Denton, Derek, Changeux, Jean-Pierre (pról.), Ros, Joandomènec (tr.)
Traducción de: The Primordial Emotions, The Dawning of Consciousness
Abbreviated title: Nicotine and synaptic transmission in the developing hippocampus (2008)
Corentin Le Magueresse, Victoria Safiulina, Jean-pierre Changeux
Nicotinic modulation of network and synaptic transmission in the immature hippocampus investigated with genetically modified mice
Allosteric Receptors after 30 Years Review (2008)
Jean-pierre Changeux, Neurobiologie Moléculaire
ture. Moreover, the conformational transition that such
DOI 10.1007/s00213-005-0295-x ORIGINAL INVESTIGATION (2008)
Carrie L. Walters, Sharon Brown, Jean-pierre Changeux, Billy Martin, M. Imad Damaj, ...
The β2 but not α7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice
Clément Léna, Daniela Popa, Régis Grailhe, Pierre Escourrou, Jean-pierre Changeux, Joëlle Adrien
The cholinergic system is involved in arousal and in rapid eye movement sleep (REMS). To evaluate the contribution of nicotinic acetylcholine receptors (nAChRs) to these functions, we studied with...
1424 REVIEW Allosteric Mechanisms of Signal Transduction (2008)
Jean-pierre Changeux, Stuart J. Edelstein
Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and...
to the activation mechanism (2008)
Thomas Grutter, Jean-pierre Changeux
An H-bond between two residues from different
Macaca Mulatta, Zhi-yan Han, Nicolas Le Noveáre, Michele Zoli, Joseph A. Hill, Nicolas Champtiaux, ...
We present here a systematic mapping of nAChR subunit mRNAs in Macaca mulatta brain. A fragment, from the transmembrane segments MIII to MIV of Macaca neuronal nAChR subunits was cloned, and shown to...
A novel mechanism of neural plasticity? (2008)
Pierre-jean Corringer, Jérôme Sallette, Jean-pierre Changeux
Nicotine enhances intracellular nicotinic receptor maturation:
lmmunocytochemical Localization of a Neuronal Nicotinic Receptor: The (2008)
Joseph A. Hill, Michele Zoli, Jean-pierre Bourgeois, Jean-pierre Changeux
We have characterized in adult rat the tissue-specific ex-
Annie Cartaud, Bernard J. Jasmin, Jean-pierre Changeux, Jean Cartaud
Direct involvement of a lamin-B-related (54 kDa) protein in the association of intermediate filaments with the postsynaptic membrane of the Torpedo marmorata electrocyte
Jean-pierre Bourgeois, Lisa M. Marubio, Ole Petter Ottersen, Eric Rinvik, ...
The distribution of the �4-subunit of the neuronal nicotinic acetylcholine receptor (nAChR) in the rat brain was examined at light and electron microscopy levels using immunohistochemical staining....
Michele Zoli B, Nicolas Lenovre B, Jean-pierre Changeux, Kjell Fuxe A
A single (-)-nicotine injection causes change with a time delay in the affinity of striatal D 2 receptors for antagonist, but not for agonist, nor in the D 2 receptor mRNA levels in the rat...
Expression of mutant Ets protein at the (2007)
Jean Cartaud, Aymeric Ravel-chapuis, Thierry Seroz, Fabien Pasteau, Lindsay M. Angus, ...
reports
based on multiple allosteric (2007)
Stuart J. Edelstein, Olivier Schaad, Eric Henry, Daniel Bertr, Jean-pierre Changeux
transitions
Anne-marie Salmon, Corinne Bru, Ana Cardona, Jean-pierre Changeux, Sonia Berrih-aknin
by antiacetylcholinesterase drugs. It is widely accepted that the neuromuscular abnormalities in MG are largely due to anti-Myasthenia gravis (MG) is an autoimmune disease targetbodies directed...
Sébastien Bohler, Steven Gay, Sonia Bertr, Pierre Jean Corringer, Stuart J. Edelstein, Jean-pierre Changeux, ...
ABSTRACT: Desensitization is a general property of ligand-gated ion channels. Because of a wide array of available subunit combinations, it generates different time constants for channel closure,...
Research Update Research News TRENDS in Biochemical Sciences Vol.26 No.8 August 2001 (2007)
Thomas Grutter, Jean-pierre Changeux
The structure of a soluble homopentameric homologue of the N-terminal extracellular domain of the nicotinic acetylcholine (ACh) receptor has recently been determined at the atomic level. These data...
LGICdb: the ligand-gated ion channel database (2007)
Nicolas Le Novre, Jean-pierre Changeux, Rcepteurs Et
Ligand-Gated Ion Channels (LGIC) are polymeric transmembrane proteins involved in the fast response to numerous neurotransmitters. All these receptors are formed by homologous subunits and the last...
Conscious, preconscious, and subliminal processing: a testable taxonomy (2006)
Dehaene, Stanislas, Changeux, Jean-Pierre, Naccache, Lionel, Sackur, Jérôme, Sergent, Claire
Of the many brain events evoked by a visual stimulus, which are specifically associated with conscious perception, andwhichmerely reflect non-conscious processing? Several recent neuroimaging studies...
Conscious, preconscious, and subliminal processing: A testable taxonomy (2006)
Stanislas Dehaene, Jean-pierre Changeux, Lionel Naccache, Jérôme Sackur, Claire Sergent
Of the many brain events evoked by a visual stimulus, which are specifically associated with conscious perception, andwhichmerelyreflectnon-conscious processing? Several recent neuroimaging studies...
Dehaene, Stanislas, Changeux, Jean-Pierre
Even in the absence of sensory inputs, cortical and thalamic neurons can show structured patterns of ongoing spontaneous activity, whose origins and functional significance are not well understood....
Stanislas Dehaene, Jean-Pierre Changeux
Computer simulations of the circuits of activity in the cerebral cortex and underlying thalamus suggest that precisely controlled oscillatory states can control the central neural processing of...
