Selective Ligand Recognition by a Diversity-Generating Retroelement Variable Protein (2008)
Jason L. Miller, Johanne Le Coq, Asher Hodes, Roman Barbalat, Jeff F. Miller, Partho Ghosh
Diversity-generating retroelements (DGRs) recognize novel ligands through massive protein sequence variation, a property shared uniquely with the adaptive immune response. Little is known about how...
Ochsenbein, Adrian F., Karrer, Urs, Klenerman, Paul, Althage, Alana, Ciurea, Adrian, Shen, Hao, ...
Cytotoxic T cell (CTL) memory was analyzed after infection with lymphocytic choriomeningitis virus (LCMV) and recombinant Listeria monocytogenes (rLM) expressing the complete nucleoprotein of LCMV...
Bouwer, H. G. Archie, Shen, Hao, Fan, Xin, Miller, Jeff F., Barry, Ronald A., Hinrichs, David J.
Infection of BALB/c mice with Listeria monocytogenes stimulates an antilisterial immune response evident by the appearance of H2-Kd-restricted CD8+ cytotoxic T lymphocytes (CTLs) specific for the...
Harvill, Eric T., Cotter, Peggy A., Yuk, Ming Huam, Miller, Jeff F.
We have examined the role of adenylate cyclase-hemolysin (CyaA) by constructing an in-frame deletion in the Bordetella bronchiseptica cyaA structural gene and comparing wild-type and cyaA deletion...
Harvill, Eric T., Cotter, Peggy A., Miller, Jeff F.
We describe here a side-by-side comparison of murine respiratory infection by Bordetella pertussis and Bordetella bronchiseptica strains whose genomes are currently being sequenced (Tohama I and...
Mattoo, Seema, Miller, Jeff F., Cotter, Peggy A.
Fimbriae are filamentous, cell surface structures which have been proposed to mediate attachment of Bordetella species to respiratory epithelium. Bordetella bronchiseptica has four known fimbrial...
Multiple Roles for Bordetella Lipopolysaccharide Molecules during Respiratory Tract Infection
Harvill, Eric T., Preston, Andrew, Cotter, Peggy A., Allen, Andrew G., Maskell, Duncan J., Miller, Jeff F.
Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica are closely related subspecies that cause respiratory tract infections in humans and other mammals and express many...
Martinez De Tejada, Guillermo, Cotter, Peggy A., Heininger, Ulrich, Camilli, Andrew, Akerley, Brian J., Mekalanos, John J., ...
In Bordetella species, the BvgAS sensory transduction system mediates an alteration between the Bvg+ phase, characterized by expression of adhesins and toxins, and the Bvg− phase, characterized by...
Fas (CD95)-Dependent Cell-Mediated Immunity to Listeria monocytogenes
Jensen, Eric R., Glass, Alison A., Clark, William R., Wing, Edward J., Miller, Jeff F., Gregory, Stephen H.
Two distinct and complementary pathways, one mediated by perforin and the other dependent upon CD95 (Fas), effect cell-mediated cytotoxicity. We examined the relative roles of these pathways in host...
Cotter, Peggy A., Yuk, Ming H., Mattoo, Seema, Akerley, Brian J., Boschwitz, Jeff, Relman, David A., ...
Adherence to ciliated respiratory epithelial cells is considered a critical early step in Bordetella pathogenesis. For Bordetella pertussis, the etiologic agent of whooping cough, several factors...
Huang, Tony Jun, Liu, Minghsun, Knight, Linda D., Grody, Wayne W., Miller, Jeff F., Ho, Chih-Ming
Single nucleotide polymorphisms are implicated as having a significant role in regulating growth, development and, thereby, human health and disease. We have developed a method for identifying single...
Heininger, Ulrich, Cotter, Peggy A., Fescemyer, Howard W., Martinez De Tejada, Guillermo, Yuk, Ming H., Miller, Jeff F., ...
The genomes of three closely related bordetellae are currently being sequenced, thus providing an opportunity for comparative genomic approaches driven by an understanding of the comparative biology...
