Marquard, Vivien, Beckmann, Lars, Heid, Iris M, Lamina, Claudia, Chang-Claude, Jenny
Abstract Background We investigated the influence of genotyping errors on the type I error rate and empirical power of two haplotype based association methods applied to candidate regions. We...
Milne, Roger L., Benítez, Javier, Nevanlinna, Heli, Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, ...
Background A recent genome-wide association study identified single-nucleotide polymorphism (SNP) 2q35-rs13387042 as a marker of susceptibility to estrogen receptor (ER)–positive breast cancer. We...
Song, Honglin, Ramus, Susan J., Kjaer, Susanne Krüger, DiCioccio, Richard A., Chenevix-Trench, Georgia, Pearce, Celeste Leigh, ...
Because both ovarian and breast cancer are hormone-related and are known to have some predisposition genes in common, we evaluated 11 of the most significant hits (six with confirmed associations...
Silvia Funke, Angela Risch, Alexandra Nieters, Michael Hoffmeister, Christa Stegmaier, Christoph M. Seiler, ...
Radiotherapy exerts part of its antineoplastic effect by generating oxidative stress, therefore genetic variation in oxidative stress-related enzymes may influence survival of rectal cancer patients....
Silvia Funke, Angela Risch, Alexandra Nieters, Michael Hoffmeister, Christa Stegmaier, Christoph M. Seiler, ...
Radiotherapy exerts part of its antineoplastic effect by generating oxidative stress, therefore genetic variation in oxidative stress-related enzymes may influence survival of rectal cancer patients....
Mittelstrass, Kirstin, Sauter, Wiebke, Rosenberger, Albert, Illig, Thomas, Timofeeva, Maria, Klopp, Norman, ...
Abstract The polymorphism SNP309 (rs2279744) in the promoter region of the MDM2 gene has been shown to alter protein expression and may play a role in the susceptibility to lung cancer. The MDM2...
Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk (2008)
Abbas, Sascha, Nieters, Alexandra, Linseisen, Jakob, Slanger, Tracy, Kropp, Silke, Mutschelknauss, Elke, ...
Abstract Introduction Vitamin D receptor (VDR) genotypes may influence breast cancer risk by altering potential anticarcinogenic effects of vitamin D, but epidemiological studies have been...
Abbas, Sascha, Linseisen, Jakob, Slanger, Tracy, Kropp, Silke, Mutschelknauss, Elke Jonny, Flesch-Janys, Dieter, ...
Various studies suggest that vitamin D may reduce breast cancer risk. Most studies assessed the effects of dietary intake only, although endogenous production is an important source of vitamin D....
Woelfelschneider, Andreas, Popanda, Odilia, Lilla, Carmen, Linseisen, Jakob, Mayer, Claudia, Celebi, Oktay, ...
Both genetic variants and messenger RNA (mRNA) expression of DNA repair and tumor suppressor genes have been investigated as molecular markers for therapy outcome. However, the phenotypic impact of...
Association of a Common AKAP9 Variant With Breast Cancer Risk: A Collaborative Analysis (2008)
Frank, Bernd, Wiestler, Miriam, Kropp, Silke, Hemminki, Kari, Spurdle, Amanda B., Sutter, Christian, ...
Data from several studies have suggested that polymorphisms in A-kinase anchoring proteins (AKAPs), which are key components of signal transduction, contribute to carcinogenesis. To evaluate the...
Dempfle, Astrid, Hein, Rebecca, Beckmann, Lars, Scherag, André, Nguyen, Thuy, Schäfer, Helmut, ...
Abstract Accounting for interactions with environmental factors in association studies may improve the power to detect genetic effects and may help identifying important environmental effect...
Comparison of measures for haplotype similarity (2007)
Marquard, Vivien, Beckmann, Lars, Bermejo, Justo L, Fischer, Christine, Chang-Claude, Jenny
Abstract Measuring the association of haplotype similarities with phenotype similarities has been used to develop statistical tests of genetic association. Previously, we applied the general approach...
Shanmugam, Kalai S., Brenner, Hermann, Hoffmeister, Michael, Chang-Claude, Jenny, Burwinkel, Barbara
The Wnt–β-catenin pathway plays a central role in colorectal tumorigenesis. Frizzled-related protein (FRZB, also termed secreted frizzled-related protein 3, sFRP3) antagonizes the signaling of...
