Iris T. Chan, Jeffery L. Kutok, Ifor R. Williams, Sarah Cohen, Ra Moore, Hirokazu Shigematsu, ...
Most patients with acute promyelocytic leukemia (APL) express PML-RAR�, the fusion product of t(15;17)(q22;q11.2). Transgenic mice expressing PML-RAR� develop APL with long latency, low...
Alu elements mediate MYB gene tandem duplication in human T-ALL (2007)
O'Neil, Jennifer Elinor, Tchinda, Joelle, Gutierrez, Alejandro, Moreau, Lisa A., Maser, Richard S., Wong, Kwok-Kin, ...
Recent studies have demonstrated that the MYB oncogene is frequently duplicated in human T cell acute lymphoblastic leukemia (T-ALL). We find that the human MYB locus is flanked by 257-bp Alu repeats...
Effects of RAS on the genesis of embryonal rhabdomyosarcoma (2007)
Langenau, David M., Keefe, Matthew D., Storer, Narie Y., Guyon, Jeffrey R., Kutok, Jeffery L., Le, Xiuning, ...
Embryonal rhabdomyosarcoma (ERMS) is a devastating cancer with specific features of muscle differentiation that can result from mutational activation of RAS family members. However, to date, RAS...
Shepard, Jennifer L., Amatruda, James F., Finkelstein, David, Ziai, James, Finley, K. Rose, Stern, Howard M., ...
Proper chromosome segregation is essential for maintenance of genomic integrity and instability resulting from failure of this process may contribute to cancer. Here, we demonstrate that a mutation...
Pondarré, Corinne, Antiochos, Brendan B., Campagna, Dean R., Clarke, Stephen L., Greer, Eric L., Deck, Kathryn M., ...
Proteins with iron–sulfur (Fe–S) clusters participate in multiple metabolic pathways throughout the cell. The mitochondrial ABC half-transporter Abcb7, which is mutated in X-linked sideroblastic...
Pondarré, Corinne, Antiochos, Brendan B., Campagna, Dean R., Clarke, Stephen L., Greer, Eric L., Deck, Kathryn M., ...
Proteins with iron-sulphur (Fe-S) clusters participate in multiple metabolic pathways throughout the cell. The mitochondrial ABC half-transporter Abcb7, which is mutated in X-linked sideroblastic...
Stover, Elizabeth H, Boulton, Christina L, Gotlib, Jason, Legare, Robert D, Amaral, Sonia M, ...
FIP1L1-PDGFRalpha causes hypereosinophilic syndrome (HES) and is inhibited by the tyrosine kinase inhibitor imatinib (Gleevec). Imatinib is a potent inhibitor of ABL, ARG, PDGFRalpha, PDGFRbeta, and...
Deguchi, Kenji, Ayton, Paul M., Carapeti, Melina, Kutok, Jeffery L., Snyder, Cynthia S., Williams, Ifor R., ...
The MOZ-TIF2 fusion is associated with acute myeloid leukemia (AML) with inv(8)(p11q13). MOZ is a MYST family histone acetyltransferase (HAT), whereas TIF2 is a nuclear receptor coactivator that...
Deguchi, Kenji, Ayton, Paul M., Carapeti, Melina, Kutok, Jeffery L., Snyder, Cynthia S., Williams, Ifor R., ...
The MOZ-TIF2 fusion is associated with acute myeloid leukemia (AML) with inv(8)(p11q13). MOZ is a MYST family histone acetyltransferase (HAT), whereas TIF2 is a nuclear receptor coactivator that...
A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9
Dash, Ajeeta B., Williams, Ifor R., Kutok, Jeffery L., Tomasson, Michael H., Anastasiadou, Ema, Lindahl, Kathleen, ...
Constitutive activation of tyrosine kinases, such as the BCR/ABL fusion associated with t(9;22)(q34;q22), is a hallmark of chronic myeloid leukemia (CML) syndromes in humans. Expression of BCR/ABL is...
Human HTm4 is a hematopoietic cell cycle regulator
Donato, José L., Ko, Jon, Kutok, Jeffery L., Cheng, Tao, Shirakawa, Taro, Mao, Xiao-Quan, ...
