein Gene Fusions Allow Accurate Measurement of Salmonella Gene Expression In Vitro and during Infection of Mammalian Cells

Hautefort, Isabelle, Proença, Maria José, Hinton, Jay C. D.

We developed a reliable and flexible green fluorescent protein (GFP)-based system for measuring gene expression in individual bacterial cells. Until now, most systems have relied upon plasmid-borne...

Transcriptional Profiling of Colicin-Induced Cell Death of Escherichia coli MG1655 Identifies Potential Mechanisms by Which Bacteriocins Promote Bacterial Diversity

Walker, Daniel, Rolfe, Matthew, Thompson, Arthur, Moore, Geoffrey R., James, Richard, Hinton, Jay C. D., ...

We report the transcriptional response of Escherichia coli MG1655 to damage induced by colicins E3 and E9, bacteriocins that kill cells through inactivation of the ribosome and degradation of...

Transcriptional Adaptation of Shigella flexneri during Infection of Macrophages and Epithelial Cells: Insights into the Strategies of a Cytosolic Bacterial Pathogen

Lucchini, Sacha, Liu, Hong, Jin, Qi, Hinton, Jay C. D., Yu, Jun

Shigella flexneri, the etiologic agent of bacillary dysentery, invades epithelial cells as well as macrophages and dendritic cells and escapes into the cytosol soon after invasion. Dissection of the...

Polynucleotide Phosphorylase Negatively Controls spv Virulence Gene Expression in Salmonella enterica †

Ygberg, Sofia Eriksson, Clements, Mark O., Rytkönen, Anne, Thompson, Arthur, Holden, David W., Hinton, Jay C. D., ...

Mutational inactivation of the cold-shock-associated exoribonuclease polynucleotide phosphorylase (PNPase; encoded by the pnp gene) in Salmonella enterica serovar Typhimurium was previously shown to...

H-NS Mediates the Silencing of Laterally Acquired Genes in Bacteria

Lucchini, Sacha, Rowley, Gary, Goldberg, Martin D, Hurd, Douglas, Harrison, Marcus, Hinton, Jay C. D

Histone-like nucleoid structuring protein (H-NS) is a modular protein that is associated with the bacterial nucleoid. We used chromatin immunoprecipitation to determine the binding sites of H-NS and...

σE-dependent small RNAs of Salmonella respond to membrane stress by accelerating global omp mRNA decay

Papenfort, Kai, Pfeiffer, Verena, Mika, Franziska, Lucchini, Sacha, Hinton, Jay C D, Vogel, Jörg

The bacterial envelope stress response (ESR) is triggered by the accumulation of misfolded outer membrane proteins (OMPs) upon envelope damage or excessive OMP synthesis, and is mediated by the...

Correction: H-NS Mediates the Silencing of Laterally Acquired Genes in Bacteria

Lucchini, Sacha, Rowley, Gary, Goldberg, Martin D, Hurd, Douglas, Harrison, Marcus, Hinton, Jay C. D

DNA Adenine Methylation Regulates Virulence Gene Expression in Salmonella enterica Serovar Typhimurium▿

Balbontín, Roberto, Rowley, Gary, Pucciarelli, M. Graciela, López-Garrido, Javier, Wormstone, Yvette, Lucchini, Sacha, ...

Transcriptomic analyses during growth in Luria-Bertani medium were performed in strain SL1344 of Salmonella enterica serovar Typhimurium and in two isogenic derivatives lacking Dam methylase. More...

MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands

Ou, Hong-Yu, He, Xinyi, Harrison, Ewan M., Kulasekara, Bridget R., Thani, Ali Bin, Kadioglu, Aras, ...

MobilomeFINDER (http://mml.sjtu.edu.cn/MobilomeFINDER) is an interactive online tool that facilitates bacterial genomic island or ‘mobile genome’ (mobilome) discovery; it integrates the ArrayOme...

SseL, a Salmonella deubiquitinase required for macrophage killing and virulence

Rytkönen, Anne, Poh, John, Garmendia, Junkal, Boyle, Cliona, Thompson, Arthur, Liu, Mei, ...

Expression of the Salmonella enterica serovar Typhimurium pathogenicity island 2 (SPI-2) type III secretion system is controlled by the two-component regulatory system SsrA-SsrB. We used a...

The Leucine-Responsive Regulatory Protein, Lrp, Activates Transcription of the fim Operon in Salmonella enterica Serovar Typhimurium via the fimZ Regulatory Gene▿

McFarland, Kirsty A., Lucchini, Sacha, Hinton, Jay C. D., Dorman, Charles J.

The fim operon of Salmonella enterica serovar Typhimurium encodes type 1 fimbriae. The expression of fim is controlled in response to environmental signals through a complex regulatory cascade...

Deep Sequencing Analysis of Small Noncoding RNA and mRNA Targets of the Global Post-Transcriptional Regulator, Hfq

Sittka, Alexandra, Lucchini, Sacha, Papenfort, Kai, Sharma, Cynthia M., Rolle, Katarzyna, Binnewies, Tim T., ...

Recent advances in high-throughput pyrosequencing (HTPS) technology now allow a thorough analysis of RNA bound to cellular proteins, and, therefore, of post-transcriptional regulons. We used HTPS to...

Jay C. D. Hinton

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