Janghoo Lim, Tong Hao, Chad Shaw, Akash J. Patel, Gábor Szabó, Jean-françois Rual, ...
Many human inherited neurodegenerative disorders are characterized by loss of balance due to cerebellar Purkinje cell (PC) degeneration. Although the disease-causing mutations have been identified...
Shifted Transversal Design smart-pooling for high coverage interactome mapping (2009)
Xin, Xiaofeng, Rual, Jean-François, Hirozane-Kishikawa, Tomoko, Hill, David E., Vidal, Marc, Boone, Charles, ...
“Smart-pooling,” in which test reagents are multiplexed in a highly redundant manner, is a promising strategy for achieving high efficiency, sensitivity, and specificity in systems-level...
Novel insights into RNAi off-target effects using C. elegansparalogs (2007)
Rual, Jean-François, Klitgord, Niels, Achaz, Guillaume
Abstract Background In the few years since its discovery, RNAi has turned into a very powerful tool for the study of gene function by allowing post-transcriptional gene silencing. The RNAi mechanism,...
Ceron, Julian, Rual, Jean-François, Chandra, Abha, Dupuy, Denis, Vidal, Marc, Van Den Heuvel, Sander
Abstract Background The retinoblastoma tumor suppressor (Rb) acts in a conserved pathway that is deregulated in most human cancers. Inactivation of the single Rb-related gene in Caenorhabditis...
Fernandez, Anita G., Gunsalus, Kristin C., Huang, Jerry, Chuang, Ling-Shiang, Ying, Nancy, Liang, Hsiao-lan, ...
Several RNA interference (RNAi)-based functional genomic projects have been performed in Caenorhabditis elegans to identify genes required during embryogenesis. These studies have demonstrated that...
Human ORFeome Version 1.1: A Platform for Reverse Proteomics (2004)
Rual, Jean-François, Hirozane-Kishikawa, Tomoko, Hao, Tong, Bertin, Nicolas, Li, Siming, Dricot, Amélie, ...
The advent of systems biology necessitates the cloning of nearly entire sets of protein-encoding open reading frames (ORFs), or ORFeomes, to allow functional studies of the corresponding proteomes....
Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based RNAi Library (2004)
Rual, Jean-François, Ceron, Julian, Koreth, John, Hao, Tong, Nicot, Anne-Sophie, Hirozane-Kishikawa, Tomoko, ...
The recently completed Caenorhabditis elegans genome sequence allows application of high-throughput (HT) approaches for phenotypic analyses using RNA interference (RNAi). As large phenotypic data...
Generation of the Brucella melitensis ORFeome Version 1.1 (2004)
Dricot, Amélie, Rual, Jean-François, Lamesch, Philippe, Bertin, Nicolas, Dupuy, Denis, Hao, Tong, ...
The bacteria of the Brucella genus are responsible for a worldwide zoonosis called brucellosis. They belong to the α-proteobacteria group, as many other bacteria that live in close association with...
WorfDB: the Caenorhabditis elegans ORFeome Database (2003)
Vaglio, Philippe, Lamesch, Philippe, Reboul, Jérôme, Rual, Jean-François, Martinez, Monica, Hill, David, ...
WorfDB (Worm ORFeome DataBase; http://worfdb.dfci.harvard.edu) was created to integrate and disseminate the data from the cloning of complete set of ∼19 000 predicted protein-encoding Open...
WorfDB: the Caenorhabditis elegans ORFeome Database (2002)
Jérôme Reboul, Jean-françois Rual, Monica Martinez, David Hill, Marc Vidal
WorfDB (Worm ORFeome DataBase;
Lopez, Pascal, Vidal, Frédérique, Martin, Luc, Lopez-Fernandez, Luis A., Rual, Jean-François, Rosen, Barry S., ...
In mouse Sertoli cells, transcription of the Inha gene encoding the α subunit of inhibin, which acts locally as a tumor suppressor, is down-regulated in tumors and in normal cells during aging....
WorfDB: the Caenorhabditis elegans ORFeome Database
Vaglio, Philippe, Lamesch, Philippe, Reboul, Jérôme, Rual, Jean-François, Martinez, Monica, Hill, David, ...
