Differential Hepatic Effects of Perfluorobutyrate Mediated by Mouse and Human PPAR-{alpha} (2009)
Foreman, Jennifer E., Chang, Shu-Ching, Ehresman, David J., Butenhoff, John L., Anderson, Cherie R., Palkar, Prajakta S., ...
Perfluorobutryate (PFBA) is a short chain perfluoroalkyl carboxylate that is structurally similar to perfluorooctanoate. Administration of PFBA can cause peroxisome proliferation, induction of...
Regulation of Peroxisome Proliferator-Activated Receptor-{alpha} by MDM2 (2009)
Gopinathan, Lakshmi, Hannon, Daniel B., Peters, Jeffrey M., Vanden Heuvel, John P.
Peroxisome proliferator–activated receptor-alpha (PPARα) belongs to the nuclear receptor (NR) family of transcription factors and regulates lipid and glucose metabolism. Like other NRs, the...
A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis (2008)
Rolf Müller, Martin Kömhoff, Jeffrey M. Peters, Sabine Müller-Brüsselbach
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a transcription factor that is activated by endogenous fatty acid ligands and by synthetic agonists. Its role...
Regulation of Peroxisome Proliferator-Activated Receptors by E6-Associated Protein (2008)
Lakshmi Gopinathan, Daniel B. Hannon, Russell W. Smith, Jeffrey M. Peters
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors (NRs) that regulate genes involved in lipid and glucose metabolism. PPAR activity is regulated by interactions with cofactors...
Shan, Weiwei, Palkar, Prajakta S., Murray, Iain A., McDevitt, Emily I., Kennett, Mary J., Kang, Boo Hyon, ...
Peroxisome proliferator–activated receptor (PPAR) β/δ–null mice exhibit exacerbated hepatotoxicity in response to administration of carbon tetrachloride (CCl4). To determine whether ligand...
A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis (2008)
Rolf Müller, Martin Kömhoff, Jeffrey M. Peters, Sabine Müller-Brüsselbach
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a transcription factor that is activated by endogenous fatty acid ligands and by synthetic agonists. Its role in the regulation of...
Regulation of Peroxisome Proliferator-Activated Receptors by E6-Associated Protein (2008)
Lakshmi Gopinathan, Daniel B. Hannon, Russell W. Smith, III, Jeffrey M. Peters
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors (NRs) that regulate genes involved in lipid and glucose metabolism. PPAR activity is regulated by interactions with cofactors...
Bility, Moses T., Devlin-Durante, Meghann K., Blazanin, Nicholas, Glick, Adam B., Ward, Jerrold M., Kang, Boo Hyon, ...
Peroxisome proliferator-activated receptor (PPAR)β/δ-null mice exhibit enhanced tumorigenesis in a two-stage chemical carcinogenesis model as compared with wild-type mice. Previous work showed that...
Hollingshead, Holly E., Borland, Michael G., Billin, Andrew N., Willson, Timothy M., Gonzalez, Frank J., Peters, Jeffrey M.
Cyclooxygenase (COX) 2-derived prostaglandin E2 (PGE2) promotes colorectal carcinoma growth and invasion, and inhibition of COX2 by non-steroidal anti-inflammatory drugs is known to inhibit these...
Regulation of Gene Expression (2007)
Perdew, Gary H., Heuvel, John P., Peters, Jeffrey M.
Regulation of Gene Expression: Molecular Mechanisms presents a comprehensive overview of methods and approaches for characterizing mechanisms of gene regulation. The text is appropriate both as a...
Hollingshead, Holly E., Killins, Renee L., Borland, Michael G., Girroir, Elizabeth E., Billin, Andrew N., Willson, Timothy M., ...
Ligands for peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) increase skeletal muscle fatty acid catabolism, improve insulin sensitivity, increase serum high-density lipoprotein...
PPARδ status and mismatch repair mediated neoplasia in the mouse intestine (2006)
Reed, Karen R, Sansom, Owen J, Hayes, Anthony J, Gescher, Andreas J, Peters, Jeffrey M, Clarke, Alan R
Abstract Background Therapeutic regulation of PPARδ activity using selective agonists has been proposed for various disorders. However, the consequences of altered peroxisome proliferator-activated...
