Jian-Guo Zhang

Analysis of 142 genes resolves the rapid diversification of the rice genus (2008)

Zou, Xin-Hui, Zhang, Fu-Min, Zhang, Jian-Guo, Zang, Li-Li, Tang, Liang, Wang, Jun, ...

Abstract Background The completion of rice genome sequencing has made rice and its wild relatives an attractive system for biological studies. Despite great efforts, phylogenetic relationships among...

Dynamics of the SPRY domain-containing SOCS box protein 2 : flexibility of key functional loops (2006)

Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...

The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...

Dynamics of the SPRY domain-containing SOCS box protein 2: flexibility of key functional loops (2006)

Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...

The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...

Dynamics of the SPRY domain-containing SOCS box protein 2 : flexibility of key functional loops (2006)

Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...

The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...

Dynamics of the SPRY domain-containing SOCS box protein 2 : flexibility of key functional loops (2006)

Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...

The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...

Dynamics of the SPRY domain-containing SOCS box protein 2: flexibility of key functional loops (2006)

Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...

The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...

Dynamics of the SPRY domain-containing SOCS box protein 2: Flexibility of key functional loops (2006)

Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...

The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...

Dynamics of the SPRY domain-containing SOCS box protein 2: Flexibility of key functional loops (2006)

Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...

The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...

Dynamics of the SPRY domain-containing SOCS box protein 2: Flexibility of key functional loops (2006)

Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...

The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...

Structure-function relationships of interleukin-6 (1993)

Zhang, Jian-Guo.

Typescript (photocopy) Addenda on front cover lining. Includes bibliographical references (leaves 160-192)

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

Nicholson, Sandra E., De Souza, David, Fabri, Louis J., Corbin, Jason, Willson, Tracy A., Zhang, Jian-Guo, ...

Suppressor of cytokine signaling-3 (SOCS-3) is one member of a family of intracellular inhibitors of signaling pathways initiated by cytokines that use, among others, the common receptor subunit...

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

Zhang, Jian-Guo, Farley, Alison, Nicholson, Sandra E., Willson, Tracy A., Zugaro, Lisa M., Simpson, Richard J., ...

The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors of several cytokine signal transduction pathways. Their expression is induced by cytokine activation of...

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

Zhang, Jian-Guo, Metcalf, Donald, Rakar, Steven, Asimakis, Maria, Greenhalgh, Christopher J., Willson, Tracy A., ...

Suppressor of Cytokine Signaling-1 (SOCS-1) is an essential physiological inhibitor of IFN-γ signaling. Mice lacking this gene die in the early postnatal period from a disease characterized by...

SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation

Krebs, Danielle L., Uren, Rachel T., Metcalf, Donald, Rakar, Steven, Zhang, Jian-Guo, Starr, Robyn, ...

SOCS-6 is a member of the suppressor of cytokine signaling (SOCS) family of proteins (SOCS-1 to SOCS-7 and CIS) which each contain a central SH2 domain and a carboxyl-terminal SOCS box. SOCS-1,...

Development of hydrocephalus in mice lacking SOCS7

Krebs, Danielle L., Metcalf, Donald, Merson, Tobias D., Voss, Anne K., Thomas, Tim, Zhang, Jian-Guo, ...

SOCS7 is a member of the suppressor of cytokine signaling (SOCS) family of proteins (SOCS1-SOCS7 and CIS). SOCS proteins are composed of an N-terminal domain of variable length, a central Src...

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling

Nicholson, Sandra E., Metcalf, Donald, Sprigg, Naomi S., Columbus, Ruth, Walker, Francesca, Silva, Anabel, ...

The suppressors of cytokine signaling (SOCS) proteins are a family of SH2 domain-containing intracellular inhibitors of cytokine signal transduction that act by several different mechanisms. Recent...

SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor–deficient mice

Lindeman, Geoffrey J., Wittlin, Sergio, Lada, Hania, Naylor, Matthew J., Santamaria, Margaret, Zhang, Jian-Guo, ...

Prolactin is essential for proliferation and differentiation of the developing mammary gland. We have explored a role for Suppressor of Cytokine Signaling 1 (SOCS1) as a modulator of the prolactin...

Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination

Emery, Ben, Cate, Holly S., Marriott, Mark, Merson, Tobias, Binder, Michele D., Snell, Cameron, ...

Enhancement of oligodendrocyte survival through activation of leukemia inhibitory factor receptor (LIFR) signaling is a candidate therapeutic strategy for demyelinating disease. However, in other...

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

Nicholson, Sandra E., De Souza, David, Fabri, Louis J., Corbin, Jason, Willson, Tracy A., Zhang, Jian-Guo, ...

Suppressor of cytokine signaling-3 (SOCS-3) is one member of a family of intracellular inhibitors of signaling pathways initiated by cytokines that use, among others, the common receptor subunit...

