Jean-Paul Squifflet

Liver transplant donation after cardiac death : experience at the University of Liège (2009)

Detry, Olivier, Seydel, Benoît, Delbouille, Marie-Hélène, Monard, Josée, Hans, Marie-France, De Roover, Arnaud, ...

Aim: Donation after cardiac death (DCD) has been proposed to partly overcome the organ donor shortage. In liver transplantation, the additional warm ischemia linked to DCD procurement may promote...

Organ Procurement After Euthanasia: Belgian Experience (2009)

Ysebaert, Dirk, Van Beeumen, G, De Greef, K, Squifflet, Jean-Paul, Detry, Olivier, De Roover, Arnaud, ...

Euthanasia was legalized in Belgium in 2002 for adults under strict conditions. The patient must be in a medically futile condition and of constant and unbearable physical or mental suffering that...

A Retrospective Monocenter Review of Simultaneous Pancreas-Kidney Transplantation. (2009)

Decker, Emmanuel, Coimbra, C, Weekers, Laurent, Detry, Olivier, Honore, Pierre, Squifflet, Jean-Paul, ...

OBJECTIVE: Herein we have reviewed a consecutive series of simultaneous pancreas-kidney (SPK) transplantations performed at our institution over a 6-year period. PATIENTS AND METHODS: The study...

The history of Pancreas Transplantation: Past, Present and Future (2008)

Squifflet, Jean-Paul, Gruessner, R, Sutherland, D, Simon, Véronique

Abstract. The first attempt to cure type 1 diabetes by pancreas transplantation was done at the University of Minnesota, in Minneapolis, on December 17, 1966, followed by a series of whole pancreas...

Immunosuppression in Pancreas Transplantation. The Euro SPK Trials and Beyond (2008)

Malaise, J, De Roover, Arnaud, Squifflet, Jean-Paul, Euro SPK, Simon, Véronique

The Immunosuppression in Pancreas Transplantation was historically based on the fact that the pancreas is an extremely immunogenic organ. Quadruple drug therapy with polyclonal or monoclonal...

The history of the EuroSPK - Study Group (2008)

Squifflet, Jean-Paul, Malaise, J, Van Ophem, D, Marcelis, V, Land, W.G, Simon, Véronique

The EuroSPK Study group was created during the 4th Spitzingsee 1997 workshop in Kühtai, Austria. Thanks to W. Land for the incentive to gather European Centres – with Switzerland and Israel –...

Immunosuppression in Pancreas Transplantation The Euro SPK Trials and Beyond (2008)

Malaise, J, De Roover, Arnaud, Squifflet, Jean-Paul, Land, W, Simon, Véronique

The Immunosuppression in Pancreas Transplantation was historically based on the fact that the pancreas is an extremely immunogenic organ. Quadruple drug therapy with polyclonal or monoclonal...

Pancreas graft drainage in recipient duodenum: Preliminary experience (2007)

De Roover, Arnaud, Coimbra Marques, Carla, Detry, Olivier, Van Kemseke, Catherine, Squifflet, Jean-Paul, Honore, Pierre, ...

Pancreas graft survival has continuously improved over the years to become a main treatment option of uncontrolled complicated diabetes. Rejection remains the major challenge as it often goes...

Actualités sur les agents immunosuppresseurs utilisés en transplantation rénale (2007)

Milicevic, Martina, Krzesinski, Jean-Marie, Squifflet, Jean-Paul

The goal of immunosuppression in transplantation is to prevent acute rejection and, more recently, chronic renal graft rejection related in part to sdide-effects of immunosuppressive therapy...

Nonadherence with immunosuppressive drugs: U.S. compared with European kidney transplant recipients (2006)

Desmyttere, A, Young, Jim, Siegal, Bonita, ...

BACKGROUND: System factors increasingly are suggested as important yet understudied correlates of nonadherence. OBJECTIVE: To explore the relationship between healthcare system and prevalence of...

Why Did it Take so Long to Start a Non-Heart-Beating Donor Program in Belgium ? (2006)

Squifflet, Jean-Paul, Simon, Véronique

The first cadaver kidney transplant, performed in June 1963 in Belgium, was from a heart beating donor (HBD). It was the first ever in the world. Since that period, almost all cadaver organs were...

Efficacy and cardiovascular safety of daclizumab, mycophenolate mofetil, tacrolimus, and early steroid withdrawal in renal transplant recipients: a multicenter, prospective, pilot trial (2005)

Squifflet, Jean-Paul, Mourad, Michel, Meurisse, Michel, ...

