An experimentally derived confidence score for binary protein-protein interactions (2009)
Braun, Pascal, Tasan, Murat, Dreze, Matija, Barrios-Rodiles, Miriam, Lemmens, Irma, Yu, Haiyuan, ...
Information on protein-protein interactions is of central importance for many areas of biomedical research. At present no method exists to systematically and experimentally assess the quality of...
Stephen W. Scherer, Rosa Pirone, Pamela Hoodless, Hyeja Kim, Bharati Bapat, Steven Gallinger, ...
and Liliana Attisano7,1 could provide major insights into the general mecha-1Program in Developmental Biology nisms underlying the development of malignancies. At Division of Gastroenterology...
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis (2003)
Xiao, Changchun, Shim, Jae-hyuck, Klüppel, Michael, Zhang, Samuel Shao-Min, Dong, Chen, Flavell, Richard A., ...
Bone morphogenetic proteins (Bmps) are members of the transforming growth factor β (TGFβ) superfamily that play critical roles during mouse embryogenesis. Signaling by Bmp receptors is mediated...
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis (2003)
Xiao, Changchun, Shim, Jae-hyuck, Klüppel, Michael, Zhang, Samuel Shao-Min, Dong, Chen, Flavell, Richard A., ...
Bone morphogenetic proteins (Bmps) are members of the transforming growth factor β (TGFβ) superfamily that play critical roles during mouse embryogenesis. Signaling by Bmp receptors is mediated...
Early endosomal regulation of Smad-dependent signaling in endothelial cells (2002)
Panopoulou, Ekaterini, Gillooly, David J., Wrana, Jeffrey L., Zerial, Marino, Stenmark, Harald, Murphy, Carol, ...
Transforming growth factor beta (TGFbeta) receptors require SARA for phosphorylation of the downstream transducing Smad proteins. SARA, a FYVE finger protein, binds to membrane lipids suggesting that...
Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins (2001)
Quinn, Zoë A., Yang, Chih-Chin, Wrana, Jeffrey L., McDermott, John C.
An emerging theme in transforming growth factor-&bgr; (TGF-&bgr;) signalling is the association of the Smad proteins with diverse groups of transcriptional regulatory proteins. Several Smad cofactors...
Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN (2001)
Stroschein, Shannon L., Bonni, Shirin, Wrana, Jeffrey L., Luo, Kunxin
FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse (2001)
Hoodless, Pamela A., Pye, Melanie, Chazaud, Claire, Labbé, Etienne, Attisano, Liliana, Rossant, Janet, ...
Brummel, Ted, Abdollah, Shirin, Haerry, Theodor E., Shimell, Mary Jane, Merriam, John, Raftery, Laurel, ...
Regulation of connective tissue cells by transforming growth factor-@--[microform]. (1991)
University Microfilms order no. UMI00298543.
Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins
Quinn, Zoë A., Yang, Chih-Chin, Wrana, Jeffrey L., McDermott, John C.
An emerging theme in transforming growth factor-β (TGF-β) signalling is the association of the Smad proteins with diverse groups of transcriptional regulatory proteins. Several Smad cofactors have...
Hgs (Hrs), a FYVE Domain Protein, Is Involved in Smad Signaling through Cooperation with SARA
Miura, Shigeto, Takeshita, Toshikazu, Asao, Hironobu, Kimura, Yutaka, Murata, Kazuko, Sasaki, Yoshiteru, ...
Smad proteins are effector molecules that transmit signals from the receptors for the transforming growth factor β (TGF-β) superfamily to the nucleus; of the Smad proteins, Smad2 and Smad4 are...
Benchabane, Hassina, Wrana, Jeffrey L.
Smad7, an inhibitor of transforming growth factor beta superfamily signaling, is induced by bone morphogenetic protein (BMP) in an inhibitory feedback loop. Here, we identify multiple BMP response...
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis
Xiao, Changchun, Shim, Jae-hyuck, Klüppel, Michael, Zhang, Samuel Shao-Min, Dong, Chen, Flavell, Richard A., ...
Bone morphogenetic proteins (Bmps) are members of the transforming growth factor β (TGFβ) superfamily that play critical roles during mouse embryogenesis. Signaling by Bmp receptors is mediated...
FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse
Hoodless, Pamela A., Pye, Melanie, Chazaud, Claire, Labbé, Etienne, Attisano, Liliana, Rossant, Janet, ...
The node and the anterior visceral endoderm (AVE) are important organizing centers that pattern the mouse embryo by establishing the anterior–posterior (A–P), dorsal–ventral (D–V), and...
Brummel, Ted, Abdollah, Shirin, Haerry, Theodor E., Shimell, Mary Jane, Merriam, John, Raftery, Laurel, ...
The TGF-β superfamily of growth and differentiation factors, including TGF-β, Activins and bone morphogenetic proteins (BMPs) play critical roles in regulating the development of many organisms....