Stanislas Dehaene, Jean-Pierre Changeux
Even in the absence of sensory inputs, cortical and thalamic neurons can show structured patterns of ongoing spontaneous activity, whose origins and functional significance are not well understood....
Dehaene, Stanislas, Changeux, Jean-Pierre
Even in the absence of sensory inputs, cortical and thalamic neurons can show structured patterns of ongoing spontaneous activity, whose origins and functional significance are not well understood....
Dehaene, Stanislas, Changeux, Jean-Pierre
Even in the absence of sensory inputs, cortical and thalamic neurons can show structured patterns of ongoing spontaneous activity, whose origins and functional significance are not well understood....
Altered map of visual space in the superior colliculus of mice lacking early retinal waves (2005)
Society Of Neuroscience, Mrsic-Flögel, Thomas, Hofer, Sonja, Creutzfeldt, Claire, Cloëz-Tayarani, Isabelle, Changeux, Jean-Pierre, ...
Dehaene, Stanislas, Changeux, Jean-Pierre
Even in the absence of sensory inputs, cortical and thalamic neurons can show structured patterns of ongoing spontaneous activity, whose origins and functional significance are not well understood....
Dehaene, Stanislas, Changeux, Jean-Pierre
Even in the absence of sensory inputs, cortical and thalamic neurons can show structured patterns of ongoing spontaneous activity, whose origins and functional significance are not well understood....
Dehaene, Stanislas, Changeux, Jean-Pierre
Even in the absence of sensory inputs, cortical and thalamic neurons can show structured patterns of ongoing spontaneous activity, whose origins and functional significance are not well understood....
Altered map of visual space in the superior colliculus of mice lacking early retinal waves (2005)
Sonja B. Hofer, Claire Creutzfeldt, Isabelle Cloëz-tayarani, Jean-pierre Changeux, Tobias Bonhoeffer, ...
During the development of the mammalian retinocollicular projection, a coarse retinotopic map is set up by the graded distribution of axon guidance molecules. Subsequent refinement of the initially...
Subtype Enriched, Retinocollicular Afferents, Cecilia Gotti, Milena Moretti, Alessio Zanardi, Annalisa Gaimarri, ...
The activation of neuronal nicotinic acetylcholine receptors (nAChRs) has been implicated in the activity-dependent development and plasticity of retina and the refinement of retinal projections....
Dehaene, Stanislas, Changeux, Jean-Pierre
Even in the absence of sensory inputs, cortical and thalamic neurons can show structured patterns of ongoing spontaneous activity, whose origins and functional significance are not well understood....
Acquisition and Performance of Delayed-response Tasks: a Neural Network Model (2005)
Gisiger, Thomas, Kerszberg, Michel, Changeux, Jean-Pierre
We study the time evolution of a neural network model as it learns the three stages of a visual delayed-matching-to-sample (DMS) task: identification of the sample, retention during delay, and...
Anne Cormier, Yoav Paas, Jean-paul Tillement, Gilbert Lagrue, Jean-pierre Changeux, Régis Grailhe
Long-term consumption of tobacco by smokers causes addiction and increases the level of neuronal nicotinic acetylcholine receptors (nAChRs) in the brain, a phenomenon known as up-regulation. Here, we...
Matilde Cordero-erausquin, Stéphanie Pons, Jean-pierre Changeux
differentially activates inhibitory and excitatory neurons in the dorsal spinal cord
Acquisition and Performance of Delayed-response Tasks: a Neural Network Model (2004)
Gisiger, Thomas, Kerszberg, Michel, Changeux, Jean-Pierre
We study the time evolution of a neural network model as it learns the three stages of a visual delayed-matching-to-sample (DMS) task: identification of the sample, retention during delay, and...
Acquisition and Performance of Delayed-response Tasks: a Neural Network Model (2004)
Gisiger, Thomas, Kerszberg, Michel, Changeux, Jean-Pierre
We study the time evolution of a neural network model as it learns the three stages of a visual delayed-matching-to-sample (DMS) task: identification of the sample, retention during delay, and...
Neural Mechanisms for Access to Consciousness (2003)
Stanislas Dehaene, Jean-pierre Changeux
Introduction: the challenge of a science of consciousness Understanding consciousness has become the ultimate intellectual challenge of this new millennium. Even if philosophers now accept the notion...
Morten Sunesen, Monique Huchet-dymanus, Morten O. Christensen, Jean-pierre Changeux
Enrichment of nicotinic acetylcholine receptors (nAChR) on the tip of the subjunctional folds of the postsynaptic membrane is a central event in the development of the vertebrate neuromuscular...
Matthew S. Grubb, Francesco M. Rossi, Jean-pierre Changeux, Ian D. Thompson
activity. Between postnatal day 1 (P1) and P10 in this species, spontaneous activity is mediated by nicotinic cholinergic transmission (Feller et al., 1996; Penn et al., 1998) and, in the form of...
Nicolas Champtiaux, Cecilia Gotti, Matilde Cordero-erausquin, Denis J. David, Cédric Przybylski, Clément Léna, ...
Nicotinic acetylcholine receptors (nAChRs) expressed by dopaminergic (DA) neurons have long been considered as potential therapeutic targets for the treatment of several neuropsychiatric diseases,...
Rapsyn Escorts the Nicotinic Acetylcholine Receptor Along the (2002)
Exocytic Pathway Via, Sophie March, Anne Devillers-thiéry, Stéphanie Pons, Jean-pierre Changeux, Jean Cartaud
ent centrifugation demonstrated that rapsyn and AChR are recovered in low-density fractions enriched in two rafts markers: caveolin-1 and flotillin-1. We propose that sorting and targeting of these...
