Wang, Xiangchun, Fukuda, Tomohiko, Li, Wenzhe, Gao, Cong-xiao, Kondo, Akihiro, Matsumoto, Akio, ...
α1,6-Fucosylation plays key roles in many biological functions, as evidenced by the study of α1,6-fucosyltransferase (Fut8) knockout (Fut8−/−) mice. Phenotypically, Fut8−/− mice exhibit...
TRPM8 mechanism of autonomic nerve response to cold in respiratory airway (2008)
Xing, Hong, Ling, Jennifer X, Chen, Meng, Johnson, Richard D, Tominaga, Makoto, Wang, Cong-Yi, ...
Abstract Breathing cold air without proper temperature exchange can induce strong respiratory autonomic responses including cough, airway constriction and mucosal secretion, and can exacerbate...
Hideyuki Ihara, Yoshitaka Ikeda, Sachiko Toma, Xiangchun Wang, Tadashi Suzuki, Jianguo Gu, ...
1 FUT8, mammalian α1,6-fucosyltransferase, catalyses the transfer of a fucose residue from a donor substrate, GDP-β-L-fucose, to the reducing terminal GlcNAc of the core structure of an...
Abstract Over the past three years Molecular Pain has grown steadily and clearly demonstrated its ability to publish novel scientific discoveries in the field of pain research in a timely fashion,...
Crystal structure of mammalian {alpha}1,6-fucosyltransferase, FUT8 (2007)
Ihara, Hideyuki, Ikeda, Yoshitaka, Toma, Sachiko, Wang, Xiangchun, Suzuki, Tadashi, Gu, Jianguo, ...
Mammalian α1,6-fucosyltransferase (FUT8) catalyses the transfer of a fucose residue from a donor substrate, guanosine 5′-diphosphate-β-l-fucose to the reducing terminal N-acetylglucosamine...
Progress and future of molecular pain (2007)
Abstract Since its launch at the beginning of 2005, Molecular Pain has published pain research articles that cover broad areas including: genetics, molecular and cellular biology, synaptic and...
Recent advances in basic neurosciences and brain disease: from synapses to behavior (2006)
Bi, Guo-Qiang, Bolshakov, Vadim, Bu, Guojun, Cahill, Catherine M, Chen, Zhou-Feng, Collingridge, Graham L, ...
Abstract Understanding basic neuronal mechanisms hold the hope for future treatment of brain disease. The 1st international conference on synapse, memory, drug addiction and pain was held in...
Shigeta, Masaki, Shibukawa, Yukinao, Ihara, Hideyuki, Miyoshi, Eiji, Taniguchi, Naoyuki, Gu, Jianguo
Aspects of the biological significance of the bisecting N‐acetylglucosamine (GlcNAc) structure on N-glycans introduced by β1,4-N-acetylglucosaminyltransferase III (GnT-III) in Neuro2a cell...
Lee, Seung Ho, Takahashi, Motoko, Honke, Koichi, Miyoshi, Eiji, Osumi, Daisuke, Sakiyama, Haruhiko, ...
α1,6-Fucosyltransferase (Fut8) catalyzes the transfer of a fucose residue from GDP-fucose to the innermost N-acetylglucosamine residue of N-glycans. Here we report that the loss of core fucosylation...
Shigeta, Masaki, Shibukawa, Yukinao, Ihara, Hideyuki, Miyoshi, Eiji, Taniguchi, Naoyuki, Gu, Jianguo
Aspects of the biological significance of the bisecting N-acetylglucosamine (GlcNAc) structure on N-glycans introduced by β1,4-N-acetylglucosaminyltransferase III (GnT-III) in Neuro2a cell...
Li, Wenzhe, Nakagawa, Takatoshi, Koyama, Nobuto, Wang, Xiangchun, Jin, Jinhua, Mizuno-Horikawa, Yoko, ...
Alpha1,6-fucosyltransferase (Fut8) plays important roles in physiological and pathological conditions. Fut8 deficient (Fut8-/-) mice exhibit growth retardation, earlier postnatal death and...
Li, Wenzhe, Nakagawa, Takatoshi, Koyama, Nobuto, Wang, Xiangchun, Jin, Jinhua, Mizuno-Horikawa, Yoko, ...
