Role of NKX2-1 in N-bis(2-hydroxypropyl)-nitrosamine-induced thyroid adenoma in mice (2009)
Hoshi, Sayuri, Hoshi, Nobuo, Okamoto, Minoru, Paiz, Jorge, Kusakabe, Takashi, Ward, Jerrold M., ...
NKX2-1 is a homeodomain transcription factor that is critical for genesis of the thyroid and transcription of the thyroid-specific genes. Nkx2-1-thyroid-conditional hypomorphic mice were previously...
La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys (2008)
Bennett, Richard S, Cress, Christina M, Ward, Jerrold M, Firestone, Cai-Yen, Murphy, Brian R, Whitehead, Stephen S
Abstract Background La Crosse virus (LACV), family Bunyaviridae, was first identified as a human pathogen in 1960 after its isolation from a 4 year-old girl with fatal encephalitis in La Crosse,...
Hartley, Janet W, Evans, Leonard H, Green, Kim Y, Naghashfar, Zohreh, Macias, Alfonso R, Zerfas, Patricia M, ...
Abstract The mouse macrophage-like cell line RAW264.7, the most commonly used mouse macrophage cell line in medical research, was originally reported to be free of replication-competent murine...
Bility, Moses T., Devlin-Durante, Meghann K., Blazanin, Nicholas, Glick, Adam B., Ward, Jerrold M., Kang, Boo Hyon, ...
Peroxisome proliferator-activated receptor (PPAR)β/δ-null mice exhibit enhanced tumorigenesis in a two-stage chemical carcinogenesis model as compared with wild-type mice. Previous work showed that...
Thomas, Johnson, Haseman, Joseph K., Goodman, Jay I., Ward, Jerrold M., Loughran, Thomas P., Spencer, Pamela J.
Large granular lymphocyte leukemia (LGLL) is a common fatal disease in aging F344 rats. The current understanding of rat LGLL and a search for mechanistic data/correlations to human leukemia were...
Prophylactic and Therapeutic Efficacy of Human Monoclonal Antibodies against H5N1 Influenza (2007)
Cameron P. Simmons, Nadia L. Bernasconi, Amorsolo L. Suguitan Jr., Kimberly Mills, Jerrold M. Ward, ...
BackgroundNew prophylactic and therapeutic strategies to combat human infections with highly pathogenic avian influenza (HPAI) H5N1 viruses are needed. We generated neutralizing anti-H5N1 human...
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice (2007)
Kim, Insook, Morimura, Keiichirou, Shah, Yatrik, Yang, Qian, Ward, Jerrold M., Gonzalez, Frank J.
The farnesoid X receptor (FXR) controls the synthesis and transport of bile acids (BAs). Mice lacking expression of FXR, designated Fxr-null, have elevated levels of serum and hepatic BAs and an...
Morimura, Keiichirou, Cheung, Connie, Ward, Jerrold M., Reddy, Janardan K., Gonzalez, Frank J.
Peroxisome proliferators, such as lipid-lowering fibrate drugs, are agonists for the peroxisome proliferator-activated receptor α (PPARα). Sustained activation of PPARα leads to the development of...
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice (2006)
Kim, Insook, Morimura, Keiichirou, Shah, Yatrik, Yang, Qian, Ward, Jerrold M., Gonzalez, Frank J.
The farnesoid X receptor (FXR) controls the synthesis and transport of bile acids. Mice lacking expression of FXR, designated Fxr-null, have elevated levels of serum and hepatic bile acids and an...
Hays, Thomas, Rusyn, Ivan, Burns, Amanda M., Kennett, Mary J., Ward, Jerrold M., Gonzalez, Frank J., ...
Prolonged administration of peroxisome proliferators to rodents typically leads to hepatocarcinogenesis. Peroxisome proliferator-activated receptor-α (PPARα) is required to mediate alterations in...
Morimura, Keiichirou, Cheung, Connie, Ward, Jerrold M., Reddy, Janardan K., Gonzalez, Frank J.
Peroxisome proliferators, such as lipid-lowering fibrate drugs, are agonists for the peroxisome proliferator-activated receptor α (PPARα). Sustained activation of PPARα leads to the development of...
Desai, Kartiki V, Michalowska, Aleksandra, Kondaiah, Paturu, Ward, Jerrold M, Shih, Joanna, Green, Jeffrey E
Understanding androgen regulation of gene expression is critical for deciphering mechanisms responsible for the transition from androgen-responsive (AR) to androgen-independent (AI) prostate cancer...
Desai, Kartiki V, Michalowska, Aleksandra, Kondaiah, Paturu, Ward, Jerrold M, Shih, Joanna, Green, Jeffrey E
Understanding androgen regulation of gene expression is critical for deciphering mechanisms responsible for the transition from androgen-responsive (AR) to androgen-independent (AI) prostate cancer...
Liu, Jie, Xie, Yaxiong, Ward, Jerrold M., Diwan, Bhalchandra A., Waalkes, Michael P.
Arsenic is a known human carcinogen. We have reported that brief exposure of pregnant C3H mice to arsenite in their drinking water during gestation induced hepatocellular carcinoma (HCC) in male...