Distribution and Pharmacology of 6-Containing Nicotinic (2002)
Acetylcholine Receptors Analyzed, Nicolas Champtiaux, Zhi-yan Han, Alain Bessis, Francesco Mattia Rossi, Michele Zoli, ...
this paper. Correspondence should be addressed to Nicolas Champtiaux, Institut Pasteur, Laboratoire de Neurobiologie Moleculaire, 25-28 Rue du Dr Roux, 75724 Paris, France. E-mail: champtia@pasteur.fr
The Diversity of Subunit Composition in nAChRs: (2002)
Evolutionary Origins Physiologic, Nicolas Le Novère, Pierre-jean Corringer, Jean-pierre Changeux
Nicotinic acetylcholine receptors are made up of homologous subunits, which are encoded by a large multigene family. The wide number of receptor oligomers generated display variable pharmacological...
La naturaleza y la norma : lo que nos hace pensar (2001)
Changeux, Jean-Pierre, Ricoeur, Paul
Traducción de: La nature et la règle. Ce qui nous fait penser
La naturaleza y la norma : lo que nos hace pensar (2001)
Changeux, Jean-Pierre, Ricoeur, Paul
968-16-6340-3
Targeting transcription to the neuromuscular synapse. Neuron (2001)
Laurent Schaeffer, Jean-pierre Changeux
by the fundamental nuclei (for references to papers demonstrating compartmentalized transcription, see Duclert and Changeux, 1995, and Sanes and Lichtman, 1999). Laboratoire de Neurobiologie...
Ruby Klink, Michele Zoli, Jean-pierre Changeux
Nicotinic acetylcholine receptors (nAChRs) on dopaminergic (DA) and GABAergic (Gaba) projection neurons of the substantia nigra (SN) and ventral tegmental area (VTA) are characterized by single-cell...
The Ligand Gated Ion Channel database: an example of a sequence database in neuroscience (2001)
Nicolas Le Novère, Jean-pierre Changeux
Multiple comparisons of receptor sequences, or receptor subunit sequences, has proved to be an invaluable tool in modern...
LGICdb: the ligand-gated ion channel database (2001)
Le Novère, Nicolas, Changeux, Jean-Pierre
Ligand-Gated Ion Channels (LGIC) are polymeric transmembrane proteins involved in the fast response to numerous neurotransmitters. All these receptors are formed by homologous subunits and the last...
Hoang-Oanh Nghiem, Lucien Bettendorff, Jean-Pierre Changeux
43K rapsyn is a peripheral protein specifically associated with the nicotinic acetylcholine receptor (nAChR) present in the postsynaptic membrane of the neuromuscular junction and of the electrocyte,...
Pharmacological and Null Mutation Approaches Reveal Nicotinic Receptor Diversity (2000)
Paul Whiteaker, Michael J. Marks, Sharon R. Grady, Ying Lu, Marina R. Picciotto, Jean-Pierre Changeux, ...
w 125 x Z.w 3 x We have developed an array of assays for nicotinic acetylcholine receptor binding and function. I a-Bungarotoxin-, y - H nico- w 3 x tine-, and H epibatidine-binding nicotinic...
Lisa M. Marubio, Jean-pierre Changeux
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels, which are involved in a wide range of neuronal functions. During the past decade, a large number of nicotinic acetylcholine...
Subunit Michael Marks, Michael J. Marks, Paul Whiteaker, Jennifer Calcaterra, Jerry A. Stitzel, Amy E. Bullock, ...
Nicotinic agonist-stimulated efflux of 86 Rb 1 from mouse brain synaptosomes was monitored continuously by on-line radioactivity detection. The concentration-effect curve following a 5-s stimulation...
Nicolas Le Nove, Pierre-jean Corringer, Jean-pierre Changeux
A refined prediction of the nicotinic acetylcholine receptor (nAChR) subunits' secondary structure was computed with third-generation algorithms. The four selected programs, PHD, Predator, DSC,...
Increased Neurodegeneration During Ageing in Mice Lacking High-Affinity Nicotine Receptors (1999)
Michele Zoli, Marina R. Picciotto, Rosaria Ferrari, Daniela Cocchi, Jean-pierre Changeux
ring ageing. b2 --/-- mice may thus serve as one possible animal model for some of the cognitive deficits and degenerative processes which take place during physiological ageing and in...
Pierre-jean Corringer, Sonia Bertr, Jean-luc Galzi, Anne Devillers-thiéry, Jean-pierre Changeux, Daniel Bertr, ...
ummary cessible to charged organic reagents (Akabas et al., 1994). Moreover, site-directed mutagenesis experi- In the a7 nicotinic acetylcholine receptors, we analyze ments carried out within or in...
Modulation of morphine analgesia in alphaCGRP mutant mice (1999)
Anne-Marie Salmon, Imad Damaj, Susumu Sekine, Marina R. Picciotto, Lisa Marubio, Jean-Pierre Changeux
9.454> 1999 Lippincott Williams & Wilkins. Key words: # and # CGRP; Homologous recombination; Hot plate; Knock-out mice; Morphine analgesia; Tail ick Introduction The calcitonin gene-related...
ON THE COOPERATIVITY OF BIOLOGICAL MEMBRANES. (1998)
Changeux, Jean-Pierre, Thiery, Jean, Tung, Yvonne, Kittel, C.
We extend the Monod-Wyman-Changeux of allosteric transitions in enzyme-substrate reactions to a membrane composed of identical units (protomers). It is supposed that each protomer can exist in two...
Identification ´ of four classes of brain nicotinic receptors using beta-2 mutant mice (1998)
Michele Zoli, Clément Léna, Marina R. Picciotto, Jean-pierre Changeux
Although the expression patterns of the neuronal nicotinic acetylcholine receptor (nAChR) subunits thus far described are known, the subunit composition of functional receptors in different brain...
A Simple Molecular Model of Neurulation (1998)
Michel Kerszberg, Jean-pierre Changeux
98. r 1998 John Wiley & Sons, Inc. Introduction The central nervous system (CNS) of the vertebrates is very different from that of invertebrates such as insects. The former acquire, from dorsal...
