Michalak, Ewa M., Vandenberg, Cassandra J., Delbridge, Alex R.D., Wu, Li, Scott, Clare L., Adams, Jerry M., ...
Although tumor development requires impaired apoptosis, we describe a novel paradigm of apoptosis-dependent tumorigenesis. Because DNA damage triggers apoptosis through p53-mediated induction of...
Coultas, Leigh, Terzano, Susanna, Thomas, Tim, Voss, Anne, Reid, Kate, Stanley, Edouard G., ...
The pro-apoptotic BH3-only members of the Bcl2 family, crucial initiators of cell death, are activated by a diverse array of developmental cues or experimentally applied stress stimuli. We have...
Coultas, Leigh, Terzano, Susanna, Thomas, Tim, Voss, Anne, Reid, Kate, Stanley, Edouard G., ...
The pro-apoptotic BH3-only members of the Bcl2 family, crucial initiators of cell death, are activated by a diverse array of developmental cues or experimentally applied stress stimuli. We have...
Coultas, Leigh, Terzano, Susanna, Thomas, Tim, Voss, Anne, Reid, Kate, Stanley, Edouard G., ...
The pro-apoptotic BH3-only members of the Bcl2 family, crucial initiators of cell death, are activated by a diverse array of developmental cues or experimentally applied stress stimuli. We have...
Coultas, Leigh, Terzano, Susanna, Thomas, Tim, Voss, Anne, Reid, Kate, Stanley, Edouard G., ...
The pro-apoptotic BH3-only members of the Bcl2 family, crucial initiators of cell death, are activated by a diverse array of developmental cues or experimentally applied stress stimuli. We have...
Leigh Coultas, Philippe Bouillet, Kate L Loveland, Sarah Meachem, Harris Perlman, Jerry M Adams, ...
Willis, Simon N., Chen, Lin, Dewson, Grant, Wei, Andrew, Naik, Edwina, Fletcher, Jamie I., ...
Commitment of cells to apoptosis is governed largely by the interaction between members of the Bcl-2 protein family. Its three subfamilies have distinct roles: The BH3-only proteins trigger apoptosis...
Willis, Simon N., Chen, Lin, Dewson, Grant, Wei, Andrew, Naik, Edwina, Fletcher, Jamie I., ...
Commitment of cells to apoptosis is governed largely by the interaction between members of the Bcl-2 protein family. Its three subfamilies have distinct roles: The BH3-only proteins trigger apoptosis...
Willis, Simon N., Chen, Lin, Dewson, Grant, Wei, Andrew, Naik, Edwina, Fletcher, Jamie I., ...
Commitment of cells to apoptosis is governed largely by the interaction between members of the Bcl-2 protein family. Its three subfamilies have distinct roles: The BH3-only proteins trigger apoptosis...
Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate (2004)
Caryn Navarro, Hamsa Puthalakath, Jerry M. Adams, Andreas Strasser, Ruth Lehmann
Vanessa S. Marsden, Liam O'Connor, Lorraine A. O'Reilly, John Silke, Donald Metcalf, Paul G. Ekert, ...
Philippe Bouillet, Jared F. Purton, Dale I. Godfrey, Li-Chen Zhang, Leigh Coultas, Hamsa Puthalakath, ...
Bouillet, Phillipe, Zhang, Li. C., Huang, D. C. S., Webb, G. C., Bottema, C. D. K., Shore, Paul, ...
Bouillet, Phillipe, Zhang, Li. C., Huang, D. C. S., Webb, G. C., Bottema, Cynthia Denise Klemme, Shore, Paul, ...
The original publication can be found at www.springerlink.com
Bouillet, Phillipe, Zhang, Li. C., Huang, D. C. S., Webb, G. C., Bottema, Cynthia Denise Klemme, Shore, Paul, ...
The original publication can be found at www.springerlink.com
Bouillet, Phillipe, Zhang, Li. C., Huang, D. C. S., Webb, G. C., Bottema, Cynthia Denise Klemme, Shore, Paul, ...
The original publication can be found at www.springerlink.com
Bouillet, Phillipe, Zhang, Li. C., Huang, D. C. S., Webb, G. C., Bottema, Cynthia Denise Klemme, Shore, Paul, ...
The original publication can be found at www.springerlink.com
Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia (1989)
Kongsuwan, Kritaya, Allen, John, Adams, Jerry M.
The presence of an altered Hox-2.4 gene in the WEHI3B murine myeloid leukemia suggests that homeobox genes may contribute to neoplasia. A survey of 31 leukemia cell lines of the myeloid, lymphoid and...
Adams, Jerry M., Webb, Elizabeth, Gerondakis, Steven, Cory, Suzanne
To investigate the DNA surrounding genes for immunoglobulin heavy chain constant (CH) regions, we have isolated two clones bearing a Cγ3 gene and two bearing a Cγ3 gene from a library of mouse...
Tyler, Brett M., Adams, Jerry M.
