Li, Huawei, Liu, Hong, Corrales, C Eduardo, Risner, Jessica R, Forrester, Jeff, Holt, Jeffrey R, ...
Abstract Background Neural differentiation of embryonic stem (ES) cells is usually achieved by induction of ectoderm in embryoid bodies followed by the enrichment of neuronal progenitors using a...
Mechanoelectrical Transduction and Adaptation in Hair Cells of the Mouse Utricle, a (2008)
Jeffrey R. Holt, David P. Corey, Ruth Anne Eatock
Hair cells of inner ear organs sensitive to frequencies above 10 Hz adapt to maintained hair bundle deflections at rates that reduce their responses to lower frequencies. Mammalian vestibular organs...
Two mechanisms for transducer adaptation in vertebrate hair cells
Holt, Jeffrey R., Corey, David P.
Deflection of the hair bundle atop a sensory hair cell modulates the open probability of mechanosensitive ion channels. In response to sustained deflections, hair cells adapt. Two fundamentally...
A Chemical-Genetic Strategy Implicates Myosin-1c in Adaptation by Hair Cells
Holt, Jeffrey R., Gillespie, Susan K.H., Provance, D. William, Shah, Kavita, Shokat, Kevan M., Corey, David P., ...
Myosin-1c (also known as myosin-Iβ) has been proposed to mediate the slow component of adaptation by hair cells, the sensory cells of the inner ear. To test this hypothesis, we mutated tyrosine-61...
Two mechanisms for transducer adaptation in vertebrate hair cells
Holt, Jeffrey R., Corey, David P.
Deflection of the hair bundle atop a sensory hair cell modulates the open probability of mechanosensitive ion channels. In response to sustained deflections, hair cells adapt. Two fundamentally...
Gillespie, Peter G., Albanesi, Joseph P., Bähler, Martin, Bement, William M., Berg, Jonathan S., Burgess, David R., ...
We suggest that the vertebrate myosin-I field adopt a common nomenclature system based on the names adopted by the Human Genome Organization (HUGO). At present, the myosin-I nomenclature is very...
Differential Distribution of Stem Cells in the Auditory and Vestibular Organs of the Inner Ear
Oshima, Kazuo, Grimm, Christian M., Corrales, C. Eduardo, Senn, Pascal, Martinez Monedero, Rodrigo, Géléoc, Gwenaëlle S.G., ...
The adult mammalian cochlea lacks regenerative capacity, which is the main reason for the permanence of hearing loss. Vestibular organs, in contrast, replace a small number of lost hair cells. The...
Schwander, Martin, Xiong, Wei, Tokita, Joshua, Lelli, Andrea, Elledge, Heather M., Kazmierczak, Piotr, ...
Deafness is the most common form of sensory impairment in humans and is frequently caused by single gene mutations. Interestingly, different mutations in a gene can cause syndromic and nonsyndromic...