Transportin-SR2 imports HIV into the nucleus (2008)
Albanese, Alberto, Arosio, Daniele, ...
BACKGROUND: The human immunodeficiency virus type 1 (HIV-1) and other lentiviruses have the capacity to infect nondividing cells like macrophages. This requires import of the preintegration complex...
Lemay, Julie, Maidou-Peindara, Priscilla, Bader, Thomas, Ennifar, Eric, Rain, Jean-Christophe, Benarous, Richard, ...
Abstract Reverse transcription of the genetic material of human immunodeficiency virus type 1 (HIV-1) is a critical step in the replication cycle of this virus. This process, catalyzed by reverse...
Identification of the LEDGF/p75 Binding Site in HIV-1 Integrase (2007)
Rain, Jean-Christophe, Emiliani, Stéphane, Benarous, Richard, ...
Lens epithelium-derived growth factor (LEDGF)/p75 is an important cellular co-factor for human immunodeficiency virus (HIV) replication. We originally identified LEDGF/p75 as a binding partner of...
Mousnier, Aurélie, Maroun, Marlène, Tempé, Denis, ...
The insertion of a DNA copy of its RNA genome into a chromosome of the host cell is mediated by the viral integrase with the help of mostly uncharacterized cellular cofactors. We have recently...
Genome-Wide Protein Interaction Screens Reveal Functional Networks Involving Sm-Like Proteins (2000)
Micheline Fromont-Racine, Andrew E. Mayes, Adeline Brunet-Simon, Jean-Christophe Rain, Alan Colley, Ian Dix, ...
A set of seven structurally related Sm proteins forms the core of the snRNP particles containing the spliceosomal U1, U2, U4 and U5 snRNAs. A search of the genomic sequence of Saccharomyces...
Functional Conservation of the Transportin Nuclear Import Pathway in Divergent Organisms
Siomi, Mikiko C., Fromont, Micheline, Rain, Jean-Christophe, Wan, Lili, Wang, Fan, Legrain, Pierre, ...
Human transportin1 (hTRN1) is the nuclear import receptor for a group of pre-mRNA/mRNA-binding proteins (heterogeneous nuclear ribonucleoproteins [hnRNP]) represented by hnRNP A1, which shuttle...
Antiviral Drug Discovery Strategy Using Combinatorial Libraries of Structurally Constrained Peptides
Real, Eléonore, Rain, Jean-Christophe, Battaglia, Véronique, Jallet, Corinne, Perrin, Pierre, Tordo, Noël, ...
We have developed a new strategy for antiviral peptide discovery by using lyssaviruses (rabies virus and rabies-related viruses) as models. Based on the mimicry of natural bioactive peptides, two...
The Splicing ATPase Prp43p Is a Component of Multiple Preribosomal Particles
Lebaron, Simon, Froment, Carine, Fromont-Racine, Micheline, Rain, Jean-Christophe, Monsarrat, Bernard, Caizergues-Ferrer, Michèle, ...
Prp43p is a putative helicase of the DEAH family which is required for the release of the lariat intron from the spliceosome. Prp43p could also play a role in ribosome synthesis, since it accumulates...
Functional Conservation of the Transportin Nuclear Import Pathway in Divergent Organisms
Siomi, Mikiko C., Fromont, Micheline, Rain, Jean-Christophe, Wan, Lili, Wang, Fan, Legrain, Pierre, ...
Human transportin1 (hTRN1) is the nuclear import receptor for a group of pre-mRNA/mRNA-binding proteins (heterogeneous nuclear ribonucleoproteins [hnRNP]) represented by hnRNP A1, which shuttle...
Antiviral Drug Discovery Strategy Using Combinatorial Libraries of Structurally Constrained Peptides
Real, Eléonore, Rain, Jean-Christophe, Battaglia, Véronique, Jallet, Corinne, Perrin, Pierre, Tordo, Noël, ...
We have developed a new strategy for antiviral peptide discovery by using lyssaviruses (rabies virus and rabies-related viruses) as models. Based on the mimicry of natural bioactive peptides, two...
The Splicing ATPase Prp43p Is a Component of Multiple Preribosomal Particles
Lebaron, Simon, Froment, Carine, Fromont-Racine, Micheline, Rain, Jean-Christophe, Monsarrat, Bernard, Caizergues-Ferrer, Michèle, ...
Prp43p is a putative helicase of the DEAH family which is required for the release of the lariat intron from the spliceosome. Prp43p could also play a role in ribosome synthesis, since it accumulates...
A functional network involved in the recycling of nucleocytoplasmic pre-60S factors
Lebreton, Alice, Saveanu, Cosmin, Decourty, Laurence, Rain, Jean-Christophe, Jacquier, Alain, Fromont-Racine, Micheline
Eukaryotic pre-ribosomes go through cytoplasmic maturation steps before entering translation. The nucleocytoplasmic proteins participating in these late stages of maturation are reimported to the...
Mousnier, Aurélie, Kubat, Nicole, Massias-Simon, Aurélie, Ségéral, Emmanuel, Rain, Jean-Christophe, Benarous, Richard, ...
HIV-1 integrase, the viral enzyme responsible for provirus integration into the host genome, can be actively degraded by the ubiquitin–proteasome pathway. Here, we identify von Hippel–Lindau...
Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1
Maiuri, M Chiara, Le Toumelin, Gaëtane, Criollo, Alfredo, Rain, Jean-Christophe, Gautier, Fabien, Juin, Philippe, ...
The anti-apoptotic proteins Bcl-2 and Bcl-XL bind and inhibit Beclin-1, an essential mediator of autophagy. Here, we demonstrate that this interaction involves a BH3 domain within Beclin-1 (residues...
Lemay, Julie, Maidou-Peindara, Priscilla, Bader, Thomas, Ennifar, Eric, Rain, Jean-Christophe, Benarous, Richard, ...
Reverse transcription of the genetic material of human immunodeficiency virus type 1 (HIV-1) is a critical step in the replication cycle of this virus. This process, catalyzed by reverse...
Genome-Wide Protein Interaction Screens Reveal Functional Networks Involving Sm-Like Proteins
Fromont-Racine, Micheline, Mayes, Andrew E., Brunet-Simon, Adeline, Rain, Jean-Christophe, Colley, Alan, Dix, Ian, ...
A set of seven structurally related Sm proteins forms the core of the snRNP particles containing the spliceosomal U1, U2, U4 and U5 snRNAs. A search of the genomic sequence of Saccharomyces...