Jeffrey Clifford Dyason

α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II (2008)

Dong, Lan-feng, Low, Pauline, Dyason, Jeffrey Clifford, Wang, Xiufang, Prochazka, L, Witting, PK, ...

α-Tocopheryl succinate (α-TOS) is a selective inducer of apoptosis in cancer cells, which involves the accumulation of reactive oxygen species (ROS). The molecular target of α-TOS has not been...

α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II (2008)

Dong, Lan-feng, Low, Pauline, Dyason, Jeffrey Clifford, Wang, Xiufang, Prochazka, L, Witting, PK, ...

α-Tocopheryl succinate (α-TOS) is a selective inducer of apoptosis in cancer cells, which involves the accumulation of reactive oxygen species (ROS). The molecular target of α-TOS has not been...

α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II (2008)

Dong, Lan-feng, Low, Pauline, Dyason, Jeffrey Clifford, Wang, Xiufang, Prochazka, L, Witting, PK, ...

α-Tocopheryl succinate (α-TOS) is a selective inducer of apoptosis in cancer cells, which involves the accumulation of reactive oxygen species (ROS). The molecular target of α-TOS has not been...

Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II (2007)

Neuzil, Jiri, Dyason, Jeffrey Clifford, Freeman, Ruth, Dong, Lan-feng, Prochazka, Lubomir, Wang, Xiufang, ...

Recently mitochondria in cancer cells have emerged as the Achilles heel for tumour destruction. Anti-cancer agents specifically targeting cancer cell mitochondria are referred to as 'mitocans'. These...

Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria (2007)

Neuzil, Jiri, Dong, Lan-feng, Ramanathapuram, Lalitha, Hahn, Tobias, Chladova, Miroslava, Wang, Xiufang, ...

Mitochondria have recently emerged as new and promising targets for cancer prevention and therapy. One of the reasons for this is that mitochondria are instrumental to many types of cell death and...

Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II (2007)

Neuzil, Jiri, Dyason, Jeffrey Clifford, Freeman, Ruth, Dong, Lan-feng, Prochazka, Lubomir, Wang, Xiufang, ...

Recently mitochondria in cancer cells have emerged as the Achilles heel for tumour destruction. Anti-cancer agents specifically targeting cancer cell mitochondria are referred to as 'mitocans'. These...

Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria (2007)

Neuzil, Jiri, Dong, Lan-feng, Ramanathapuram, Lalitha, Hahn, Tobias, Chladova, Miroslava, Wang, Xiufang, ...

Mitochondria have recently emerged as new and promising targets for cancer prevention and therapy. One of the reasons for this is that mitochondria are instrumental to many types of cell death and...

Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity (2007)

Tindal, David James, Dyason, Jeffrey Clifford, Thomson, Robin Joy, Suzuki, Takashi, Ueyama, Hiroo, Kuwahara, Yohta, ...

The X-ray crystal structure of the paramyxoviral surface glycoprotein haemagglutinin-neuraminidase (HN) from Newcastle Disease virus was used as a template to design inhibitors of the HN from human...

Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II (2007)

Neuzil, Jiri, Dyason, Jeffrey Clifford, Freeman, Ruth, Dong, Lan-feng, Prochazka, Lubomir, Wang, Xiufang, ...

Recently mitochondria in cancer cells have emerged as the Achilles heel for tumour destruction. Anti-cancer agents specifically targeting cancer cell mitochondria are referred to as 'mitocans'. These...

Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria (2007)

Neuzil, Jiri, Dong, Lan-feng, Ramanathapuram, Lalitha, Hahn, Tobias, Chladova, Miroslava, Wang, Xiufang, ...

Mitochondria have recently emerged as new and promising targets for cancer prevention and therapy. One of the reasons for this is that mitochondria are instrumental to many types of cell death and...

STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core (2006)

Haselhorst, Thomas Erwin, Blanchard, Helen, Frank, Martin, Kraschnefski, Mark, Kiefel, Milton, Szyczew, Alexander Jeffery, ...

The VP8* subunit of rotavirus spike protein VP4 contains a sialic acid (Sia)-binding domain important for host cell attachment and infection. In this study, the binding epitope of the...

STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core (2006)

Haselhorst, Thomas Erwin, Blanchard, Helen, Frank, Martin, Kraschnefski, Mark, Kiefel, Milton, Szyczew, Alexander Jeffery, ...

The VP8* subunit of rotavirus spike protein VP4 contains a sialic acid (Sia)-binding domain important for host cell attachment and infection. In this study, the binding epitope of the...

Structural analysis of a designed inhibitor complexed with the hemagglutinin-neuraminidase of Newcastle disease virus (2006)

Ryan, Charlotte, Zaitsev, Viateslav, Tindal, David James, Dyason, Jeffrey Clifford, Thomson, Robin Joy, Alymova, Irina, ...