The Toxicology of Ligands for Peroxisome Proliferator-Activated Receptors (PPAR) (2006)
Peraza, Marjorie A., Burdick, Andrew D., Marin, Holly E., Gonzalez, Frank J., Peters, Jeffrey M.
Peroxisome proliferator-activated receptors (PPARs) are ligand activated transcription factors that modulate target gene expression in response to endogenous and exogenous ligands. Ligands for the...
Kim, Dae J., Prabhu, K.Sandeep, Gonzalez, Frank J., Peters, Jeffrey M.
Inhibition of cyclooxygenase-2 (COX2) by non-steroidal anti-inflammatory drugs (NSAID) is known to suppress skin carcinogenesis. It was further suggested that inhibition of COX2-derived...
The Aryl Hydrocarbon Receptor Directly Regulates Expression of the Potent Mitogen Epiregulin (2006)
Patel, Rushang D., Kim, Dae Joon, Peters, Jeffrey M., Perdew, Gary H.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known to cause a large number of adverse effects, mediated largely by its binding to the aryl-hydrocarbon receptor (AhR) and subsequent modulation of...
Kim, Dae J., Prabhu, K. Sandeep, Gonzalez, Frank J., Peters, Jeffrey M.
Inhibition of cyclooxygenase-2 (COX2) by non-steroidal anti-inflammatory drugs (NSAID) is known to suppress skin carcinogenesis. It was further suggested that inhibition of COX2-derived...
Clemencet, Marie-Claude, Muzio, Giuliana, Trombetta, Antonella, Peters, Jeffrey M, Gonzalez, Frank J, Canuto, Rosa A, ...
Humans appear to be refractory to some effects of peroxisome proliferators including alterations in cell proliferation, whereas rodents are susceptible. In this study, differences between the human...
Clemencet, Marie-Claude, Muzio, Giuliana, Trombetta, Antonella, Peters, Jeffrey M, Gonzalez, Frank J, Canuto, Rosa A, ...
Humans appear to be refractory to some effects of peroxisome proliferators including alterations in cell proliferation, whereas rodents are susceptible. In this study, differences between the human...
Hays, Thomas, Rusyn, Ivan, Burns, Amanda M., Kennett, Mary J., Ward, Jerrold M., Gonzalez, Frank J., ...
Prolonged administration of peroxisome proliferators to rodents typically leads to hepatocarcinogenesis. Peroxisome proliferator-activated receptor-α (PPARα) is required to mediate alterations in...
The Aryl Hydrocarbon Receptor Directly Regulates Expression of the Potent Mitogen Epiregulin (2005)
Patel, Rushang D., Kim, Dae Joon, Peters, Jeffrey M., Perdew, Gary H.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known to cause a large number of adverse effects, mediated largely by its binding to the aryl-hydrocarbon receptor (AhR) and subsequent modulation of...
The Toxicology of Ligands for Peroxisome Proliferator-Activated Receptors (PPAR) (2005)
Peraza, Marjorie A., Burdick, Andrew D., Marin, Holly E., Gonzalez, Frank J., Peters, Jeffrey M.
Peroxisome proliferator-activated receptors (PPARs) are ligand activated transcription factors that modulate target gene expression in response to endogenous and exogenous ligands. Ligands for the...
Nicol, Christopher J., Yoon, Michung, Ward, Jerrold M., Yamashida, Masamichi, Fukamachi, Katsumi, Peters, Jeffrey M., ...
Peroxisome proliferator activated receptor γ (PPARγ), a member of the nuclear receptor superfamily, plays a role in adipocyte differentiation, type II diabetes, macrophage response to inflammation,...
Hays, Thomas, Rusyn, Ivan, Burns, Amanda M., Kennett, Mary J., Ward, Jerrold M., Gonzalez, Frank J., ...
Prolonged administration of peroxisome proliferators to rodents typically leads to hepatocarcinogenesis. Peroxisome proliferator-activated receptor-α (PPARα) is required to mediate alterations in...