Proper control of cell cycle progression is critical for the constant self-renewal, differentiation, and homeostasis of the hematopoietic system. Cells of all types share the common cell cycle...
Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction
Schmollinger, Jan C., Vonderheide, Robert H., Hoar, Kara M., Maecker, Britta, Schultze, Joachim L., Hodi, F. Stephen, ...
The identification of antigens associated with tumor destruction is a major goal of cancer immunology. Vaccination with irradiated tumor cells engineered to secrete granulocyte–macrophage colony...
Bad-deficient mice develop diffuse large B cell lymphoma
Ranger, Ann M., Zha, Jiping, Harada, Hisashi, Datta, Sandeep Robert, Danial, Nika N., Gilmore, Andrew P., ...
The proapoptotic activity of the “BH3-only” molecule BAD can be differentially regulated by survival factor signaling. Bad-deficient mice lacking both BAD long and BAD short proteins proved...
Proapoptotic BID is required for myeloid homeostasis and tumor suppression
Zinkel, Sandra S., Ong, Christy C., Ferguson, David O., Iwasaki, Hiromi, Akashi, Koichi, Bronson, Roderick T., ...
The proper expansion and contraction of hematopoietic cells requires tight regulation of cell death. BID, a “BH3-only” molecule, amplifies death receptor signals connecting the extrinsic to...
Chan, Iris T., Kutok, Jeffery L., Williams, Ifor R., Cohen, Sarah, Kelly, Lauren, Shigematsu, Hirokazu, ...
Oncogenic ras alleles are among the most common mutations found in patients with acute myeloid leukemia (AML). Previously, the role of oncogenic ras in cancer was assessed in model systems...
Kutok, Jeffery L., Klumpp, Sherry, Simon, Meredith, MacKey, John J., Nguyen, Vuong, Middeldorp, Jaap M., ...
Epstein-Barr virus (EBV) is a human oncogenic herpesvirus associated with epithelial cell and B-cell malignancies. EBV infection of B lymphocytes is essential for acute and persistent EBV infection...
In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish
Langenau, David M., Ferrando, Adolfo A., Traver, David, Kutok, Jeffery L., Hezel, John-Paul D., Kanki, John P., ...
Transgenic zebrafish that express GFP under control of the T cell-specific tyrosine kinase (lck) promoter were used to analyze critical aspects of the immune system, including patterns of T cell...
Chen, Jing, DeAngelo, Daniel J., Kutok, Jeffery L., Williams, Ifor R., Lee, Benjamin H., Wadleigh, Martha, ...
Human stem cell leukemia-lymphoma syndrome usually presents itself as a myeloproliferative disorder (MPD) that evolves to acute myeloid leukemia and/or lymphoma. The syndrome associated with...
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors
Berghmans, Stéphane, Murphey, Ryan D., Wienholds, Erno, Neuberg, Donna, Kutok, Jeffery L., Fletcher, Christopher D. M., ...
TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving...
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease
Wang, Jing, Iwasaki, Hiromi, Krivtsov, Andrei, Febbo, Phillip G, Thorner, Aaron R, Ernst, Patricia, ...
Chromosomal translocations that fuse the mixed lineage leukemia (MLL) gene with multiple partners typify acute leukemias of infancy as well as therapy-related leukemias. We utilized a conditional...
Langenau, David M., Feng, Hui, Berghmans, Stephane, Kanki, John P., Kutok, Jeffery L., Look, A. Thomas
We have created a stable transgenic rag2-EGFP-mMyc zebrafish line that develops GFP-labeled T cell acute lymphoblastic leukemia (T-ALL), allowing visualization of the onset and spread of this...
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility
Shepard, Jennifer L., Amatruda, James F., Stern, Howard M., Subramanian, Aravind, Finkelstein, David, Ziai, James, ...
A major goal of cancer research has been to identify genes that contribute to cancer formation. The similar pathology between zebrafish and human tumors, as well as the past success of large-scale...
Dimitroff, Charles J., Descheny, Leyla, Trujillo, Natalia, Kim, Robert, Nguyen, Vuong, Huang, Wei, ...