We have used heteroduplex analysis to investigate the sequences surrounding the germline Cγ1 and Cγ3 genes, and to compare them with those surrounding the Cμ gene. We detected an inverted...
N-formylmethionyl-sRNA as the initiator of protein synthesis. (1966)
Capecchi, Mario R.;, Adams, Jerry M;
A bizarre fast about Nterminal groups of bacterial proteins. Instead of a random mixture, that the great majority of N-terminal groups were either methionine or alanine. This finding suggested that...
N-formylmethionyl-sRNA as the initiator of protein synthesis. (1966)
Capecchi, Mario R.;, Adams, Jerry M;
A bizarre fast about Nterminal groups of bacterial proteins. Instead of a random mixture, that the great majority of N-terminal groups were either methionine or alanine. This finding suggested that...
N-formylmethionyl-sRNA as the initiator of protein synthesis. (1966)
Capecchi, Mario R.;, Adams, Jerry M;
A bizarre fast about Nterminal groups of bacterial proteins. Instead of a random mixture, that the great majority of N-terminal groups were either methionine or alanine. This finding suggested that...
Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1
Moriishi, Kohji, Huang, David C. S., Cory, Suzanne, Adams, Jerry M.
The Bcl-2 family of proteins regulates apoptosis, the cell death program triggered by activation of certain proteases (caspases). An attractive model for how Bcl-2 and its closest relatives prevent...
Apoptosis regulator Bcl-w is essential for spermatogenesis but appears otherwise redundant
Print, Cristin G., Loveland, Kate L., Gibson, Leonie, Meehan, Terri, Stylianou, Anna, Wreford, Nigel, ...
Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the embryo and adult. The recently isolated bcl-w gene encodes a pro-survival member of the Bcl-2 family, which...
Ogilvy, Sarah, Metcalf, Donald, Print, Cristin G., Bath, Mary L., Harris, Alan W., Adams, Jerry M.
Bcl-2, which can both reduce apoptosis and retard cell cycle entry, is thought to have important roles in hematopoiesis. To evaluate the impact of its ubiquitous overexpression within this system, we...
Bcl-2 Retards Cell Cycle Entry through p27Kip1, pRB Relative p130, and Altered E2F Regulation
Vairo, Gino, Soos, Timothy J., Upton, Todd M., Zalvide, Juan, DeCaprio, James A., Ewen, Mark E., ...
Independent of its antiapoptotic function, Bcl-2 can, through an undetermined mechanism, retard entry into the cell cycle. Cell cycle progression requires the phosphorylation by cyclin-dependent...
Grossmann, Mathis, O’Reilly, Lorraine A., Gugasyan, Raffi, Strasser, Andreas, Adams, Jerry M., Gerondakis, Steve
Rel and RelA, individually dispensable for lymphopoiesis, serve unique functions in activated B and T cells. Here their combined roles in lymphocyte development were examined in chimeric mice...
Coultas, Leigh, Bouillet, Philippe, Stanley, Edouard G., Brodnicki, Thomas C., Adams, Jerry M., Strasser, Andreas
The BH3-only members of the Bcl-2 protein family are essential for initiation of programmed cell death and stress-induced apoptosis. We have determined the expression pattern in mice of the BH3-only...
Willis, Simon N., Chen, Lin, Dewson, Grant, Wei, Andrew, Naik, Edwina, Fletcher, Jamie I., ...
Commitment of cells to apoptosis is governed largely by the interaction between members of the Bcl-2 protein family. Its three subfamilies have distinct roles: The BH3-only proteins trigger apoptosis...
Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis
Coultas, Leigh, Bouillet, Philippe, Loveland, Kate L, Meachem, Sarah, Perlman, Harris, Adams, Jerry M, ...
The BH3-only proteins of the Bcl-2 family initiate apoptosis through the activation of Bax-like relatives. Loss of individual BH3-only proteins can lead either to no phenotype, as in mice lacking...
Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1
Moriishi, Kohji, Huang, David C. S., Cory, Suzanne, Adams, Jerry M.
The Bcl-2 family of proteins regulates apoptosis, the cell death program triggered by activation of certain proteases (caspases). An attractive model for how Bcl-2 and its closest relatives prevent...
Apoptosis regulator Bcl-w is essential for spermatogenesis but appears otherwise redundant
Print, Cristin G., Loveland, Kate L., Gibson, Leonie, Meehan, Terri, Stylianou, Anna, Wreford, Nigel, ...
Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the embryo and adult. The recently isolated bcl-w gene encodes a pro-survival member of the Bcl-2 family, which...
Ogilvy, Sarah, Metcalf, Donald, Print, Cristin G., Bath, Mary L., Harris, Alan W., Adams, Jerry M.
Bcl-2, which can both reduce apoptosis and retard cell cycle entry, is thought to have important roles in hematopoiesis. To evaluate the impact of its ubiquitous overexpression within this system, we...