WorfDB (Worm ORFeome DataBase; http://worfdb.dfci.harvard.edu) was created to integrate and disseminate the data from the cloning of complete set of ∼19 000 predicted protein-encoding Open Reading...
Human ORFeome Version 1.1: A Platform for Reverse Proteomics
Rual, Jean-François, Hirozane-Kishikawa, Tomoko, Hao, Tong, Bertin, Nicolas, Li, Siming, Dricot, Amélie, ...
The advent of systems biology necessitates the cloning of nearly entire sets of protein-encoding open reading frames (ORFs), or ORFeomes, to allow functional studies of the corresponding proteomes....
Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based RNAi Library
Rual, Jean-François, Ceron, Julian, Koreth, John, Hao, Tong, Nicot, Anne-Sophie, Hirozane-Kishikawa, Tomoko, ...
The recently completed Caenorhabditis elegans genome sequence allows application of high-throughput (HT) approaches for phenotypic analyses using RNA interference (RNAi). As large phenotypic data...
Generation of the Brucella melitensis ORFeome Version 1.1
Dricot, Amélie, Rual, Jean-François, Lamesch, Philippe, Bertin, Nicolas, Dupuy, Denis, Hao, Tong, ...
The bacteria of the Brucella genus are responsible for a worldwide zoonosis called brucellosis. They belong to the α-proteobacteria group, as many other bacteria that live in close association with...
New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clones
Fernandez, Anita G., Gunsalus, Kristin C., Huang, Jerry, Chuang, Ling-Shiang, Ying, Nancy, Liang, Hsiao-lan, ...
Several RNA interference (RNAi)-based functional genomic projects have been performed in Caenorhabditis elegans to identify genes required during embryogenesis. These studies have demonstrated that...
Lopez, Pascal, Vidal, Frédérique, Martin, Luc, Lopez-Fernandez, Luis A., Rual, Jean-François, Rosen, Barry S., ...
In mouse Sertoli cells, transcription of the Inha gene encoding the α subunit of inhibin, which acts locally as a tumor suppressor, is down-regulated in tumors and in normal cells during aging....
WorfDB: the Caenorhabditis elegans ORFeome Database
Vaglio, Philippe, Lamesch, Philippe, Reboul, Jérôme, Rual, Jean-François, Martinez, Monica, Hill, David, ...
WorfDB (Worm ORFeome DataBase; http://worfdb.dfci.harvard.edu) was created to integrate and disseminate the data from the cloning of complete set of ∼19 000 predicted protein-encoding Open Reading...
Human ORFeome Version 1.1: A Platform for Reverse Proteomics
Rual, Jean-François, Hirozane-Kishikawa, Tomoko, Hao, Tong, Bertin, Nicolas, Li, Siming, Dricot, Amélie, ...
The advent of systems biology necessitates the cloning of nearly entire sets of protein-encoding open reading frames (ORFs), or ORFeomes, to allow functional studies of the corresponding proteomes....
Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based RNAi Library
Rual, Jean-François, Ceron, Julian, Koreth, John, Hao, Tong, Nicot, Anne-Sophie, Hirozane-Kishikawa, Tomoko, ...
The recently completed Caenorhabditis elegans genome sequence allows application of high-throughput (HT) approaches for phenotypic analyses using RNA interference (RNAi). As large phenotypic data...
Generation of the Brucella melitensis ORFeome Version 1.1
Dricot, Amélie, Rual, Jean-François, Lamesch, Philippe, Bertin, Nicolas, Dupuy, Denis, Hao, Tong, ...
The bacteria of the Brucella genus are responsible for a worldwide zoonosis called brucellosis. They belong to the α-proteobacteria group, as many other bacteria that live in close association with...
New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clones
Fernandez, Anita G., Gunsalus, Kristin C., Huang, Jerry, Chuang, Ling-Shiang, Ying, Nancy, Liang, Hsiao-lan, ...
Several RNA interference (RNAi)-based functional genomic projects have been performed in Caenorhabditis elegans to identify genes required during embryogenesis. These studies have demonstrated that...