Prostate tumor cells, which characteristically metastasize to bone, initiate binding interactions with bone marrow endothelium under blood flow conditions through binding interactions with...
Wagner, Katharina, Zhang, Pu, Rosenbauer, Frank, Drescher, Bettina, Kobayashi, Susumu, Radomska, Hanna S., ...
The lineage-determining transcription factor CCAAT enhancer binding protein α (C/EBPα) is required for myeloid differentiation. Decreased function or expression of C/EBPα is often found in human...
Juszczynski, Przemyslaw, Kutok, Jeffery L., Li, Cheng, Mitra, Joydeep, Aguiar, Ricardo C. T., Shipp, Margaret A.
BAL1 is a transcription modulator that is overexpressed in chemoresistant, diffuse large B-cell lymphomas (DLBCLs). BAL1 complexes with a recently described DELTEX family member termed BBAP. Herein,...
A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9
Dash, Ajeeta B., Williams, Ifor R., Kutok, Jeffery L., Tomasson, Michael H., Anastasiadou, Ema, Lindahl, Kathleen, ...
Constitutive activation of tyrosine kinases, such as the BCR/ABL fusion associated with t(9;22)(q34;q22), is a hallmark of chronic myeloid leukemia (CML) syndromes in humans. Expression of BCR/ABL is...
Human HTm4 is a hematopoietic cell cycle regulator
Donato, José L., Ko, Jon, Kutok, Jeffery L., Cheng, Tao, Shirakawa, Taro, Mao, Xiao-Quan, ...
Proper control of cell cycle progression is critical for the constant self-renewal, differentiation, and homeostasis of the hematopoietic system. Cells of all types share the common cell cycle...
Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction
Schmollinger, Jan C., Vonderheide, Robert H., Hoar, Kara M., Maecker, Britta, Schultze, Joachim L., Hodi, F. Stephen, ...
The identification of antigens associated with tumor destruction is a major goal of cancer immunology. Vaccination with irradiated tumor cells engineered to secrete granulocyte–macrophage colony...
Bad-deficient mice develop diffuse large B cell lymphoma
Ranger, Ann M., Zha, Jiping, Harada, Hisashi, Datta, Sandeep Robert, Danial, Nika N., Gilmore, Andrew P., ...
The proapoptotic activity of the “BH3-only” molecule BAD can be differentially regulated by survival factor signaling. Bad-deficient mice lacking both BAD long and BAD short proteins proved...
Proapoptotic BID is required for myeloid homeostasis and tumor suppression
Zinkel, Sandra S., Ong, Christy C., Ferguson, David O., Iwasaki, Hiromi, Akashi, Koichi, Bronson, Roderick T., ...
The proper expansion and contraction of hematopoietic cells requires tight regulation of cell death. BID, a “BH3-only” molecule, amplifies death receptor signals connecting the extrinsic to...
Chan, Iris T., Kutok, Jeffery L., Williams, Ifor R., Cohen, Sarah, Kelly, Lauren, Shigematsu, Hirokazu, ...
Oncogenic ras alleles are among the most common mutations found in patients with acute myeloid leukemia (AML). Previously, the role of oncogenic ras in cancer was assessed in model systems...
Kutok, Jeffery L., Klumpp, Sherry, Simon, Meredith, MacKey, John J., Nguyen, Vuong, Middeldorp, Jaap M., ...
Epstein-Barr virus (EBV) is a human oncogenic herpesvirus associated with epithelial cell and B-cell malignancies. EBV infection of B lymphocytes is essential for acute and persistent EBV infection...
In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish
Langenau, David M., Ferrando, Adolfo A., Traver, David, Kutok, Jeffery L., Hezel, John-Paul D., Kanki, John P., ...
Transgenic zebrafish that express GFP under control of the T cell-specific tyrosine kinase (lck) promoter were used to analyze critical aspects of the immune system, including patterns of T cell...
Chen, Jing, DeAngelo, Daniel J., Kutok, Jeffery L., Williams, Ifor R., Lee, Benjamin H., Wadleigh, Martha, ...