Ying Lu, Sharon Grady, Michael J. Marks, Marina Picciotto, Jean-Pierre Changeux, Allan C. Collins
Several recent electrophysiological studies have demonstrated that nicotinic agonists stimulate the release of #-aminobutyric acid (GABA) from rodent brain tissue. Our studies used a neurochemical...
Desensitization Neuronal, Nicotinic Acetylcholine Receptors, Sonia Bertr, Sébastien Bohler, Stuart J. Edelstein, ...
Introduction of the #4 residues 183--191 into #7 subunit sequence (chimera C 2 ) selectively increased the apparent affinities for equilibrium binding and for ion channel activation by acetylcholine,...
Ivermectin: A Positive Allosteric Effector of the (1998)
Neuronal Nicotinic Acetylcholine, Nicotinic Acetylcholine Receptor, Ryoko M. Krause, Bruno Buisson, Sonia Bertrand, Pierre-jean Corringer, ...
We report that preapplication of ivermectin, in the micromolar range, strongly enhances the subsequent acetylcholine-evoked current of the neuronal chick or human #7 nicotinic acetylcholine receptors...
Laurent Schaeffer, Nathalie Duclert, Monique Huchet-dymanus, Jean-pierre Changeux
this report, we have demonstrated that the N-box, which we previously had shown to be a crucial element for the subsynaptic expression of the AChR d- and e-subunits, is also an activating element in...
Single Binding Versus Single Channel Recordings: A New Approach to Study Ionotropic Receptors (1997)
Stuart Edelstein Olivier, Ionotropic Receptors, Jean-pierre Changeux
: The observation of ligand binding to a single molecule has become feasible with recent developments in laser-based fluorescence microscopy. We have simulated such single ligand-binding events for...
Ions in Nicotinic Facilitation of GABA Release in Mouse Thalamus (1997)
Cle Ment Le, Clément Léna, Jean-pierre Changeux
this paper is to further examine the mechanisms of action of nAChRs that increase the release of neurotransmitter in the absence of sodium channel activity.
Alain Bessis, Jean-pierre Changeux, David S. LATCHMAN
this paper). The division of Brn-3a and Brn-3b subdomains I, II, III and IV is as follows, Brn-3a : subdomain I, amino acids (aa) 1 to 40 ; subdomain II, aa 41 to 108 ; subdomain III, aa 109 to 267 ;...
Subunit Gene Received, Aymeric Duclert, Nathalie Savatier, Laurent Schaeffer, Jean-pierre Changeux
this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate...
Michele Zoli, Nicolas Le Novkre, Joseph A. Hill, Jean-pierre Changeux
In the present study we have investigated the anatomical distribution pattern of nAChR (~3, 0~4, p2, and f34 subunit mRNAs during prenatal and perinatal development of the rat CNS and PNS. Three main...
Changeux, Jean-Pierre, Connes, Alain
Traducción de: Matière à pensée
The Wisconsin Card Sorting Test: Theoretical Analysis and Modeling in a Neuronal Network (1991)
Dehaene, Stanislas, Changeux, Jean-Pierre
Neuropsychologists commonly use the Wisconsin Card Sorting Test as a test of the integrity of frontal lobe functions. However, an account of its range of validity and of the neuronal mechanisms...
El hombre neuronal / J. P. Changeux; tr. por C. Janés. (1985)
Traducción de: L'homme neuronal
Lester, Henry A., Changeux, Jean-Pierre, Sheridan, Robert E.
When solutions containing agonists are applied to the innervated face of an Electrophorus electroplaque, the membrane's conductance increases. The agonist-induced conductance is increased at more...
Lester, Henry A., Changeux, Jean-Pierre, Sheridan, Robert E.
When solutions containing agonists are applied to the innervated face of an Electrophorus electroplaque, the membrane's conductance increases. The agonist-induced conductance is increased at more...
Sur les propriétés allostériques de la L-thréonine désaminase d'Escherichia Coli K 12 / (1964)
Thesis (doctoral)--Université de Paris, 1964.
Sur les propriétés allostériques de la L-thréonine-désaminase d'Eschesrichia coli K 12 / (1964)
Errata slip inserted.
Paas-Rozner, Miri, Dayan, Molly, Paas, Yoav, Changeux, Jean-Pierre, Wirguin, Itzhak, Sela, Michael, ...
Myasthenia gravis (MG) and experimental autoimmune MG (EAMG) are T cell-regulated, antibody-mediated autoimmune diseases. The major autoantigen in MG is the nicotinic acetylcholine receptor (AChR)....
Gramolini, Anthony O., Angus, Lindsay M., Schaeffer, Laurent, Burton, Edward A., Tinsley, Jonathon M., Davies, Kay E., ...
The modulation of utrophin gene expression in muscle by the nerve-derived factor agrin plausibly involves the trophic factor ARIA/heregulin. Here we show that heregulin treatment of mouse and human...
Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons
Léna, Clément, De Kerchove D’Exaerde, Alban, Cordero-Erausquin, Matilde, Le Novère, Nicolas, Changeux, Jean-Pierre
The neurons of the locus ceruleus are responsible for most of the noradrenergic innervation in the brain and nicotine potentiates noradrenaline release from their terminals. Here we investigated the...
Bessis, Alain, Champtiaux, Nicolas, Chatelin, Laurent, Changeux, Jean-Pierre
The neuron-restrictive silencer element (NRSE) has been identified in several neuronal genes and confers neuron specificity by silencing transcription in nonneuronal cells. NRSE is present in the...
A hierarchical neuronal network for planning behavior
Dehaene, Stanislas, Changeux, Jean-Pierre
Planning a goal-directed sequence of behavior is a higher function of the human brain that relies on the integrity of prefrontal cortical areas. In the Tower of London test, a puzzle in which beads...
A neuronal model of a global workspace in effortful cognitive tasks
Dehaene, Stanislas, Kerszberg, Michel, Changeux, Jean-Pierre
A minimal hypothesis is proposed concerning the brain processes underlying effortful tasks. It distinguishes two main computational spaces: a unique global workspace composed of distributed and...
