Cadmium-containing nanoparticles: Perspectives on pharmacology and toxicology of quantum dots (2009)
Rzigalinski, Beverly A., Strobl, Jeannine S.
The field of nanotechnology is rapidly expanding with the development of novel nanopharmaceuticals that have potential for revolutionizing medical treatment. The rapid pace of expansion in this field...
Jeannine S. Strobl, Meredith Cassell, Sheila M. Mitchell, Christopher M. Reilly, David S. Lindsay
Toxoplasma gondii is a well-recognized cause of disease in congenitally infected and immunocompromised individuals. Histone deacetylases (HDAC) comprise a family of enzymes that participate in the...
Novel Histone Deacetylase Inhibitors (1998)
Strobl, Jeannine S., Martirosyan, Anna R.
The goal of this project is to develop new drugs for cell differentiation therapy of breast cancer. Our central hypothesis is antimalarials and structurally related quinoline compounds are histone...
Augmentation of the Differentiation Response to Antitumor Antimalarials (1998)
Rahim, Rayhana, Strobl, Jeannine S.
An impeding Challenge to breast cancer drug therapies is the availability of more effective and less toxic chemotherapeutic agents that do not relay harm to neighboring normal breast cells and...
Novel Histone Deacetylase Inhibitors (1998)
Advanced breast cancer is not curable by existing treatment regimens. The purpose of this project is to discover new drugs to treat breast cancer that act to restore the differentiated and...
Augmentation of the Differentiation Response to Antitumor Antimalarials (1998)
Rahim, Rayhana, Strobl, Jeannine S.
We have shown that the quinoline antimalarials chioroquine (CQ) and hydroxychioroquine (HCQ) inhibit proliferation and induce differentiation in breast cancer cell lines without toxicity to normal...
Methylation of either cytosine in the recognition sequence CGCG inhibits ThaI cleavage of DNA (1984)
Strobl, Jeannine S., Thompson, E.Brad
ThaI (CGCG) sites which overlap HhaI (GCGC) sites in ΦX174 and pBR322 DNA were methylated in vitro with HhaI methylase and S-adenosylmethionine to yield CGmCG, or mCGCG or mCGmCG (5-methylcytosine,...