Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms (2005)
Rohde, Mikkel, Daugaard, Mads, Jensen, Mette Hartvig, Helin, Kristian, Nylandsted, Jesper, Jäättelä, Marja
Whereas the stress-inducible heat-shock protein 70 (Hsp70) has gained plenty of attention as a putative target for tumor therapy, little is known about the role of other Hsp70 proteins in cancer....
Hansson, Oskar, Nylandsted, Jesper, Castilho, Roger F, Leist, Marcel, Jäättelä, Marja, Brundin, Patrik
Abstract is not available
Olsson, Tomas, Hansson, Oskar, Nylandsted, Jesper, Jäättelä, Marja, Smith, Maj-Lis, Wieloch, Tadeusz
Abstract is not available
Hansson, Oskar, Nylandsted, Jesper, Castilho, Roger F., Leist, Marcel, Jäätela, Marja, Brundin, Patrik
Huntingtons disease (HD) is a neurodegenerative disorder caused by expansion of a polyglutamine tract in a protein called huntingtin. The inducible form of heat shock protein 70 (Hsp70) has been...
Eradication of Glioblastoma, and Breast and Colon Carcinoma Xenografts by Hsp70 Depletion (2002)
Nylandsted, Jesper, Wick, Wolfgang, Hirt, Ulrich A., Brand, Karsten, Rohde, Mikkel, Leist, Marcel, ...
Heat shock protein 70 (Hsp70) is an antiapoptotic chaperone protein highly expressed in human tumors. Here we demonstrate that locoregional application of adenovirus expressing antisense Hsp70 cDNA...
Nylandsted, Jesper, Rohde, Mikkel, Brand, Karsten, Bastholm, Lone, Elling, Folmer, Jäättelä, Marja
Heat shock protein 70 is an antiapoptotic chaperone protein highly expressed in human breast tumors and tumor cell lines. Here, we demonstrate that the mere inhibition of its synthesis by adenoviral...
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms
Rohde, Mikkel, Daugaard, Mads, Jensen, Mette Hartvig, Helin, Kristian, Nylandsted, Jesper, Jäättelä, Marja
Whereas the stress-inducible heat-shock protein 70 (Hsp70) has gained plenty of attention as a putative target for tumor therapy, little is known about the role of other Hsp70 proteins in cancer....
Nylandsted, Jesper, Rohde, Mikkel, Brand, Karsten, Bastholm, Lone, Elling, Folmer, Jäättelä, Marja
Heat shock protein 70 is an antiapoptotic chaperone protein highly expressed in human breast tumors and tumor cell lines. Here, we demonstrate that the mere inhibition of its synthesis by adenoviral...
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms
Rohde, Mikkel, Daugaard, Mads, Jensen, Mette Hartvig, Helin, Kristian, Nylandsted, Jesper, Jäättelä, Marja
Whereas the stress-inducible heat-shock protein 70 (Hsp70) has gained plenty of attention as a putative target for tumor therapy, little is known about the role of other Hsp70 proteins in cancer....
Apoptosome-Independent Activation of the Lysosomal Cell Death Pathway by Caspase-9▿ †
Gyrd-Hansen, Mads, Farkas, Thomas, Fehrenbacher, Nicole, Bastholm, Lone, Høyer-Hansen, Maria, Elling, Folmer, ...
The apoptosome, a heptameric complex of Apaf-1, cytochrome c, and caspase-9, has been considered indispensable for the activation of caspase-9 during apoptosis. By using a large panel of genetically...
Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization
Nylandsted, Jesper, Gyrd-Hansen, Mads, Danielewicz, Agnieszka, Fehrenbacher, Nicole, Lademann, Ulrik, Høyer-Hansen, Maria, ...
Heat shock protein 70 (Hsp70) is a potent survival protein whose depletion triggers massive caspase-independent tumor cell death. Here, we show that Hsp70 exerts its prosurvival function by...