Alpha1,6-fucosyltransferase (Fut8) plays important roles in physiological and pathological conditions. Fut8 deficient (Fut8-/-) mice exhibit growth retardation, earlier postnatal death and...
Crystal Structure of Mammalian {alpha}1,6-Fucosyltransferase, FUT8 (2006)
Ihara, Hideyuki, Ikeda, Yoshitaka, Toma, Sachiko, Wang, Xiangchun, Suzuki, Tadashi, Gu, Jianguo, ...
FUT8, mammalian α1,6-fucosyltransferase, catalyses the transfer of a fucose residue from a donor substrate, GDP-β-L-fucose, to the reducing terminal GlcNAc of the core structure of an...
Li, Wenzhe, Nakagawa, Takatoshi, Koyama, Nobuto, Wang, Xiangchun, Jin, Jinhua, Mizuno-Horikawa, Yoko, ...
Alpha1,6-fucosyltransferase (Fut8) plays important roles in physiological and pathological conditions. Fut8-deficient (Fut8−/−) mice exhibit growth retardation, earlier postnatal death, and...
Shigeta, Masaki, Shibukawa, Yukinao, Ihara, Hideyuki, Miyoshi, Eiji, Taniguchi, Naoyuki, Gu, Jianguo
Aspects of the biological significance of the bisecting N-acetylglucosamine (GlcNAc) structure on N-glycans introduced by β1,4-N-acetylglucosaminyltransferase III (GnT-III) in Neuro2a cell...
Li, Wenzhe, Nakagawa, Takatoshi, Koyama, Nobuto, Wang, Xiangchun, Jin, Jinhua, Mizuno-Horikawa, Yoko, ...
Alpha1,6-fucosyltransferase (Fut8) plays important roles in physiological and pathological conditions. Fut8 deficient (Fut8-/-) mice exhibit growth retardation, earlier postnatal death and...
Li, Wenzhe, Nakagawa, Takatoshi, Koyama, Nobuto, Wang, Xiangchun, Jin, Jinhua, Mizuno-Horikawa, Yoko, ...
Alpha1,6-fucosyltransferase (Fut8) plays important roles in physiological and pathological conditions. Fut8 deficient (Fut8-/-) mice exhibit growth retardation, earlier postnatal death and...
Crystal Structure of Mammalian {alpha}1,6-Fucosyltransferase, FUT8 (2006)
Ihara, Hideyuki, Ikeda, Yoshitaka, Toma, Sachiko, Wang, Xiangchun, Suzuki, Tadashi, Gu, Jianguo, ...
FUT8, mammalian α1,6-fucosyltransferase, catalyses the transfer of a fucose residue from a donor substrate, GDP-β-L-fucose, to the reducing terminal GlcNAc of the core structure of an...
Tao, Yuan-Xiang, Gu, Jianguo, Stephens, Robert L
Abstract Glutamate is a neurotransmitter critical for spinal excitatory synaptic transmission and for generation and maintenance of spinal states of pain hypersensitivity via activation of glutamate...
Guo, Dehuang, Ling, Jennifer, Wang, Mong-Heng, She, Jin-Xiong, Gu, Jianguo, Wang, Cong-Yi
Abstract Divalent metal ions such as copper, manganese, and cobalt are essential for cell development, differentiation, function and survival. These essential metal ions are delivered into...
Molecular pain, a new era of pain research and medicine (2005)
Gu, Jianguo, Zhuo, Min, Caterina, Michael, MacDermott, Amy B, Malmberg, Annika, Neugebauer, Volker, ...
Abstract Molecular pain is a relatively new and rapidly expanding research field that represents an advanced step from conventional pain research. Molecular pain research addresses physiological and...
Bisecting GlcNAc mediates the binding of annexin V to Hsp47 (2005)
Gao, Cong-xiao, Miyoshi, Eiji, Uozumi, Naofumi, Takamiya, Rina, Wang, Xiangchun, Noda, Katsuhisa, ...
The bisecting N-acetylglucosamine (GlcNAc) structure, formed through catalysis by UDP-N-acetylglucosamine : β-d-mannoside β-1,4-N-acetylglucosaminyltansferase III (GnT-III), is responsible for a...
Bisecting GlcNAc Mediates the Binding of Annexin V to Hsp47 (2005)
Gao, Cong-xiao, Miyoshi, Eiji, Uozumi, Naofumi, Takamiya, Rina, Wang, Xiangchun, Noda, Katsuhisa, ...
