Jay P. Sanford

TETANUS AND DIPHTHERIA ANTITOXIN LEVELS FOLLOWING A HOSPITAL-BASED ADULT IMMUNIZATION PROGRAM (1975)

THORLEY, JEFFREY D., HOLMES, RANDALL K., SANFORD, JAY P.

A hospital-based program to immunize adults against tetanus unless specific contraindications to immunization are present has been in effect at Parkland Memorial Hospital since 1959. Adsorbed tetanus...

Defective cellular immunity in renal failure: depression of reactivity of lymphocytes to phytohemagglutinin by renal failure serum

Newberry, W. Marcus, Sanford, Jay P.

In defining host resistance factors in uremia, experiments were designed to assess the effect of renal failure serum upon the reactivity of normal human lymphocytes to phytohemagglutinin in vitro....

Local immune response in experimental pyelonephritis

Lehmann, James D., Smith, James W., Miller, Thomas E., Barnett, Jack A., Sanford, Jay P.

Experiments using an in vitro method of assessing protein synthesis by 14C amino acid incorporation were designed to determine whether pyelonephritic kidneys were capable of local antibody...

Escherichia Coli Bacteremia in the Squirrel Monkey I. EFFECT OF COBRA VENOM FACTOR TREATMENT

Gilbert, David N., Barnett, Jack A., Sanford, Jay P.

Squirrel monkeys were significantly depleted of complement by a nontoxic protein constituent of cobra venom, and the influence of cobra factor (CoF) treatment on the course of Escherichia coli...

Interfering Effect of Incubation in Carbon Dioxide on the Identification of Pneumococci by Optochin Discs

Ragsdale, A. Ruth, Sanford, Jay P.

Incubation of pneumococci in a CO2 environment decreases the zone sizes produced by optochin discs, with the result that pneumococcal-like organisms require further study.

Comparison of the Pulmonary Bactericidal Capacity of Mice and Rats Against Strains of Pseudomonas aeruginosa1

Southern, Paul M., Pierce, Alan K., Sanford, Jay P.

After aerosol deposition of Pseudomonas aeruginosa strains in mice and rats, completely different patterns of pulmonary bacterial clearance were observed in each animal species.

Area-sampling Technique for Quantitative Pharyngeal Cultures

Johanson, Waldemar G., Pierce, Alan K., Sanford, Jay P.

An area-sampling device for obtaining quantitative samples of the oropharyngeal bacterial flora is described and illustrative data are presented.

Clearance of Serratia marcescens from Lungs of Normal Mice

Southern, Paul M., Pierce, Alan K., Sanford, Jay P.

After aerosol deposition of Serratia marcescens in mice, initial delayed pulmonary clearance was followed between 4 and 24 hr later by progressive elimination.

Effects of Divalent Cations on Binding of Aminoglycoside Antibiotics to Human Serum Proteins and to Bacteria

Ramirez-Ronda, Carlos H., Holmes, Randall K., Sanford, Jay P.

Binding of gentamicin and related deoxystreptamine-containing aminoglycoside antibiotics to proteins in human serum can vary significantly with changes in experimental conditions. The concentrations...

Prospective Comparative Study of Variable Dosage and Variable Frequency Regimens for Administration of Gentamicin

Goodman, Edward L., Van Gelder, James, Holmes, Randall, Hull, Alan R., Sanford, Jay P.

In patients with impaired renal function, careful adjustment of gentamicin dosage is required to achieve therapeutic yet nontoxic concentrations. Two regimens that differ in pharmacodynamic...

Resistance of Pseudomonas aeruginosa to Gentamicin and Related Aminoglycoside Antibiotics

Holmes, Randall K., Minshew, Barbara H., Gould, Kenneth, Sanford, Jay P.

This study was undertaken to investigate biochemical, genetic, and epidemiological aspects of resistance to aminoglycoside antibiotics among 650 consecutive isolates of Pseudomonas aeruginosa from...

Transferrable Resistance to Tobramycin in Klebsiella pneumoniae and Enterobacter cloacae Associated with Enzymatic Acetylation of Tobramycin

Minshew, Barbara H., Holmes, Randall K., Sanford, Jay P., Baxter, Charles R.

Among gram-negative bacilli isolated from burn wound cultures, some strains of Enterobacteriaceae were resistant to tobramycin (minimal inhibitory concentration [MIC]≥ 20 μg/ml) but susceptible to...

Defective cellular immunity in renal failure: depression of reactivity of lymphocytes to phytohemagglutinin by renal failure serum

Newberry, W. Marcus, Sanford, Jay P.

In defining host resistance factors in uremia, experiments were designed to assess the effect of renal failure serum upon the reactivity of normal human lymphocytes to phytohemagglutinin in vitro....

Local immune response in experimental pyelonephritis

Lehmann, James D., Smith, James W., Miller, Thomas E., Barnett, Jack A., Sanford, Jay P.

