Jean-Claude Petit

Effect of Antibiotic Therapy on Human Fecal Microbiota and the Relation to the Development of Clostridium difficile. (2008)

De La Cochetière, Marie-France, Durand, T., Lalande, Valérie, Petit, Jean-Claude, Potel, Gilles, Beaugerie, Laurent

The gastrointestinal tract is a complex ecosystem. Recent studies have shown that the human fecal microbiota is composed of a consortium of microorganism. It is known that antibiotic treatment alters...

Effect of Antibiotic Therapy on Human Fecal Microbiota and the Relation to the Development of Clostridium difficile. (2008)

De La Cochetière, Marie-France, Durand, T., Lalande, Valérie, Petit, Jean-Claude, Potel, Gilles, Beaugerie, Laurent

The gastrointestinal tract is a complex ecosystem. Recent studies have shown that the human fecal microbiota is composed of a consortium of microorganism. It is known that antibiotic treatment alters...

Effect of Antibiotic Therapy on Human Fecal Microbiota and the Relation to the Development of Clostridium difficile. (2008)

De La Cochetière, Marie-France, Durand, T., Lalande, Valérie, Petit, Jean-Claude, Potel, Gilles, Beaugerie, Laurent

The gastrointestinal tract is a complex ecosystem. Recent studies have shown that the human fecal microbiota is composed of a consortium of microorganism. It is known that antibiotic treatment alters...

First outbreak of multidrug-resistant Klebsiella pneumoniae carrying blaVIM-1 and blaSHV-5 in a French university hospital (2006)

Kassis-Chikhani, Najiby, Decré, Dominique, Gautier, Valérie, Burghoffer, Béatrice, Saliba, Faouzi, Mathieu, Daniele, ...

Objectives: We studied eight imipenem-resistant isolates of Klebsiella pneumoniae involved in an outbreak in a French teaching hospital. Methods: The eight isolates were recovered from clinical...

First outbreak of multidrug-resistant Klebsiella pneumoniae carrying blaVIM-1 and blaSHV-5 in a French university hospital (2005)

Kassis-Chikhani, Najiby, Decré, Dominique, Gautier, Valérie, Burghoffer, Béatrice, Saliba, Faouzi, Mathieu, Daniele, ...

Objectives: We studied eight imipenem-resistant isolates of Klebsiella pneumoniae involved in an outbreak in a French teaching hospital. Methods: The eight isolates were recovered from clinical...

Outbreak of multi-resistant Klebsiella oxytoca involving strains with extended-spectrum {beta}-lactamases and strains with extended-spectrum activity of the chromosomal {beta}-lactamase (2004)

Decré, Dominique, Burghoffer, Béatrice, Gautier, Valérie, Petit, Jean-Claude, Arlet, Guillaume

Objectives: This study was conducted to analyse broad-spectrum cephalosporin-resistant Klebsiella oxytoca strains. Methods: The 57 isolates studied were recovered from clinical specimens (n=23) or...

Outbreak of multi-resistant Klebsiella oxytoca involving strains with extended-spectrum {beta}-lactamases and strains with extended-spectrum activity of the chromosomal {beta}-lactamase (2004)

Decré, Dominique, Burghoffer, Béatrice, Gautier, Valérie, Petit, Jean-Claude, Arlet, Guillaume

Objectives: This study was conducted to analyse broad-spectrum cephalosporin-resistant Klebsiella oxytoca strains. Methods: The 57 isolates studied were recovered from clinical specimens (n=23) or...

Le stockage des dechets radioactifs : perspective historique et analyse sociotechnique / (1993)

Petit, Jean-Claude.

Thesis (doctoral)--L'École Nationale Supérieure des Mines de Paris (Centre de Sociologie de l'Innovation), 1993.

Epidemiology of Recurrences or Reinfections of Clostridium difficile-Associated Diarrhea

Barbut, Frédéric, Richard, Anne, Hamadi, Kheira, Chomette, Valérie, Burghoffer, Béatrice, Petit, Jean-Claude

Approximately 15 to 35% of patients with a first episode of Clostridium difficile-associated diarrhea relapse within 2 months. Between 1994 and 1997, strains from 93 hospitalized patients with C....

Comparison of PCR-Ribotyping, Arbitrarily Primed PCR, and Pulsed-Field Gel Electrophoresis for Typing Clostridium difficile

Bidet, Philippe, Lalande, Valérie, Salauze, Béatrice, Burghoffer, Béatrice, Avesani, Véronique, Delmée, Michel, ...

Clostridium difficile is now recognized as the major agent responsible for nosocomial diarrhea in adults. Among the genotyping methods available, arbitrarily primed PCR (AP-PCR), PCR-ribotyping, and...

Antimicrobial Susceptibilities and Serogroups of Clinical Strains of Clostridium difficile Isolated in France in 1991 and 1997

Barbut, Frédéric, Decré, Dominique, Burghoffer, Béatrice, Lesage, Danièle, Delisle, Françoise, Lalande, Valérie, ...

Glycopeptides (vancomycin and teicoplanin) and metronidazole are the drugs of choice for the treatment of Clostridium difficile infections, but trends in susceptibility patterns have not been...

gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile

Dridi, Larbi, Tankovic, Jacques, Burghoffer, Béatrice, Barbut, Frédéric, Petit, Jean-Claude

A total of 198 nonrepetitive clinical strains of Clostridium difficile isolated from different French hospitals in 1991 (n = 100) and 1997 (n = 98) were screened for decreased susceptibility to...

