Characterization of the human Nα-terminal acetyltransferase B enzymatic complex (2009)
Ametzazurra, Amagoia, Gázquez, Cristina, Lasa, Marta, Larrea, Esther, Prieto, Jesús, Aldabe, Rafael
Abstract Background Human N α -acetyltransferase complex B (hNatB) is integrated by hNaa20p (hNAT5/hNAT3) and hNaa25p (hMDM20) proteins. Previous data have shown that this enzymatic complex is...
Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease (2009)
Grizot, Sylvestre, Smith, Julianne, Daboussi, Fayza, Prieto, Jesús, Redondo, Pilar, Merino, Nekane, ...
Sequence-specific endonucleases recognizing long target sequences are emerging as powerful tools for genome engineering. These endonucleases could be used to correct deleterious mutations or to...
Prieto, Jesús, Redondo, Pilar, Padró, Daniel, Arnould, Sylvain, Epinat, Jean-Charles, Pâques, Frédéric, ...
Meganucleases are sequence-specific endonucleases with large cleavage sites that can be used to induce efficient homologous gene targeting in cultured cells and plants. These enzymes open novel...
Santamaría, Enrique, Hevia, Henar, Muñoz, Javier, Fernández-Irigoyen, Joaquín, Segura, Victor, Prieto, Jesús, ...
Engineering Th determinants for efficient priming of humoral and cytotoxic T cell responses (2003)
Lasarte, Juan José, Casares, Noelia, Sarobe, Pablo, Ruiz, Marta, Prieto, Jesús, ...
To engineer Th determinants (THd) to prime help for humoral or cytotoxic T cell responses, we modified ovalbumin [OVA323–337] and myoglobin [MYO106–118] eliciting Th1 and Th0...
Casares, Noelia, Lasarte, Juan José, Sarobe, Pablo, Pérez-Mediavilla, Luis Alberto, Ruiz, Marta, ...
Immunization of BALB/c mice with peptide HVSGHRMAWDMMMNWA, encompassing residues 121–135 from hepatitis C virus E1 protein, induced CD4+ Th1 cells as well as a long-lasting CD8+ cytotoxic...
Sarobe, Pablo, Lasarte, Juan José, Casares, Noelia, Baixeras, Elena, Labarga, Pablo, ...
Patients infected with hepatitis C virus (HCV) have an impaired response against HCV antigens while keeping immune competence for other antigens. We hypothesized that expression of HCV proteins in...
Fortes, Puri, Cuevas, Yolanda, Guan, Fei, Liu, Peng, Pentlicky, Sara, Jung, Stephen P., ...
Reducing or eliminating expression of a given gene is likely to require multiple methods to ensure coverage of all of the genes in a given mammalian cell. We and others [Furth, P. A., Choe, W. T.,...
Sarobe, Pablo, Lasarte, Juan José, Zabaleta, Aintzane, Arribillaga, Laura, Arina, Ainhoa, Melero, Ignacio, ...
Hepatitis C virus (HCV) chronic infection is characterized by low or undetectable cellular immune responses against HCV antigens. Some studies have suggested that HCV proteins manipulate the immune...
Anion exchanger 2 is essential for spermiogenesis in mice
Medina, Juan F., Recalde, Sergio, Prieto, Jesús, Lecanda, Jon, Sáez, Elena, Funk, Colin D., ...
Na+-independent anion exchangers (AE) mediate electroneutral exchange of Cl- for \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb}...
Sarobe, Pablo, Lasarte, Juan José, Casares, Noelia, Baixeras, Elena, Labarga, Pablo, ...
Patients infected with hepatitis C virus (HCV) have an impaired response against HCV antigens while keeping immune competence for other antigens. We hypothesized that expression of HCV proteins in...
Fortes, Puri, Cuevas, Yolanda, Guan, Fei, Liu, Peng, Pentlicky, Sara, Jung, Stephen P., ...
Reducing or eliminating expression of a given gene is likely to require multiple methods to ensure coverage of all of the genes in a given mammalian cell. We and others [Furth, P. A., Choe, W. T.,...
Sarobe, Pablo, Lasarte, Juan José, Zabaleta, Aintzane, Arribillaga, Laura, Arina, Ainhoa, Melero, Ignacio, ...