Nicol, Christopher J., Yoon, Michung, Ward, Jerrold M., Yamashida, Masamichi, Fukamachi, Katsumi, Peters, Jeffrey M., ...
Peroxisome proliferator activated receptor γ (PPARγ), a member of the nuclear receptor superfamily, plays a role in adipocyte differentiation, type II diabetes, macrophage response to inflammation,...
Hays, Thomas, Rusyn, Ivan, Burns, Amanda M., Kennett, Mary J., Ward, Jerrold M., Gonzalez, Frank J., ...
Prolonged administration of peroxisome proliferators to rodents typically leads to hepatocarcinogenesis. Peroxisome proliferator-activated receptor-α (PPARα) is required to mediate alterations in...
Waalkes, Michael P., Ward, Jerrold M., Diwan, Bhalchandra A.
Arsenic is a recognized human carcinogen and development of rodent models remains a critically important research objective. Since gestation can be a period of high sensitivity to chemical...
Enhanced Acetaminophen Toxicity by Activation of the Pregnane X Receptor (2004)
Guo, Grace L., Moffit, Jeff, Nicol, Christopher J., Ward, Jerrold M., Aleksunes, Lauren, Slitt, Angela, ...
The pregnane X receptor (PXR) is a ligand-activated transcription factor and member of the nuclear receptor superfamily. Activation of PXR represents an important mechanism for the induction of...
Nicol, Christopher J., Yoon, Michung, Ward, Jerrold M., Yamashita, Masamichi, Fukamachi, Katsumi, Peters, Jeffrey M., ...
Peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily, plays a role in adipocyte differentiation, type II diabetes, macrophage response to inflammation...
Enhanced Acetaminophen Toxicity by Activation of the Pregnane X Receptor (2004)
Guo, Grace L., Moffit, Jeff S., Nicol, Christopher J., Ward, Jerrold M., Aleksunes, Lauren A., Slitt, Angela L., ...
The pregnane X receptor (PXR) is a ligand-activated transcription factor and member of the nuclear receptor superfamily. Activation of PXR represents an important mechanism for the induction of...
Ras-GRF1 signaling is required for normal β-cell development and glucose homeostasis (2003)
Font De Mora, Jaime, Esteban, Luis Miguel, Burks, Deborah J., Núñez, Alejandro, Garcés, Carmen, García-Barrado, María José, ...
Final full-text version of the paper available at: http://www.nature.com/emboj/journal/v22/n12/index.html
Liu, Jie, Xie, Yaxiong, Ward, Jerrold M., Diwan, Bhalchandra A., Waalkes, Michael P.
Arsenic is a known human carcinogen. We have reported that brief exposure of pregnant C3H mice to arsenite in the drinking water during gestation induces hepatocellular carcinoma (HCC) in male...
Waalkes, Michael P., Ward, Jerrold M., Diwan, Bhalchandra A.
Arsenic is a recognized human carcinogen and development of rodent models remains a critically important research objective. Since gestation can be a period of high sensitivity to chemical...
Chen, Li-Yuan, Shieh, Jeng-Jer, Lin, Baochuan, Pan, Chi-Jiunn, Gao, Ji-Liang, Murphy, Philip M., ...
Glycogen storage disease type Ib (GSD-Ib) is caused by a deficiency in the glucose-6-phosphate transporter (G6PT). In addition to disrupted glucose homeostasis, GSD-Ib patients have unexplained and...
Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2 (2003)
Kimura, Shioko, Kawabe, Mayumi, Yu, Aiming, Morishima, Hideki, Fernandez-Salguero, Pedro, Hammons, George J., ...
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant of the heterocyclic amines found in cooked meat. Based on in vitro studies with rats and humans, CYP1A2 is...
Chen, Li-Yuan, Shieh, Jeng-Jer, Lin, Baochuan, Pan, Chi-Jiunn, Gao, Ji-Liang, Murphy, Philip M., ...
Glycogen storage disease type Ib (GSD-Ib) is caused by a deficiency in the glucose-6-phosphate transporter (G6PT). In addition to disrupted glucose homeostasis, GSD-Ib patients have unexplained and...
Liu, Jie, Xie, Yaxiong, Ward, Jerrold M., Diwan, Bhalchandra A., Waalkes, Michael P.
Arsenic is a known human carcinogen. We have reported that brief exposure of pregnant C3H mice to arsenite in the drinking water during gestation induces hepatocellular carcinoma (HCC) in male...
Waalkes, Michael P., Ward, Jerrold M., Diwan, Bhalchandra A.
Arsenic is a recognized human carcinogen and development of rodent models remains a critically important research objective. Since gestation can be a period of high sensitivity to chemical...
Chen, Li-Yuan, Shieh, Jeng-Jer, Lin, Baochuan, Pan, Chi-Jiunn, Gao, Ji-Liang, Murphy, Philip M., ...
Glycogen storage disease type Ib (GSD-Ib) is caused by a deficiency in the glucose-6-phosphate transporter (G6PT). In addition to disrupted glucose homeostasis, GSD-Ib patients have unexplained and...
