Uchida, Kazumi, Danenberg, Peter V, Danenberg, Kathleen D, Grem, Jean L
Abstract Background Over-expression of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) in tumor tissue is associated with insensitivity to 5-fluorouracil (5-FU). Over-expression...
Leonard, Gregory D, Wright, Maurice A, Quinn, Mary G, Fioravanti, Suzanne, Harold, Nancy, Schuler, Barbara, ...
Abstract Background New chemotherapy regimens for patients with colorectal cancer have improved survival, but at the cost of clinical toxicity. Oxaliplatin, an agent used in first-line therapy for...
Yee, Lorrin K., Allegra, Carmen J., Steinberg, Seth M., Grem, Jean L.
Background: We previously reported that recombinant interferon α-2a (IFN α-2a) therapy was associated with a dose-dependent decrease in fluorouracil (5-FU) clearance. Purpose: In this study, we...
Pentostatin in Hairy Cell Leukemia: Treatment by the Special Exception Mechanism (1989)
Grem, Jean L., King, Susan A., Cheson, Bruce D., Leyland-Jones, Brian, Wittes, Robert E.
An analysis of the clinical outcomes in 66 patients with hairy cell leukemia treated with pentostain under the Special Exception mechanism of the Division of Cancer Treatment, National Cancer...
Toxicity of Levamisole and 5-Fluorouracil in Human Colon Carcinoma Cells (1989)
Grem, Jean L, Allegra, Carmen J.
The combination of 5-fluorouracil (5-FU) with the immunomodulator levamisole (Lev) has been clinically tested in patients with metastatic colorectal carcinoma and as adjuvant therapy following...
The Role of Methotrexate in Osteosarcoma (1988)
Grem, Jean L., King, Susan A., Wittes, Robert E., Leyland-Jones, Brian
High-dose methotrexate (MTX) is one of the agents currently used in intensive adjuvant chemotherapy regimens for nonmetastatic osteosarcoma. To elucidate the role of high-dose MTX in this disease, we...
Cephalotaxine Esters: Antileukemic Advance or Therapeutic Failure? (1988)
Grem, Jean L., Cheson, Bruce D., King, Susan A., Leyland-Jones, Brian, Suffness, Matthew
Clinical trails conducted in the People's Republic of china and the United States of the antileukemic efficacy of the cephalotaxine esters are reviewed. Harringtonine has been incorporated into...
Leonard, Gregory D, Wright, Maurice A, Quinn, Mary G, Fioravanti, Suzanne, Harold, Nancy, Schuler, Barbara, ...
Leonard, Gregory D, Wright, Maurice A, Quinn, Mary G, Fioravanti, Suzanne, Harold, Nancy, Schuler, Barbara, ...
Webster, Richard G, Brain, Keith L, Wilson, Richard H, Grem, Jean L, Vincent, Angela
Oxaliplatin, an effective cytotoxic treatment in combination with 5-fluorouracil for colorectal cancer, is associated with sensory, motor and autonomic neurotoxicity. Motor symptoms include...