Prevalence and Genetic Characterization of Toxin A Variant Strains of Clostridium difficile among Adults and Children with Diarrhea in France

Barbut, Frédéric, Lalande, Valérie, Burghoffer, Béatrice, Thien, Huong Vu, Grimprel, Emmanuel, Petit, Jean-Claude

Toxin A variant strains (toxin A-negative, toxin B-positive strains) of Clostridium difficile have been reported to be responsible for diarrhea or pseudomembranous colitis in humans. These strains...

Fast and Accurate Quantitative Detection of Helicobacter pylori and Identification of Clarithromycin Resistance Mutations in H. pylori Isolates from Gastric Biopsy Specimens by Real-Time PCR

Lascols, Christine, Lamarque, Dominique, Costa, Jean-Marc, Copie-Bergman, Christiane, Le Glaunec, Jeanne-Marie, Deforges, Lionel, ...

Rapid identification of patients infected with clarithromycin-resistant Helicobacter pylori without the need for culture can help to avoid useless prescriptions of clarithromycin. We developed and...

Single and Double Mutations in gyrA but Not in gyrB Are Associated with Low- and High-Level Fluoroquinolone Resistance in Helicobacter pylori

Tankovic, Jacques, Lascols, Christine, Sculo, Quentin, Petit, Jean-Claude, Soussy, Claude-James

In one French hospital the rate of resistance to ciprofloxacin in Helicobacter pylori was 3.3% (2 of 60 strains) in 1999. The six resistant clinical strains (four from 1996 and two from 1999) and...

Prevalence and Characterization of a Binary Toxin (Actin-Specific ADP-Ribosyltransferase) from Clostridium difficile

Gonçalves, Carina, Decré, Dominique, Barbut, Frédéric, Burghoffer, Béatrice, Petit, Jean-Claude

In addition to the two large clostridial cytotoxins (TcdA and TcdB), some strains of Clostridium difficile also produce an actin-specific ADP-ribosyltransferase, called binary toxin CDT. We used a...

Epidemiology of Recurrences or Reinfections of Clostridium difficile-Associated Diarrhea

Barbut, Frédéric, Richard, Anne, Hamadi, Kheira, Chomette, Valérie, Burghoffer, Béatrice, Petit, Jean-Claude

Approximately 15 to 35% of patients with a first episode of Clostridium difficile-associated diarrhea relapse within 2 months. Between 1994 and 1997, strains from 93 hospitalized patients with C....

Comparison of PCR-Ribotyping, Arbitrarily Primed PCR, and Pulsed-Field Gel Electrophoresis for Typing Clostridium difficile

Bidet, Philippe, Lalande, Valérie, Salauze, Béatrice, Burghoffer, Béatrice, Avesani, Véronique, Delmée, Michel, ...

Clostridium difficile is now recognized as the major agent responsible for nosocomial diarrhea in adults. Among the genotyping methods available, arbitrarily primed PCR (AP-PCR), PCR-ribotyping, and...

Antimicrobial Susceptibilities and Serogroups of Clinical Strains of Clostridium difficile Isolated in France in 1991 and 1997

Barbut, Frédéric, Decré, Dominique, Burghoffer, Béatrice, Lesage, Danièle, Delisle, Françoise, Lalande, Valérie, ...

Glycopeptides (vancomycin and teicoplanin) and metronidazole are the drugs of choice for the treatment of Clostridium difficile infections, but trends in susceptibility patterns have not been...

gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile

Dridi, Larbi, Tankovic, Jacques, Burghoffer, Béatrice, Barbut, Frédéric, Petit, Jean-Claude

A total of 198 nonrepetitive clinical strains of Clostridium difficile isolated from different French hospitals in 1991 (n = 100) and 1997 (n = 98) were screened for decreased susceptibility to...

Prevalence and Genetic Characterization of Toxin A Variant Strains of Clostridium difficile among Adults and Children with Diarrhea in France

Barbut, Frédéric, Lalande, Valérie, Burghoffer, Béatrice, Thien, Huong Vu, Grimprel, Emmanuel, Petit, Jean-Claude

Toxin A variant strains (toxin A-negative, toxin B-positive strains) of Clostridium difficile have been reported to be responsible for diarrhea or pseudomembranous colitis in humans. These strains...

Fast and Accurate Quantitative Detection of Helicobacter pylori and Identification of Clarithromycin Resistance Mutations in H. pylori Isolates from Gastric Biopsy Specimens by Real-Time PCR

Lascols, Christine, Lamarque, Dominique, Costa, Jean-Marc, Copie-Bergman, Christiane, Le Glaunec, Jeanne-Marie, Deforges, Lionel, ...

Rapid identification of patients infected with clarithromycin-resistant Helicobacter pylori without the need for culture can help to avoid useless prescriptions of clarithromycin. We developed and...

Single and Double Mutations in gyrA but Not in gyrB Are Associated with Low- and High-Level Fluoroquinolone Resistance in Helicobacter pylori

Tankovic, Jacques, Lascols, Christine, Sculo, Quentin, Petit, Jean-Claude, Soussy, Claude-James

In one French hospital the rate of resistance to ciprofloxacin in Helicobacter pylori was 3.3% (2 of 60 strains) in 1999. The six resistant clinical strains (four from 1996 and two from 1999) and...

Prevalence and Characterization of a Binary Toxin (Actin-Specific ADP-Ribosyltransferase) from Clostridium difficile

Gonçalves, Carina, Decré, Dominique, Barbut, Frédéric, Burghoffer, Béatrice, Petit, Jean-Claude

In addition to the two large clostridial cytotoxins (TcdA and TcdB), some strains of Clostridium difficile also produce an actin-specific ADP-ribosyltransferase, called binary toxin CDT. We used a...

Why do we need fundamental research?

PETIT, JEAN-CLAUDE

Research is considered as a major component of innovation and a key to the development of modern societies. However, fundamental research, which essentially aims at improving our understanding of...