Sun, Mao-Sen, Pan, Chi-Jiunn, Shieh, Jeng-Jer, Ghosh, Abhijit, Chen, Li-Yuan, Mansfield, Brian C., ...
Deficiency of glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, causes glycogen storage disease type Ia (GSD-Ia), an autosomal recessive disorder characterized by growth...
Esteban, Luis Miguel, Fernández-Medarde, Alberto, Ward, Jerrold M., Santos De Dios, Eugenio, Vicario-Abejón, Carlos, Fernández-Salguero, P., ...
Mammalian cells harbor three highly homologous and widely expressed members of the ras family (H-ras, N-ras, and K-ras), but it remains unclear whether they play specific or overlapping cellular...
Ras-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development (2000)
Esteban, Luis Miguel, Fernández-Medarde, Alberto, López, Eva, Yienger, Kate, Ward, Jerrold M., Tessarollo, Lino, ...
The mammalian sos1 and sos2 genes encode highly homologous members of the Son-of-sevenless family of guanine nucleotide exchange factors. They are ubiquitously expressed and play key roles in...
Gary A. Boorman, David L. McCormick, Jerrold M. Ward, Joseph K. Haseman, Robert C. Sills
Boorman, G.A., McCormick, D.L., Ward, J.M., Haseman, J.K. and Sills, R.C. Magnetic Fields and Mammary Cancer in Rodents: A Critical Review and Evaluation of Published Literature. Epidemiological data...
Leukemia and Lymphoma Incidence in Rodents Exposed to Low-Frequency Magnetic Fields (2000)
Gary A. Boorman, Charles N. Rafferty, Jerrold M. Ward, Robert C. Sills
Boorman, G.A., Rafferty, C.N., Ward, J.M. and Sills, R.C. Leukemia and Lymphoma Incidence in Rodents Exposed to Low-Frequency Magnetic Fields. A weak association between residential or occupational...
Kimura, Shioko, Kawabe, Mayumi, Ward, Jerrold M., Morishima, Hideki, Kadlubar, Fred F., Hammons, George J., ...
4-Aminobiphenyl (4-ABP), a potent carcinogen in rodents (liver cancer) and human (bladder cancer), is found as an environmental contaminant and in tobacco smoke. Hemoglobin adducts and lung DNA...
Bakács, Tibor, Lee, Jaetae, Moreno, M. Belen, Zacharchuk, Charles M., Cole, Michael S., Yun Tso, J., ...
In the present study we tested whether T cells retargeted with a bispecific antibody (bsAb) could block the growth of lung metastases of syngeneic mammary adenocarcinoma in immunocompetent mice....
Tamano, Seiko, Merlino, Glenn T., Ward, Jerrold M.
The carcinogenic and tumor-promoting effects of human transforming growth factor α (TGF-α) overexpression were examined in a two-stage chemical carcinogenesis protocol using TGF-α transgenic mouse...
Ward, Jerrold M., Fox, James G., Anver, Miriam R., Haines, Diana C., George, Cathi V., Collins, Michael J., ...
Background: In the autumn of 1992, a novel form of chronic, active hepatitis of unknown etiology was discovered in mice at the national Cancer Institute-Frederick Cancer Research and Development...
Ice, Jerry M., Diwan, Bhalchandra A., Hu, Henry, Ward, Jerrold M., Nims, Raymond W., Lubet, Ronald A.
To test predictions that barbiturates which are long-acting sedatives and/or strong inducers of CYP2B-mediated monooxygenase activities would be effective promoters of hepato-carcinogenesis, a...
Enomoto, Takayuki, Weghorst, Christopher M., Ward, Jerrold M., Anderson, Lucy M., Perantoni, Alan O., Rice, Jerry M.
Previous reports from several laboratories have consistently shown that ∼30% of spontaneous hepatocellular adenomas and 70–80% of spontaneous hepatocellular carcinomas found in aged B6C3F1...
Ja-June, Jang, Weghorst, Christopher M., Henneman, John R., Devor, Deborah E., Ward, Jerrold M.
The progression of hepatocellular adenomas to carcinomas has been less well documented in mice than in rats. We studied progression of spontaneous and chemically induced hepatocellular adenomas in...
Diwan, Bhalchandra A., Lubet, Ronald A., Ward, Jerrold M., Hrabie, Joseph A., Rice, Jerry M.
The tumor-promoting and carcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in the liver and in other organs were quantified and compared to those of phenobarbital (PB) in...
Mouse Liver Carcinogenesis: Mechanisms and Relevance (1991)
GOODMAN, JAY I., WARD, JERROLD M., POPP, JAMES A., KLAUNIG, JAMES E., FOX, TONY R.
Symposium Overview: Mouse Liver Carcinogenesis: Mechanisms and Relevance. GOODMAN, J. I., WARD, J. M., POPP, J. A., KALUNIG, J. E., AND FOX, T. R. (1991). Fundam. Appl. Toxicol. 17, 651–665.
Konishi, Noboru, Donovan, Paul J., Ward, Jerrold M.
To evaluate the effects of renal carcinogens and tumor promoters on gap junctional intercellular communication (IC) and colony formation, two rat kidney epithelial cell lines were examined in vitro....
