Perfettini, Jean-Luc, Nardacci, Roberta, Bourouba, Mehdi, Subra, Frédéric, Gros, Laurent, Séror, Claire, ...
DNA damage can activate the oncosuppressor protein ataxia telangiectasia mutated (ATM), which phosphorylates the histone H2AX within characteristic DNA damage foci. Here, we show that ATM undergoes...
Perfettini, Jean-Luc, Nardacci, Roberta, Bourouba, Mehdi, Subra, Frédéric, Gros, Laurent, Séror, Claire, ...
DNA damage can activate the oncosuppressor protein ataxia telangiectasia mutated (ATM), which phosphorylates the histone H2AX within characteristic DNA damage foci. Here, we show that ATM undergoes...
Perfettini, Jean-Luc, Nardacci, Roberta, Bourouba, Mehdi, Subra, Frédéric, Gros, Laurent, Séror, Claire, ...
DNA damage can activate the oncosuppressor protein ataxia telangiectasia mutated (ATM), which phosphorylates the histone H2AX within characteristic DNA damage foci. Here, we show that ATM undergoes...
Perfettini, Jean-Luc, Darville, Toni, Gachelin, Gabriel, Souque, Philippe, Huerre, Michel, Dautry-Varsat, Alice, ...
The pathology observed during Chlamydia infection is due initially to localized tissue damage caused by the infection itself, followed by deleterious host inflammatory responses that lead to...
Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope
Castedo, Maria, Roumier, Thomas, Blanco, Julià, Ferri, Karine F., Barretina, Jordi, Tintignac, Lionel A., ...
Syncytia arising from the fusion of cells expressing the HIV-1-encoded Env gene with cells expressing the CD4/CXCR4 complex undergo apoptosis following the nuclear translocation of mammalian target...
Role of Bcl-2 Family Members in Caspase-Independent Apoptosis during Chlamydia Infection
Perfettini, Jean-Luc, Reed, John C., Israël, Nicole, Martinou, Jean-Claude, Dautry-Varsat, Alice, Ojcius, David M.
Infection with an obligate intracellular bacterium, the Chlamydia trachomatis lymphogranuloma venereum (LGV/L2) strain or the guinea pig inclusion conjunctivitis serovar of Chlamydia psittaci, leads...
Perfettini, Jean-Luc, Darville, Toni, Dautry-Varsat, Alice, Rank, Roger G., Ojcius, David M.
The effect of gamma interferon (IFN-γ) on apoptosis due to infection by Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) was studied in epithelial cells in culture and in...
Inhibition of Macroautophagy Triggers Apoptosis†
Boya, Patricia, González-Polo, Rosa-Ana, Casares, Noelia, Perfettini, Jean-Luc, Dessen, Philippe, Larochette, Nathanael, ...
Mammalian cells were observed to die under conditions in which nutrients were depleted and, simultaneously, macroautophagy was inhibited either genetically (by a small interfering RNA targeting Atg5,...
Perfettini, Jean-Luc, Darville, Toni, Gachelin, Gabriel, Souque, Philippe, Huerre, Michel, Dautry-Varsat, Alice, ...
The pathology observed during Chlamydia infection is due initially to localized tissue damage caused by the infection itself, followed by deleterious host inflammatory responses that lead to...
Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope
Castedo, Maria, Roumier, Thomas, Blanco, Julià, Ferri, Karine F., Barretina, Jordi, Tintignac, Lionel A., ...
Syncytia arising from the fusion of cells expressing the HIV-1-encoded Env gene with cells expressing the CD4/CXCR4 complex undergo apoptosis following the nuclear translocation of mammalian target...
Role of Bcl-2 Family Members in Caspase-Independent Apoptosis during Chlamydia Infection
Perfettini, Jean-Luc, Reed, John C., Israël, Nicole, Martinou, Jean-Claude, Dautry-Varsat, Alice, Ojcius, David M.
Infection with an obligate intracellular bacterium, the Chlamydia trachomatis lymphogranuloma venereum (LGV/L2) strain or the guinea pig inclusion conjunctivitis serovar of Chlamydia psittaci, leads...
Perfettini, Jean-Luc, Darville, Toni, Dautry-Varsat, Alice, Rank, Roger G., Ojcius, David M.
The effect of gamma interferon (IFN-γ) on apoptosis due to infection by Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) was studied in epithelial cells in culture and in...
Inhibition of Macroautophagy Triggers Apoptosis†
Boya, Patricia, González-Polo, Rosa-Ana, Casares, Noelia, Perfettini, Jean-Luc, Dessen, Philippe, Larochette, Nathanael, ...
Mammalian cells were observed to die under conditions in which nutrients were depleted and, simultaneously, macroautophagy was inhibited either genetically (by a small interfering RNA targeting Atg5,...
Characterization of Cell Death Pathways in Human Immunodeficiency Virus-Associated Encephalitis
Nardacci, Roberta, Antinori, Andrea, Larocca, Luigi Maria, Arena, Vincenzo, Amendola, Alessandra, Perfettini, Jean-Luc, ...
Human immunodeficiency virus (HIV)-associated dementia is a neurodegenerative syndrome characterized by cognitive decline, personality change, and motor deficits. HIV-associated encephalitis (HAE),...
Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
Perfettini, Jean-Luc, Castedo, Maria, Nardacci, Roberta, Ciccosanti, Fabiola, Boya, Patricia, Roumier, Thomas, ...
The proapoptotic activity of the transcription factor p53 critically depends on the phosphorylation of serine 46 (p53S46P). Here, we show that syncytia containing p53S46P could be detected in lymph...
Perfettini, Jean-Luc, Roumier, Thomas, Castedo, Maria, Larochette, Nathanael, Boya, Patricia, Raynal, Brigitte, ...
The coculture of cells expressing the HIV-1 envelope glycoprotein complex (Env) with cells expressing CD4 results into cell fusion, deregulated mitosis, and subsequent cell death. Here, we show that...
Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion
Boya, Patricia, Andreau, Karine, Poncet, Delphine, Zamzami, Naoufal, Perfettini, Jean-Luc, Metivier, Didier, ...
A number of diseases are due to lysosomal destabilization, which results in damaging cell loss. To investigate the mechanisms of lysosomal cell death, we characterized the cytotoxic action of two...
Perfettini, Jean-Luc, Nardacci, Roberta, Bourouba, Mehdi, Subra, Frédéric, Gros, Laurent, Séror, Claire, ...
DNA damage can activate the oncosuppressor protein ataxia telangiectasia mutated (ATM), which phosphorylates the histone H2AX within characteristic DNA damage foci. Here, we show that ATM undergoes...