Andrieu, Nadine, Goldgar, David E., Easton, Douglas F., Rookus, Matti, Brohet, Richard, Antoniou, Antonis C., ...
Hoffmeister, Michael, Chang-Claude, Jenny, Brenner, Hermann
Large-bowel endoscopy with removal of polyps strongly reduces colorectal cancer risk. In epidemiologic studies, ascertainment of large-bowel endoscopies often relies on self-reports and might be...
Rinaldi, Sabina, Dossus, Laure, Lukanova, Annekatrin, Peeters, Petra H M, Allen, Naomi E, Key, Timothy, ...
Abstract is not available
Risk of endometrial cancer in relationship to cigarette smoking: Results from the EPIC study. (2007)
Al-Zoughool, Mustafa, Dossus, Laure, Kaaks, Rudolf, Clavel-Chapelon, Françoise, Tjonneland, Anne, Olsen, Anja, ...
Abstract is not available
Brohet, Richard M, Goldgar, David E, Easton, Douglas F, Antoniou, Antonis C, Andrieu, Nadine, Chang-Claude, Jenny, ...
Abstract is not available
Lahmann, Petra H., Friedenreich, Christine, Jantine Schuit, A., Salvini, Simonetta, Allen, Naomi E., Key, Tim J., ...
There is convincing evidence for a decreased risk of breast cancer with increased physical activity. Uncertainties remain, however, about the role of different types of physical activity on breast...
Tjonneland, Anne, Christensen, Jane, Olsen, Anja, Stripp, Connie, Thomsen, Birthe L., Overvad, Kim, ...
Objective Most epidemiologic studies have suggested an increased risk of breast cancer with increasing alcohol intake. Using data from 274,688 women participating in the European Prospective...
Ambrosone, Christine B, Tian, Chunqiao, Ahn, Jiyoung, Kropp, Silke, Helmbold, Irmgard, Von Fournier, Dietrich, ...
Abstract Introduction The cytotoxic effects of radiation therapy are mediated primarily through increased formation of hydroxyl radicals and reactive oxygen species, which can damage cells, proteins...
A Genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth, ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
A Genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth, ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
A Genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth M., ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
Andrieu, Nadine, Goldgar, David E., Easton, Douglas F., Rookus, Matti, Brohet, Richard, Antoniou, Antonis C., ...
Multiparity, young age at first childbirth, and breast-feeding are associated with a reduced risk of breast cancer in the general population. The breast cancer predisposition gene, BRCA1, regulates...
A genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth, ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
Lahmann, Petra H, Friedenreich, Christine, Schuit, A Jantine, Salvini, Simonetta, Allen, Naomi E, Key, Tim J, ...
Abstract is not available
Ambrosone, Christine B., Chang-Claude, Jenny
Women with earlier stage breast cancer who receive breast conserving surgery and radiation therapy have a generally good prognosis. However, among 15-20% of these women, breast cancer recurs, and a...
Nadine, Andrieu, Easton, Douglas, Chang-Claude, Jenny, Rookus, Matti, Brohet, Richard, Cardis, Elisabeth, ...
PURPOSE: Women who carry germline mutations in the BRCA1 and BRCA2 genes are at greatly increased risk of breast cancer (BC). Numerous studies have shown that moderate to high doses of ionizing...
Andrieu, Nadine, Goldgar, David, Easton, Douglas, Rookus, Matti, Brohet, Richard, Antoniou, Antonis, ...
BACKGROUND: Multiparity, young age at first childbirth, and breast-feeding are associated with a reduced risk of breast cancer in the general population. The breast cancer predisposition gene, BRCA1,...
Andrieu, Nadine, Goldgar, David, Easton, Douglas, Rookus, Matti, Brohet, Richard, Antoniou, Antonis, ...
BACKGROUND: Multiparity, young age at first childbirth, and breast-feeding are associated with a reduced risk of breast cancer in the general population. The breast cancer predisposition gene, BRCA1,...
Nadine, Andrieu, Easton, Douglas, Chang-Claude, Jenny, Rookus, Matti, Brohet, Richard, Cardis, Elisabeth, ...
PURPOSE: Women who carry germline mutations in the BRCA1 and BRCA2 genes are at greatly increased risk of breast cancer (BC). Numerous studies have shown that moderate to high doses of ionizing...
A Genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth, ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
A Genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth, ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
A Genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth M., ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
A Genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth M., ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
A Genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth M., ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
Andrieu, Nadine, Goldgar, David, Easton, Douglas, Rookus, Matti, Brohet, Richard, Antoniou, Antonis, ...