LGICdb: the ligand-gated ion channel database
Le Novère, Nicolas, Changeux, Jean-Pierre
Ligand-Gated Ion Channels (LGIC) are polymeric transmembrane proteins involved in the fast response to numerous neurotransmitters. All these receptors are formed by homologous subunits and the last...
Tonic nicotinic modulation of serotoninergic transmission in the spinal cord
Cordero-Erausquin, Matilde, Changeux, Jean-Pierre
The spinal serotoninergic projection from the raphe magnus has been shown to modulate nociceptive inputs, and activation of this projection mediates nicotine-elicited analgesia. Here, we investigate...
A method for soluble overexpression of the α7 nicotinic acetylcholine receptor extracellular domain
Fischer, Markus, Corringer, Pierre-Jean, Schott, Karin, Bacher, Adelbert, Changeux, Jean-Pierre
We describe the construction of a soluble protein carrying the N-terminal extracellular domain (ECD) of the α7 subunit of the nicotinic acetylcholine receptor. The approach was to fuse the α7 ECD...
Rossi, Francesco Mattia, Pizzorusso, Tommaso, Porciatti, Vittorio, Marubio, Lisa M., Maffei, Lamberto, Changeux, Jean-Pierre
In the mammalian visual system the formation of eye-specific layers at the thalamic level depends on retinal waves of spontaneous activity, which rely on nicotinic acetylcholine receptor activation....
Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites
Le Novère, Nicolas, Grutter, Thomas, Changeux, Jean-Pierre
We constructed a three-dimensional model of the amino-terminal extracellular domain of three major types of nicotinic acetylcholine receptor, (α7)5, (α4)2(β2)3, and (α1)2β1γδ, on the basis of...
Experimentally based model of a complex between a snake toxin and the α7 nicotinic receptor
Fruchart-Gaillard, Carole, Gilquin, Bernard, Antil-Delbeke, Stéphanie, Le Novère, Nicolas, Tamiya, Toru, Corringer, Pierre-Jean, ...
To understand how snake neurotoxins interact with nicotinic acetylcholine receptors, we have elaborated an experimentally based model of the α–cobratoxin–α7 receptor complex. This model was...
Cohen, Gary, Han, Zhi-Yan, Grailhe, Régis, Gallego, Jorge, Gaultier, Claude, Changeux, Jean-Pierre, ...
Nicotine exposure diminishes the protective breathing and arousal responses to stress (hypoxia). By exacerbating sleep-disordered breathing, this disturbance could underpin the well established...
Nicotine activates immature “silent” connections in the developing hippocampus
Maggi, Laura, Le Magueresse, Corentin, Changeux, Jean-Pierre, Cherubini, Enrico
In the hippocampus at birth, most glutamatergic synapses are immature and functionally “silent” either because the neurotransmitter is released in insufficient amount to activate low-affinity...
Grutter, Thomas, Prado De Carvalho, Lia, Le Novère, Nicolas, Corringer, Pierre Jean, Edelstein, Stuart, Changeux, Jean-Pierre
The molecular mechanisms of nicotinic receptor activation are still largely unknown. The crystallographic structure of the acetylcholine binding protein (AChBP) reveals a single H-bond between two...
Dehaene, Stanislas, Sergent, Claire, Changeux, Jean-Pierre
The subjective experience of perceiving visual stimuli is accompanied by objective neuronal activity patterns such as sustained activity in primary visual area (V1), amplification of perceptual...
Executive and social behaviors under nicotinic receptor regulation
Granon, Sylvie, Faure, Philippe, Changeux, Jean-Pierre
Nicotine enhances several cognitive and psychomotor behaviors, and nicotinic antagonists cause impairments in tasks requiring cognitive effort. To explore the contribution of nicotinic receptors to...
Paas, Yoav, Cartaud, Jean, Recouvreur, Michel, Grailhe, Regis, Dufresne, Virginie, Pebay-Peyroula, Eva, ...
Nicotinic acetylcholine receptors (AChRs) belong to a superfamily of oligomeric proteins that transduce electric signals across the cell membrane on binding of neurotransmitters. These receptors...
Podleski, Thomas, Meunier, Jean-Claude, Changeux, Jean-Pierre
p-(trimethyl ammonium) benzene diazonium difluoroborate (TDF), an affinity-labeling reagent of the acetylcholine receptor site(s), which in the normal cell acts as an irreversible inhibitor becomes a...
ON THE ASSOCIATION OF TYROCIDINE WITH ACETYLCHOLINESTERASE*
Changeux, Jean-Pierre, Ryter, Antoinette, Leuzinger, Walo, Barrand, Plana, Podleski, Thomas
In studies of several polypeptide antibiotics with a high affinity for a variety of biological membranes, tyrocidine was found to bind specifically to acetylcholinesterase, an enzyme localized in...
Phosphorylation-Elicited Quaternary Changes of GA Binding Protein in Transcriptional Activation
Sunesen, Morten, Huchet-Dymanus, Monique, Christensen, Morten O., Changeux, Jean-Pierre
Enrichment of nicotinic acetylcholine receptors (nAChR) on the tip of the subjunctional folds of the postsynaptic membrane is a central event in the development of the vertebrate neuromuscular...
Use of a Snake Venom Toxin to Characterize the Cholinergic Receptor Protein*
Changeux, Jean-Pierre, Kasai, Michiki, Lee, Chen-Yuan
α-Bungarotoxin, a polypeptide of mol wt 8000 purified from the venom of Bungarus multicinctus, blocks irreversibly and specifically the excitation by cholinergic agonists on the isolated electroplax...
ON THE COOPERATIVITY OF BIOLOGICAL MEMBRANES*
Changeux, Jean-Pierre, Thiéry, Jean, Tung, Yvonne, Kittel, C.
Reconstitution of a Chemically Excitable Membrane
Hazelbauer, Gerald L., Changeux, Jean-Pierre
Membrane fragments rich in cholinergic (nicotinic) receptor sites, purified from homogenates of Torpedo marmorata electric organ, are dissolved in high concentrations of Na cholate and Tris buffer in...
