Scheinfeldt, Laura B., Biswas, Shameek, Madeoy, Jennifer, Connelly, Caitlin F., Schadt, Eric E., Akey, Joshua M.
Mutations in the human gene ALMS1 result in Alström Syndrome, which presents with early childhood obesity and insulin resistance leading to Type 2 diabetes. Previous genomewide scans for selection...
TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations (2006)
Akey, Joshua M., Swanson, Willie J., Madeoy, Jennifer, Eberle, Michael, Shriver, Mark D.
A striking footprint of positive selection was recently identified on chromosome 7q34–35 that spans at least 115 kb and encompasses four known genes (KEL, TRPV5, TRPV6, EPHB6). The signature...
Genomic signatures of positive selection in humans and the limits of outlier approaches (2006)
Kelley, Joanna L., Madeoy, Jennifer, Calhoun, John C., Swanson, Willie, Akey, Joshua M.
Identifying regions of the human genome that have been targets of positive selection will provide important insights into recent human evolutionary history and may facilitate the search for complex...
Genomic signatures of positive selection in humans and the limits of outlier approaches (2006)
Kelley, Joanna L., Madeoy, Jennifer, Calhoun, John C., Swanson, Willie, Akey, Joshua M.
Identifying regions of the human genome that have been targets of positive selection will provide important insights into recent human evolutionary history and may facilitate the search for complex...
TRPV6 Exhibits Unusual Patterns of Polymorphism and Divergence in Worldwide Populations (2006)
Akey, Joshua M., Swanson, Willie J., Madeoy, Jennifer, Eberle, Michael, Shriver, Mark D.
A striking footprint of positive selection was recently identified on chromosome 7q34-35 that spans at least 115 kb and encompasses four known genes (KEL, TRPV5, TRPV6, EPHB6). The signature of...
Genomic signatures of positive selection in humans and the limits of outlier approaches
Kelley, Joanna L., Madeoy, Jennifer, Calhoun, John C., Swanson, Willie, Akey, Joshua M.
Identifying regions of the human genome that have been targets of positive selection will provide important insights into recent human evolutionary history and may facilitate the search for complex...
Gene-Expression Variation Within and Among Human Populations
Storey, John D., Madeoy, Jennifer, Strout, Jeanna L., Wurfel, Mark, Ronald, James, Akey, Joshua M.
Understanding patterns of gene-expression variation within and among human populations will provide important insights into the molecular basis of phenotypic diversity and the interpretation of...