Jennifer S. Michaelson

Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study (2009)

Schwartz, Noa, Rubinstein, Tamar, Burkly, Linda C, Collins, Christopher E, Blanco, Irene, Su, Lihe, ...

Abstract Introduction TNF-like weak inducer of apoptosis (TWEAK) has been implicated as a mediator of chronic inflammatory processes via prolonged activation of the NF-κB pathway in several tissues,...

The Role of b-Catenin in Mammary Gland Carcinogenesis (2003)

Michaelson, Jennifer S.

Wnt signaling molecules have been implicated in mouse mammary carcinogenesis. Beta-catenin, a downstream molecule in the Wnt pathway, activates transcription of target genes. Our studies are aimed at...

Identification of 3{alpha}-hs4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiation (1995)

Michaelson, Jennifer S., Giannini, Sandra L., Birshtein, Barbara K.

In addition to Eμ, several elements downstream of the IgH cluster, i.e. 3' of the Cα gene, areinvolved in regulating IgH gene rearrangement and expression. This entire downstream regulatory region...

Homeodomain-Interacting Protein Kinase 1 Modulates Daxx Localization, Phosphorylation, and Transcriptional Activity

Ecsedy, Jeffrey A., Michaelson, Jennifer S., Leder, Philip

We describe an interaction between homeodomain-interacting protein kinase 1 (HIPK1) and Daxx, two transcriptional regulators important in transducing growth-regulatory signals. We demonstrate that...

Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development

Michaelson, Jennifer S., Bader, Debra, Kuo, Frank, Kozak, Christine, Leder, Philip

The mammalian Daxx gene has been identified in a diverse set of yeast interaction trap experiments. Although a facilitating role for Daxx in Fas-induced apoptosis has been suggested, Daxx’s...

TWEAK induces liver progenitor cell proliferation

Jakubowski, Aniela, Ambrose, Christine, Parr, Michael, Lincecum, John M., Wang, Monica Z., Zheng, Timothy S., ...

Progenitor (“oval”) cell expansion accompanies many forms of liver injury, including alcohol toxicity and submassive parenchymal necrosis as well as experimental injury models featuring blocked...

Homeodomain-Interacting Protein Kinase 1 Modulates Daxx Localization, Phosphorylation, and Transcriptional Activity

Ecsedy, Jeffrey A., Michaelson, Jennifer S., Leder, Philip

We describe an interaction between homeodomain-interacting protein kinase 1 (HIPK1) and Daxx, two transcriptional regulators important in transducing growth-regulatory signals. We demonstrate that...

Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development

Michaelson, Jennifer S., Bader, Debra, Kuo, Frank, Kozak, Christine, Leder, Philip

The mammalian Daxx gene has been identified in a diverse set of yeast interaction trap experiments. Although a facilitating role for Daxx in Fas-induced apoptosis has been suggested, Daxx’s...

TWEAK induces liver progenitor cell proliferation

Jakubowski, Aniela, Ambrose, Christine, Parr, Michael, Lincecum, John M., Wang, Monica Z., Zheng, Timothy S., ...

Progenitor (“oval”) cell expansion accompanies many forms of liver injury, including alcohol toxicity and submassive parenchymal necrosis as well as experimental injury models featuring blocked...

TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration

Girgenrath, Mahasweta, Weng, Shawn, Kostek, Christine A, Browning, Beth, Wang, Monica, Brown, Sharron AN, ...

Inflammation participates in tissue repair through multiple mechanisms including directly regulating the cell fate of resident progenitor cells critical for successful regeneration. Upon surveying...