The bisecting GlcNAc structure, formed via catalysis by N-acetylglucosaminyltransferase III (GnT-III), is responsible for a variety of biological functions. We have previously shown that annexin V, a...
Gu, Jianguo, Zhao, Yanyang, Isaji, Tomoya, Shibukawa, Yukinao, Ihara, Hideyuki, Takahashi, Motoko, ...
A rat pheochromocytoma cell line (PC12), when transfected with β1,4-N-acetylglucosaminyltransferase III (GnT-III), which catalyzes the formation of a bisecting GlcNAc structure in N-glycans,...
Nishiuchi, Ryoko, Murayama, Ohoshi, Fujiwara, Hironobu, Gu, Jianguo, Kawakami, Toru, Aimoto, Saburo, ...
Integrins α3&bgr;1 and α6&bgr;1 are two major laminin receptors expressed on the surface of mammalian cells. Interactions of cells with laminins through these integrins play important roles in cell...
Gu, Jianguo, Zhao, Yanyang, Isaji, Tomoya, Shibukawa, Yukinao, Ihara, Hideyuki, Takahashi, Motoko, ...
A rat pheochromocytoma cell line (PC12), when transfected with β1,4-N-acetylglucosaminyltransferase III (GnT-III), which catalyzes the formation of a bisecting GlcNAc structure in N-glycans,...
Gu, Jianguo, Zhao, Yanyang, Isaji, Tomoya, Shibukawa, Yukinao, Ihara, Hideyuki, Takahashi, Motoko, ...
A rat pheochromocytoma cell line (PC12), when transfected with β1,4-N-acetylglucosaminyltransferase III (GnT-III), which catalyzes the formation of a bisecting GlcNAc structure in N-glycans,...
PTEN Gene and Integrin Signaling in Cancer (1999)
Tamura, Masahito, Gu, Jianguo, Tran, Huan, Yamada, Kenneth M.
Integrins are major adhesion- and signaling-receptor proteins that mediate cell migration and invasion. They also trigger a variety of signal transduction pathways and regulate cytoskeletal...
Carbohydrate-deficient glycoprotein syndrome (CDGS) is a congenital disorder characterized by neurological and developmental defects. We have examined the expressions of the small proteoglycans...
Gu, Jianguo, Nishikawa, Atsushi, Tsuruoka, Nobuo, Ohno, Masao, Yamaguchi, Nozomi, Kangawa, Kenji, ...
A ySl-eN-acetylglucosaminyltransferase (GnT-V) [EC 2.4.1.155] which catalyzes the transfer of W-acetylglucosamine from UDP-N-acetylglucosamine to a-D-6-mannoside has been purified up to 20,000-fold...
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
Podsypanina, Katrina, Ellenson, Lora Hedrick, Nemes, Adriana, Gu, Jianguo, Tamura, Masahito, Yamada, Kenneth M., ...
Pten/Mmac1+/− heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type allele was...
Molecular pain, a new era of pain research and medicine
Gu, Jianguo, Zhuo, Min, Caterina, Michael, MacDermott, Amy B, Malmberg, Annika, Neugebauer, Volker, ...
Molecular pain is a relatively new and rapidly expanding research field that represents an advanced step from conventional pain research. Molecular pain research addresses physiological and...
Guo, Dehuang, Ling, Jennifer, Wang, Mong-Heng, She, Jin-Xiong, Gu, Jianguo, Wang, Cong-Yi
Divalent metal ions such as copper, manganese, and cobalt are essential for cell development, differentiation, function and survival. These essential metal ions are delivered into intracellular...
Tao, Yuan-Xiang, Gu, Jianguo, Stephens, Robert L
Glutamate is a neurotransmitter critical for spinal excitatory synaptic transmission and for generation and maintenance of spinal states of pain hypersensitivity via activation of glutamate...
Wang, Xiangchun, Inoue, Shinya, Gu, Jianguo, Miyoshi, Eiji, Noda, Katsuhisa, Li, Wenzhe, ...
The core fucosylation (α1,6-fucosylation) of glycoproteins is widely distributed in mammalian tissues, and is altered under pathological conditions. To investigate physiological functions of the...
