Crystal structures of saposins A and C (2006)
Ahn, Victoria E., Leyko, Paul, Alattia, Jean-René, Chen, Lu, Privé, Gilbert G.
Saposins A and C are sphingolipid activator proteins required for the lysosomal breakdown of galactosylceramide and glucosylceramide, respectively. The saposins interact with lipids, leading to an...
Crystal structures of saposins A and C (2006)
Ahn, Victoria E., Leyko, Paul, Alattia, Jean-René, Chen, Lu, Privé, Gilbert G.
Saposins A and C are sphingolipid activator proteins required for the lysosomal breakdown of galactosylceramide and glucosylceramide, respectively. The saposins interact with lipids, leading to an...
Crystal structures of saposins A and C
Ahn, Victoria E., Leyko, Paul, Alattia, Jean-René, Chen, Lu, Privé, Gilbert G.
Saposins A and C are sphingolipid activator proteins required for the lysosomal breakdown of galactosylceramide and glucosylceramide, respectively. The saposins interact with lipids, leading to an...
Molecular imaging of membrane interfaces reveals mode of β-glucosidase activation by saposin C
Alattia, Jean-René, Shaw, James E., Yip, Christopher M., Privé, Gilbert G.
Acid β-glucosidase (GCase) is a soluble lysosomal enzyme responsible for the hydrolysis of glucose from glucosylceramide and requires activation by the small nonenzymatic protein saposin C (sapC) to...