The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells. (2008)
Mamani-Matsuda, Maria, Cosma, Antonio, Weller, Sandra, Faili, Ahmad, Staib, Caroline, Garçon, Loïc, ...
The fact that you can vaccinate a child at 5 years of age and find lymphoid B cells and antibodies specific for this vaccination 70 years later remains an immunologic enigma. It has never been...
The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells. (2008)
Mamani-Matsuda, Maria, Cosma, Antonio, Weller, Sandra, Faili, Ahmad, Staib, Caroline, Garçon, Loïc, ...
The fact that you can vaccinate a child at 5 years of age and find lymphoid B cells and antibodies specific for this vaccination 70 years later remains an immunologic enigma. It has never been...
DNA polymerases in adaptive immunity. (2008)
Weill, Jean-Claude, Reynaud, Claude-Agnès
To cope with an unpredictable variety of potential pathogenic insults, the immune system must generate an enormous diversity of recognition structures, and it does so by making stepwise modifications...
Gueranger, Quentin, Stary, Anne, Aoufouchi, Saïd, Faili, Ahmad, Sarasin, Alain, Reynaud, Claude-Agnès, ...
Genes coding for DNA polymerases eta, iota and zeta, or for both Pol eta and Pol iota have been inactivated by homologous recombination in the Burkitt's lymphoma BL2 cell line, thus providing for the...
DNA polymerases in adaptive immunity. (2008)
Weill, Jean-Claude, Reynaud, Claude-Agnès
To cope with an unpredictable variety of potential pathogenic insults, the immune system must generate an enormous diversity of recognition structures, and it does so by making stepwise modifications...
Gueranger, Quentin, Stary, Anne, Aoufouchi, Saïd, Faili, Ahmad, Sarasin, Alain, Reynaud, Claude-Agnès, ...
Genes coding for DNA polymerases eta, iota and zeta, or for both Pol eta and Pol iota have been inactivated by homologous recombination in the Burkitt's lymphoma BL2 cell line, thus providing for the...
Proteasomal degradation restricts the nuclear lifespan of AID. (2008)
Aoufouchi, Said, Faili, Ahmad, Zober, Carole, D'Orlando, Orietta, Weller, Sandra, Weill, Jean-Claude, ...
Activation-induced cytidine deaminase (AID) initiates all postrearrangement processes that diversify the immunoglobulin repertoire by specific deamination of cytidines at the immunoglobulin (Ig)...
Proteasomal degradation restricts the nuclear lifespan of AID. (2008)
Aoufouchi, Said, Faili, Ahmad, Zober, Carole, D'Orlando, Orietta, Weller, Sandra, Weill, Jean-Claude, ...
Activation-induced cytidine deaminase (AID) initiates all postrearrangement processes that diversify the immunoglobulin repertoire by specific deamination of cytidines at the immunoglobulin (Ig)...
Weller, Sandra, Mamani-Matsuda, Maria, Picard, Capucine, Cordier, Corinne, Lecoeuche, Damiana, Gauthier, Frédéric, ...
T cell-dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell-independent responses. We used this dissociation to analyze the repertoire...
Weller, Sandra, Mamani-Matsuda, Maria, Picard, Capucine, Cordier, Corinne, Lecoeuche, Damiana, Gauthier, Frédéric, ...
T cell-dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell-independent responses. We used this dissociation to analyze the repertoire...
Weller, Sandra, Mamani-Matsuda, Maria, Picard, Capucine, Cordier, Corinne, Lecoeuche, Damiana, Gauthier, Frédéric, ...
T cell-dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell-independent responses. We used this dissociation to analyze the repertoire...
Proteasomal degradation restricts the nuclear lifespan of AID. (2008)
Aoufouchi, Said, Faili, Ahmad, Zober, Carole, D'Orlando, Orietta, Weller, Sandra, Weill, Jean-Claude, ...
Activation-induced cytidine deaminase (AID) initiates all postrearrangement processes that diversify the immunoglobulin repertoire by specific deamination of cytidines at the immunoglobulin (Ig)...