Bcl-2 Retards Cell Cycle Entry through p27Kip1, pRB Relative p130, and Altered E2F Regulation
Vairo, Gino, Soos, Timothy J., Upton, Todd M., Zalvide, Juan, DeCaprio, James A., Ewen, Mark E., ...
Independent of its antiapoptotic function, Bcl-2 can, through an undetermined mechanism, retard entry into the cell cycle. Cell cycle progression requires the phosphorylation by cyclin-dependent...
Grossmann, Mathis, O’Reilly, Lorraine A., Gugasyan, Raffi, Strasser, Andreas, Adams, Jerry M., Gerondakis, Steve
Rel and RelA, individually dispensable for lymphopoiesis, serve unique functions in activated B and T cells. Here their combined roles in lymphocyte development were examined in chimeric mice...
Coultas, Leigh, Bouillet, Philippe, Stanley, Edouard G., Brodnicki, Thomas C., Adams, Jerry M., Strasser, Andreas
The BH3-only members of the Bcl-2 protein family are essential for initiation of programmed cell death and stress-induced apoptosis. We have determined the expression pattern in mice of the BH3-only...
Willis, Simon N., Chen, Lin, Dewson, Grant, Wei, Andrew, Naik, Edwina, Fletcher, Jamie I., ...
Commitment of cells to apoptosis is governed largely by the interaction between members of the Bcl-2 protein family. Its three subfamilies have distinct roles: The BH3-only proteins trigger apoptosis...
Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis
Coultas, Leigh, Bouillet, Philippe, Loveland, Kate L, Meachem, Sarah, Perlman, Harris, Adams, Jerry M, ...
The BH3-only proteins of the Bcl-2 family initiate apoptosis through the activation of Bax-like relatives. Loss of individual BH3-only proteins can lead either to no phenotype, as in mice lacking...
Erlacher, Miriam, Michalak, Ewa M., Kelly, Priscilla N., Labi, Verena, Niederegger, Harald, Coultas, Leigh, ...
Numerous p53 target genes have been implicated in DNA damage–induced apoptosis signaling, but proapoptotic Bcl-2 (B-cell leukemia 2) family members of the BH3 (Bcl-2 homolog region [BH] 3)–only...
Naik, Edwina, Michalak, Ewa M., Villunger, Andreas, Adams, Jerry M., Strasser, Andreas
To identify the mechanisms of ultraviolet radiation (UVR)–induced cell death, for which the tumor suppressor p53 is essential, we have analyzed mouse embryonic fibroblasts (MEFs) and keratinocytes...
Uren, Rachel T., Dewson, Grant, Chen, Lin, Coyne, Stephanie C., Huang, David C.S., Adams, Jerry M., ...
The Bcl-2 family regulates apoptosis by controlling mitochondrial integrity. To clarify whether its prosurvival members function by sequestering their Bcl-2 homology 3 (BH3)–only ligands or their...
Marsden, Vanessa S., Ekert, Paul G., Van Delft, Mark, Vaux, David L., Adams, Jerry M., Strasser, Andreas
Apoptosis in response to developmental cues and stress stimuli is mediated by caspases that are regulated by the Bcl-2 protein family. Although caspases 2 and 9 have each been proposed as the apical...
Wilson-Annan, Julie, O'Reilly, Lorraine A., Crawford, Simon A., Hausmann, George, Beaumont, Jennifer G., Parma, Loes P., ...
Prosurvival Bcl-2–like proteins, like Bcl-w, are thought to function on organelles such as the mitochondrion and to be targeted to them by their hydrophobic COOH-terminal domain. We unexpectedly...
Hausmann, George, O'Reilly, Lorraine A., Van Driel, Rosemary, Beaumont, Jennifer G., Strasser, Andreas, Adams, Jerry M., ...
How Bcl-2 and its pro-survival relatives prevent activation of the caspases that mediate apoptosis is unknown, but they appear to act through the caspase activator apoptosis protease–activating...
Endogenous bcl-2 is not required for the development of Eμ-myc–induced B-cell lymphoma
Kelly, Priscilla N., Puthalakath, Hamsa, Adams, Jerry M., Strasser, Andreas
Although myc and bcl-2 synergize in tumor development, particularly lymphomagenesis, it is not known whether endogenous bcl-2 is required for myc-induced tumorigenesis. To investigate the role of...
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax
Fletcher, Jamie I., Meusburger, Sarina, Hawkins, Christine J., Riglar, David T., Lee, Erinna F., Fairlie, W. Douglas, ...
A central issue in the control of apoptosis is whether its essential mediators Bax and Bak must be restrained by Bcl-2-like prosurvival relatives to prevent their damaging mitochondria and unleashing...
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins
Mérino, Delphine, Giam, Maybelline, Hughes, Peter D., Siggs, Owen M., Heger, Klaus, O'Reilly, Lorraine A., ...
Proteins of the Bcl-2 family are critical regulators of apoptosis, but how its BH3-only members activate the essential effectors Bax and Bak remains controversial. The indirect activation model...