BACKGROUND: Multiparity, young age at first childbirth, and breast-feeding are associated with a reduced risk of breast cancer in the general population. The breast cancer predisposition gene, BRCA1,...
Nadine, Andrieu, Easton, Douglas, Chang-Claude, Jenny, Rookus, Matti, Brohet, Richard, Cardis, Elisabeth, ...
PURPOSE: Women who carry germline mutations in the BRCA1 and BRCA2 genes are at greatly increased risk of breast cancer (BC). Numerous studies have shown that moderate to high doses of ionizing...
Andrieu, Nadine, Goldgar, David E., Easton, Douglas F., Rookus, Matti, Brohet, Richard, Antoniou, Antonis C., ...
Background: Multiparity, young age at first childbirth, and breast-feeding are associated with a reduced risk of breast cancer in the general population. The breast cancer predisposition gene, BRCA1,...
A Genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth M., ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
Haplotype-sharing analysis using Mantel statistics for combined genetic effects (2005)
Beckmann, Lars, Fischer, Christine, Obreiter, Markus, Rabes, Michael, Chang-Claude, Jenny
Abstract We applied a new approach based on Mantel statistics to analyze the Genetic Analysis Workshop 14 simulated data with prior knowledge of the answers. The method was developed in order to...
Verla-Tebit, Emaculate, Wang-Gohrke, Shan, Chang-Claude, Jenny
Abstract Introduction Studies on the association between the cytochrome P450c17α gene ( CYP17 ) 5'-untranslated region Msp A1 genetic polymorphism and breast cancer risk have yielded inconsistent...
Lilla, Carmen, Risch, Angela, Kropp, Silke, Chang-Claude, Jenny
Abstract Introduction Sulfotransferase 1A1 (encoded by SULT1A1 ) is involved in the metabolism of procarcinogens such as heterocyclic amines and polycyclic aromatic hydrocarbons, both of which are...
Kaaks, Rudolf, Berrino, Franco, Key, Timothy, Rinaldi, Sabina, Dossus, Laure, Biessy, Carine, ...
Background: Contrasting etiologic hypotheses about the role of endogenous sex steroids in breast cancer development among premenopausal women implicate ovarian androgen excess and progesterone...
Fischer, Christine, Beckmann, Lars, Majoram, Paul, Meerman, Gerard Te, Chang-Claude, Jenny
Haplotype sharing analysis was used to investigate the association of affection status with single nucleotide polymorphism (SNP) haplotypes within candidate gene 1 in one sample each from the...
Steindorf, Karen, Schmidt, Martina, Kropp, Silke, Chang-Claude, Jenny
Important aspects of the recognized inverse relation between physical activity and breast cancer risk are still under discussion. Data on physical activity from sports, occupational activity,...
Thompson, Deborah, Szabo, Csilla I., Mangion, Jon, Oldenburg, Rogier A., Odefrey, Fabrice, Seal, Sheila, ...
The known susceptibility genes for breast cancer, including BRCA1 and BRCA2, only account for a minority of the familial aggregation of the disease. A recent study of 77 multiple case breast cancer...
Meijers-Heijboer, Hanne, Van Den, Ans, Klijn, Jan, Wasielewski, Marijke, De Snoo, Anja, Oldenburg, Rogier, ...
Mutations in BRCA1 and BRCA2 confer a high risk of breast and ovarian cancer1, but account for only a small fraction of breast cancer susceptibility1, 2. To find additional genes conferring...
Active and Passive Smoking and Risk of Breast Cancer by Age 50 Years among German Women (2002)
Kropp, Silke, Chang-Claude, Jenny
Recent studies suggest that both active and passive smokers have an increased risk of breast cancer compared with women who have never been either actively or passively exposed. Data on lifetime...
Kropp, Silke, Becher, Heiko, Nieters, Alexandra, Chang-Claude, Jenny
Studies of the association between alcohol drinking and breast cancer show a tendency towards an increase in risk for high consumption levels but yield less consistent results for low-to-moderate...
Andreas Ziegler, Christian Kastner, Jenny Chang-claude
Generalised estimating equations have been well established to draw inference for the marginal mean from follow-up data. Many studies suer from missing data that may result in biased parameter...
