NF-kappaB activation in premalignant mouse tal-1/scl thymocytes and tumors (2003)
O'Neil, Jennifer, Ventura, Juan-Jose, Hermance, Nicole M., Kelliher, Michelle A.
TAL-1/SCL activation is a common genetic event in pediatric T-cell acute lymphoblastic leukemia (T-ALL). Expression of tal-1/scl or a DNA binding mutant of tal-1/scl induces arrest of thymocyte...
Sequestration and Inhibition of Daxx-Mediated Transcriptional Repression by PML
Li, Hui, Leo, Christopher, Zhu, Jiang, Wu, Xiaoyang, O'Neil, Jennifer, Park, Eun-Ju, ...
PML fuses with retinoic acid receptor α (RARα) in the t(15;17) translocation that causes acute promyelocytic leukemia (APL). In addition to localizing diffusely throughout the nucleoplasm, PML...
Sequestration and Inhibition of Daxx-Mediated Transcriptional Repression by PML
Li, Hui, Leo, Christopher, Zhu, Jiang, Wu, Xiaoyang, O'Neil, Jennifer, Park, Eun-Ju, ...
PML fuses with retinoic acid receptor α (RARα) in the t(15;17) translocation that causes acute promyelocytic leukemia (APL). In addition to localizing diffusely throughout the nucleoplasm, PML...
Palomero, Teresa, Lim, Wei Keat, Odom, Duncan T., Sulis, Maria Luisa, Real, Pedro J., Margolin, Adam, ...
The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T cell development and in the pathogenesis over...
Activating Notch1 mutations in mouse models of T-ALL
O'Neil, Jennifer, Calvo, Jennifer, McKenna, Keith, Krishnamoorthy, Veena, Aster, Jon C., Bassing, Craig H., ...
Recent studies have demonstrated that most patients with T-cell acute lymphocytic leukemia (T-ALL) have activating mutations in NOTCH1. We sought to determine whether these mutations are also...
Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia
Palomero, Teresa, Odom, Duncan T., O'Neil, Jennifer, Ferrando, Adolfo A., Margolin, Adam, Neuberg, Donna S., ...
Aberrant expression of 1 or more transcription factor oncogenes is a critical component of the molecular pathogenesis of human T-cell acute lymphoblastic leukemia (T-ALL); however, oncogenic...
O'Neil, Jennifer, Grim, Jonathan, Strack, Peter, Rao, Sudhir, Tibbitts, Deanne, Winter, Christopher, ...
γ-secretase inhibitors (GSIs) can block NOTCH receptor signaling in vitro and therefore offer an attractive targeted therapy for tumors dependent on deregulated NOTCH activity. To clarify the basis...
Guo, Zhuyan, Dose, Marei, Kovalovsky, Damian, Chang, Rui, O'Neil, Jennifer, Look, A. Thomas, ...
Activation of β-catenin has been causatively linked to the etiology of colon cancer. Conditional stabilization of this molecule in pro-T cells promotes thymocyte development without the requirement...
Alu elements mediate MYB gene tandem duplication in human T-ALL
O'Neil, Jennifer, Tchinda, Joelle, Gutierrez, Alejandro, Moreau, Lisa, Maser, Richard S., Wong, Kwok-Kin, ...
Recent studies have demonstrated that the MYB oncogene is frequently duplicated in human T cell acute lymphoblastic leukemia (T-ALL). We find that the human MYB locus is flanked by 257-bp Alu repeats...