Konishi, Noboru, Diwan, Bhalachandra A., Ward, Jerrold M.
The renal tumor promoting activity of barbital sodium (BBNa) and the role of renal tubular cell hyperplasia in tumor promotion following initiation with streptoxotocin (STZ) was investigated. Six...
Takayuki, Enomoto, Ward, Jerrold M., Perantoni, Alan O.
Bladder tumors were induced in male K344/NCr rats by administration of N-butyl-N-(4-hydroxybutyl)nltrosamine (BBN) at 500 p.p.m. in their drinking water for 12 weeks. Twenty-one bladder tumors...
WARD, JERROLD M., TSUDA, HIROYUKI, TATEMATSU, MASAE, HAGIWARA, AKIHIRO, ITO, NOBUYUKI
Hepatotoxicity of Agents That Enhance Formation of Focal Hepatocellular Proliferative Lesions (Putative Preneoplastic Foci) in a Rapid Rat Liver Bioassay. WARD, J. M., TSUDA, H., TATEMATSU, M.,...
HAGIWARA, AKIHIRO, DIWAN, BHALCHANDRA A., WARD, JERROLD M.
The nephrotoxicity of barbital sodium (NaBB), a renal and urinary bladder tumor promoter, was investigated in male F344/NCr rats. In an 8-week toxicity study, NaBB was administered to 6-week-old...
Diwan, Bhalchandra A., Ward, Jerrold M., Rice, Jerry M.
In order to analyze the genetics of susceptibility to promotion of hepatocarcinogenesis in DBA/2NCr and C57BL/6NCr mice by phenobarbital (PB), reciprocal F1 hybrid male mice were given 90 mg...
Stowers, S.Jill, Wiseman, Roger W., Ward, Jerrold M., Miller, Elizabeth C., Miller, James A., Anderson, Marshall W., ...
DNA from B6C3F1 mouse and Fischer 344 rat liver tumors induced by N-nitrosodiethylamine (DEN) were examined for the ability to induce morphological transformation of NIH3T3 cells. DNAs from 14 of 33...
Kasprzak, Kazimierz S., Ward, Jerrold M., Poirier, Lionel A., Reichardt, Della A., Denn, Alfred C., Reynolds, Craig W.
The effects of magnesium carbonate (MgCarb) on carcinogenesis and natural killer (NK) cell modulation by nickel subsulfide (NI3S2) were studied. Male Fischer F344/NCr rats, 50–90 g body wt, 20...
Diwan, Bhalchandra A., Rice, Jerry M., Ward, Jerrold M.
The widely used benzodiazepine tranquilizers diazepam and oxazepam promoted development of hepatocellular hyperplastic foci and hepatocellular neoplasms (adenomas and carcinomas) when they were fed...
Diwan, Bhalchandra A., Rice, Jerry M., Ohshima, Masato, Ward, Jerrold M.
Selected inbred strains of mice were compared with respect to their susceptibility to two-stage liver carcinogenesis. Five-week-old male mice of strains C57BL/6NCr (C57), C3H/HeNCrMTV- (C3H)...
Ward, Jerrold M., Pardue, Robert L., Junker, James L., Takahashi, Kiyoshi, Shih, Thomas Y., Weislow, Owen S.
An affinity purified sheep IgG antibody to a 20 amino acid peptide from the carboxyterminal end of RasHa p21 was used to localize RasHa p21 on fixed tissue sections of Harvey sarcoma (HaSV)...
HAGIWARA, AKJHIRO, WARD, JERROLD M.
The Chronic Hepatotoxic, Tumor-Promoting, and Carcinogenic Effects of Acetaminophen in Male B6C3F1 Mice. HAGIWARA, A., AND WARD, J.M. (1986). Fundam. Appl. Toxicol. 7, 376-386. Acetaminophen (ACT),...
Ward, Jerrold M., Ohshima, Masato
Aged female F344/NCr rats were exposed to phenobarbital (PB), 500 p.p.m. in the drinking water, from 26 months of age, for periods of 4, 8 or 9–27 weeks. In groups of control and PB-exposed...
Diwan, Bhalchandra A., Ward, Jerrold M., Rice, Jerry M., Colburn, Nancy H., Spangler, Edwin F.
Di(2-ethylhexyl)phthalate (DEHP), a confirmed promoter of hepatocellular cardnogenesis in mice, was studied for tumorpromoting activity on the skin of SENCAR mice in vivo and on JB6 mouse epidermal...
A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors
Crabtree, Judy S., Scacheri, Peter C., Ward, Jerrold M., Garrett-Beal, Lisa, Emmert-Buck, Michael R., Edgemon, Keith A., ...
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant cancer syndrome, characterized primarily by multiple tumors in the parathyroid glands, endocrine pancreas, and anterior pituitary....
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice
Gnarra, James R., Ward, Jerrold M., Porter, Forbes D., Wagner, Joseph R., Devor, Deborah E., Grinberg, Alex, ...
Inheritance of an inactivated form of the VHL tumor suppressor gene predisposes patients to develop von Hippel–Lindau disease, and somatic VHL inactivation is an early genetic event leading to the...
Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz[a]anthracene-induced lymphomas
Buters, Jeroen T. M., Sakai, Shuichi, Richter, Thomas, Pineau, Thierry, Alexander, David L., Savas, Uzen, ...
CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype, thus establishing that...
Peters, Jeffrey M., Lee, Susanna S. T., Li, Wen, Ward, Jerrold M., Gavrilova, Oksana, Everett, Carrie, ...
To determine the physiological roles of peroxisome proliferator-activated receptor β (PPARβ), null mice were constructed by targeted disruption of the ligand binding domain of the murine PPARβ...
Ras-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development
Esteban, Luis M., Fernández-Medarde, Alberto, López, Eva, Yienger, Kate, Guerrero, Carmen, Ward, Jerrold M., ...
The mammalian sos1 and sos2 genes encode highly homologous members of the Son-of-sevenless family of guanine nucleotide exchange factors. They are ubiquitously expressed and play key roles in...
Esteban, Luis M., Vicario-Abejón, Carlos, Fernández-Salguero, Pedro, Fernández-Medarde, Alberto, Swaminathan, Nalini, Yienger, Kate, ...
Mammalian cells harbor three highly homologous and widely expressed members of the ras family (H-ras, N-ras, and K-ras), but it remains unclear whether they play specific or overlapping cellular...
Helicobacter typhlonius sp. nov., a Novel Murine Urease-Negative Helicobacter Species
Franklin, Craig L., Gorelick, Peter L., Riley, Lela K., Dewhirst, Floyd E., Livingston, Robert S., Ward, Jerrold M., ...
Over the past decade, several Helicobacter species have been isolated from rodents. With the advent of PCR for the diagnosis of infectious agents, it has become clear that several previously...
Fox, James G., Gorelick, Peter L., Kullberg, Marika C., Ge, Zhongming, Dewhirst, Floyd E., Ward, Jerrold M.
A spiral-shaped bacterium with bipolar, single-sheathed flagella was isolated from the intestines of IL-10 (interleukin-10)-deficient (IL-10−/−) mice with inflammatory bowel disease. The organism...
Hayhurst, Graham P., Lee, Ying-Hue, Lambert, Gilles, Ward, Jerrold M., Gonzalez, Frank J.
The numerous functions of the liver are controlled primarily at the transcriptional level by the concerted actions of a limited number of hepatocyte-enriched transcription factors (hepatocyte nuclear...
Niimi, Tomoaki, Nagashima, Kunio, Ward, Jerrold M., Minoo, Parviz, Zimonjic, Drazen B., Popescu, Nicholas C., ...
T/EBP/NKX2.1, a member of the NKX family of homeodomain-containing transcription factors, regulates the expression of a number of genes in lung and thyroid. Here we describe the isolation and...
Kullberg, Marika C., Ward, Jerrold M., Gorelick, Peter L., Caspar, Patricia, Hieny, Sara, Cheever, Allen, ...
Mice rendered deficient in interleukin-10 (IL-10) by gene targeting (IL-10−/− mice) develop chronic enterocolitis resembling human inflammatory bowel disease (IBD) when maintained in conventional...
IL-6 transgenic mouse model for extraosseous plasmacytoma
Kovalchuk, Alexander L., Kim, Joong Su, Park, Sung Sup, Coleman, Allen E., Ward, Jerrold M., Morse, Herbert C., ...
Plasma cell neoplasms in humans comprise plasma cell myeloma, otherwise known as multiple myeloma, Ig deposition and heavy chain diseases, and plasmacytoma (PCT). A subset of PCT, designated...
Matsusue, Kimihiko, Haluzik, Martin, Lambert, Gilles, Yim, Sun-Hee, Gavrilova, Oksana, Ward, Jerrold M., ...
To elucidate the function of PPARγ in leptin-deficient mouse (ob/ob) liver, a PPARγ liver-null mouse on an ob/ob background, ob/ob-PPARγ(fl/fl)AlbCre+, was produced using a floxed PPARγ allele,...
Ras-GRF1 signaling is required for normal β-cell development and glucose homeostasis
Font De Mora, Jaime, Esteban, Luis Miguel, Burks, Deborah J., Núñez, Alejandro, Garcés, Carmen, García-Barrado, María José, ...
Development of diabetes generally reflects an inadequate mass of insulin-producing β-cells. β-cell proliferation and differentiation are regulated by a variety of growth factors and hormones,...
Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout
Crabtree, Judy S., Scacheri, Peter C., Ward, Jerrold M., McNally, Sara R., Swain, Gary P., Montagna, Cristina, ...
Patients with multiple endocrine neoplasia type 1 (MEN1) develop multiple endocrine tumors, primarily affecting the parathyroid, pituitary, and endocrine pancreas, due to the inactivation of the MEN1...
Qian, Xiaolan, Esteban, Luis, Vass, William C., Upadhyaya, Cheerag, Papageorge, Alex G., Yienger, Kate, ...
Targeted disruption of both alleles of mouse sos1, which encodes a Ras-specific exchange factor, conferred mid-gestational embryonic lethality that was secondary to impaired placental development and...