This single-arm, open-label, pilot study was designed to assess the efficacy and cardiovascular safety profile of daclizumab, a humanized monoclonal interleukin (IL)-2Ralpha antibody, in combination...

Minimization of immunosuppressive therapy after renal transplantation: results of a randomized controlled trial (2005)

Van Hooff, Johannes P, Squifflet, Jean-Paul, Salmela, Kaija, Rigotti, Paolo, Jindal, Rahul M, ...

Modern immunosuppressive regimens reduce the acute rejection rate by combining a cornerstone immunosuppressant like tacrolimus or cyclosporine with adjunctive agents like corticosteroids,...

Efficacy and cardiovascular safety of daclizumab, mycophenolate mofetil,tacrolimus, and early steroid withdrawal in renal transplant recipients: a multicenter,prospective, pilot trial (2005)

Abramowicz, Daniel, Vanrenterghem, Yves, Squifflet, Jean-Paul, Kuypers, Dirk, Mourad, Michel, Meurisse, Michel, ...

This single-arm, open-label, pilot study was designed to assess the efficacy and cardiovascular safety profile of daclizumab, a humanized monoclonal interleukin (IL)-2Ra antibody, in combination with...

The construct and concurrent validity of the EQ-5D in a renal transplant population (2004)

Van Hooff, Johannes P, Squifflet, Jean-Paul, ...

OBJECTIVES: Cost-utility analysis in renal transplant populations requires the use of a generic instrument for health status measurement that generates a single value for health. Such instruments...

The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients (2004)

Van Hooff, Johannes P, Klinger, Marian, Wlodarczyk, Zbigniew, Squifflet, Jean-Paul, Mourad, Georges, ...

BACKGROUND: In animal and in vitro models, FK778 inhibits acute rejection, modifies vasculopathy, and shows anti-viral activity. We report first efficacy and safety data of FK778 in human kidney...

Efficacy and safety of tacrolimus compared with cyclosporine microemulsion in primary simultaneous pancreas-kidney transplantation: 1-year results of a large multicenter trial (2004)

Malaise, Jacques, Saudek, Frantisek, Land, Walter, Fernandez-Cruz, Laureano, Margreiter, Raimund, ...

BACKGROUND: Simultaneous pancreas-kidney transplantation (SPK) transplantation has become an accepted therapy for type 1 diabetic patients with end-stage renal disease. This open-label, multicenter...

Health-related quality of life and symptom experience in tacrolimus-based regimens after renal transplantation: a multicentre study (2003)

Van Hooff, Johannes P, Squifflet, Jean-Paul, Margodt, Dave, Mullens, Monique, ...

Tacrolimus is increasingly used as a baseline immunosuppressant after renal transplantation. This multicentre study assessed health-related quality of life and symptom experience in renal transplant...

A prospective randomized multicenter study of tacrolimus in combination with sirolimus in renal-transplant recipients (2003)

Squifflet, Jean-Paul, Wlodarczyk, Zbigniew, Paczek, Leszek

BACKGROUND: Recently, sirolimus (SRL) was introduced as an immunosuppressant in solid-organ transplantation. This study evaluated combinations of SRL and tacrolimus (Tac). METHODS: This 6-month study...

Benelux experience with a combination of tacrolimus and mycophenolate mofetil: 4-year results (2002)

Squifflet, Jean-Paul

Department of Internal Medicine, University Hospital Maastricht, PO Box 5800, NL-6202 AZ Maastricht, The Netherlands. jho@sint.azm.nl

Outcome of cadaver kidney transplantation in 23 patients with type 2 diabetes mellitus (2001)

Mieghem, Ann Van, Fonck, Catherine, Coosemans, Willy, Vandeleene, Bernard, Vanrenterghem, Yves, Squifflet, Jean-Paul, ...

Background. Type 2 diabetes mellitus (DM) is a growing cause of end‐stage renal failure worldwide. Yet, only a minority of type 2 diabetics are considered today for kidney...

Human herpes virus 8 infection in kidney transplant patients in Belgium (2000)

Sheldon, Julie, Henry, Stéphanie, Mourad, Michel, Bodéus, Monique, Squifflet, Jean-Paul, Schulz, Thomas F., ...

Background. Kaposi sarcoma (KS) may arise as a complication of kidney transplantation. In the Saint Luc Teaching Hospital in Brussels, patients of both Belgian and foreign origin are...