Angelakopoulos, Haroula, Loock, Katharina, Sisul, David M., Jensen, Eric R., Miller, Jeff F., Hohmann, Elizabeth L.
Listeria monocytogenes is an intracellular bacterial pathogen which causes bacteremia and has a tropism for the central nervous system and a propensity to cause maternofetal infection. L....
Liu, Minghsun, Gingery, Mari, Doulatov, Sergei R., Liu, Yichin, Hodes, Asher, Baker, Stephen, ...
Liu et al. recently described a group of related temperate bacteriophages that infect Bordetella subspecies and undergo a unique template-dependent, reverse transcriptase-mediated tropism switching...
Widney, Daniel P., Hu, Yan, Foreman-Wykert, Amy K., Bui, Kim C., Nguyen, Tam T., Lu, Bao, ...
Intranasal inoculation of mice with Bordetella bronchiseptica produces a transient pneumonia that is cleared over several weeks in a process known to require both neutrophils and lymphocytes. In this...
Vergara-Irigaray, Nuria, Chávarri-Martínez, Alberto, Rodríguez-Cuesta, Juan, Miller, Jeff F., Cotter, Peggy A., Martínez De Tejada, Guillermo
The BvgAS system of Bordetella pertussis was traditionally considered to mediate a transition between two phenotypic phases (Bvg+ and Bvg−) in response to environmental signals. We characterized a...
Kozak, Natalia A., Mattoo, Seema, Foreman-Wykert, Amy K., Whitelegge, Julian P., Miller, Jeff F.
We have recently described a multicomponent cascade that regulates type III secretion in Bordetella. This cascade includes a group of proteins, BtrU, BtrW, and BtrV, that contain an array of domains...
Ochsenbein, Adrian F., Karrer, Urs, Klenerman, Paul, Althage, Alana, Ciurea, Adrian, Shen, Hao, ...
Cytotoxic T cell (CTL) memory was analyzed after infection with lymphocytic choriomeningitis virus (LCMV) and recombinant Listeria monocytogenes (rLM) expressing the complete nucleoprotein of LCMV...
Bouwer, H. G. Archie, Shen, Hao, Fan, Xin, Miller, Jeff F., Barry, Ronald A., Hinrichs, David J.
Infection of BALB/c mice with Listeria monocytogenes stimulates an antilisterial immune response evident by the appearance of H2-Kd-restricted CD8+ cytotoxic T lymphocytes (CTLs) specific for the...
Harvill, Eric T., Cotter, Peggy A., Yuk, Ming Huam, Miller, Jeff F.
We have examined the role of adenylate cyclase-hemolysin (CyaA) by constructing an in-frame deletion in the Bordetella bronchiseptica cyaA structural gene and comparing wild-type and cyaA deletion...
Harvill, Eric T., Cotter, Peggy A., Miller, Jeff F.
We describe here a side-by-side comparison of murine respiratory infection by Bordetella pertussis and Bordetella bronchiseptica strains whose genomes are currently being sequenced (Tohama I and...
Mattoo, Seema, Miller, Jeff F., Cotter, Peggy A.
Fimbriae are filamentous, cell surface structures which have been proposed to mediate attachment of Bordetella species to respiratory epithelium. Bordetella bronchiseptica has four known fimbrial...
Multiple Roles for Bordetella Lipopolysaccharide Molecules during Respiratory Tract Infection
Harvill, Eric T., Preston, Andrew, Cotter, Peggy A., Allen, Andrew G., Maskell, Duncan J., Miller, Jeff F.
Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica are closely related subspecies that cause respiratory tract infections in humans and other mammals and express many...
Martinez De Tejada, Guillermo, Cotter, Peggy A., Heininger, Ulrich, Camilli, Andrew, Akerley, Brian J., Mekalanos, John J., ...
In Bordetella species, the BvgAS sensory transduction system mediates an alteration between the Bvg+ phase, characterized by expression of adhesins and toxins, and the Bvg− phase, characterized by...