A Theory of the Epigenesis of Neuronal Networks by Selective Stabilization of Synapses
Changeux, Jean-Pierre, Courrége, Philippe, Danchin, Antoine
A formalism is introduced to represent the connective organization of an evolving neuronal network and the effects of environment on this organization by stabilization or degeneration of labile...
Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb
Mechawar, Naguib, Saghatelyan, Armen, Grailhe, Régis, Scoriels, Linda, Gheusi, Gilles, Gabellec, Marie-Madeleine, ...
Cholinergic axons and nicotinic receptors are abundant in all layers of the olfactory bulb (OB), the main region of newborn neuron integration in the adult brain. Here, we report that the OB granule...
Strochlic, Laure, Cartaud, Annie, Mejat, Alexandre, Grailhe, Régis, Schaeffer, Laurent, Changeux, Jean-Pierre, ...
The muscle-specific receptor tyrosine kinase (MuSK) is part of a receptor complex, activated by neural agrin, that orchestrates the differentiation of the neuromuscular junction (NMJ). To gain...
Dehaene, Stanislas, Changeux, Jean-Pierre
Even in the absence of sensory inputs, cortical and thalamic neurons can show structured patterns of ongoing spontaneous activity, whose origins and functional significance are not well understood....
De Kerchove D'Exaerde, Alban, Cartaud, Jean, Ravel-Chapuis, Aymeric, Seroz, Thierry, Pasteau, Fabien, Angus, Lindsay M., ...
The localized transcription of several muscle genes at the motor endplate is controlled by the Ets transcription factor GABP. To evaluate directly its contribution to the formation of the...
Pore conformations and gating mechanism of a Cys-loop receptor
Paas, Yoav, Gibor, Gilad, Grailhe, Regis, Savatier-Duclert, Nathalie, Dufresne, Virginie, Sunesen, Morten, ...
Neurons regulate the propagation of chemoelectric signals throughout the nervous system by opening and closing ion channels, a process known as gating. Here, histidine-based metal-binding sites were...
Normal Mode Analysis Suggests a Quaternary Twist Model for the Nicotinic Receptor Gating Mechanism
Taly, Antoine, Delarue, Marc, Grutter, Thomas, Nilges, Michael, Le Novère, Nicolas, Corringer, Pierre-Jean, ...
We present a three-dimensional model of the homopentameric α7 nicotinic acetylcholine receptor (nAChR), that includes the extracellular and membrane domains, developed by comparative modeling on the...
Molecular tuning of fast gating in pentameric ligand-gated ion channels
Grutter, Thomas, De Carvalho, Lia Prado, Dufresne, Virginie, Taly, Antoine, Edelstein, Stuart J., Changeux, Jean-Pierre
Neurotransmitters such as acetylcholine (ACh) and glycine mediate fast synaptic neurotransmission by activating pentameric ligand-gated ion channels (LGICs). These receptors are allosteric...
A neurocomputational hypothesis for nicotine addiction
Gutkin, Boris S., Dehaene, Stanislas, Changeux, Jean-Pierre
We present a hypothetical neurocomputational model that combines a set of neural circuits at the molecular, cellular, and system levels and accounts for several neurobiological and behavioral...
Paas-Rozner, Miri, Dayan, Molly, Paas, Yoav, Changeux, Jean-Pierre, Wirguin, Itzhak, Sela, Michael, ...
Myasthenia gravis (MG) and experimental autoimmune MG (EAMG) are T cell-regulated, antibody-mediated autoimmune diseases. The major autoantigen in MG is the nicotinic acetylcholine receptor (AChR)....
Gramolini, Anthony O., Angus, Lindsay M., Schaeffer, Laurent, Burton, Edward A., Tinsley, Jonathon M., Davies, Kay E., ...
The modulation of utrophin gene expression in muscle by the nerve-derived factor agrin plausibly involves the trophic factor ARIA/heregulin. Here we show that heregulin treatment of mouse and human...
Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons
Léna, Clément, De Kerchove D’Exaerde, Alban, Cordero-Erausquin, Matilde, Le Novère, Nicolas, Changeux, Jean-Pierre
The neurons of the locus ceruleus are responsible for most of the noradrenergic innervation in the brain and nicotine potentiates noradrenaline release from their terminals. Here we investigated the...
Bessis, Alain, Champtiaux, Nicolas, Chatelin, Laurent, Changeux, Jean-Pierre
The neuron-restrictive silencer element (NRSE) has been identified in several neuronal genes and confers neuron specificity by silencing transcription in nonneuronal cells. NRSE is present in the...
A hierarchical neuronal network for planning behavior
Dehaene, Stanislas, Changeux, Jean-Pierre
Planning a goal-directed sequence of behavior is a higher function of the human brain that relies on the integrity of prefrontal cortical areas. In the Tower of London test, a puzzle in which beads...
A neuronal model of a global workspace in effortful cognitive tasks
Dehaene, Stanislas, Kerszberg, Michel, Changeux, Jean-Pierre
A minimal hypothesis is proposed concerning the brain processes underlying effortful tasks. It distinguishes two main computational spaces: a unique global workspace composed of distributed and...
LGICdb: the ligand-gated ion channel database
Le Novère, Nicolas, Changeux, Jean-Pierre
Ligand-Gated Ion Channels (LGIC) are polymeric transmembrane proteins involved in the fast response to numerous neurotransmitters. All these receptors are formed by homologous subunits and the last...
Tonic nicotinic modulation of serotoninergic transmission in the spinal cord
Cordero-Erausquin, Matilde, Changeux, Jean-Pierre
The spinal serotoninergic projection from the raphe magnus has been shown to modulate nociceptive inputs, and activation of this projection mediates nicotine-elicited analgesia. Here, we investigate...