Viruses of the Paramyxoviridae family are the leading cause of respiratory disease in children. The human parainfluenza viruses (hPIV) are members of the Paramyxovirinae subfamily, which also...

Modelling, synthesis and biological evaluation of novel glucoronide-based probes of Vibrio cholerae sialidase (2006)

Mann, Maretta, Thomson, Robin Joy, Dyason, Jeffrey Clifford, McAtamney, Sarah, Von Itzstein, Mark

The development of sialidase inhibitors is an area of continuing interest due to their potential use as therapeutic agents to combat viral and bacterial infections. Herein, we report our studies...

Unsaturated N-acetyl-D-glycosaminuronic acid glycosides as inhibitors of influenza virus sialidase (2006)

Mann, Maretta, Islam, Tasneem, Dyason, Jeffrey Clifford, Florio, Pas, Trower, Carolyn J., Thomson, Robin Joy, ...

The threat of pandemic influenza is a significant concern of governments worldwide. There is a very limited and relatively expensive armament to tackle such a pandemic should it occur. This fact...

STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core (2006)

Haselhorst, Thomas Erwin, Blanchard, Helen, Frank, Martin, Kraschnefski, Mark, Kiefel, Milton, Szyczew, Alexander Jeffery, ...

The VP8* subunit of rotavirus spike protein VP4 contains a sialic acid (Sia)-binding domain important for host cell attachment and infection. In this study, the binding epitope of the...

NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Liakatos, Angela, Kiefel, Milton, Dyason, Jeffrey Clifford, Von Itzstein, Mark, ...

Nuclear magnetic resonance (NMR) spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalyzed by Trypanosoma cruzi...

NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Liakatos, Angela, Kiefel, Milton, Dyason, Jeffrey Clifford, Von Itzstein, Mark

Nuclear magnetic resonance (NMR) spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalyzed by Trypanosoma cruzi...

NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Liakatos, Angela, Kiefel, Milton, Dyason, Jeffrey Clifford, Von Itzstein, Mark

Nuclear magnetic resonance (NMR) spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalyzed by Trypanosoma cruzi...

NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Liakatos, Angela, Kiefel, Milton, Dyason, Jeffrey Clifford, Von Itzstein, Mark

Nuclear magnetic resonance (NMR) spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalyzed by Trypanosoma cruzi...

A Study of the Active Site of Influenza Virus Sialidase: An Approach to the Rational Design of Novel Anti-influenza Drugs (1996)

Itzstein, Mark Von, Dyason, Jeffrey Clifford, Oliver, Stuart W., White, Hume F., Wu, Wen-Yang, Kok, Gaik B., ...

The development of sialidase inhibitor-based potential anti-influenza drugs using rational drug design techniques has been of recent interest. The present study details an investigation of the active...

A Study of the Active Site of Influenza Virus Sialidase: An Approach to the Rational Design of Novel Anti-influenza Drugs (1996)

Itzstein, Mark Von, Dyason, Jeffrey Clifford, Oliver, Stuart W., White, Hume F., Wu, Wen-Yang, Kok, Gaik B., ...

The development of sialidase inhibitor-based potential anti-influenza drugs using rational drug design techniques has been of recent interest. The present study details an investigation of the active...

A Study of the Active Site of Influenza Virus Sialidase: An Approach to the Rational Design of Novel Anti-influenza Drugs (1996)

Itzstein, Mark Von, Dyason, Jeffrey Clifford, Oliver, Stuart W., White, Hume F., Wu, Wen-Yang, Kok, Gaik B., ...

The development of sialidase inhibitor-based potential anti-influenza drugs using rational drug design techniques has been of recent interest. The present study details an investigation of the active...

Rational design of potent sialidase-based inhibitors of influenza virus replication (1993)

Itzstein, Mark Von, Wu, Wen-Yang, Kok, Gaik B., Pegg, Michael S., Dyason, Jeffrey Clifford, Jin, Betty, ...

Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus in cell...

Rational design of potent sialidase-based inhibitors of influenza virus replication (1993)

Itzstein, Mark Von, Wu, Wen-Yang, Kok, Gaik B., Pegg, Michael S., Dyason, Jeffrey Clifford, Jin, Betty, ...

Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus in cell...

Rational design of potent sialidase-based inhibitors of influenza virus replication (1993)

Itzstein, Mark Von, Wu, Wen-Yang, Kok, Gaik B., Pegg, Michael S., Dyason, Jeffrey Clifford, Jin, Betty, ...

Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus in cell...

Lewis-Base Adducts of group 11 Metal compounds. XXXIII : Structural characterization of two novel 'trigonal planar' halobis(N-base)copper(I) complexes (1988)

Dyason, Jeffrey Clifford, Engelhardt, Lutz M., Healy, Peter Conrad, Kildea, John D., White, Allan H.