Experiments using an in vitro method of assessing protein synthesis by 14C amino acid incorporation were designed to determine whether pyelonephritic kidneys were capable of local antibody...

Escherichia Coli Bacteremia in the Squirrel Monkey I. EFFECT OF COBRA VENOM FACTOR TREATMENT

Gilbert, David N., Barnett, Jack A., Sanford, Jay P.

Squirrel monkeys were significantly depleted of complement by a nontoxic protein constituent of cobra venom, and the influence of cobra factor (CoF) treatment on the course of Escherichia coli...

Interfering Effect of Incubation in Carbon Dioxide on the Identification of Pneumococci by Optochin Discs

Ragsdale, A. Ruth, Sanford, Jay P.

Incubation of pneumococci in a CO2 environment decreases the zone sizes produced by optochin discs, with the result that pneumococcal-like organisms require further study.

Comparison of the Pulmonary Bactericidal Capacity of Mice and Rats Against Strains of Pseudomonas aeruginosa1

Southern, Paul M., Pierce, Alan K., Sanford, Jay P.

After aerosol deposition of Pseudomonas aeruginosa strains in mice and rats, completely different patterns of pulmonary bacterial clearance were observed in each animal species.

Area-sampling Technique for Quantitative Pharyngeal Cultures

Johanson, Waldemar G., Pierce, Alan K., Sanford, Jay P.

An area-sampling device for obtaining quantitative samples of the oropharyngeal bacterial flora is described and illustrative data are presented.

Clearance of Serratia marcescens from Lungs of Normal Mice

Southern, Paul M., Pierce, Alan K., Sanford, Jay P.

After aerosol deposition of Serratia marcescens in mice, initial delayed pulmonary clearance was followed between 4 and 24 hr later by progressive elimination.

Effects of Divalent Cations on Binding of Aminoglycoside Antibiotics to Human Serum Proteins and to Bacteria

Ramirez-Ronda, Carlos H., Holmes, Randall K., Sanford, Jay P.

Binding of gentamicin and related deoxystreptamine-containing aminoglycoside antibiotics to proteins in human serum can vary significantly with changes in experimental conditions. The concentrations...

Prospective Comparative Study of Variable Dosage and Variable Frequency Regimens for Administration of Gentamicin

Goodman, Edward L., Van Gelder, James, Holmes, Randall, Hull, Alan R., Sanford, Jay P.

In patients with impaired renal function, careful adjustment of gentamicin dosage is required to achieve therapeutic yet nontoxic concentrations. Two regimens that differ in pharmacodynamic...

Resistance of Pseudomonas aeruginosa to Gentamicin and Related Aminoglycoside Antibiotics

Holmes, Randall K., Minshew, Barbara H., Gould, Kenneth, Sanford, Jay P.

This study was undertaken to investigate biochemical, genetic, and epidemiological aspects of resistance to aminoglycoside antibiotics among 650 consecutive isolates of Pseudomonas aeruginosa from...

Transferrable Resistance to Tobramycin in Klebsiella pneumoniae and Enterobacter cloacae Associated with Enzymatic Acetylation of Tobramycin

Minshew, Barbara H., Holmes, Randall K., Sanford, Jay P., Baxter, Charles R.

Among gram-negative bacilli isolated from burn wound cultures, some strains of Enterobacteriaceae were resistant to tobramycin (minimal inhibitory concentration [MIC]≥ 20 μg/ml) but susceptible to...

A MECHANISM OF THE GLYCOGENOLYTIC ACTION OF BACTERIAL ENDOTOXIN

Sanford, Jay P., Barnett, Jack A., Gott, Cora

These experiments have demonstrated that liver glycogen may rise or fall after endotoxin administration, depending upon the antecedent diet and that total adrenalectomy followed by corticosteroid...

THE ROLE OF IMMUNITY IN THE PATHOGENESIS OF EXPERIMENTAL HEMATOGENOUS PYELONEPHRITIS

Sanford, Jay P., Hunter, Betty W., Souda, Lona L.

Hematogenous pyelonephritis was produced in rats utilizing multiple strains of Escherichia coli, a strain of Klebsiella pneumoniae, and a strain of Proteus mirabilis. Three patterns of hematogenous...

LOCALIZATION AND FATE OF ESCHERICHIA COLI IN HEMATOGENOUS PYELONEPHRITIS

Sanford, Jay P., Hunter, Betty W., Donaldson, Paul

1. Hematogenous E. coli pyelonephritis was produced in rats. The localization of the organisms and the persistence of bacterial antigens was followed by fluorescent antibody techniques as well as by...

THE ROLE OF IMMUNITY IN THE PATHOGENESIS OF EXPERIMENTAL RETROGRADE PYELONEPHRITIS

Hunter, Betty W., Akins, Lona L., Sanford, Jay P.

Retrograde pyelonephritis was produced in rats by the intravesical injection of Proteus mirabilis. When animals were preimmunized against Proteus mirabilis by (a) prior infection, (b) administration...