Nguyen, Cuong Q, Sharma, Ashok, Lee, Byung Ha, She, Jin-Xiong, McIndoe, Richard A, Peck, Ammon B
Abstract Introduction Recently, we reported the development of the C57BL/6.NOD- Aec1Aec2 mouse that carries two genetic intervals derived from the non-obese diabetic (NOD) mouse capable of conferring...
Lai, Yinglei, Eckenrode, Sarah E, She, Jin-Xiong
Abstract Background Different microarray data sets can be collected for studying the same or similar diseases. We expect to achieve a more efficient analysis of differential expression if an...
Liu, Siyang, Wang, Hongjie, Jin, Yulan, Podolsky, Robert, Reddy, MV Prasad Linga, Pedersen, Jennifer, ...
Genome-wide association (GWA) studies revealed a number of single nucleotide polymorphisms (SNPs) significantly associated with type 1 diabetes (T1D). In an attempt to confirm some of these candidate...
Zhou, Li, Wang, Hongjie, Zhong, Xing, Jin, Yulan, Mi, Qing-Sheng, Sharma, Ashok, ...
Abstract Background CD8 + NKT-like cells are naturally occurring but rare T cells that express both T cell and natural killer cell markers. These cells may play key roles in establishing tolerance to...
Lai, Yinglei, Adam, Bao-ling, Podolsky, Robert, She, Jin-Xiong
Motivation: Due to advances in experimental technologies, such as microarray, mass spectrometry and nuclear magnetic resonance, it is feasible to obtain large-scale data sets, in which measurements...
Wilson, Karen HS, McIndoe, Richard A, Eckenrode, Sarah, Morel, Laurence, Agarwal, Anupam, Croker, Byron P, ...
Abstract Background Despite multiple causes, Chronic Kidney Disease is commonly associated with proteinuria. A previous study on Non Obese Diabetic mice (NOD), which spontaneously develop type 1...
Purohit, Sharad, Podolsky, Robert, Collins, Christin, Zheng, Weipeng, Schatz, Desmond, Muir, Andy, ...
Abstract Background Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) plays a critical role in downregulation of antigen-activated immune response and polymorphisms at the CTLA-4 gene have been...
Guo, Dehuang, Ling, Jennifer, Wang, Mong-Heng, She, Jin-Xiong, Gu, Jianguo, Wang, Cong-Yi
Abstract Divalent metal ions such as copper, manganese, and cobalt are essential for cell development, differentiation, function and survival. These essential metal ions are delivered into...
Molecular cloning and characterization of the mouse Acdpgene family (2004)
Wang, Cong-Yi, Yang, Ping, Shi, Jing-Da, Purohit, Sharad, Guo, Dehuang, An, Haiqian, ...
Abstract Background We have recently cloned and characterized a novel gene family named ancient conserved domain protein ( ACDP ) in humans. To facilitate the functional study of this novel gene...
Bmc Genomics, Cong-yi Wang, Ping Yang, Jing-da Shi, Sharad Purohit, Dehuang Guo, ...
Research article Molecular cloning and characterization of the mouse Acdp gene family
Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes
She, Jin-Xiong, Ellis, Tamir M., Wilson, S. Brian, Wasserfall, Clive H., Marron, Michele, Reimsneider, Sharon, ...
Markedly elevated levels of serum IL-4 were reported previously in 50% of a small group of type 1 diabetes nonprogessors. To determine the patterns of expression for this phenotype, a larger cohort...
Molecular cloning and characterization of the mouse Acdp gene family
Wang, Cong-Yi, Yang, Ping, Shi, Jing-Da, Purohit, Sharad, Guo, Dehuang, An, Haiqian, ...
Guo, Dehuang, Ling, Jennifer, Wang, Mong-Heng, She, Jin-Xiong, Gu, Jianguo, Wang, Cong-Yi
Divalent metal ions such as copper, manganese, and cobalt are essential for cell development, differentiation, function and survival. These essential metal ions are delivered into intracellular...
Purohit, Sharad, Podolsky, Robert, Collins, Christin, Zheng, Weipeng, Schatz, Desmond, Muir, Andy, ...
Wilson, Karen HS, McIndoe, Richard A, Eckenrode, Sarah, Morel, Laurence, Agarwal, Anupam, Croker, Byron P, ...
Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes
She, Jin-Xiong, Ellis, Tamir M., Wilson, S. Brian, Wasserfall, Clive H., Marron, Michele, Reimsneider, Sharon, ...
Markedly elevated levels of serum IL-4 were reported previously in 50% of a small group of type 1 diabetes nonprogessors. To determine the patterns of expression for this phenotype, a larger cohort...
Molecular cloning and characterization of the mouse Acdp gene family
Wang, Cong-Yi, Yang, Ping, Shi, Jing-Da, Purohit, Sharad, Guo, Dehuang, An, Haiqian, ...
Guo, Dehuang, Ling, Jennifer, Wang, Mong-Heng, She, Jin-Xiong, Gu, Jianguo, Wang, Cong-Yi
Divalent metal ions such as copper, manganese, and cobalt are essential for cell development, differentiation, function and survival. These essential metal ions are delivered into intracellular...
Purohit, Sharad, Podolsky, Robert, Collins, Christin, Zheng, Weipeng, Schatz, Desmond, Muir, Andy, ...
Wilson, Karen HS, McIndoe, Richard A, Eckenrode, Sarah, Morel, Laurence, Agarwal, Anupam, Croker, Byron P, ...
Yang, Lijun, Zhao, Hongshan, Li, Shi-Wu, Ahrens, Kim, Collins, Christine, Eckenrode, Sarah, ...
Using cDNA microarrays we determined the gene expression patterns in the human acute promyelocytic leukemia (APL) cell line NB4 during all-trans retinoic acid (ATRA)-induced differentiation. We...
Zhou, Li, Wang, Hongjie, Zhong, Xing, Jin, Yulan, Mi, Qing-Sheng, Sharma, Ashok, ...
Global gene expression profiling of in vitro cultured CD8+ T cells that express natural killer cell markers revealed differential expression of about 3,000 genes between these cells and naïve CD8+ T...
Biomarkers for Type 1 Diabetes
Purohit, Sharad, She, Jin-Xiong
Type 1 diabetes (T1D) is an autoimmune disorder characterized by the immune destruction of the insulin producing β cells of the pancreatic islets. Autoimmunity towards pancreatic antigens results...
A statistical framework for integrating two microarray data sets in differential expression analysis
Han, Junyan, Zhong, Jinxin, Wei, Wenzhong, Wang, Ying, Huang, Yafei, Yang, Ping, ...
OBJECTIVE—The implication of innate immunity in type 1 diabetes development has long been proposed. High-mobility group box 1 (HMGB1), an evolutionarily conserved chromosomal protein, was recently...