Bility, Moses T., Thompson, Jerry T., McKee, Richard H., David, Raymond M., Butala, John H., Vanden Heuvel, John P., ...
Administration of phthalates is known to cause toxicity and liver cancer in rodents through the activation of PPARs, and the monoesters appear to be the active metabolites that function as ligands of...
Nicol, Christopher J., Yoon, Michung, Ward, Jerrold M., Yamashita, Masamichi, Fukamachi, Katsumi, Peters, Jeffrey M., ...
Peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily, plays a role in adipocyte differentiation, type II diabetes, macrophage response to inflammation...
Kiss, Andras, Ortiz-Aguayo, Roberto, Sharp, Richard, Merlino, Glenn, Thorgeirsson, Snorri S., Gonzalez, Frank J., ...
The mechanisms underlying peroxisome proliferator-induced hepatocarcinogenesis are not understood. Because of the uncertainty of human cancer risk associated with peroxisome proliferators,...
Peters, Jeffrey M., Rusyn, Ivan, Rose, Michelle L., Gonzalez, Frank J., Thurman, Ronald G.
Peroxisome proliferators increase hepatocyte proliferation and cause liver tumors in rodents, yet the mechanism of action is not understood. Based on studies with null mice it is known that...
Peters, Jeffrey M., Lee, Susanna S. T., Li, Wen, Ward, Jerrold M., Gavrilova, Oksana, Everett, Carrie, ...
To determine the physiological roles of peroxisome proliferator-activated receptor β (PPARβ), null mice were constructed by targeted disruption of the ligand binding domain of the murine PPARβ...
In Vivo Regulation of Hepatitis B Virus Replication by Peroxisome Proliferators†
Guidotti, Luca G., Eggers, Carrie M., Raney, Anneke K., Chi, Susan Y., Peters, Jeffrey M., Gonzalez, Frank J., ...
The role of the peroxisome proliferator-activated receptor α (PPARα) in regulating hepatitis B virus (HBV) transcription and replication in vivo was investigated in an HBV transgenic mouse model....
Hill, Molly R., Clarke, Stephen, Rodgers, Kerry, Thornhill, Brandi, Peters, Jeffrey M., Gonzalez, Frank J., ...
Inflammatory mediators orchestrate the host immune and metabolic response to acute bacterial infections and mediate the events leading to septic shock. Tumor necrosis factor (TNF) has long been...
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Kersten, Sander, Seydoux, Josiane, Peters, Jeffrey M., Gonzalez, Frank J., Desvergne, Béatrice, Wahli, Walter
Prolonged deprivation of food induces dramatic changes in mammalian metabolism, including the release of large amounts of fatty acids from the adipose tissue, followed by their oxidation in the...
PPARδ status and mismatch repair mediated neoplasia in the mouse intestine
Reed, Karen R, Sansom, Owen J, Hayes, Anthony J, Gescher, Andreas J, Peters, Jeffrey M, Clarke, Alan R
PPARδ regulates glucose metabolism and insulin sensitivity
Lee, Chih-Hao, Olson, Peter, Hevener, Andrea, Mehl, Isaac, Chong, Ling-Wa, Olefsky, Jerrold M., ...
The metabolic syndrome is a collection of obesity-related disorders. The peroxisome proliferator-activated receptors (PPARs) regulate transcription in response to fatty acids and, as such, are...
Peters, Jeffrey M., Lee, Susanna S. T., Li, Wen, Ward, Jerrold M., Gavrilova, Oksana, Everett, Carrie, ...
To determine the physiological roles of peroxisome proliferator-activated receptor β (PPARβ), null mice were constructed by targeted disruption of the ligand binding domain of the murine PPARβ...
In Vivo Regulation of Hepatitis B Virus Replication by Peroxisome Proliferators†
Guidotti, Luca G., Eggers, Carrie M., Raney, Anneke K., Chi, Susan Y., Peters, Jeffrey M., Gonzalez, Frank J., ...
The role of the peroxisome proliferator-activated receptor α (PPARα) in regulating hepatitis B virus (HBV) transcription and replication in vivo was investigated in an HBV transgenic mouse model....