Human stem cell leukemia-lymphoma syndrome usually presents itself as a myeloproliferative disorder (MPD) that evolves to acute myeloid leukemia and/or lymphoma. The syndrome associated with...
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors
Berghmans, Stéphane, Murphey, Ryan D., Wienholds, Erno, Neuberg, Donna, Kutok, Jeffery L., Fletcher, Christopher D. M., ...
TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving...
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease
Wang, Jing, Iwasaki, Hiromi, Krivtsov, Andrei, Febbo, Phillip G, Thorner, Aaron R, Ernst, Patricia, ...
Chromosomal translocations that fuse the mixed lineage leukemia (MLL) gene with multiple partners typify acute leukemias of infancy as well as therapy-related leukemias. We utilized a conditional...
Langenau, David M., Feng, Hui, Berghmans, Stephane, Kanki, John P., Kutok, Jeffery L., Look, A. Thomas
We have created a stable transgenic rag2-EGFP-mMyc zebrafish line that develops GFP-labeled T cell acute lymphoblastic leukemia (T-ALL), allowing visualization of the onset and spread of this...
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility
Shepard, Jennifer L., Amatruda, James F., Stern, Howard M., Subramanian, Aravind, Finkelstein, David, Ziai, James, ...
A major goal of cancer research has been to identify genes that contribute to cancer formation. The similar pathology between zebrafish and human tumors, as well as the past success of large-scale...
Wagner, Katharina, Zhang, Pu, Rosenbauer, Frank, Drescher, Bettina, Kobayashi, Susumu, Radomska, Hanna S., ...
The lineage-determining transcription factor CCAAT enhancer binding protein α (C/EBPα) is required for myeloid differentiation. Decreased function or expression of C/EBPα is often found in human...
Juszczynski, Przemyslaw, Kutok, Jeffery L., Li, Cheng, Mitra, Joydeep, Aguiar, Ricardo C. T., Shipp, Margaret A.
BAL1 is a transcription modulator that is overexpressed in chemoresistant, diffuse large B-cell lymphomas (DLBCLs). BAL1 complexes with a recently described DELTEX family member termed BBAP. Herein,...
Expression of Geminin as a Marker of Cell Proliferation in Normal Tissues and Malignancies
Wohlschlegel, James A., Kutok, Jeffery L., Weng, Andrew P., Dutta, Anindya
Geminin interacts with a DNA replication initiation factor, Cdt1p, to suppress initiation of DNA replication in a Xenopus egg extract based cell-free system, leading to the expectation that the...
Evidence for ineffective erythropoiesis in severe sickle cell disease
Wu, Catherine J., Krishnamurti, Lakshamanan, Kutok, Jeffery L., Biernacki, Melinda, Rogers, Shelby, Zhang, Wandi, ...
Peripheral destruction of sickled erythrocytes is a cardinal feature of sickle cell disease (SCD). Less well established is the potential contribution of ineffective erythropoiesis to the...
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype
Growney, Joseph D., Shigematsu, Hirokazu, Li, Zhe, Lee, Benjamin H., Adelsperger, Jennifer, Rowan, Rebecca, ...
Homozygous loss of function of Runx1 (Runt-related transcription factor 1 gene) during murine development results in an embryonic lethal phenotype characterized by a complete lack of definitive...
A SCID-hu in vivo model of human Waldenström macroglobulinemia
Tassone, Pierfrancesco, Neri, Paola, Kutok, Jeffery L., Tournilhac, Olivier, Santos, Daniel Ditzel, Hatjiharissi, Evdoxia, ...
The preclinical evaluation of investigational agents for Waldenström macroglobulinemia (WM) has been limited by the lack of in vivo models that enable the use of explanted patient cells. We describe...
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer
Shepard, Jennifer L., Amatruda, James F., Finkelstein, David, Ziai, James, Finley, K. Rose, Stern, Howard M., ...
Proper chromosome segregation is essential for maintenance of genomic integrity and instability resulting from failure of this process may contribute to cancer. Here, we demonstrate that a mutation...