Single-crystal X-ray structure determinations are recorded for two unusual trigonal planar XCuL2 species, X = halogen, L = monodentate N- base. For iodobis (2-methylquinoline)copper(I) (1) crystals...

Lewis-Base Adducts of group 11 Metal compounds. XXXIII : Structural characterization of two novel 'trigonal planar' halobis(N-base)copper(I) complexes (1988)

Dyason, Jeffrey Clifford, Engelhardt, Lutz M., Healy, Peter Conrad, Kildea, John D., White, Allan H.

Single-crystal X-ray structure determinations are recorded for two unusual trigonal planar XCuL2 species, X = halogen, L = monodentate N- base. For iodobis (2-methylquinoline)copper(I) (1) crystals...

Lewis-base Adducts of Group 1B Metal(I) Compounds. XXIII : Synthesis and structures of the tris(3,5-dimethylpyridine)copper(I) halides, [(C7H9N)3CuX], X = Cl, Br, I (1986)

Dyason, Jeffrey Clifford, Engelhardt, Lutz M., Healy, Peter Conrad, White, Allan H.

The crystal structures of the title compounds, (C7H9N)3CuX, X = Cl , Br, I [(1), (2), (3)], have been determined by single-crystal X-ray methods at 295 K, being refined to residuals of 0.022, 0.053,...

Lewis-base adducts of group 11 Metal(I) compounds. XXV : Synthesis and structural properties of tris(triphenylphosphine)copper(I) perchlorate and nitrate (1986)

Dyason, Jeffrey Clifford, Engelhardt, Lutz M., Healy, Peter Conrad, Trundle, Helen Louise, White, Allan H.

The compounds (PPh3)3CuOClO3 and (PPh3)3CuONO2(as its mono-ethanol solvate) have been characterized by single-crystal structure analysis. Crystals of the perchlorate are trigonal , P3, a 18.748(8), c...

Lewis-base Adducts of Group 1B Metal(I) Compounds. XXIII : Synthesis and structures of the tris(3,5-dimethylpyridine)copper(I) halides, [(C7H9N)3CuX], X = Cl, Br, I (1986)

Dyason, Jeffrey Clifford, Engelhardt, Lutz M., Healy, Peter Conrad, White, Allan H.

The crystal structures of the title compounds, (C7H9N)3CuX, X = Cl , Br, I [(1), (2), (3)], have been determined by single-crystal X-ray methods at 295 K, being refined to residuals of 0.022, 0.053,...

Lewis-base adducts of group 11 Metal(I) compounds. XXV : Synthesis and structural properties of tris(triphenylphosphine)copper(I) perchlorate and nitrate (1986)

Dyason, Jeffrey Clifford, Engelhardt, Lutz M., Healy, Peter Conrad, Trundle, Helen Louise, White, Allan H.

The compounds (PPh3)3CuOClO3 and (PPh3)3CuONO2(as its mono-ethanol solvate) have been characterized by single-crystal structure analysis. Crystals of the perchlorate are trigonal , P3, a 18.748(8), c...

Lewis-base adducts of Group 1B metal(I) compounds. Part 17. Synthesis and crystal structures of adducts of copper(I) cyanide with nitrogen bases (1985)

Dyason, Jeffrey Clifford, Healy, Peter Conrad, Engelhardt, Lutz M., Pakawatchai, Chaveng, Patrick, Vincent A., White, Allan H.

Compounds of the type [Cu(CN) L,] [L = diethylamine, (1 ), triethylamine, (2), 4-methylpyridine, (3), or 1 ,1 0-phenanthroline, (4)] have been synthesized by recrystallization of copper(i) cyanide...

Lewis-base adducts of Group 1B metal(I) compounds. Part 17. Synthesis and crystal structures of adducts of copper(I) cyanide with nitrogen bases (1985)

Dyason, Jeffrey Clifford, Healy, Peter Conrad, Engelhardt, Lutz M., Pakawatchai, Chaveng, Patrick, Vincent A., White, Allan H.

Compounds of the type [Cu(CN) L,] [L = diethylamine, (1 ), triethylamine, (2), 4-methylpyridine, (3), or 1 ,1 0-phenanthroline, (4)] have been synthesized by recrystallization of copper(i) cyanide...

Lewis-base adducts of Group 1B metal(I) compounds. Part 17. Synthesis and crystal structures of adducts of copper(I) cyanide with nitrogen bases (1985)

Dyason, Jeffrey Clifford, Healy, Peter Conrad, Engelhardt, Lutz M., Pakawatchai, Chaveng, Patrick, Vincent A., White, Allan H.

