Jayendra Prasad

The Protein Kinase Clk/Sty Directly Modulates SR Protein Activity: Both Hyper- and Hypophosphorylation Inhibit Splicing

Prasad, Jayendra, Colwill, Karen, Pawson, Tony, Manley, James L.

The splicing of mammalian mRNA precursors requires both protein phosphorylation and dephosphorylation, likely involving modification of members of the SR protein family of splicing factors. Several...

ASAP, a Novel Protein Complex Involved in RNA Processing and Apoptosis

Schwerk, Christian, Prasad, Jayendra, Degenhardt, Kurt, Erdjument-Bromage, Hediye, White, Eileen, Tempst, Paul, ...

Different isoforms of a protein complex termed the apoptosis- and splicing-associated protein (ASAP) were isolated from HeLa cell extract. ASAP complexes are composed of the polypeptides SAP18 and...

Regulation and Substrate Specificity of the SR Protein Kinase Clk/Sty

Prasad, Jayendra, Manley, James L.

SR proteins constitute a family of splicing factors that play key roles in both constitutive and regulated splicing in metazoan organisms. The proteins are extensively phosphorylated, and kinases...

Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins

Lemaire, Raphael, Prasad, Jayendra, Kashima, Tsuyoshi, Gustafson, Jennifer, Manley, James L., Lafyatis, Robert

Pre-mRNA splicing is a widely used regulatory mechanism for controlling gene expression, and a family of conserved proteins, SR proteins, participate in both constitutive and alternative splicing....

The Protein Kinase Clk/Sty Directly Modulates SR Protein Activity: Both Hyper- and Hypophosphorylation Inhibit Splicing

Prasad, Jayendra, Colwill, Karen, Pawson, Tony, Manley, James L.

The splicing of mammalian mRNA precursors requires both protein phosphorylation and dephosphorylation, likely involving modification of members of the SR protein family of splicing factors. Several...

ASAP, a Novel Protein Complex Involved in RNA Processing and Apoptosis

Schwerk, Christian, Prasad, Jayendra, Degenhardt, Kurt, Erdjument-Bromage, Hediye, White, Eileen, Tempst, Paul, ...

Different isoforms of a protein complex termed the apoptosis- and splicing-associated protein (ASAP) were isolated from HeLa cell extract. ASAP complexes are composed of the polypeptides SAP18 and...

Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins

Lemaire, Raphael, Prasad, Jayendra, Kashima, Tsuyoshi, Gustafson, Jennifer, Manley, James L., Lafyatis, Robert

Pre-mRNA splicing is a widely used regulatory mechanism for controlling gene expression, and a family of conserved proteins, SR proteins, participate in both constitutive and alternative splicing....

Regulation and Substrate Specificity of the SR Protein Kinase Clk/Sty

Prasad, Jayendra, Manley, James L.

SR proteins constitute a family of splicing factors that play key roles in both constitutive and regulated splicing in metazoan organisms. The proteins are extensively phosphorylated, and kinases...

Regulation of Plant Developmental Processes by a Novel Splicing Factor

Ali, Gul Shad, Palusa, Saiprasad G., Golovkin, Maxim, Prasad, Jayendra, Manley, James L., Reddy, Anireddy S.N.

Serine/arginine-rich (SR) proteins play important roles in constitutive and alternative splicing and other aspects of mRNA metabolism. We have previously isolated a unique plant SR protein (SR45)...