Oncogenic K-ras cooperates with PML-RARα to induce an acute promyelocytic leukemia-like disease
Chan, Iris T., Kutok, Jeffery L., Williams, Ifor R., Cohen, Sarah, Moore, Sandra, Shigematsu, Hirokazu, ...
Most patients with acute promyelocytic leukemia (APL) express PML-RARα, the fusion product of t(15;17)(q22;q11.2). Transgenic mice expressing PML-RARα develop APL with long latency, low penetrance,...
Gill, Michael B., Kutok, Jeffery L., Fingeroth, Joyce D.
The thymidine kinase (TK) encoded by Epstein-Barr virus (EBV) differs not only from that of the alphaherpesviruses but also from that of the gamma-2 herpesvirus subfamily. Because cellular location...
Le, Xiuning, Langenau, David M., Keefe, Matthew D., Kutok, Jeffery L., Neuberg, Donna S., Zon, Leonard I.
RAS family members are among the most frequently mutated oncogenes in human cancers. Given the utility of zebrafish in both chemical and genetic screens, developing RAS-induced cancer models will...
Effects of RAS on the genesis of embryonal rhabdomyosarcoma
Langenau, David M., Keefe, Matthew D., Storer, Narie Y., Guyon, Jeffrey R., Kutok, Jeffery L., Le, Xiuning, ...
Embryonal rhabdomyosarcoma (ERMS) is a devastating cancer with specific features of muscle differentiation that can result from mutational activation of RAS family members. However, to date, RAS...
Mani, Sendurai A., Yang, Jing, Brooks, Mary, Schwaninger, Gunda, Zhou, Alicia, Miura, Naoyuki, ...
The metastatic spread of epithelial cancer cells from the primary tumor to distant organs mimics the cell migrations that occur during embryogenesis. Using gene expression profiling, we have found...
Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
Zangani, Michael M., Frøyland, Marianne, Qiu, Gao Yue, Meza-Zepeda, Leonardo A., Kutok, Jeffery L., Thompson, Keith M., ...
B cell lymphomas have been associated with chronic infections and autoimmunity. However, most lymphomas develop in the absence of any known chronic antigenic stimulation. B cells process their highly...
Juszczynski, Przemyslaw, Ouyang, Jing, Monti, Stefano, Rodig, Scott J., Takeyama, Kunihiko, Abramson, Jeremy, ...
Classical Hodgkin lymphomas (cHLs) contain small numbers of neoplastic Reed–Sternberg (RS) cells within an extensive inflammatory infiltrate that includes abundant T helper (Th)-2 and T regulatory...
Kiziltepe, Tanyel, Hideshima, Teru, Ishitsuka, Kenji, Ocio, Enrique M., Raje, Noopur, Catley, Laurence, ...
Here we investigated the cytotoxicity of JS-K, a prodrug designed to release nitric oxide (NO•) following reaction with glutathione S-transferases, in multiple myeloma (MM). JS-K showed significant...
Alu elements mediate MYB gene tandem duplication in human T-ALL
O'Neil, Jennifer, Tchinda, Joelle, Gutierrez, Alejandro, Moreau, Lisa, Maser, Richard S., Wong, Kwok-Kin, ...
Recent studies have demonstrated that the MYB oncogene is frequently duplicated in human T cell acute lymphoblastic leukemia (T-ALL). We find that the human MYB locus is flanked by 257-bp Alu repeats...
Chen, Linfeng, Monti, Stefano, Juszczynski, Przemyslaw, Daley, John, Chen, Wen, Witzig, Thomas E., ...
The role of B-cell receptor (BCR)–mediated survival signals in diffuse large B-cell lymphoma (DLBCL) remains undefined. Ligand-induced BCR signaling induces receptor oligomerization, Igα/β...
Chan, Gordon, Kalaitzidis, Demetrios, Usenko, Tatiana, Kutok, Jeffery L., Yang, Wentian, Mohi, M. Golam, ...
PTPN11, which encodes the tyrosine phosphatase SHP2, is mutated in approximately 35% of patients with juvenile myelomonocytic leukemia (JMML) and at a lower incidence in other neoplasms. To model...