Hepatitis C virus (HCV) chronic infection is characterized by low or undetectable cellular immune responses against HCV antigens. Some studies have suggested that HCV proteins manipulate the immune...
Anion exchanger 2 is essential for spermiogenesis in mice
Medina, Juan F., Recalde, Sergio, Prieto, Jesús, Lecanda, Jon, Sáez, Elena, Funk, Colin D., ...
Na+-independent anion exchangers (AE) mediate electroneutral exchange of Cl- for \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb}...
A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences
Smith, Julianne, Grizot, Sylvestre, Arnould, Sylvain, Duclert, Aymeric, Epinat, Jean-Charles, Chames, Patrick, ...
Meganucleases, or homing endonucleases (HEs) are sequence-specific endonucleases with large (>14 bp) cleavage sites that can be used to induce efficient homologous gene targeting in cultured cells...
Inefficient Chronic Activation of Parietal Cells in Ae2a,b−/− Mice
Recalde, Sergio, Muruzábal, Francisco, Looije, Norbert, Kunne, Cindy, Burrell, María A., Sáez, Elena, ...
In parietal cells, basolateral Ae2 Cl−/HCO3− exchanger (Slc4a2) appears to compensate for luminal H+ pumping while providing Cl− for apical secretion. In mouse and rat, mRNA variants Ae2a,...
Narvaiza, Iñigo, Aparicio, Oscar, Vera, María, Razquin, Nerea, Bortolanza, Sergia, Prieto, Jesús, ...
RNA interference with viral vectors that express short hairpin RNAs (shRNAs) has emerged as a powerful tool for functional genomics and therapeutic purposes. However, little is known about shRNA in...
Prieto, Jesús, Redondo, Pilar, Padró, Daniel, Arnould, Sylvain, Epinat, Jean-Charles, Pâques, Frédéric, ...
Meganucleases are sequence-specific endonucleases with large cleavage sites that can be used to induce efficient homologous gene targeting in cultured cells and plants. These enzymes open novel...
Upregulation of Indoleamine 2,3-Dioxygenase in Hepatitis C Virus Infection▿
Larrea, Esther, Riezu-Boj, José I., Gil-Guerrero, Lucía, Casares, Noelia, Aldabe, Rafael, Sarobe, Pablo, ...
Indoleamine 2,3-dioxygenase (IDO) is induced by proinflammatory cytokines and by CTLA-4-expressing T cells and constitutes an important mediator of peripheral immune tolerance. In chronic hepatitis...
Iñiguez, Maria, Berasain, Carmen, Martinez-Ansó, Eduardo, Bustos, Matilde, Fortes, Puri, Pennica, Diane, ...
Ischemia-reperfusion (I/R) liver injury occurs when blood flow is restored after prolonged ischemia. A short interruption of blood flow (ischemic preconditioning [IP]) induces tolerance to subsequent...
Arenas, Fabián, Hervias, Isabel, Úriz, Miriam, Joplin, Ruth, Prieto, Jesús, Medina, Juan F.
Primary biliary cirrhosis (PBC) is a cholestatic disease associated with autoimmune phenomena and alterations in both biliary bicarbonate excretion and expression of the bicarbonate carrier AE2. The...
Marcaida, María José, Prieto, Jesús, Redondo, Pilar, Nadra, Alejandro D., Alibés, Andreu, Serrano, Luis, ...
Homing endonucleases, also known as meganucleases, are sequence-specific enzymes with large DNA recognition sites. These enzymes can be used to induce efficient homologous gene targeting in cells and...
Characterization of the human Nα-terminal acetyltransferase B enzymatic complex
Ametzazurra, Amagoia, Gázquez, Cristina, Lasa, Marta, Larrea, Esther, Prieto, Jesús, Aldabe, Rafael
Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease
Grizot, Sylvestre, Smith, Julianne, Daboussi, Fayza, Prieto, Jesús, Redondo, Pilar, Merino, Nekane, ...
Sequence-specific endonucleases recognizing long target sequences are emerging as powerful tools for genome engineering. These endonucleases could be used to correct deleterious mutations or to...