Studies on the CPA cysteine peptidase in the Leishmania infantumgenome strain JPCM5 (2006)
Denise, Hubert, Poot, Jacqueline, Jiménez, Maribel, Ambit, Audrey, Herrmann, Daland C, Vermeulen, Arno N, ...
Abstract Background Visceral leishmaniasis caused by members of the Leishmania donovani complex is often fatal in the absence of treatment. Research has been hampered by the lack of good laboratory...
The SNARE protein family of Leishmania major (2006)
Besteiro, Sébastien, Coombs, Graham H, Mottram, Jeremy C
Abstract Background Leishmania major is a protozoan parasite with a highly polarised cell shape that depends upon endocytosis and exocytosis from a single area of the plasma membrane, the flagellar...
Parsons, Marilyn, Worthey, Elizabeth A, Ward, Pauline N, Mottram, Jeremy C
Abstract Background The trypanosomatids Leishmania major , Trypanosoma brucei and Trypanosoma cruzi cause some of the most debilitating diseases of humankind: cutaneous leishmaniasis, African...
Grant, Karen M., Dunion, Morag H., Yardley, Vanessa, Skaltsounis , Alexios-Leandros, Marko, Doris, Eisenbrand, Gerhard, ...
The CRK3 cyclin-dependent kinase of Leishmania has been shown by genetic manipulation of the parasite to be essential for proliferation. We present data which demonstrate that chemical inhibition of...
Knockaert, Marie, Wieking, Karen, Schmitt, Sophie, Leost, Maryse, Grant, Karen M., Mottram, Jeremy C., ...
Numerous inhibitors of cyclin-dependent kinases and glycogen synthase kinase-3 (GSK-3) are being developed in view of their potential applications against cancers and neurodegenerative disorders....
The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana. (2001)
Hassan, Paul, Fergusson, David, Grant, Karen M., Mottram, Jeremy C.
The Leishmania mexicana CRK3 gene encodes a cdc2-related protein kinase with activity towards histone H1. Attempts to disrupt both alleles of CRK3 in the promastigote life-cycle stage resulted in...
Knockaert, Marie, Gray, N., Damiens, E., Grellier, P., Grant, Karen M., ...
Background: Chemical inhibitors of cyclin-dependent kinases (CDKs) have great therapeutic potential against various proliferative and neurodegenerative disorders. Olomoucine, a 2,6,9-trisubstituted...
Hilley, James D., Zawadzki, Jody L., McConville, Malcolm J., Coombs, Graham H., Mottram, Jeremy C.
The major surface proteins of the parasitic protozoon Leishmania mexicana are anchored to the plasma membrane by glycosylphosphatidylinositol (GPI) anchors. We have cloned the L. mexicana GPI8 gene...
Coombs, Graham H., Mottram, Jeremy C.
Methionine γ-lyase, the enzyme which catalyzes the single-step conversion of methionine to α-ketobutyrate, ammonia, and methanethiol, is highly active in many anaerobic pathogenic microorganisms...
Lillico, Simon, Field, Mark C., Blundell, Pat, Coombs, Graham H., Mottram, Jeremy C.
The survival of Trypanosoma brucei, the causative agent of Sleeping Sickness and Nagana, is facilitated by the expression of a dense surface coat of glycosylphosphatidylinositol (GPI)-anchored...
Denise, Hubert, McNeil, Kathryn, Brooks, Darren R., Alexander, James, Coombs, Graham H., Mottram, Jeremy C.
Leishmania mexicana mutants deficient in the multicopy CPB gene array have reduced virulence, demonstrated by poor lesion growth in BALB/c mice and induction of a protective Th1 response. Reinsertion...
Grant, Karen M., Dunion, Morag H., Yardley, Vanessa, Skaltsounis, Alexios-Leandros, Marko, Doris, Eisenbrand, Gerhard, ...
The CRK3 cyclin-dependent kinase of Leishmania has been shown by genetic manipulation of the parasite to be essential for proliferation. We present data which demonstrate that chemical inhibition of...
Corradin, Sally, Ransijn, Adriana, Corradin, Giampietro, Bouvier, Jacques, Delgado, Maria Belen, Fernandez-Carneado, Jimena, ...
The zinc metalloprotease gp63 (leishmanolysin; promastigote surface protease) is expressed at high density at the surface of Leishmania promastigotes. Efficient non-toxic inhibitors of gp63 do not...
The Genome of the Kinetoplastid Parasite, Leishmania major
Ivens, Alasdair C., Peacock, Christopher S., Worthey, Elizabeth A., Murphy, Lee, Aggarwal, Gautam, Berriman, Matthew, ...
Smith, Brian O., Picken, Nichola C., Westrop, Gareth D., Bromek, Krystyna, Mottram, Jeremy C., Coombs, Graham H.
Clan CA, family C1 cysteine peptidases (CPs) are important virulence factors and drug targets in parasites that cause neglected diseases. Natural CP inhibitors of the I42 family, known as ICP, occur...
Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5
Denise, Hubert, Poot, Jacqueline, Jiménez, Maribel, Ambit, Audrey, Herrmann, Daland C, Vermeulen, Arno N, ...
Hilley, James D., Zawadzki, Jody L., McConville, Malcolm J., Coombs, Graham H., Mottram, Jeremy C.
The major surface proteins of the parasitic protozoon Leishmania mexicana are anchored to the plasma membrane by glycosylphosphatidylinositol (GPI) anchors. We have cloned the L. mexicana GPI8 gene...
Coombs, Graham H., Mottram, Jeremy C.
Methionine γ-lyase, the enzyme which catalyzes the single-step conversion of methionine to α-ketobutyrate, ammonia, and methanethiol, is highly active in many anaerobic pathogenic microorganisms...
Lillico, Simon, Field, Mark C., Blundell, Pat, Coombs, Graham H., Mottram, Jeremy C.
The survival of Trypanosoma brucei, the causative agent of Sleeping Sickness and Nagana, is facilitated by the expression of a dense surface coat of glycosylphosphatidylinositol (GPI)-anchored...
Denise, Hubert, McNeil, Kathryn, Brooks, Darren R., Alexander, James, Coombs, Graham H., Mottram, Jeremy C.
Leishmania mexicana mutants deficient in the multicopy CPB gene array have reduced virulence, demonstrated by poor lesion growth in BALB/c mice and induction of a protective Th1 response. Reinsertion...
Grant, Karen M., Dunion, Morag H., Yardley, Vanessa, Skaltsounis, Alexios-Leandros, Marko, Doris, Eisenbrand, Gerhard, ...
The CRK3 cyclin-dependent kinase of Leishmania has been shown by genetic manipulation of the parasite to be essential for proliferation. We present data which demonstrate that chemical inhibition of...
Corradin, Sally, Ransijn, Adriana, Corradin, Giampietro, Bouvier, Jacques, Delgado, Maria Belen, Fernandez-Carneado, Jimena, ...
The zinc metalloprotease gp63 (leishmanolysin; promastigote surface protease) is expressed at high density at the surface of Leishmania promastigotes. Efficient non-toxic inhibitors of gp63 do not...
Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5
Denise, Hubert, Poot, Jacqueline, Jiménez, Maribel, Ambit, Audrey, Herrmann, Daland C, Vermeulen, Arno N, ...
Hammarton, Tansy C, Kramer, Susanne, Tetley, Laurence, Boshart, Michael, Mottram, Jeremy C
Polo-like kinases (PLKs) are conserved eukaryotic cell cycle regulators, which play multiple roles, particularly during mitosis. The function of Trypanosoma brucei PLK was investigated in procyclic...