Jean L. Chang

Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome (2007)

Margulies, Elliott H., Cooper, Gregory M., Asimenos, George, Thomas, Daryl J., Dewey, Colin N., Siepel, Adam, ...

A key component of the ongoing ENCODE project involves rigorous comparative sequence analyses for the initially targeted 1% of the human genome. Here, we present orthologous sequence generation,...

Initial sequence of the chimpanzee genome and comparison with the human genome (2005)

Mikkelsen, Tarjei S., Hillier, LaDeana W., Eichler, Evan E., Zody, Michael C., Jaffe, David B., Yang, Shiaw-Pyng, ...

Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences...

Identification of mixups among DNA sequencing plates (2002)

Stojanovic, Nikola, Chang, Jean L., Lehoczky, Jessica, Zody, Michael C., Dewar, Ken

Motivation: During the process of high-throughput genome sequencing there are opportunities for mixups of reagents and data associated with particular projects. The sequencing templates or sequence...

An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing

Margulies, Elliott H., Vinson, Jade P., Miller, Webb, Jaffe, David B., Lindblad-Toh, Kerstin, Chang, Jean L., ...

With the recent completion of a high-quality sequence of the human genome, the challenge is now to understand the functional elements that it encodes. Comparative genomic analysis offers a powerful...

An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing

Margulies, Elliott H., Vinson, Jade P., Miller, Webb, Jaffe, David B., Lindblad-Toh, Kerstin, Chang, Jean L., ...

With the recent completion of a high-quality sequence of the human genome, the challenge is now to understand the functional elements that it encodes. Comparative genomic analysis offers a powerful...

Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome

Margulies, Elliott H., Cooper, Gregory M., Asimenos, George, Thomas, Daryl J., Dewey, Colin N., Siepel, Adam, ...

A key component of the ongoing ENCODE project involves rigorous comparative sequence analyses for the initially targeted 1% of the human genome. Here, we present orthologous sequence generation,...

A semiautomated approach to gene discovery through expressed sequence tag data mining: Discovery of new human transporter genes

Brown, Shoshana, Chang, Jean L., Sadee, Wolfgang, Babbitt, Patricia C.

Identification and functional characterization of the genes in the human genome remain a major challenge. A principal source of publicly available information used for this purpose is the National...