Gender Differences in the Healthy Worker Effect among Synthetic Vitreous Fiber Workers (1999)
Lea, C. Suzanne, Hertz-Picciotto, Irva, Andersen, Aage, Chang-Claude, Jenny, Olsen, Jørgen H., Pesatori, Angela C., ...
The aim of this study was to determine whether the healthy worker effect and its component parts operate similarly for women and men. A cohort of workers from 14 synthetic vitreous fiber factories in...
Ambrosone, Christine B., Chang-Claude, Jenny
Women with earlier stage breast cancer who receive breast conserving surgery and radiation therapy have a generally good prognosis. However, among 15-20% of these women, breast cancer recurs, and a...
Ambrosone, Christine B., Chang-Claude, Jenny
Women with earlier stage breast cancer who receive breast conserving surgery and radiation therapy have a generally good prognosis. However, among 15-20% of these women, breast cancer recurs, and a...
A. Ziegler, M. Blettner, C. Kastner, Jenny Chang-claude
The Generalized Estimating Equations (GEE) is an approach to analyze correlated data. It is applied here to data from an epidemiological study of oesophageal cancer in a high incidence area in China...
Dietary and Lifestyle Determinants of Mortality among German Vegetarians (1993)
CHANG-CLAUDE, JENNY, FRENTZEL-BEYME, RAINER
Lifestyle characteristics of a cohort of 1904 Germans adhering mainly to a vegetarian duet were examined in reladon to their mortality after 11 years of follow-up. Poisson regression modelling was...
Thompson, Deborah, Szabo, Csilla I., Mangion, Jon, Oldenburg, Rogier A., Odefrey, Fabrice, Seal, Sheila, ...
The known susceptibility genes for breast cancer, including BRCA1 and BRCA2, only account for a minority of the familial aggregation of the disease. A recent study of 77 multiple case breast cancer...
Thompson, Deborah, Szabo, Csilla I., Mangion, Jon, Oldenburg, Rogier A., Odefrey, Fabrice, Seal, Sheila, ...
The known susceptibility genes for breast cancer, including BRCA1 and BRCA2, only account for a minority of the familial aggregation of the disease. A recent study of 77 multiple case breast cancer...
Ambrosone, Christine B, Tian, Chunqiao, Ahn, Jiyoung, Kropp, Silke, Helmbold, Irmgard, Von Fournier, Dietrich, ...
An Evaluation of Genetic Heterogeneity in 145 Breast-Ovarian Cancer Families
Narod, Steven A., Ford, Deborah, Devilee, Peter, Barkardottir, Rosa B., Lynch, Henry T., Smith, Simon A., ...
The breast-ovary cancer–family syndrome is a dominant predisposition to cancer of the breast and ovaries which has been mapped to chromosome region 17ql2-q21. The majority, but not all, of...
Garcia-Closas, Montserrat, Hall, Per, Nevanlinna, Heli, Pooley, Karen, Morrison, Jonathan, Richesson, Douglas A., ...
A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9),...
Dempfle, Astrid, Hein, Rebecca, Beckmann, Lars, Scherag, André, Nguyen, Thuy Trang, Schäfer, Helmut, ...
Accounting for interactions with environmental factors in association studies may improve the power to detect genetic effects and may help identifying important environmental effect modifiers. The...
Comparison of measures for haplotype similarity
Marquard, Vivien, Beckmann, Lars, Bermejo, Justo L, Fischer, Christine, Chang-Claude, Jenny
Measuring the association of haplotype similarities with phenotype similarities has been used to develop statistical tests of genetic association. Previously, we applied the general approach of...
Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene
Mittelstrass, Kirstin, Sauter, Wiebke, Rosenberger, Albert, Illig, Thomas, Timofeeva, Maria, Klopp, Norman, ...
The polymorphism SNP309 (rs2279744) in the promoter region of the MDM2 gene has been shown to alter protein expression and may play a role in the susceptibility to lung cancer. The MDM2 protein is a...
Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk
Abbas, Sascha, Nieters, Alexandra, Linseisen, Jakob, Slanger, Tracy, Kropp, Silke, Mutschelknauss, Elke Jonny, ...
Allen, Naomi E, Key, Timothy J, Dossus, Laure, Rinaldi, Sabina, Cust, Anne, Lukanova, Annekatrin, ...
Epidemiological data show that reproductive and hormonal factors are involved in the etiology of endometrial cancer, but there is little data on the association with endogenous sex hormone levels. We...