A method for soluble overexpression of the α7 nicotinic acetylcholine receptor extracellular domain
Fischer, Markus, Corringer, Pierre-Jean, Schott, Karin, Bacher, Adelbert, Changeux, Jean-Pierre
We describe the construction of a soluble protein carrying the N-terminal extracellular domain (ECD) of the α7 subunit of the nicotinic acetylcholine receptor. The approach was to fuse the α7 ECD...
Rossi, Francesco Mattia, Pizzorusso, Tommaso, Porciatti, Vittorio, Marubio, Lisa M., Maffei, Lamberto, Changeux, Jean-Pierre
In the mammalian visual system the formation of eye-specific layers at the thalamic level depends on retinal waves of spontaneous activity, which rely on nicotinic acetylcholine receptor activation....
Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites
Le Novère, Nicolas, Grutter, Thomas, Changeux, Jean-Pierre
We constructed a three-dimensional model of the amino-terminal extracellular domain of three major types of nicotinic acetylcholine receptor, (α7)5, (α4)2(β2)3, and (α1)2β1γδ, on the basis of...
Experimentally based model of a complex between a snake toxin and the α7 nicotinic receptor
Fruchart-Gaillard, Carole, Gilquin, Bernard, Antil-Delbeke, Stéphanie, Le Novère, Nicolas, Tamiya, Toru, Corringer, Pierre-Jean, ...
To understand how snake neurotoxins interact with nicotinic acetylcholine receptors, we have elaborated an experimentally based model of the α–cobratoxin–α7 receptor complex. This model was...
Cohen, Gary, Han, Zhi-Yan, Grailhe, Régis, Gallego, Jorge, Gaultier, Claude, Changeux, Jean-Pierre, ...
Nicotine exposure diminishes the protective breathing and arousal responses to stress (hypoxia). By exacerbating sleep-disordered breathing, this disturbance could underpin the well established...
Nicotine activates immature “silent” connections in the developing hippocampus
Maggi, Laura, Le Magueresse, Corentin, Changeux, Jean-Pierre, Cherubini, Enrico
In the hippocampus at birth, most glutamatergic synapses are immature and functionally “silent” either because the neurotransmitter is released in insufficient amount to activate low-affinity...
Grutter, Thomas, Prado De Carvalho, Lia, Le Novère, Nicolas, Corringer, Pierre Jean, Edelstein, Stuart, Changeux, Jean-Pierre
The molecular mechanisms of nicotinic receptor activation are still largely unknown. The crystallographic structure of the acetylcholine binding protein (AChBP) reveals a single H-bond between two...
Dehaene, Stanislas, Sergent, Claire, Changeux, Jean-Pierre
The subjective experience of perceiving visual stimuli is accompanied by objective neuronal activity patterns such as sustained activity in primary visual area (V1), amplification of perceptual...
Executive and social behaviors under nicotinic receptor regulation
Granon, Sylvie, Faure, Philippe, Changeux, Jean-Pierre
Nicotine enhances several cognitive and psychomotor behaviors, and nicotinic antagonists cause impairments in tasks requiring cognitive effort. To explore the contribution of nicotinic receptors to...
Paas, Yoav, Cartaud, Jean, Recouvreur, Michel, Grailhe, Regis, Dufresne, Virginie, Pebay-Peyroula, Eva, ...
Nicotinic acetylcholine receptors (AChRs) belong to a superfamily of oligomeric proteins that transduce electric signals across the cell membrane on binding of neurotransmitters. These receptors...
Podleski, Thomas, Meunier, Jean-Claude, Changeux, Jean-Pierre
p-(trimethyl ammonium) benzene diazonium difluoroborate (TDF), an affinity-labeling reagent of the acetylcholine receptor site(s), which in the normal cell acts as an irreversible inhibitor becomes a...
ON THE ASSOCIATION OF TYROCIDINE WITH ACETYLCHOLINESTERASE*
Changeux, Jean-Pierre, Ryter, Antoinette, Leuzinger, Walo, Barrand, Plana, Podleski, Thomas
In studies of several polypeptide antibiotics with a high affinity for a variety of biological membranes, tyrocidine was found to bind specifically to acetylcholinesterase, an enzyme localized in...
Phosphorylation-Elicited Quaternary Changes of GA Binding Protein in Transcriptional Activation
Sunesen, Morten, Huchet-Dymanus, Monique, Christensen, Morten O., Changeux, Jean-Pierre
Enrichment of nicotinic acetylcholine receptors (nAChR) on the tip of the subjunctional folds of the postsynaptic membrane is a central event in the development of the vertebrate neuromuscular...
Use of a Snake Venom Toxin to Characterize the Cholinergic Receptor Protein*
Changeux, Jean-Pierre, Kasai, Michiki, Lee, Chen-Yuan
α-Bungarotoxin, a polypeptide of mol wt 8000 purified from the venom of Bungarus multicinctus, blocks irreversibly and specifically the excitation by cholinergic agonists on the isolated electroplax...
ON THE COOPERATIVITY OF BIOLOGICAL MEMBRANES*
Changeux, Jean-Pierre, Thiéry, Jean, Tung, Yvonne, Kittel, C.
Reconstitution of a Chemically Excitable Membrane
Hazelbauer, Gerald L., Changeux, Jean-Pierre
Membrane fragments rich in cholinergic (nicotinic) receptor sites, purified from homogenates of Torpedo marmorata electric organ, are dissolved in high concentrations of Na cholate and Tris buffer in...
A Theory of the Epigenesis of Neuronal Networks by Selective Stabilization of Synapses
Changeux, Jean-Pierre, Courrége, Philippe, Danchin, Antoine
A formalism is introduced to represent the connective organization of an evolving neuronal network and the effects of environment on this organization by stabilization or degeneration of labile...
Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb
Mechawar, Naguib, Saghatelyan, Armen, Grailhe, Régis, Scoriels, Linda, Gheusi, Gilles, Gabellec, Marie-Madeleine, ...
