Jeffrey C. Buchsbaum

Proteolytic Cleavage of Cyclin E Leads to Inactivation of Associated Kinase Activity and Amplification of Apoptosis in Hematopoietic Cells

Mazumder, Suparna, Gong, Bendi, Chen, Quan, Drazba, Judith A., Buchsbaum, Jeffrey C., Almasan, Alexandru

Cyclin E/Cdk2 is a critical regulator of cell cycle progression from G1 to S in mammalian cells and has an established role in oncogenesis. Here we examined the role of deregulated cyclin E...

Proteolytic Cleavage of Cyclin E Leads to Inactivation of Associated Kinase Activity and Amplification of Apoptosis in Hematopoietic Cells

Mazumder, Suparna, Gong, Bendi, Chen, Quan, Drazba, Judith A., Buchsbaum, Jeffrey C., Almasan, Alexandru

Cyclin E/Cdk2 is a critical regulator of cell cycle progression from G1 to S in mammalian cells and has an established role in oncogenesis. Here we examined the role of deregulated cyclin E...