Compounds of the type [Cu(CN) L,] [L = diethylamine, (1 ), triethylamine, (2), 4-methylpyridine, (3), or 1 ,1 0-phenanthroline, (4)] have been synthesized by recrystallization of copper(i) cyanide...

Lewis-Base Adducts of Group 1B Metal(I) Compounds. XX : Synthesis, spectroscopic and structural studies of acetonitrile-solvated triphenylphosphine-copper(I) perchlorate adducts (1985)

Barron, Peter, Dyason, Jeffrey Clifford, Engelhardt, Lutz M., Healy, Peter Conrad, White, Allan H.

The compounds, [(PPh3)4Cu] ClO4, (I), [(CH3CN)( PPh3)2 Cu] ClO4, (2), and [(CH3CN)2(PPh3)2Cu]-ClO4, (3) ( PPh3 = triphenylphosphine ), have been characterized by solid-state 31P n.m.r . spectroscopy...

Lewis-Base Adducts of Group 1B Metal(I) Compounds. XXII : Crystal structure of 'bis(pyridine)silver(I) perchlorate' (1985)

Dyason, Jeffrey Clifford, Healy, Peter Conrad, Engelhardt, Lutz M., White, Allan H.

Determination of the crystal structure of 'bis (pyridine)silver(I) perchlorate' by single-crystal X-ray methods shows it to be of 2.4:1 pyridine:silver (I) perchlorate stoichiometry , the structure...

Lewis-Base Adducts of Group 1B Metal(I) Compounds. XX : Synthesis, spectroscopic and structural studies of acetonitrile-solvated triphenylphosphine-copper(I) perchlorate adducts (1985)

Barron, Peter, Dyason, Jeffrey Clifford, Engelhardt, Lutz M., Healy, Peter Conrad, White, Allan H.

The compounds, [(PPh3)4Cu] ClO4, (I), [(CH3CN)( PPh3)2 Cu] ClO4, (2), and [(CH3CN)2(PPh3)2Cu]-ClO4, (3) ( PPh3 = triphenylphosphine ), have been characterized by solid-state 31P n.m.r . spectroscopy...

Lewis-Base Adducts of Group 1B Metal(I) Compounds. XXII : Crystal structure of 'bis(pyridine)silver(I) perchlorate' (1985)

Dyason, Jeffrey Clifford, Healy, Peter Conrad, Engelhardt, Lutz M., White, Allan H.

Determination of the crystal structure of 'bis (pyridine)silver(I) perchlorate' by single-crystal X-ray methods shows it to be of 2.4:1 pyridine:silver (I) perchlorate stoichiometry , the structure...

Lewis-Base Adducts of Group 1B Metal Compounds. VI : Crystal structure of the 1 : 2 adduct of copper(I) iodide with pyridine (1984)

Dyason, Jeffrey Clifford, Engelhardt, Lutz M., Healy, Peter Conrad, White, Allan H.

Copper(I) iodide on recrystallization from neat pyridine yields a 1 : 2 adduct; it is established by single-crystal X-ray diffraction methods at 295 K that this is a µµ'-diiodobridged dimer, with...

Lewis-Base Adducts of Group 1B Metal Compounds. VI : Crystal structure of the 1 : 2 adduct of copper(I) iodide with pyridine (1984)

Dyason, Jeffrey Clifford, Engelhardt, Lutz M., Healy, Peter Conrad, White, Allan H.

Copper(I) iodide on recrystallization from neat pyridine yields a 1 : 2 adduct; it is established by single-crystal X-ray diffraction methods at 295 K that this is a µµ'-diiodobridged dimer, with...

Crystal structure and infrared spectrum of anhydrous guanidinium copper(II) carbonate (1981)

Dyason, Jeffrey Clifford, Healy, Peter Conrad, Skelton, Brian W., White, Allan H.

The crystal structure of the title compound, [CN,H,],[Cu(C03)~], has been determined and shown to contain a new form of the [{Cul'(CO,),},] polymer, the carbonate disposition being correlated with...

Crystal structure and infrared spectrum of anhydrous guanidinium copper(II) carbonate (1981)

Dyason, Jeffrey Clifford, Healy, Peter Conrad, Skelton, Brian W., White, Allan H.

The crystal structure of the title compound, [CN,H,],[Cu(C03)~], has been determined and shown to contain a new form of the [{Cul'(CO,),},] polymer, the carbonate disposition being correlated with...

Crystal structure and infrared spectrum of anhydrous guanidinium copper(II) carbonate (1981)

Dyason, Jeffrey Clifford, Healy, Peter Conrad, Skelton, Brian W., White, Allan H.

The crystal structure of the title compound, [CN,H,],[Cu(C03)~], has been determined and shown to contain a new form of the [{Cul'(CO,),},] polymer, the carbonate disposition being correlated with...