Jeremy R. Graff

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. (1998)

Herman, James G., Umar, Asad, Polyak, Kornelia, Graff, Jeremy R., Ahuja, Nita, Issa, Jean-Pierre J., ...

Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal cancer. We report that hypermethylation of the 5' CpG island of hMLH1 is...

Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression

McGregor, Lisa M., McCune, Bryan K., Graff, Jeremy R., McDowell, Philip R., Romans, Katherine E., Yancopoulos, George D., ...

Although initiating mutations in the ret protooncogene have been found in familial and sporadic medullary thyroid carcinoma (MTC), the molecular events underlying subsequent tumor progression stages...

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

Herman, James G., Umar, Asad, Polyak, Kornelia, Graff, Jeremy R., Ahuja, Nita, Issa, Jean-Pierre J., ...

Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island of hMLH1 is...

Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression

McGregor, Lisa M., McCune, Bryan K., Graff, Jeremy R., McDowell, Philip R., Romans, Katherine E., Yancopoulos, George D., ...

Although initiating mutations in the ret protooncogene have been found in familial and sporadic medullary thyroid carcinoma (MTC), the molecular events underlying subsequent tumor progression stages...

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

Herman, James G., Umar, Asad, Polyak, Kornelia, Graff, Jeremy R., Ahuja, Nita, Issa, Jean-Pierre J., ...

Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island of hMLH1 is...

Expression of Group IIA Secretory Phospholipase A2 Is Elevated in Prostatic Intraepithelial Neoplasia and Adenocarcinoma

Jiang, Jiazhong, Neubauer, Blake Lee, Graff, Jeremy R., Chedid, Marcio, Thomas, James E., Roehm, Neal W., ...

Phospholipase A2 (PLA2) enzymes release arachidonic acid from cellular phospholipids in a variety of mammalian tissues, including prostate. Group IIa secretory PLA2 (sPLA2) can generate arachidonate...

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

Graff, Jeremy R., Konicek, Bruce W., Vincent, Thomas M., Lynch, Rebecca L., Monteith, David, Weir, Spring N., ...

Expression of eukaryotic translation initiation factor 4E (eIF4E) is commonly elevated in human and experimental cancers, promoting angiogenesis and tumor growth. Elevated eIF4E levels selectively...