Cholinergic axons and nicotinic receptors are abundant in all layers of the olfactory bulb (OB), the main region of newborn neuron integration in the adult brain. Here, we report that the OB granule...
Strochlic, Laure, Cartaud, Annie, Mejat, Alexandre, Grailhe, Régis, Schaeffer, Laurent, Changeux, Jean-Pierre, ...
The muscle-specific receptor tyrosine kinase (MuSK) is part of a receptor complex, activated by neural agrin, that orchestrates the differentiation of the neuromuscular junction (NMJ). To gain...
Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function
Cohen, Gary, Roux, Jean-Christophe, Grailhe, Régis, Malcolm, Girvan, Changeux, Jean-Pierre, Lagercrantz, Hugo
We investigated the role played by β2-containing neuronal nicotinic receptors [nicotinic acetylcholine receptors (nAChRs)] in mediating nicotine's side effects in the fetus and newborn. Pregnant WT...
Dehaene, Stanislas, Changeux, Jean-Pierre
Even in the absence of sensory inputs, cortical and thalamic neurons can show structured patterns of ongoing spontaneous activity, whose origins and functional significance are not well understood....
Pore conformations and gating mechanism of a Cys-loop receptor
Paas, Yoav, Gibor, Gilad, Grailhe, Regis, Savatier-Duclert, Nathalie, Dufresne, Virginie, Sunesen, Morten, ...
Neurons regulate the propagation of chemoelectric signals throughout the nervous system by opening and closing ion channels, a process known as gating. Here, histidine-based metal-binding sites were...
Normal Mode Analysis Suggests a Quaternary Twist Model for the Nicotinic Receptor Gating Mechanism
Taly, Antoine, Delarue, Marc, Grutter, Thomas, Nilges, Michael, Le Novère, Nicolas, Corringer, Pierre-Jean, ...
We present a three-dimensional model of the homopentameric α7 nicotinic acetylcholine receptor (nAChR), that includes the extracellular and membrane domains, developed by comparative modeling on the...
De Kerchove D'Exaerde, Alban, Cartaud, Jean, Ravel-Chapuis, Aymeric, Seroz, Thierry, Pasteau, Fabien, Angus, Lindsay M., ...
The localized transcription of several muscle genes at the motor endplate is controlled by the Ets transcription factor GABP. To evaluate directly its contribution to the formation of the...
Molecular tuning of fast gating in pentameric ligand-gated ion channels
Grutter, Thomas, De Carvalho, Lia Prado, Dufresne, Virginie, Taly, Antoine, Edelstein, Stuart J., Changeux, Jean-Pierre
Neurotransmitters such as acetylcholine (ACh) and glycine mediate fast synaptic neurotransmission by activating pentameric ligand-gated ion channels (LGICs). These receptors are allosteric...
A neurocomputational hypothesis for nicotine addiction
Gutkin, Boris S., Dehaene, Stanislas, Changeux, Jean-Pierre
We present a hypothetical neurocomputational model that combines a set of neural circuits at the molecular, cellular, and system levels and accounts for several neurobiological and behavioral...
Taly, Antoine, Corringer, Pierre-Jean, Grutter, Thomas, De Carvalho, Lia Prado, Karplus, Martin, Changeux, Jean-Pierre
Nicotinic acetylcholine receptors (nAChR) are pentameric ligand-gated ion channels composed of subunits that consist of an extracellular domain that carries the ligand-binding site and a distinct...
Le Magueresse, Corentin, Safiulina, Victoria, Changeux, Jean-Pierre, Cherubini, Enrico
The hippocampus, a key structure in learning and memory processes, receives a powerful cholinergic innervation from the septum and contains nicotinic acetylcholine receptors (nAChRs). Early in...
Live imaging of neural structure and function by fibred fluorescence microscopy
Vincent, Pierre, Maskos, Uwe, Charvet, Igor, Bourgeais, Laurence, Stoppini, Luc, Leresche, Nathalie, ...
Only a few methods permit researchers to study selected regions of the central and peripheral nervous systems with a spatial and time resolution sufficient to image the function of neural structures....
Long-term effects of chronic nicotine exposure on brain nicotinic receptors
Besson, Morgane, Granon, Sylvie, Mameli-Engvall, Monica, Cloëz-Tayarani, Isabelle, Maubourguet, Nicolas, Cormier, Anne, ...
Chronic nicotine exposure results in long-term homeostatic regulation of nicotinic acetylcholine receptors (nAChRs) that play a key role in the adaptative cellular processes leading to addiction....
The question is raised of the relevance of experimental work with the mouse and some of its genetically modified individuals in the study of consciousness. Even if this species does not go far beyond...
Changeux, Jean-Pierre, Podleski, Thomas, Meunier, Jean-Claude
Several properties of the enzyme acetylcholinesterase (AChE) isolated in vitro are compared with those of the membrane receptor(s) of acetylcholine expressed by the in vivo electrical response of the...
Kabbani, Nadine, Woll, Matthew P., Levenson, Robert, Lindstrom, Jon M., Changeux, Jean-Pierre
Nicotine acetylcholine receptors (nAChRs) comprise a family of ligand-gated channels widely expressed in the mammalian brain. The β2 subunit is an abundant protein subunit critically involved in the...
Behavioral Sequence Analysis Reveals a Novel Role for ß2* Nicotinic Receptors in Exploration
Maubourguet, Nicolas, Lesne, Annick, Changeux, Jean-Pierre, Maskos, Uwe, Faure, Philippe
Nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central nervous system and modulate neuronal function in most mammalian brain structures. The contribution of defined...
Interplay of β2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion
Avale, Maria Elena, Faure, Philippe, Pons, Stéphanie, Robledo, Patricia, Deltheil, Thierry, David, Denis J., ...
Acetylcholine (ACh) is a known modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic ACh receptors (nAChRs). Yet, the subunit composition and specific...
Reflections of a neuroscientist on the origins of ethics
The increased globalization of economics, communications and of medical care raises many issues of ethics and science and their applications on the global scale. A critical question to consider is...