Kimura, Yuki, Jones, Nina, Klüppel, Michael, Hirashima, Masanori, Tachibana, Kazunobu, Cohn, Jason B., ...
Loss-of-function mutations in the murine dominant white spotting/c-kit locus affect a diverse array of biological processes and cell lineages and cause a range of phenotypes, including severe anemia,...
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis
Lee-Hoeflich, Si Tuen, Causing, Carrie G, Podkowa, Monika, Zhao, Xin, Wrana, Jeffrey L, Attisano, Liliana
The growth and morphological differentiation of dendrites are critical events in the establishment of proper neuronal connectivity and neural function. One extrinsic factor, BMP7, has been shown to...
Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN
Stroschein, Shannon L., Bonni, Shirin, Wrana, Jeffrey L., Luo, Kunxin
Smad proteins mediate transforming growth factor-β (TGF-β) signaling to regulate cell growth and differentiation. SnoN is an important negative regulator of TGF-β signaling that functions to...
Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins
Quinn, Zoë A., Yang, Chih-Chin, Wrana, Jeffrey L., McDermott, John C.
An emerging theme in transforming growth factor-β (TGF-β) signalling is the association of the Smad proteins with diverse groups of transcriptional regulatory proteins. Several Smad cofactors have...
Hgs (Hrs), a FYVE Domain Protein, Is Involved in Smad Signaling through Cooperation with SARA
Miura, Shigeto, Takeshita, Toshikazu, Asao, Hironobu, Kimura, Yutaka, Murata, Kazuko, Sasaki, Yoshiteru, ...
Smad proteins are effector molecules that transmit signals from the receptors for the transforming growth factor β (TGF-β) superfamily to the nucleus; of the Smad proteins, Smad2 and Smad4 are...
Benchabane, Hassina, Wrana, Jeffrey L.
Smad7, an inhibitor of transforming growth factor beta superfamily signaling, is induced by bone morphogenetic protein (BMP) in an inhibitory feedback loop. Here, we identify multiple BMP response...
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis
Xiao, Changchun, Shim, Jae-hyuck, Klüppel, Michael, Zhang, Samuel Shao-Min, Dong, Chen, Flavell, Richard A., ...
Bone morphogenetic proteins (Bmps) are members of the transforming growth factor β (TGFβ) superfamily that play critical roles during mouse embryogenesis. Signaling by Bmp receptors is mediated...
Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN
Stroschein, Shannon L., Bonni, Shirin, Wrana, Jeffrey L., Luo, Kunxin
Smad proteins mediate transforming growth factor-β (TGF-β) signaling to regulate cell growth and differentiation. SnoN is an important negative regulator of TGF-β signaling that functions to...
FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse
Hoodless, Pamela A., Pye, Melanie, Chazaud, Claire, Labbé, Etienne, Attisano, Liliana, Rossant, Janet, ...
The node and the anterior visceral endoderm (AVE) are important organizing centers that pattern the mouse embryo by establishing the anterior–posterior (A–P), dorsal–ventral (D–V), and...
Brummel, Ted, Abdollah, Shirin, Haerry, Theodor E., Shimell, Mary Jane, Merriam, John, Raftery, Laurel, ...
The TGF-β superfamily of growth and differentiation factors, including TGF-β, Activins and bone morphogenetic proteins (BMPs) play critical roles in regulating the development of many organisms....
Kimura, Yuki, Jones, Nina, Klüppel, Michael, Hirashima, Masanori, Tachibana, Kazunobu, Cohn, Jason B., ...
Loss-of-function mutations in the murine dominant white spotting/c-kit locus affect a diverse array of biological processes and cell lineages and cause a range of phenotypes, including severe anemia,...
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis
Lee-Hoeflich, Si Tuen, Causing, Carrie G, Podkowa, Monika, Zhao, Xin, Wrana, Jeffrey L, Attisano, Liliana
The growth and morphological differentiation of dendrites are critical events in the establishment of proper neuronal connectivity and neural function. One extrinsic factor, BMP7, has been shown to...
Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development
Izzi, Luisa, Silvestri, Cristoforo, Von Both, Ingo, Labbé, Etienne, Zakin, Lise, Wrana, Jeffrey L, ...
Mixl1 is a member of the Mix/Bix family of paired-like homeodomain proteins and is required for proper axial mesendoderm morphogenesis and endoderm formation during mouse development. Mix/Bix...
To, Ciric, Kulkarni, Sarang, Pawson, Tony, Honda, Tadashi, Gribble, Gordon W., Sporn, Michael B., ...
The anti-tumor synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO)-imidazolide (CDDO-Im) ectopically activates the transforming growth factor β (TGFβ)-Smad pathway and...
Townsend, Todd A., Wrana, Jeffrey L., Davis, George E., Barnett, Joey V.
Valvular heart disease due to congenital abnormalities or pathology is a major cause of mortality and morbidity. Understanding the cellular processes and molecules that regulate valve formation and...