Jennifer M. Ritchie

EspFU, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7 (2007)

Ritchie, Jennifer M., Brady, Michael J., Riley, Kathleen N., Ho, Theresa Deland, Campellone, Kenneth Geno, Herman, Ira M., ...

Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 induces filamentous actin-rich 'pedestals' on intestinal epithelial cells. Pedestal formation in vitro requires translocation of bacterial effectors...

Dam methyltransferase is required for stable lysogeny of the Shiga toxin (Stx2)-encoding bacteriophage 933W of enterohemorrhagic Escherichia coli O157:H7 (2007)

Murphy, Kenan C., Ritchie, Jennifer M., Waldor, Matthew K., Lobner-Olesen, Anders, Marinus, Martin G.

Shiga toxin 2 (Stx2), one of the principal virulence factors of enterohemorrhagic Escherichia coli, is encoded by 933W, a lambda-like prophage. 933W prophage induction contributes to Stx2 production,...

A Stable Bioluminescent Construct of Escherichia coli O157:H7 for Hazard Assessments of Long-Term Survival in the Environment

Ritchie, Jennifer M., Campbell, Graeme R., Shepherd, Jill, Beaton, Yvonne, Jones, Davey, Killham, Ken, ...

A chromosomally lux-marked (Tn5 luxCDABE) strain of nontoxigenic Escherichia coli O157:H7 was constructed by transposon mutagenesis and shown to have retained the O157, H7, and intimin phenotypes....

Critical Roles for stx2, eae, and tir in Enterohemorrhagic Escherichia coli-Induced Diarrhea and Intestinal Inflammation in Infant Rabbits

Ritchie, Jennifer M., Thorpe, Cheleste M., Rogers, Arlin B., Waldor, Matthew K.

Enterohemorrhagic Escherichia coli (EHEC) is a group of food-borne pathogens that can cause diarrhea, colitis, and the hemolytic uremic syndrome (HUS). The importance of several of the proposed EHEC...

The Locus of Enterocyte Effacement-Encoded Effector Proteins All Promote Enterohemorrhagic Escherichia coli Pathogenicity in Infant Rabbits

Ritchie, Jennifer M., Waldor, Matthew K.

The genes encoding the enterohemorrhagic Escherichia coli (EHEC) type III secretion system (TTSS) and five effector proteins secreted by the TTSS are located on the locus of enterocyte effacement...

In Vivo Transduction of an Stx-Encoding Phage in Ruminants

Cornick, Nancy A., Helgerson, Amy F., Mai, Volker, Ritchie, Jennifer M., Acheson, David W. K.

We assessed the ability of a kanamycin-marked Stx phage to move into a commensal, ovine Escherichia coli strain in the ruminant gastrointestinal tract. Transduction was detected in 19/24 sheep...

A Stable Bioluminescent Construct of Escherichia coli O157:H7 for Hazard Assessments of Long-Term Survival in the Environment

Ritchie, Jennifer M., Campbell, Graeme R., Shepherd, Jill, Beaton, Yvonne, Jones, Davey, Killham, Ken, ...

A chromosomally lux-marked (Tn5 luxCDABE) strain of nontoxigenic Escherichia coli O157:H7 was constructed by transposon mutagenesis and shown to have retained the O157, H7, and intimin phenotypes....

Critical Roles for stx2, eae, and tir in Enterohemorrhagic Escherichia coli-Induced Diarrhea and Intestinal Inflammation in Infant Rabbits

Ritchie, Jennifer M., Thorpe, Cheleste M., Rogers, Arlin B., Waldor, Matthew K.

Enterohemorrhagic Escherichia coli (EHEC) is a group of food-borne pathogens that can cause diarrhea, colitis, and the hemolytic uremic syndrome (HUS). The importance of several of the proposed EHEC...

The Locus of Enterocyte Effacement-Encoded Effector Proteins All Promote Enterohemorrhagic Escherichia coli Pathogenicity in Infant Rabbits

Ritchie, Jennifer M., Waldor, Matthew K.

The genes encoding the enterohemorrhagic Escherichia coli (EHEC) type III secretion system (TTSS) and five effector proteins secreted by the TTSS are located on the locus of enterocyte effacement...

In Vivo Transduction of an Stx-Encoding Phage in Ruminants

Cornick, Nancy A., Helgerson, Amy F., Mai, Volker, Ritchie, Jennifer M., Acheson, David W. K.

We assessed the ability of a kanamycin-marked Stx phage to move into a commensal, ovine Escherichia coli strain in the ruminant gastrointestinal tract. Transduction was detected in 19/24 sheep...

Dam Methyltransferase Is Required for Stable Lysogeny of the Shiga Toxin (Stx2)-Encoding Bacteriophage 933W of Enterohemorrhagic Escherichia coli O157:H7▿

Murphy, Kenan C., Ritchie, Jennifer M., Waldor, Matthew K., Løbner-Olesen, Anders, Marinus, M. G.

Shiga toxin 2 (Stx2), one of the principal virulence factors of enterohemorrhagic Escherichia coli, is encoded by 933W, a lambda-like prophage. 933W prophage induction contributes to Stx2 production,...

Type 2 Secretion Promotes Enterohemorrhagic Escherichia coli Adherence and Intestinal Colonization▿

Ho, Theresa D., Davis, Brigid M., Ritchie, Jennifer M., Waldor, Matthew K.

Enterohemorrhagic Escherichia coli (EHEC) is a noninvasive food-borne pathogen that colonizes the distal ileum and colon. Proteins encoded in the EHEC locus of enterocyte effacement (LEE)...

Transient Shielding of Intimin and the Type III Secretion System of Enterohemorrhagic and Enteropathogenic Escherichia coli by a Group 4 Capsule▿ †

Shifrin, Yulia, Peleg, Adi, Ilan, Ophir, Nadler, Chen, Kobi, Simi, Baruch, Kobi, ...

Enterohemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC, respectively) strains represent a major global health problem. Their virulence is mediated by the concerted activity of an...

CadA Negatively Regulates Escherichia coli O157:H7 Adherence and Intestinal Colonization▿ †

Vazquez-Juarez, Roberto C., Kuriakose, Jeeba A., Rasko, David A., Ritchie, Jennifer M., Kendall, Melissa M., Slater, Terry M., ...

Adherence of pathogenic Escherichia coli strains to intestinal epithelia is essential for infection. For enterohemorrhagic E. coli (EHEC) serotype O157:H7, we have previously demonstrated that...