Hill, Molly R., Clarke, Stephen, Rodgers, Kerry, Thornhill, Brandi, Peters, Jeffrey M., Gonzalez, Frank J., ...
Inflammatory mediators orchestrate the host immune and metabolic response to acute bacterial infections and mediate the events leading to septic shock. Tumor necrosis factor (TNF) has long been...
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Kersten, Sander, Seydoux, Josiane, Peters, Jeffrey M., Gonzalez, Frank J., Desvergne, Béatrice, Wahli, Walter
Prolonged deprivation of food induces dramatic changes in mammalian metabolism, including the release of large amounts of fatty acids from the adipose tissue, followed by their oxidation in the...
PPARδ regulates glucose metabolism and insulin sensitivity
Lee, Chih-Hao, Olson, Peter, Hevener, Andrea, Mehl, Isaac, Chong, Ling-Wa, Olefsky, Jerrold M., ...
The metabolic syndrome is a collection of obesity-related disorders. The peroxisome proliferator-activated receptors (PPARs) regulate transcription in response to fatty acids and, as such, are...
PPARδ status and mismatch repair mediated neoplasia in the mouse intestine
Reed, Karen R, Sansom, Owen J, Hayes, Anthony J, Gescher, Andreas J, Peters, Jeffrey M, Clarke, Alan R
Klaunig, James E., Babich, Michael A., Cook, Jon C., David, Raymond M., DeLuca, John G., McKee, Richard H., ...
Transcriptional network governing the angiogenic switch in human pancreatic cancer
Abdollahi, Amir, Schwager, Christian, Kleeff, Jörg, Esposito, Irene, Domhan, Sophie, Peschke, Peter, ...
A shift of the angiogenic balance to the proangiogenic state, termed the “angiogenic switch,” is a hallmark of cancer progression. Here we devise a strategy for identifying genetic participants...
COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARδ activation
Ghosh, Mallika, Wang, Haibin, Ai, Youxi, Romeo, Elisa, Luyendyk, James P., Peters, Jeffrey M., ...
Although cyclooxygenase (COX)-2 inhibitors (coxibs) are effective in controlling inflammation, pain, and tumorigenesis, their use is limited by the recent revelation of increased adverse...
Michalik, Liliane, Desvergne, Béatrice, Tan, Nguan Soon, Basu-Modak, Sharmila, Escher, Pascal, Rieusset, Jennifer, ...
We show here that the α, β, and γ isotypes of peroxisome proliferator–activated receptor (PPAR) are expressed in the mouse epidermis during fetal development and that they disappear...
A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis
Müller, Rolf, Kömhoff, Martin, Peters, Jeffrey M., Müller-Brüsselbach, Sabine
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a transcription factor that is activated by endogenous fatty acid ligands and by synthetic agonists. Its role in the regulation of...
Deregulation of tumor angiogenesis and blockade of tumor growth in PPARβ-deficient mice
Müller-Brüsselbach, Sabine, Kömhoff, Martin, Rieck, Markus, Meissner, Wolfgang, Kaddatz, Kerstin, Adamkiewicz, Jürgen, ...
The peroxisome proliferator-activated receptor-β (PPARβ) has been implicated in tumorigenesis, but its precise role remains unclear. Here, we show that the growth of syngeneic Pparb wild-type...
Regulation of Peroxisome Proliferator-Activated Receptors by E6-Associated Protein
Gopinathan, Lakshmi, Hannon, Daniel B., Smith III, Russell W., Peters, Jeffrey M., Vanden Heuvel, John P.
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors (NRs) that regulate genes involved in lipid and glucose metabolism. PPAR activity is regulated by interactions with cofactors...
Shan, Weiwei, Palkar, Prajakta S., Murray, Iain A., McDevitt, Emily I., Kennett, Mary J., Kang, Boo Hyon, ...
Peroxisome proliferator–activated receptor (PPAR) β/δ–null mice exhibit exacerbated hepatotoxicity in response to administration of carbon tetrachloride (CCl4). To determine whether ligand...