DNA polymerases in adaptive immunity. (2008)
Weill, Jean-Claude, Reynaud, Claude-Agnès
To cope with an unpredictable variety of potential pathogenic insults, the immune system must generate an enormous diversity of recognition structures, and it does so by making stepwise modifications...
Gueranger, Quentin, Stary, Anne, Aoufouchi, Saïd, Faili, Ahmad, Sarasin, Alain, Reynaud, Claude-Agnès, ...
Genes coding for DNA polymerases eta, iota and zeta, or for both Pol eta and Pol iota have been inactivated by homologous recombination in the Burkitt's lymphoma BL2 cell line, thus providing for the...
The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells. (2008)
Mamani-Matsuda, Maria, Cosma, Antonio, Weller, Sandra, Faili, Ahmad, Staib, Caroline, Garçon, Loïc, ...
The fact that you can vaccinate a child at 5 years of age and find lymphoid B cells and antibodies specific for this vaccination 70 years later remains an immunologic enigma. It has never been...
Faili, Ahmad, Aoufouchi, Said, Weller, Sandra, Vuillier, Françoise, Stary, Anne, Sarasin, Alain, ...
Base substitutions, deletions, and duplications are observed at the immunoglobulin locus in DNA sequences involved in class switch recombination (CSR). These mutations are dependent upon...
Faili, Ahmad, Aoufouchi, Said, Weller, Sandra, Vuillier, Françoise, Stary, Anne, Sarasin, Alain, ...
Base substitutions, deletions, and duplications are observed at the immunoglobulin locus in DNA sequences involved in class switch recombination (CSR). These mutations are dependent upon...
Delbos, Frédéric, Aoufouchi, Said, Faili, Ahmad, Weill, Jean-Claude, Reynaud, Claude-Agnès
Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2-MSH6...
Delbos, Frédéric, Aoufouchi, Said, Faili, Ahmad, Weill, Jean-Claude, Reynaud, Claude-Agnès
Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2-MSH6...
Delbos, Frédéric, Aoufouchi, Said, Faili, Ahmad, Weill, Jean-Claude, Reynaud, Claude-Agnès
Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2-MSH6...
Bertocci, Barbara, De Smet, Annie, Weill, Jean-Claude, Reynaud, Claude-Agnès
DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of the pol X family that share homology in sequence and functional domain organization. We...
Bertocci, Barbara, De Smet, Annie, Weill, Jean-Claude, Reynaud, Claude-Agnès
DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of the pol X family that share homology in sequence and functional domain organization. We...
Bertocci, Barbara, De Smet, Annie, Weill, Jean-Claude, Reynaud, Claude-Agnès
DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of the pol X family that share homology in sequence and functional domain organization. We...
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse. (2005)
Delbos, Frédéric, De Smet, Annie, Faili, Ahmad, Aoufouchi, Said, Weill, Jean-Claude, Reynaud, Claude-Agnès
The mutation pattern of immunoglobulin genes was studied in mice deficient for DNA polymerase eta, a translesional polymerase whose inactivation is responsible for the xeroderma pigmentosum variant...
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse. (2005)
Delbos, Frédéric, De Smet, Annie, Faili, Ahmad, Aoufouchi, Said, Weill, Jean-Claude, Reynaud, Claude-Agnès
The mutation pattern of immunoglobulin genes was studied in mice deficient for DNA polymerase eta, a translesional polymerase whose inactivation is responsible for the xeroderma pigmentosum variant...
Normal immune system development in mice lacking the Deltex-1 RING finger domain. (2005)
Storck, Sébastien, Delbos, Frédéric, Stadler, Nicolas, Thirion-Delalande, Catherine, Bernex, Florence, Verthuy, Christophe, ...
The Notch signaling pathway controls several cell fate decisions during lymphocyte development, from T-cell lineage commitment to the peripheral differentiation of B and T lymphocytes. Deltex-1 is a...