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

Zhang, Jian-Guo, Farley, Alison, Nicholson, Sandra E., Willson, Tracy A., Zugaro, Lisa M., Simpson, Richard J., ...

The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors of several cytokine signal transduction pathways. Their expression is induced by cytokine activation of...

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

Zhang, Jian-Guo, Metcalf, Donald, Rakar, Steven, Asimakis, Maria, Greenhalgh, Christopher J., Willson, Tracy A., ...

Suppressor of Cytokine Signaling-1 (SOCS-1) is an essential physiological inhibitor of IFN-γ signaling. Mice lacking this gene die in the early postnatal period from a disease characterized by...

SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation

Krebs, Danielle L., Uren, Rachel T., Metcalf, Donald, Rakar, Steven, Zhang, Jian-Guo, Starr, Robyn, ...

SOCS-6 is a member of the suppressor of cytokine signaling (SOCS) family of proteins (SOCS-1 to SOCS-7 and CIS) which each contain a central SH2 domain and a carboxyl-terminal SOCS box. SOCS-1,...

SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor–deficient mice

Lindeman, Geoffrey J., Wittlin, Sergio, Lada, Hania, Naylor, Matthew J., Santamaria, Margaret, Zhang, Jian-Guo, ...

Prolactin is essential for proliferation and differentiation of the developing mammary gland. We have explored a role for Suppressor of Cytokine Signaling 1 (SOCS1) as a modulator of the prolactin...

Development of hydrocephalus in mice lacking SOCS7

Krebs, Danielle L., Metcalf, Donald, Merson, Tobias D., Voss, Anne K., Thomas, Tim, Zhang, Jian-Guo, ...

SOCS7 is a member of the suppressor of cytokine signaling (SOCS) family of proteins (SOCS1-SOCS7 and CIS). SOCS proteins are composed of an N-terminal domain of variable length, a central Src...

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling

Nicholson, Sandra E., Metcalf, Donald, Sprigg, Naomi S., Columbus, Ruth, Walker, Francesca, Silva, Anabel, ...

The suppressors of cytokine signaling (SOCS) proteins are a family of SH2 domain-containing intracellular inhibitors of cytokine signal transduction that act by several different mechanisms. Recent...

Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination

Emery, Ben, Cate, Holly S., Marriott, Mark, Merson, Tobias, Binder, Michele D., Snell, Cameron, ...

Enhancement of oligodendrocyte survival through activation of leukemia inhibitory factor receptor (LIFR) signaling is a candidate therapeutic strategy for demyelinating disease. However, in other...

Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene

Alexander, Warren S., Viney, Elizabeth M., Zhang, Jian-Guo, Metcalf, Donald, Kauppi, Maria, Hyland, Craig D., ...

An N-ethyl-N-nitrosourea mutagenesis screen in mice was performed to isolate regulators of circulating platelet number. We report here recessive thrombocytopenia and kidney disease in plt1 mice,...

Agm1/Pgm3-Mediated Sugar Nucleotide Synthesis Is Essential for Hematopoiesis and Development▿

Greig, Kylie T., Antonchuk, Jennifer, Metcalf, Donald, Morgan, Phillip O., Krebs, Danielle L., Zhang, Jian-Guo, ...

Carbohydrate modification of proteins includes N-linked and O-linked glycosylation, proteoglycan formation, glycosylphosphatidylinositol anchor synthesis, and O-GlcNAc modification. Each of these...

An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor

Huyton, Trevor, Zhang, Jian-Guo, Luo, Cindy S., Lou, Mei-Zhen, Hilton, Douglas J., Nicola, Nicos A., ...

Leukemia inhibitory factor (LIF) receptor is a cell surface receptor that mediates the actions of LIF and other IL-6 type cytokines through the formation of high-affinity signaling complexes with...

Dynamics of the SPRY domain–containing SOCS box protein 2: Flexibility of key functional loops

Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...

The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...

Analysis of 142 genes resolves the rapid diversification of the rice genus

Zou, Xin-Hui, Zhang, Fu-Min, Zhang, Jian-Guo, Zang, Li-Li, Tang, Liang, Wang, Jun, ...

The relationships among all diploid genome types of the rice genus were clarified using 142 single-copy genes

Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy

White, Christine A., Zhang, Jian-Guo, Salamonsen, Lois A., Baca, Manuel, Fairlie, W. Douglas, Metcalf, Donald, ...

Blastocyst implantation is a critical stage in the establishment of pregnancy. Leukemia inhibitory factor (LIF) is essential for mouse blastocyst implantation and also plays a role in human...

Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia

Kile, Benjamin T., Panopoulos, Athanasia D., Stirzaker, Roslynn A., Hacking, Douglas F., Tahtamouni, Lubna H., Willson, Tracy A., ...

A pivotal mediator of actin dynamics is the protein cofilin, which promotes filament severing and depolymerization, facilitating the breakdown of existing filaments, and the enhancement of filament...