Kurtzman, Cletus P., Robnett, Christie J., Ward, Jerrold M., Brayton, Cory, Gorelick, Peter, Walsh, Thomas J.
A yeast causing widespread infection of laboratory mice was identified from 26S rRNA gene sequences as Candida pintolopesii. To determine the relationship of C. pintolopesii with other members of the...
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals
Hisa, Tomoyuki, Spence, Sally E, Rachel, Rivka A, Fujita, Masami, Nakamura, Takuro, Ward, Jerrold M, ...
Meis1 and Hoxa9 expression is upregulated by retroviral integration in murine myeloid leukemias and in human leukemias carrying MLL translocations. Both genes also cooperate to induce leukemia in a...
Morimura, Keiichirou, Cheung, Connie, Ward, Jerrold M., Reddy, Janardan K., Gonzalez, Frank J.
Peroxisome proliferators, such as lipid-lowering fibrate drugs, are agonists for the peroxisome proliferator-activated receptor α (PPARα). Sustained activation of PPARα leads to the development of...
Dph3, a Small Protein Required for Diphthamide Biosynthesis, Is Essential in Mouse Development
Liu, Shihui, Wiggins, Jason F., Sreenath, Taduru, Kulkarni, Ashok B., Ward, Jerrold M., Leppla, Stephen H.
The translation elongation factor 2 in eukaryotes (eEF-2) contains a unique posttranslationally modified histidine residue, termed diphthamide, which serves as the only target for diphtheria toxin...
A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors
Crabtree, Judy S., Scacheri, Peter C., Ward, Jerrold M., Garrett-Beal, Lisa, Emmert-Buck, Michael R., Edgemon, Keith A., ...
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant cancer syndrome, characterized primarily by multiple tumors in the parathyroid glands, endocrine pancreas, and anterior pituitary....
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice
Gnarra, James R., Ward, Jerrold M., Porter, Forbes D., Wagner, Joseph R., Devor, Deborah E., Grinberg, Alex, ...
Inheritance of an inactivated form of the VHL tumor suppressor gene predisposes patients to develop von Hippel–Lindau disease, and somatic VHL inactivation is an early genetic event leading to the...
Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz[a]anthracene-induced lymphomas
Buters, Jeroen T. M., Sakai, Shuichi, Richter, Thomas, Pineau, Thierry, Alexander, David L., Savas, Uzen, ...
CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype, thus establishing that...
Peters, Jeffrey M., Lee, Susanna S. T., Li, Wen, Ward, Jerrold M., Gavrilova, Oksana, Everett, Carrie, ...
To determine the physiological roles of peroxisome proliferator-activated receptor β (PPARβ), null mice were constructed by targeted disruption of the ligand binding domain of the murine PPARβ...
Ras-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development
Esteban, Luis M., Fernández-Medarde, Alberto, López, Eva, Yienger, Kate, Guerrero, Carmen, Ward, Jerrold M., ...
The mammalian sos1 and sos2 genes encode highly homologous members of the Son-of-sevenless family of guanine nucleotide exchange factors. They are ubiquitously expressed and play key roles in...
Esteban, Luis M., Vicario-Abejón, Carlos, Fernández-Salguero, Pedro, Fernández-Medarde, Alberto, Swaminathan, Nalini, Yienger, Kate, ...
Mammalian cells harbor three highly homologous and widely expressed members of the ras family (H-ras, N-ras, and K-ras), but it remains unclear whether they play specific or overlapping cellular...
Helicobacter typhlonius sp. nov., a Novel Murine Urease-Negative Helicobacter Species
Franklin, Craig L., Gorelick, Peter L., Riley, Lela K., Dewhirst, Floyd E., Livingston, Robert S., Ward, Jerrold M., ...
Over the past decade, several Helicobacter species have been isolated from rodents. With the advent of PCR for the diagnosis of infectious agents, it has become clear that several previously...
Fox, James G., Gorelick, Peter L., Kullberg, Marika C., Ge, Zhongming, Dewhirst, Floyd E., Ward, Jerrold M.
A spiral-shaped bacterium with bipolar, single-sheathed flagella was isolated from the intestines of IL-10 (interleukin-10)-deficient (IL-10−/−) mice with inflammatory bowel disease. The organism...
Hayhurst, Graham P., Lee, Ying-Hue, Lambert, Gilles, Ward, Jerrold M., Gonzalez, Frank J.
The numerous functions of the liver are controlled primarily at the transcriptional level by the concerted actions of a limited number of hepatocyte-enriched transcription factors (hepatocyte nuclear...
Niimi, Tomoaki, Nagashima, Kunio, Ward, Jerrold M., Minoo, Parviz, Zimonjic, Drazen B., Popescu, Nicholas C., ...
T/EBP/NKX2.1, a member of the NKX family of homeodomain-containing transcription factors, regulates the expression of a number of genes in lung and thyroid. Here we describe the isolation and...
Kullberg, Marika C., Ward, Jerrold M., Gorelick, Peter L., Caspar, Patricia, Hieny, Sara, Cheever, Allen, ...
