Interactions between Sox9 and {beta}-catenin control chondrocyte differentiation (2004)
Akiyama, Haruhiko, Lyons, Jon P., Mori-Akiyama, Yuko, Yang, Xiaohong, Zhang, Ren, Zhang, Zhaoping, ...
Chondrogenesis is a multistep process that is essential for endochondral bone formation. Previous results have indicated a role for β-catenin and Wnt signaling in this pathway. Here we show the...
Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice
Sirito, Mario, Lin, Qun, Deng, Jian Min, Behringer, Richard R., Sawadogo, Michèle
USF1 and USF2 are ubiquitously expressed transcription factors implicated as antagonists of the c-Myc protooncoprotein in the control of cellular proliferation. To determine the biological role of...
Shawlot, William, Deng, Jian Min, Behringer, Richard R.
The Xenopus cerberus gene encodes a secreted factor that is expressed in the anterior endomesoderm of gastrula stage embryos and can induce the formation of ectopic heads when its mRNA is injected...
Bi, Weimin, Huang, Wendong, Whitworth, Deanne J., Deng, Jian Min, Zhang, Zhaoping, Behringer, Richard R., ...
In humans, SOX9 heterozygous mutations cause the severe skeletal dysmorphology syndrome campomelic dysplasia. Except for clinical descriptions, little is known about the pathogenesis of this disease....
Iris hypoplasia in mice that lack the alternatively spliced Pax6(5a) isoform
Singh, Sanjaya, Mishra, Rajnikant, Arango, Nelson A., Deng, Jian Min, Behringer, Richard R., Saunders, Grady F.
PAX6 is an evolutionarily conserved transcription factor that plays a critical role in vertebrate and invertebrate eye formation. Heterozygous null mutations in the PAX6 gene result in aniridia in...
Gao, Fei, Maiti, Sourindra, Sun, Guizhi, Ordonez, Nelson G., Udtha, Malini, Deng, Jian Min, ...
Renal failure is a frequent and costly complication of many chronic diseases, including diabetes and hypertension. One common feature of renal failure is glomerulosclerosis, the pathobiology of which...
Deficiency in SNM1 Abolishes an Early Mitotic Checkpoint Induced by Spindle Stress†
Akhter, Shamima, Richie, Christopher T., Deng, Jian Min, Brey, Eric, Zhang, Xiaoshan, Patrick, Charles, ...
Spindle poisons represent an important class of anticancer drugs that act by interfering with microtubule polymerization and dynamics and thereby induce mitotic checkpoints and apoptosis. Here we...
Interactions between Sox9 and β-catenin control chondrocyte differentiation
Akiyama, Haruhiko, Lyons, Jon P., Mori-Akiyama, Yuko, Yang, Xiaohong, Zhang, Ren, Zhang, Zhaoping, ...
Chondrogenesis is a multistep process that is essential for endochondral bone formation. Previous results have indicated a role for β-catenin and Wnt signaling in this pathway. Here we show the...
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors
Akiyama‡, Haruhiko, Kim‡, Jung-Eun, Nakashima, Kazuhisa, Balmes, Gener, Iwai, Naomi, Deng, Jian Min, ...
The transcription factor Sox9 is expressed in all chondroprogenitors and has an essential role in chondrogenesis. Sox9 is also expressed in other tissues, including central nervous system, neural...
The Ter mutation in the Dead-end gene causes germ cell loss and testicular germ cell tumours
Youngren, Kirsten K., Coveney, Douglas, Peng, Xiaoning, Bhattacharya, Chitralekha, Schmidt, Laura S., Nickerson, Michael L., ...
The Ter mutation causes primordial germ cell (PGC) loss on all mouse genetic backgrounds (Fig. 1a) with deficiency of PGCs1 starting at embryonic day 8. Ter is also a potent modifier of spontaneous...
Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice
Sirito, Mario, Lin, Qun, Deng, Jian Min, Behringer, Richard R., Sawadogo, Michèle
USF1 and USF2 are ubiquitously expressed transcription factors implicated as antagonists of the c-Myc protooncoprotein in the control of cellular proliferation. To determine the biological role of...
Shawlot, William, Deng, Jian Min, Behringer, Richard R.
The Xenopus cerberus gene encodes a secreted factor that is expressed in the anterior endomesoderm of gastrula stage embryos and can induce the formation of ectopic heads when its mRNA is injected...
Bi, Weimin, Huang, Wendong, Whitworth, Deanne J., Deng, Jian Min, Zhang, Zhaoping, Behringer, Richard R., ...
In humans, SOX9 heterozygous mutations cause the severe skeletal dysmorphology syndrome campomelic dysplasia. Except for clinical descriptions, little is known about the pathogenesis of this disease....
Iris hypoplasia in mice that lack the alternatively spliced Pax6(5a) isoform
Singh, Sanjaya, Mishra, Rajnikant, Arango, Nelson A., Deng, Jian Min, Behringer, Richard R., Saunders, Grady F.
PAX6 is an evolutionarily conserved transcription factor that plays a critical role in vertebrate and invertebrate eye formation. Heterozygous null mutations in the PAX6 gene result in aniridia in...
Interactions between Sox9 and β-catenin control chondrocyte differentiation
Akiyama, Haruhiko, Lyons, Jon P., Mori-Akiyama, Yuko, Yang, Xiaohong, Zhang, Ren, Zhang, Zhaoping, ...
Chondrogenesis is a multistep process that is essential for endochondral bone formation. Previous results have indicated a role for β-catenin and Wnt signaling in this pathway. Here we show the...
Gao, Fei, Maiti, Sourindra, Sun, Guizhi, Ordonez, Nelson G., Udtha, Malini, Deng, Jian Min, ...
Renal failure is a frequent and costly complication of many chronic diseases, including diabetes and hypertension. One common feature of renal failure is glomerulosclerosis, the pathobiology of which...
Deficiency in SNM1 Abolishes an Early Mitotic Checkpoint Induced by Spindle Stress†
Akhter, Shamima, Richie, Christopher T., Deng, Jian Min, Brey, Eric, Zhang, Xiaoshan, Patrick, Charles, ...
Spindle poisons represent an important class of anticancer drugs that act by interfering with microtubule polymerization and dynamics and thereby induce mitotic checkpoints and apoptosis. Here we...
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors
Akiyama‡, Haruhiko, Kim‡, Jung-Eun, Nakashima, Kazuhisa, Balmes, Gener, Iwai, Naomi, Deng, Jian Min, ...
The transcription factor Sox9 is expressed in all chondroprogenitors and has an essential role in chondrogenesis. Sox9 is also expressed in other tissues, including central nervous system, neural...
Gao, Fei, Maiti, Sourindra, Alam, Nargis, Zhang, Zhen, Deng, Jian Min, Behringer, Richard R., ...
Mutation of the transcription factor and tumor suppressor gene WT1 results in a range of genitourinary anomalies in humans, including 46,XY gonadal dysgenesis, indicating that WT1 plays a critical...
Cthrc1 Is a Positive Regulator of Osteoblastic Bone Formation
Kimura, Hiroaki, Kwan, Kin Ming, Zhang, Zhaoping, Deng, Jian Min, Darnay, Bryant G., Behringer, Richard R., ...
CA125/MUC16 Is Dispensable for Mouse Development and Reproduction
Cheon, Dong-Joo, Wang, Ying, Deng, Jian Min, Lu, Zhen, Xiao, Lianchun, Chen, Chun-Ming, ...
Cancer antigen 125 (CA125) is a blood biomarker that is routinely used to monitor the progression of human epithelial ovarian cancer (EOC) and is encoded by MUC16, a member of the mucin gene family....