Coburn, Jenifer, Fischer, Joshua R., Leong, John M.
The Lyme disease spirochetes, comprised of at least three closely related species, Borrelia burgdorferi, Borrelia garinii and Borrelia afzelii, are fascinating and enigmatic bacterial pathogens. They...
Leong, John M., Wang, Hong, Magoun, Loranne, Field, Jodie A., Morrissey, Pamela E., Robbins, Douglas, ...
The Lyme disease spirochete, Borrelia burgdorferi, infects multiple tissues, such as the heart, joint, skin, and nervous system and has been shown to recognize heparan sulfate and dermatan sulfate...
Stockbauer, Kathryn E., Magoun, Loranne, Liu, Mengyao, Burns, Eugene H., Gubba, Siddeswar, Renish, Sarah, ...
The human pathogenic bacterium group A Streptococcus produces an extracellular cysteine protease [streptococcal pyrogenic exotoxin B (SpeB)] that is a critical virulence factor for invasive disease...
Coburn, Jenifer, Frank, Dara W.
The multiple effects of Pseudomonas aeruginosa type III secretion have largely been attributed to variations in cytotoxin expression between strains. Here we show that the target cell type is also...
Ntchobo, Hyacinthe, Rothermel, Holly, Chege, Wambui, Steere, Allen C., Coburn, Jenifer
Antibody responses to p66, a candidate integrin ligand of Borrelia burgdorferi, were studied in 79 patients with early or late manifestations of Lyme disease. The central portion of p66 was...
Delineation of Borrelia burgdorferi p66 Sequences Required for Integrin αIIbβ3 Recognition
Defoe, Gillianne, Coburn, Jenifer
The outer membrane protein p66 of the Lyme disease agent, Borrelia burgdorferi, has been identified as a candidate ligand for β3-chain integrins. To identify portions of p66 required for integrin...
Leong, John M., Wang, Hong, Magoun, Loranne, Field, Jodie A., Morrissey, Pamela E., Robbins, Douglas, ...
The Lyme disease spirochete, Borrelia burgdorferi, infects multiple tissues, such as the heart, joint, skin, and nervous system and has been shown to recognize heparan sulfate and dermatan sulfate...
Integrins αvβ3 and α5β1 Mediate Attachment of Lyme Disease Spirochetes to Human Cells
Coburn, Jenifer, Magoun, Loranne, Bodary, Sarah C., Leong, John M.
Borrelia burgdorferi (sensu lato), the agent of Lyme disease, is able to cause chronic, multisystemic infections in human and animal hosts. Attachment of the spirochete to host cells is likely to be...
Cugini, Carla, Medrano, Melisa, Schwan, Tom G., Coburn, Jenifer
Borrelia burgdorferi is maintained in an infection cycle between mammalian and arthropod hosts. Appropriate gene expression by B. burgdorferi at different stages of this cycle is probably essential...
Coburn, Jenifer, Cugini, Carla
Borrelia burgdorferi, the agent of Lyme disease, expresses several adhesion molecules that are probably required for initial establishment of infection in mammalian hosts, and for colonization of...
Rocha, Claudia L., Coburn, Jenifer, Rucks, Elizabeth A., Olson, Joan C.
Pseudomonas aeruginosa exoenzyme S (ExoS) is a type III secretion (TTS) effector, which includes both a GTPase-activating protein (GAP) activity toward the Rho family of low-molecular-weight G (LMWG)...
Steere, Allen C., Coburn, Jenifer, Glickstein, Lisa
Since its identification nearly 30 years ago, Lyme disease has continued to spread, and there have been increasing numbers of cases in the northeastern and north central US. The Lyme disease agent,...
Stockbauer, Kathryn E., Magoun, Loranne, Liu, Mengyao, Burns, Eugene H., Gubba, Siddeswar, Renish, Sarah, ...
The human pathogenic bacterium group A Streptococcus produces an extracellular cysteine protease [streptococcal pyrogenic exotoxin B (SpeB)] that is a critical virulence factor for invasive disease...
Coburn, Jenifer, Frank, Dara W.
The multiple effects of Pseudomonas aeruginosa type III secretion have largely been attributed to variations in cytotoxin expression between strains. Here we show that the target cell type is also...
Ntchobo, Hyacinthe, Rothermel, Holly, Chege, Wambui, Steere, Allen C., Coburn, Jenifer
Antibody responses to p66, a candidate integrin ligand of Borrelia burgdorferi, were studied in 79 patients with early or late manifestations of Lyme disease. The central portion of p66 was...
Delineation of Borrelia burgdorferi p66 Sequences Required for Integrin αIIbβ3 Recognition
Defoe, Gillianne, Coburn, Jenifer
The outer membrane protein p66 of the Lyme disease agent, Borrelia burgdorferi, has been identified as a candidate ligand for β3-chain integrins. To identify portions of p66 required for integrin...
Leong, John M., Wang, Hong, Magoun, Loranne, Field, Jodie A., Morrissey, Pamela E., Robbins, Douglas, ...
The Lyme disease spirochete, Borrelia burgdorferi, infects multiple tissues, such as the heart, joint, skin, and nervous system and has been shown to recognize heparan sulfate and dermatan sulfate...
Integrins αvβ3 and α5β1 Mediate Attachment of Lyme Disease Spirochetes to Human Cells
Coburn, Jenifer, Magoun, Loranne, Bodary, Sarah C., Leong, John M.
Borrelia burgdorferi (sensu lato), the agent of Lyme disease, is able to cause chronic, multisystemic infections in human and animal hosts. Attachment of the spirochete to host cells is likely to be...
Cugini, Carla, Medrano, Melisa, Schwan, Tom G., Coburn, Jenifer
Borrelia burgdorferi is maintained in an infection cycle between mammalian and arthropod hosts. Appropriate gene expression by B. burgdorferi at different stages of this cycle is probably essential...
Coburn, Jenifer, Cugini, Carla
Borrelia burgdorferi, the agent of Lyme disease, expresses several adhesion molecules that are probably required for initial establishment of infection in mammalian hosts, and for colonization of...
Rocha, Claudia L., Coburn, Jenifer, Rucks, Elizabeth A., Olson, Joan C.
Pseudomonas aeruginosa exoenzyme S (ExoS) is a type III secretion (TTS) effector, which includes both a GTPase-activating protein (GAP) activity toward the Rho family of low-molecular-weight G (LMWG)...
Steere, Allen C., Coburn, Jenifer, Glickstein, Lisa
Since its identification nearly 30 years ago, Lyme disease has continued to spread, and there have been increasing numbers of cases in the northeastern and north central US. The Lyme disease agent,...
Regulators of Expression of the Oligopeptide Permease A Proteins of Borrelia burgdorferi▿
Medrano, Melisa S., Ding, Yanpeng, Wang, Xing-Guo, Lu, Peng, Coburn, Jenifer, Hu, Linden T.
Borrelia burgdorferi undergoes an infectious cycle that requires adaptation to different hosts and marked differences in environment. B. burgdorferi copes with its different environments by...
High Prevalence of Spirochetosis in Cholera Patients, Bangladesh
Nelson, Eric J., Tanudra, Angela, Chowdhury, Ashrafuzzaman, Kane, Anne V., Qadri, Firdausi, Calderwood, Stephen B., ...
The microbes that accompany the etiologic agent of cholera, Vibrio cholerae, are only now being defined. In this study, spirochetes from the genus Brachyspira were identified at high titers in more...