Mice rendered deficient in interleukin-10 (IL-10) by gene targeting (IL-10−/− mice) develop chronic enterocolitis resembling human inflammatory bowel disease (IBD) when maintained in conventional...
IL-6 transgenic mouse model for extraosseous plasmacytoma
Kovalchuk, Alexander L., Kim, Joong Su, Park, Sung Sup, Coleman, Allen E., Ward, Jerrold M., Morse, Herbert C., ...
Plasma cell neoplasms in humans comprise plasma cell myeloma, otherwise known as multiple myeloma, Ig deposition and heavy chain diseases, and plasmacytoma (PCT). A subset of PCT, designated...
Matsusue, Kimihiko, Haluzik, Martin, Lambert, Gilles, Yim, Sun-Hee, Gavrilova, Oksana, Ward, Jerrold M., ...
To elucidate the function of PPARγ in leptin-deficient mouse (ob/ob) liver, a PPARγ liver-null mouse on an ob/ob background, ob/ob-PPARγ(fl/fl)AlbCre+, was produced using a floxed PPARγ allele,...
Ras-GRF1 signaling is required for normal β-cell development and glucose homeostasis
Font De Mora, Jaime, Esteban, Luis Miguel, Burks, Deborah J., Núñez, Alejandro, Garcés, Carmen, García-Barrado, María José, ...
Development of diabetes generally reflects an inadequate mass of insulin-producing β-cells. β-cell proliferation and differentiation are regulated by a variety of growth factors and hormones,...
Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout
Crabtree, Judy S., Scacheri, Peter C., Ward, Jerrold M., McNally, Sara R., Swain, Gary P., Montagna, Cristina, ...
Patients with multiple endocrine neoplasia type 1 (MEN1) develop multiple endocrine tumors, primarily affecting the parathyroid, pituitary, and endocrine pancreas, due to the inactivation of the MEN1...
Qian, Xiaolan, Esteban, Luis, Vass, William C., Upadhyaya, Cheerag, Papageorge, Alex G., Yienger, Kate, ...
Targeted disruption of both alleles of mouse sos1, which encodes a Ras-specific exchange factor, conferred mid-gestational embryonic lethality that was secondary to impaired placental development and...
Kurtzman, Cletus P., Robnett, Christie J., Ward, Jerrold M., Brayton, Cory, Gorelick, Peter, Walsh, Thomas J.
A yeast causing widespread infection of laboratory mice was identified from 26S rRNA gene sequences as Candida pintolopesii. To determine the relationship of C. pintolopesii with other members of the...
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals
Hisa, Tomoyuki, Spence, Sally E, Rachel, Rivka A, Fujita, Masami, Nakamura, Takuro, Ward, Jerrold M, ...
Meis1 and Hoxa9 expression is upregulated by retroviral integration in murine myeloid leukemias and in human leukemias carrying MLL translocations. Both genes also cooperate to induce leukemia in a...
Dph3, a Small Protein Required for Diphthamide Biosynthesis, Is Essential in Mouse Development
Liu, Shihui, Wiggins, Jason F., Sreenath, Taduru, Kulkarni, Ashok B., Ward, Jerrold M., Leppla, Stephen H.
The translation elongation factor 2 in eukaryotes (eEF-2) contains a unique posttranslationally modified histidine residue, termed diphthamide, which serves as the only target for diphtheria toxin...
Ivanov, Sergey V., Ward, Jerrold M., Tessarollo, Lino, McAreavey, Dorothea, Sachdev, Vandana, Fananapazir, Lameh, ...
CACNA2D2 is a putative tumor suppressor gene located in the human chromosome 3p21.3 region that shows frequent allelic imbalances in lung, breast, and other cancers. The α2δ-2 protein encoded by...
Prophylactic and Therapeutic Efficacy of Human Monoclonal Antibodies against H5N1 Influenza
Simmons, Cameron P, Bernasconi, Nadia L, Suguitan, Amorsolo L, Mills, Kimberly, Ward, Jerrold M, Chau, Nguyen Van Vinh, ...
Cameron Simmons and colleagues provide proof of concept that human monoclonal antibodies with neutralizing activity can be rapidly generated from peripheral blood of convalescent patients and are...
Ward, Jerrold M., Yoon, Michung, Anver, Miriam R., Haines, Diana C., Kudo, Gen, Gonzalez, Frank J., ...
The C57BL/6, 129, and B6,129 mouse strains or stocks have been commonly used to generate targeted mutant mice. The pathology of these mice is not well characterized. In studies of these aging mice,...
Milner, Joshua D., Ward, Jerrold M., Keane-Myers, Andrea, Paul, William E.
Lymphopenia and restricted T cell repertoires in humans are often associated with severe eosinophilic disease and a T cell Th2 bias. To examine the pathogenesis of this phenomenon, C57BL/6...
Hartley, Janet W, Evans, Leonard H, Green, Kim Y, Naghashfar, Zohreh, Macias, Alfonso R, Zerfas, Patricia M, ...
The mouse macrophage-like cell line RAW264.7, the most commonly used mouse macrophage cell line in medical research, was originally reported to be free of replication-competent murine leukemia virus...