Normal immune system development in mice lacking the Deltex-1 RING finger domain. (2005)
Storck, Sébastien, Delbos, Frédéric, Stadler, Nicolas, Thirion-Delalande, Catherine, Bernex, Florence, Verthuy, Christophe, ...
The Notch signaling pathway controls several cell fate decisions during lymphocyte development, from T-cell lineage commitment to the peripheral differentiation of B and T lymphocytes. Deltex-1 is a...
Splenic marginal zone B cells in humans: where do they mutate their Ig receptor? (2005)
Weller, Sandra, Reynaud, Claude-Agnès, Weill, Jean-Claude
Human IgM+ IgD+ CD27+ B cells have mutated Ig genes and harbor a splenic marginal zone (MZ) phenotype. In this issue, the group of R. K?rs has studied the expression of the enzyme activation-induced...
Splenic marginal zone B cells in humans: where do they mutate their Ig receptor? (2005)
Weller, Sandra, Reynaud, Claude-Agnès, Weill, Jean-Claude
Human IgM+ IgD+ CD27+ B cells have mutated Ig genes and harbor a splenic marginal zone (MZ) phenotype. In this issue, the group of R. K?rs has studied the expression of the enzyme activation-induced...
Vaccination against encapsulated bacteria in humans: paradoxes. (2005)
Weller, Sandra, Reynaud, Claude-Agnès, Weill, Jean-Claude
Infection with encapsulated bacteria can be prevented by vaccination with capsular polysaccharides, either plain or conjugated to a protein carrier. However, results concerning these vaccinations...
Vaccination against encapsulated bacteria in humans: paradoxes. (2005)
Weller, Sandra, Reynaud, Claude-Agnès, Weill, Jean-Claude
Infection with encapsulated bacteria can be prevented by vaccination with capsular polysaccharides, either plain or conjugated to a protein carrier. However, results concerning these vaccinations...
Vaccination against encapsulated bacteria in humans: paradoxes. (2005)
Weller, Sandra, Reynaud, Claude-Agnès, Weill, Jean-Claude
Infection with encapsulated bacteria can be prevented by vaccination with capsular polysaccharides, either plain or conjugated to a protein carrier. However, results concerning these vaccinations...
Splenic marginal zone B cells in humans: where do they mutate their Ig receptor? (2005)
Weller, Sandra, Reynaud, Claude-Agnès, Weill, Jean-Claude
Human IgM+ IgD+ CD27+ B cells have mutated Ig genes and harbor a splenic marginal zone (MZ) phenotype. In this issue, the group of R. K?rs has studied the expression of the enzyme activation-induced...
Normal immune system development in mice lacking the Deltex-1 RING finger domain. (2005)
Storck, Sébastien, Delbos, Frédéric, Stadler, Nicolas, Thirion-Delalande, Catherine, Bernex, Florence, Verthuy, Christophe, ...
The Notch signaling pathway controls several cell fate decisions during lymphocyte development, from T-cell lineage commitment to the peripheral differentiation of B and T lymphocytes. Deltex-1 is a...
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse. (2005)
Delbos, Frédéric, De Smet, Annie, Faili, Ahmad, Aoufouchi, Said, Weill, Jean-Claude, Reynaud, Claude-Agnès
The mutation pattern of immunoglobulin genes was studied in mice deficient for DNA polymerase eta, a translesional polymerase whose inactivation is responsible for the xeroderma pigmentosum variant...
A bird's eye view on human B cells. (2004)
Weill, Jean-Claude, Weller, Sandra, Reynaud, Claude-Agnès
We show in this review that there is a continuum between the chicken B-cell system classified as the first GALT model described and the human B-cell system. We propose that humans have conserved for...
A bird's eye view on human B cells. (2004)
Weill, Jean-Claude, Weller, Sandra, Reynaud, Claude-Agnès
We show in this review that there is a continuum between the chicken B-cell system classified as the first GALT model described and the human B-cell system. We propose that humans have conserved for...
Weller, Sandra, Braun, Moritz, Tan, Bruce, Rosenwald, Andreas, Cordier, Corinne, Conley, Mary Ellen, ...