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
Podsypanina, Katrina, Ellenson, Lora Hedrick, Nemes, Adriana, Gu, Jianguo, Tamura, Masahito, Yamada, Kenneth M., ...
Pten/Mmac1+/− heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type allele was...
Molecular pain, a new era of pain research and medicine
Gu, Jianguo, Zhuo, Min, Caterina, Michael, MacDermott, Amy B, Malmberg, Annika, Neugebauer, Volker, ...
Molecular pain is a relatively new and rapidly expanding research field that represents an advanced step from conventional pain research. Molecular pain research addresses physiological and...
Guo, Dehuang, Ling, Jennifer, Wang, Mong-Heng, She, Jin-Xiong, Gu, Jianguo, Wang, Cong-Yi
Divalent metal ions such as copper, manganese, and cobalt are essential for cell development, differentiation, function and survival. These essential metal ions are delivered into intracellular...
Wang, Xiangchun, Inoue, Shinya, Gu, Jianguo, Miyoshi, Eiji, Noda, Katsuhisa, Li, Wenzhe, ...
The core fucosylation (α1,6-fucosylation) of glycoproteins is widely distributed in mammalian tissues, and is altered under pathological conditions. To investigate physiological functions of the...
Tao, Yuan-Xiang, Gu, Jianguo, Stephens, Robert L
Glutamate is a neurotransmitter critical for spinal excitatory synaptic transmission and for generation and maintenance of spinal states of pain hypersensitivity via activation of glutamate...
Recent advances in basic neurosciences and brain disease: from synapses to behavior
Bi, Guo-Qiang, Bolshakov, Vadim, Bu, Guojun, Cahill, Catherine M, Chen, Zhou-Feng, Collingridge, Graham L, ...
Understanding basic neuronal mechanisms hold the hope for future treatment of brain disease. The 1st international conference on synapse, memory, drug addiction and pain was held in beautiful...
Progress and future of molecular pain
Since its launch at the beginning of 2005, Molecular Pain has published pain research articles that cover broad areas including: genetics, molecular and cellular biology, synaptic and neuronal...
Over the past three years Molecular Pain has grown steadily and clearly demonstrated its ability to publish novel scientific discoveries in the field of pain research in a timely fashion, hence...
Gu, Jianguo, Tamura, Masahito, Yamada, Kenneth M.
The tumor suppressor PTEN dephosphorylates focal adhesion kinase (FAK) and inhibits integrin-mediated cell spreading and cell migration. We demonstrate here that expression of PTEN selectively...
Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten
Gu, Jianguo, Tamura, Masahito, Pankov, Roumen, Danen, Erik H.J., Takino, Takahisa, Matsumoto, Kazue, ...
Cell migration is modulated by regulatory molecules such as growth factors, oncogenes, and the tumor suppressor PTEN. We previously described inhibition of cell migration by PTEN and restoration of...
Shigeta, Masaki, Sanzen, Noriko, Ozawa, Masayuki, Gu, Jianguo, Hasegawa, Hitoshi, Sekiguchi, Kiyotoshi
CD151, a member of the tetraspanin family proteins, tightly associates with integrin α3β1 and localizes at basolateral surfaces of epithelial cells. We found that overexpression of CD151 in A431...
TRPM8 mechanism of autonomic nerve response to cold in respiratory airway
Xing, Hong, Ling, Jennifer X, Chen, Meng, Johnson, Richard D, Tominaga, Makoto, Wang, Cong-Yi, ...
Breathing cold air without proper temperature exchange can induce strong respiratory autonomic responses including cough, airway constriction and mucosal secretion, and can exacerbate existing asthma...
Biochemical visualization of cell surface molecular clustering in living cells
Kotani, Norihiro, Gu, Jianguo, Isaji, Tomoya, Udaka, Keiko, Taniguchi, Naoyuki, Honke, Koichi
Many plasma membrane-resident molecules cluster with other molecules to collaborate in a variety of biological events. We herein report a sensitive and simple method to identify components of cell...
Potential of N-glycan in cell adhesion and migration as either a positive or negative regulator
Gu, Jianguo, Taniguchi, Naoyuki
Glycosylation is one of the most abundant posttranslational modification reactions, and nearly half of all known proteins in eukaryotes are glycosylated. In fact, changes in oligosaccharide structure...