Choukèr, Alexander, Thiel, Manfred, Lukashev, Dmitriy, Ward, Jerrold M, Kaufmann, Ines, Apasov, Sergey, ...
Whole body exposure of wild type control littermates and A2A adenosine receptor (A2AR) gene deleted mice to low oxygen containing inspired gas mixture allowed the investigation of the mechanism that...
La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys
Bennett, Richard S, Cress, Christina M, Ward, Jerrold M, Firestone, Cai-Yen, Murphy, Brian R, Whitehead, Stephen S
Comparative Neuropathogenesis and Neurovirulence of Attenuated Flaviviruses in Nonhuman Primates▿ †
Maximova, Olga A., Ward, Jerrold M., Asher, David M., St. Claire, Marisa, Finneyfrock, Brad W., Speicher, James M., ...
Based on previous preclinical evaluation in mice and monkeys, the chimeric TBEV/DEN4Δ30 virus, carrying the prM and E protein genes from a highly virulent Far Eastern strain of tick-borne...
Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man
Lim, Jean K., Lisco, Andrea, McDermott, David H., Huynh, Linda, Ward, Jerrold M., Johnson, Bernard, ...
West Nile virus (WNV) is a re-emerging pathogen that can cause fatal encephalitis. In mice, susceptibility to WNV has been reported to result from a single point mutation in oas1b, which encodes...
Oakley, Miranda S., McCutchan, Thomas F., Anantharaman, Vivek, Ward, Jerrold M., Faucette, Laurence, Erexson, Cindy, ...
Cerebral malaria (CM) is a primary cause of malaria-associated deaths among young African children. Yet no diagnostic tools are available that could be used to predict which of the children infected...
Sood, Cindy L., Ward, Jerrold M., Moss, Bernard
The vaccinia virus I5L open reading frame encodes a 79-amino-acid protein, with two predicted transmembrane domains, that is conserved among all sequenced members of the chordopoxvirus subfamily. No...
Collin, Nicolas, Gomes, Regis, Teixeira, Clarissa, Cheng, Lily, Laughinghouse, Andre, Ward, Jerrold M., ...
Immunity to a sand fly salivary protein protects against visceral leishmaniasis (VL) in hamsters. This protection was associated with the development of cellular immunity in the form of a...
Moayeri, Mahtab, Crown, Devorah, Dorward, David W., Gardner, Don, Ward, Jerrold M., Li, Yan, ...
Anthrax lethal toxin (LT) induces vascular insufficiency in experimental animals through unknown mechanisms. In this study, we show that neuronal nitric oxide synthase (nNOS) deficiency in mice...
Bukreyev, Alexander, Yang, Lijuan, Fricke, Jens, Cheng, Lily, Ward, Jerrold M., Murphy, Brian R., ...
Respiratory syncytial virus (RSV) readily infects and reinfects during infancy and throughout life, despite maternal antibodies and immunity from prior infection and without the need for significant...
Perdue, Kathy A, Copeland, Michelle K, Karjala, Zuzana, Cheng, Lily I, Ward, Jerrold M, Elkins, William R
Spironucleus muris is an unacceptable infectious agent for most rodent colonies. Exposure of sentinel mice to dirty bedding and examination of sentinel intestinal smears was not sufficient for...
Visceral and Neural Larva Migrans in Rhesus Macaques
Gozalo, Alfonso S, Maximova, Olga A, StClaire, Marisa C, Montali, Richard J, Ward, Jerrold M, Cheng, Lily I, ...
Large ascarid larvae within granulomas were noted histologically in the mesenteric and pancreatic lymph nodes of 13 of 21 rhesus macaques (Macaca mulatta) euthanized as part of an experimental viral...
Liu, Qi, Cheng, Lily I., Yi, Liang, Zhu, Nannan, Wood, Adam, Changpriroa, Cattlena May, ...
Nicotinamide dinucleotide phosphate oxidase-deficient (p47phox−/−) mice are a model of human chronic granulomatous disease; these mice are prone to develop systemic infections and inflammatory...
Pathology of Captive Moustached Tamarins (Saguinus mystax)
Gozalo, Alfonso S, Cheng, Lily I, Claire, Marisa E St, Ward, Jerrold M, Elkins, William R
The pathology of 33 moustached tamarins (Saguinus mystax) previously used in hepatitis A and GB virus studies is reported. Chronic lesions in colon, heart, and kidney were common in the monkeys and...
Buchholz, Ursula J., Ward, Jerrold M., Lamirande, Elaine W., Heinze, Britta, Krempl, Christine D., Collins, Peter L.
Pneumonia virus of mice (PVM) strain 15 causes fatal pneumonia in mice and provides a convenient model for human respiratory syncytial virus pathogenesis and immunobiology. We prepared PVM mutants...
Pathogenic Roles of CD14, Galectin-3, and OX40 during Experimental Cerebral Malaria in Mice
Oakley, Miranda S., Majam, Victoria, Mahajan, Babita, Gerald, Noel, Anantharaman, Vivek, Ward, Jerrold M., ...
An in-depth knowledge of the host molecules and biological pathways that contribute towards the pathogenesis of cerebral malaria would help guide the development of novel prognostics and...