The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27(+) (IgM(+)IgD(+)CD27(+)) "memory" B cells carrying a mutated...
Weller, Sandra, Braun, Moritz, Tan, Bruce, Rosenwald, Andreas, Cordier, Corinne, Conley, Mary Ellen, ...
The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27(+) (IgM(+)IgD(+)CD27(+)) "memory" B cells carrying a mutated...
Weller, Sandra, Braun, Moritz, Tan, Bruce, Rosenwald, Andreas, Cordier, Corinne, Conley, Mary Ellen, ...
The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27(+) (IgM(+)IgD(+)CD27(+)) "memory" B cells carrying a mutated...
A bird's eye view on human B cells. (2004)
Weill, Jean-Claude, Weller, Sandra, Reynaud, Claude-Agnès
We show in this review that there is a continuum between the chicken B-cell system classified as the first GALT model described and the human B-cell system. We propose that humans have conserved for...
'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally (2002)
Isabel García-Cao, Marta García-Cao, Juan Martín-Caballero, Luis M. Criado, Peter Klatt, Juana M. Flores, ...
Ahmad Faili, Said Aoufouchi, Eric Flatter, Quentin Guéranger, Claude-Agnès Reynaud, Jean-Claude Weill
AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line (2002)
Ahmad Faili, Said Aoufouchi, Quentin Guéranger, Carole Zober, Anne Léon, Barbara Bertocci, ...
Two novel human and mouse DNA polymerases of the polX family (2000)
Aoufouchi, Said, Flatter, Eric, Dahan, Auriel, Faili, Ahmad, Bertocci, Barbara, Storck, Sebastien, ...
We describe here two novel mouse and human DNA polymerases: one (pol &lgr;) has homology with DNA polymerase &bgr; while the other one (pol µ) is closer to terminal deoxynucleotidyltransferase....
Dahan, Auriel, Reynaud, Claude-Agnès, Weill, Jean-Claude
We have recently reported the sequence of a chicken Ig λ light chain cDNA clone, isolated from a spleen partial cDNA library (1).In this paper, we describe the characterization of a cDNA clone...
A glycoprotein from parotid saliva /--by Jean-Claude Weill. (1965)
Photocopy of typescript.
Weller, Sandra, Faili, Ahmad, Garcia, Corinne, Braun, Moritz C., Le Deist, Françoise, De Saint Basile, Geneviève, ...
Somatically mutated IgM+-only and IgM+IgD+CD27+ B lymphocytes comprise ≈25% of the human peripheral B cell pool. These cells phenotypically resemble class-switched B cells and have therefore been...
Defect in IgV gene somatic hypermutation in Common Variable Immuno-Deficiency syndrome
Levy, Yves, Gupta, Neetu, Le Deist, Françoise, Garcia, Corinne, Fischer, Alain, Weill, Jean-Claude, ...
Common Variable Immuno-Deficiency (CVID) is the most common symptomatic primary antibody-deficiency syndrome, but the basic immunologic defects underlying this syndrome are not well defined. We...
Two novel human and mouse DNA polymerases of the polX family
Aoufouchi, Said, Flatter, Eric, Dahan, Auriel, Faili, Ahmad, Bertocci, Barbara, Storck, Sebastien, ...
We describe here two novel mouse and human DNA polymerases: one (pol λ) has homology with DNA polymerase β while the other one (pol µ) is closer to terminal deoxynucleotidyltransferase. However...
‘Super p53’ mice exhibit enhanced DNA damage response, are tumor resistant and age normally
García-Cao, Isabel, García-Cao, Marta, Martín-Caballero, Juan, Criado, Luis M., Klatt, Peter, Flores, Juana M., ...
The tumor suppressor p53 is critical in preventing cancer due to its ability to trigger proliferation arrest and cell death upon the occurrence of a variety of stresses, most notably, DNA damage and...
Normal Immune System Development in Mice Lacking the Deltex-1 RING Finger Domain
Storck, Sébastien, Delbos, Frédéric, Stadler, Nicolas, Thirion-Delalande, Catherine, Bernex, Florence, Verthuy, Christophe, ...
