Diwan, Bhalchandra A., Henneman, John R., Rice, Jerry M., Nims, Raymond W.
To investigate the promoting effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) on liver and thyroid carcinogenesis of rats at doses that cause maximal induction of hepatic CYP2B,...
Higinbotham, Kathleen G., Rice, Jerry M., Reed, Carl D., Watatani, Masahiro, Enomoto, Takayuki, Anderson, Lucy M., ...
Renal mesenchymal tumors were induced at high incidence in F344 rats by a single intraperitoneal injection of methyl(methoxymethyl)nitrosamine (DMN-OMe) within 48 h after birth. DNAs from 18 of 35...
Munoz, Eliana F., Diwan, Bhalchandra A., Calvert, Richard J., Weghorst, Christopher M., Anderson, John, Rice, Jerry M., ...
Cisplatin is an anticancer agent sometimes used in pregnant women. It is also a potent initiator of skin tumors in mice when administered transplacentally. For characterization of the transplacental...
Tamano, Seiko, Ward, Jerrold M., Diwan, Bhalchandra A., Keefer, Larry K., Weghorst, Christopher M., Calvert, Richard J., ...
Glyceryl trinitrate (GTN) was previously reported to induce hepatocellular carcinoma (HCC) in rats after prolonged feeding. The present experiments were undertaken to evaluate the histogenesis and...
Diwan, Bhalchandra A., Rice, Jerry M.
Wilms' tumor of kidney, a common human childhood neoplasm, is modeled by nephroblastomas induced by prenatal exposure of some rodents to alkylating agents. Noble (Nb) rats are especially susceptible....
Ward, Jerrold M., Fox, James G., Anver, Miriam R., Haines, Diana C., George, Cathi V., Collins, Michael J., ...
Background: In the autumn of 1992, a novel form of chronic, active hepatitis of unknown etiology was discovered in mice at the national Cancer Institute-Frederick Cancer Research and Development...
Hecht, Stephen S., Trushin, Neil, Reid-Quinn, Cheri A., Burak, Eric S., Jones, Ann Butler, Southers, Janice L., ...
The metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was examined in the patas monkey, in order to provide further information about NNK metabolic...
Diwan, Bhalchandra A., Henneman, John R., Nims, Raymond W., Rice, Jerry M.
To investigate the liver tumor promoting effects of phenytoin (5, 5-diphenylhydantoin; DPH), 5 week old male D2B6F1 mice were given a single i.p. dose of 90 mg N-nitrosodiethylamine (NDEA)/kg...
Lu, Lee-Jane W., Anderson, Lucy M., Jones, Ann B., Moskal, Thomas J., Salazar, James J., Hokanson, James A., ...
Since DNA adducts have been detected in the placentae of pregnant women who smoke cigarettes, the importance of these adducts as biomarkers of fetal exposure and risk has been evaluated using a...
Enomoto, Takayuki, Weghorst, Christopher M., Ward, Jerrold M., Anderson, Lucy M., Perantoni, Alan O., Rice, Jerry M.
Previous reports from several laboratories have consistently shown that ∼30% of spontaneous hepatocellular adenomas and 70–80% of spontaneous hepatocellular carcinomas found in aged B6C3F1...
Diwan, Bhalchandra A., Lubet, Ronald A., Ward, Jerrold M., Hrabie, Joseph A., Rice, Jerry M.
The tumor-promoting and carcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in the liver and in other organs were quantified and compared to those of phenobarbital (PB) in...
Diwan, Bhalchandra A., Kasprzak, Kazimierz S., Rice, Jerry M.
Nickel(II) acetate (NiAcet), a soluble nickel salt known to be an effective initiator of renal epithelial tumors in adult rats, was studied for possible transplacental carcinogenicity. Pregnant...
Kaufmann, William K., Rice, Jerry M., MacKenzie, Susan A., Smith, Gary J., Wenk, Martin L., Devor, Deborah, ...
Hepatocyte proliferation and damage to DNA were characterized during the initiation phase of carcinogenesis in livers of rats that had received a single administration of the methylating agent...
Kasprzak, Kazimierz S., Diwan, Bhalchandra A., Konishi, Noboru, Misra, Manoj, Rice, Jerry M.
Soluble nickel(II) ion, given to male F344/NCr rats as a single i.p. injection of nickel(II) acetate tetrahydrate at a dose of 90 μmol/kg body weight at 5 weeks of age, proved an effective...
Anderson, Lucy M., Enomoto, Takayuki, Perantoni, Alan O., Riggs, Charles W., Kovatch, Robert M., Reed, Carl D., ...
N-Nitrosocimetidine (NCM) is a derivative of the drug cimetidine, a methylguanidine derivative used in the treatment of peptic ulcer, and is known to be inactive as a complete mouse skin carcinogen,...
ANDERSON, LUCY M, HAGIWARA, AKIHIRO H, KOVATCH, ROBERT M, REHM, SABINE, RICE, JERRY M
Transplacental Initiation of Liver, Lung, Neurogenic, and Connective Tissue Tumors by N-Nitroso Compounds in Mice. ANDERSON, L. M., HAGIWARA, A., KOVATCH, R. M., REHM, S., AND RICE, J. M. (1989)....
Diwan, Bhalchandra A., Ohshima, Masato, Rice, Jerry M.
Comparative effects of four barbiturates, phenobarbital (PB), amobarbital (AB), sodium barbital (NaBB), and barbituric acid (BA) on the development of neoplasms in the intestinal tract and other...
Diwan, Bhalchandra A., Ward, Jerrold M., Rice, Jerry M.
In order to analyze the genetics of susceptibility to promotion of hepatocarcinogenesis in DBA/2NCr and C57BL/6NCr mice by phenobarbital (PB), reciprocal F1 hybrid male mice were given 90 mg...
Diwan, Bhalchandra A., Rice, Jerry M., Ward, Jerrold M.
The widely used benzodiazepine tranquilizers diazepam and oxazepam promoted development of hepatocellular hyperplastic foci and hepatocellular neoplasms (adenomas and carcinomas) when they were fed...
Diwan, Bhalchandra A., Rice, Jerry M., Ohshima, Masato, Ward, Jerrold M.
Selected inbred strains of mice were compared with respect to their susceptibility to two-stage liver carcinogenesis. Five-week-old male mice of strains C57BL/6NCr (C57), C3H/HeNCrMTV- (C3H)...
Diwan, Bhalchandra A., Ward, Jerrold M., Rice, Jerry M., Colburn, Nancy H., Spangler, Edwin F.
Di(2-ethylhexyl)phthalate (DEHP), a confirmed promoter of hepatocellular cardnogenesis in mice, was studied for tumorpromoting activity on the skin of SENCAR mice in vivo and on JB6 mouse epidermal...
Williams, Gary M., Ohmori, Takaaki, Katayama, Shoichi, Rice, Jerry M.
Administration of phenobarbital for 5 to 7.5 weeks to aged C3HfB/HeN mice with spontaneous liver tumors produced an enhancement of gamma glutamyl transpeptidase activity in the tumors and a...
Carcinogenesis: a late effect of irreversible toxic damage during development
Intrauterine and early postnatal life are periods of exceptionally high susceptibility to certain kinds of chemical carcinogens. The most potent known transplacental carcinogens are direct acting...
Carcinogenesis: a late effect of irreversible toxic damage during development
Intrauterine and early postnatal life are periods of exceptionally high susceptibility to certain kinds of chemical carcinogens. The most potent known transplacental carcinogens are direct acting...