Fas (CD95)-Dependent Cell-Mediated Immunity to Listeria monocytogenes
Jensen, Eric R., Glass, Alison A., Clark, William R., Wing, Edward J., Miller, Jeff F., Gregory, Stephen H.
Two distinct and complementary pathways, one mediated by perforin and the other dependent upon CD95 (Fas), effect cell-mediated cytotoxicity. We examined the relative roles of these pathways in host...
Cotter, Peggy A., Yuk, Ming H., Mattoo, Seema, Akerley, Brian J., Boschwitz, Jeff, Relman, David A., ...
Adherence to ciliated respiratory epithelial cells is considered a critical early step in Bordetella pathogenesis. For Bordetella pertussis, the etiologic agent of whooping cough, several factors...
Huang, Tony Jun, Liu, Minghsun, Knight, Linda D., Grody, Wayne W., Miller, Jeff F., Ho, Chih-Ming
Single nucleotide polymorphisms are implicated as having a significant role in regulating growth, development and, thereby, human health and disease. We have developed a method for identifying single...
Heininger, Ulrich, Cotter, Peggy A., Fescemyer, Howard W., Martinez De Tejada, Guillermo, Yuk, Ming H., Miller, Jeff F., ...
The genomes of three closely related bordetellae are currently being sequenced, thus providing an opportunity for comparative genomic approaches driven by an understanding of the comparative biology...
Angelakopoulos, Haroula, Loock, Katharina, Sisul, David M., Jensen, Eric R., Miller, Jeff F., Hohmann, Elizabeth L.
Listeria monocytogenes is an intracellular bacterial pathogen which causes bacteremia and has a tropism for the central nervous system and a propensity to cause maternofetal infection. L....
Liu, Minghsun, Gingery, Mari, Doulatov, Sergei R., Liu, Yichin, Hodes, Asher, Baker, Stephen, ...
Liu et al. recently described a group of related temperate bacteriophages that infect Bordetella subspecies and undergo a unique template-dependent, reverse transcriptase-mediated tropism switching...
Widney, Daniel P., Hu, Yan, Foreman-Wykert, Amy K., Bui, Kim C., Nguyen, Tam T., Lu, Bao, ...
Intranasal inoculation of mice with Bordetella bronchiseptica produces a transient pneumonia that is cleared over several weeks in a process known to require both neutrophils and lymphocytes. In this...
Vergara-Irigaray, Nuria, Chávarri-Martínez, Alberto, Rodríguez-Cuesta, Juan, Miller, Jeff F., Cotter, Peggy A., Martínez De Tejada, Guillermo
The BvgAS system of Bordetella pertussis was traditionally considered to mediate a transition between two phenotypic phases (Bvg+ and Bvg−) in response to environmental signals. We characterized a...
Kozak, Natalia A., Mattoo, Seema, Foreman-Wykert, Amy K., Whitelegge, Julian P., Miller, Jeff F.
We have recently described a multicomponent cascade that regulates type III secretion in Bordetella. This cascade includes a group of proteins, BtrU, BtrW, and BtrV, that contain an array of domains...
Campylobacter jejuni Colonization of Mice with Limited Enteric Flora
Chang, Christopher, Miller, Jeff F.
We have developed experimental murine Campylobacter infection models which demonstrate efficient establishment and reproducible, high-level colonization. Following oral inoculation, wild-type C3H...
Type I Interferon Production Enhances Susceptibility to Listeria monocytogenes Infection
O'Connell, Ryan M., Saha, Supriya K., Vaidya, Sagar A., Bruhn, Kevin W., Miranda, Gustavo A., Zarnegar, Brian, ...
Numerous bacterial products such as lipopolysaccharide potently induce type I interferons (IFNs); however, the contribution of this innate response to host defense against bacterial infection remains...
Selective Ligand Recognition by a Diversity-Generating Retroelement Variable Protein
Miller, Jason L, Coq, Johanne Le, Hodes, Asher, Barbalat, Roman, Miller, Jeff F, Ghosh, Partho
Diversity-generating retroelements (DGRs) recognize novel ligands through massive protein sequence variation, a property shared uniquely with the adaptive immune response. Little is known about how...