The Notch signaling pathway controls several cell fate decisions during lymphocyte development, from T-cell lineage commitment to the peripheral differentiation of B and T lymphocytes. Deltex-1 is a...
Weller, Sandra, Faili, Ahmad, Garcia, Corinne, Braun, Moritz C., Le Deist, Françoise, De Saint Basile, Geneviève, ...
Somatically mutated IgM+-only and IgM+IgD+CD27+ B lymphocytes comprise ≈25% of the human peripheral B cell pool. These cells phenotypically resemble class-switched B cells and have therefore been...
Defect in IgV gene somatic hypermutation in Common Variable Immuno-Deficiency syndrome
Levy, Yves, Gupta, Neetu, Le Deist, Françoise, Garcia, Corinne, Fischer, Alain, Weill, Jean-Claude, ...
Common Variable Immuno-Deficiency (CVID) is the most common symptomatic primary antibody-deficiency syndrome, but the basic immunologic defects underlying this syndrome are not well defined. We...
Two novel human and mouse DNA polymerases of the polX family
Aoufouchi, Said, Flatter, Eric, Dahan, Auriel, Faili, Ahmad, Bertocci, Barbara, Storck, Sebastien, ...
We describe here two novel mouse and human DNA polymerases: one (pol λ) has homology with DNA polymerase β while the other one (pol µ) is closer to terminal deoxynucleotidyltransferase. However...
‘Super p53’ mice exhibit enhanced DNA damage response, are tumor resistant and age normally
García-Cao, Isabel, García-Cao, Marta, Martín-Caballero, Juan, Criado, Luis M., Klatt, Peter, Flores, Juana M., ...
The tumor suppressor p53 is critical in preventing cancer due to its ability to trigger proliferation arrest and cell death upon the occurrence of a variety of stresses, most notably, DNA damage and...
Normal Immune System Development in Mice Lacking the Deltex-1 RING Finger Domain
Storck, Sébastien, Delbos, Frédéric, Stadler, Nicolas, Thirion-Delalande, Catherine, Bernex, Florence, Verthuy, Christophe, ...
The Notch signaling pathway controls several cell fate decisions during lymphocyte development, from T-cell lineage commitment to the peripheral differentiation of B and T lymphocytes. Deltex-1 is a...
Weill, Jean-Claude, Radman, Miroslav
Our genome has evolved to perpetuate itself through the maintenance of the species via an uninterrupted chain of reproductive somas. Accordingly, evolution is not concerned with diseases occurring...
Delbos, Frédéric, Aoufouchi, Said, Faili, Ahmad, Weill, Jean-Claude, Reynaud, Claude-Agnès
Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2–MSH6...
Faili, Ahmad, Aoufouchi, Said, Weller, Sandra, Vuillier, Françoise, Stary, Anne, Sarasin, Alain, ...
Base substitutions, deletions, and duplications are observed at the immunoglobulin locus in DNA sequences involved in class switch recombination (CSR). These mutations are dependent upon...
Do developing B cells need antigen?
Weill, Jean-Claude, Reynaud, Claude-Agnès
Just as potentially useful T cells are positively selected by MHC–peptide complexes in the thymus, it has been proposed that self or commensal bacterial epitopes might select B cell populations...
Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouse
Delbos, Frédéric, De Smet, Annie, Faili, Ahmad, Aoufouchi, Said, Weill, Jean-Claude, Reynaud, Claude-Agnès
The mutation pattern of immunoglobulin genes was studied in mice deficient for DNA polymerase η, a translesional polymerase whose inactivation is responsible for the xeroderma pigmentosum variant...
Cocea, Laurentiu, De Smet, Annie, Saghatchian, Mahasti, Fillatreau, Simon, Ferradini, Laurent, Schurmans, Stéphane, ...
We have shown previously that a mutation of the KI-KII site immediately 5′ to Jκ1 on the mouse immunoglobulin light chain κ locus reduces the rearrangement level in cis, although it does not...