Jin-Yong Jeong

Distinctiveness of Genotypes of Helicobacter pylori in Calcutta, India

Mukhopadhyay, Asish K., Kersulyte, Dangeruta, Jeong, Jin-Yong, Datta, Simanti, Ito, Yoshiyuki, Chowdhury, Abhijit, ...

The genotypes of 78 strains of Helicobacter pylori from Calcutta, India (55 from ulcer patients and 23 from more-benign infections), were studied, with a focus on putative virulence genes and neutral...

Sequential Inactivation of rdxA (HP0954) and frxA (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in Helicobacter pylori

Jeong, Jin-Yong, Mukhopadhyay, Asish K., Dailidiene, Daiva, Wang, Yipeng, Velapatiño, Billie, Gilman, Robert H., ...

Helicobacter pylori is a human-pathogenic bacterial species that is subdivided geographically, with different genotypes predominating in different parts of the world. Here we test and extend an...

Metronidazole Activation Is Mutagenic and Causes DNA Fragmentation in Helicobacter pylori and in Escherichia coli Containing a Cloned H. pylori rdxA+ (Nitroreductase) Gene

Sisson, Gary, Jeong, Jin-Yong, Goodwin, Avery, Bryden, Louis, Rossler, Norma, Lim-Morrison, Sabrina, ...

Much of the normal high sensitivity of wild-type Helicobacter pylori to metronidazole (Mtz) depends on rdxA (HP0954), a gene encoding a novel nitroreductase that catalyzes the conversion of Mtz from...

Roles of FrxA and RdxA Nitroreductases of Helicobacter pylori in Susceptibility and Resistance to Metronidazole

Jeong, Jin-Yong, Mukhopadhyay, Asish K., Akada, Junko K., Dailidiene, Daiva, Hoffman, Paul S., Berg, Douglas E.

The relative importance of the frxA and rdxA nitroreductase genes of Helicobacter pylori in metronidazole (MTZ) susceptibility and resistance has been controversial. Jeong et al. (J. Bacteriol....

Mouse-Colonizing Helicobacter pylori SS1 Is Unusually Susceptible to Metronidazole Due to Two Complementary Reductase Activities

Jeong, Jin-Yong, Berg, Douglas E.

In most strains of Helicobacter pylori, mutational inactivation of the rdxA (HP0954) gene, which encodes a nitroreductase that converts metronidazole (MTZ) from a harmless prodrug to a mutagenic and...

The fdxA Ferredoxin Gene Can Down-Regulate frxA Nitroreductase Gene Expression and Is Essential in Many Strains of Helicobacter pylori

Mukhopadhyay, Asish K., Jeong, Jin-Yong, Dailidiene, Daiva, Hoffman, Paul S., Berg, Douglas E.

Very few examples of metabolic regulation are known in the gastric pathogen Helicobacter pylori. An unanticipated case was suggested, however, upon finding two types of metronidazole...

Detection of qnr in Clinical Isolates of Escherichia coli from Korea

Jeong, Jin-Yong, Yoon, Hyun Jung, Kim, Eun Sil, Lee, Yoola, Choi, Sang-Ho, Kim, Nam Joong, ...

qnr was detected in 2 of 260 Escherichia coli clinical isolates collected from a Korean hospital during the period 2001 to 2003. The two strains were not clonally related. qnr was located in In4...

Distinctiveness of Genotypes of Helicobacter pylori in Calcutta, India

Mukhopadhyay, Asish K., Kersulyte, Dangeruta, Jeong, Jin-Yong, Datta, Simanti, Ito, Yoshiyuki, Chowdhury, Abhijit, ...

The genotypes of 78 strains of Helicobacter pylori from Calcutta, India (55 from ulcer patients and 23 from more-benign infections), were studied, with a focus on putative virulence genes and neutral...

Sequential Inactivation of rdxA (HP0954) and frxA (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in Helicobacter pylori

Jeong, Jin-Yong, Mukhopadhyay, Asish K., Dailidiene, Daiva, Wang, Yipeng, Velapatiño, Billie, Gilman, Robert H., ...

Helicobacter pylori is a human-pathogenic bacterial species that is subdivided geographically, with different genotypes predominating in different parts of the world. Here we test and extend an...

Metronidazole Activation Is Mutagenic and Causes DNA Fragmentation in Helicobacter pylori and in Escherichia coli Containing a Cloned H. pylori rdxA+ (Nitroreductase) Gene

Sisson, Gary, Jeong, Jin-Yong, Goodwin, Avery, Bryden, Louis, Rossler, Norma, Lim-Morrison, Sabrina, ...

Much of the normal high sensitivity of wild-type Helicobacter pylori to metronidazole (Mtz) depends on rdxA (HP0954), a gene encoding a novel nitroreductase that catalyzes the conversion of Mtz from...

Roles of FrxA and RdxA Nitroreductases of Helicobacter pylori in Susceptibility and Resistance to Metronidazole

Jeong, Jin-Yong, Mukhopadhyay, Asish K., Akada, Junko K., Dailidiene, Daiva, Hoffman, Paul S., Berg, Douglas E.

The relative importance of the frxA and rdxA nitroreductase genes of Helicobacter pylori in metronidazole (MTZ) susceptibility and resistance has been controversial. Jeong et al. (J. Bacteriol....

Mouse-Colonizing Helicobacter pylori SS1 Is Unusually Susceptible to Metronidazole Due to Two Complementary Reductase Activities

Jeong, Jin-Yong, Berg, Douglas E.

In most strains of Helicobacter pylori, mutational inactivation of the rdxA (HP0954) gene, which encodes a nitroreductase that converts metronidazole (MTZ) from a harmless prodrug to a mutagenic and...

The fdxA Ferredoxin Gene Can Down-Regulate frxA Nitroreductase Gene Expression and Is Essential in Many Strains of Helicobacter pylori

Mukhopadhyay, Asish K., Jeong, Jin-Yong, Dailidiene, Daiva, Hoffman, Paul S., Berg, Douglas E.

Very few examples of metabolic regulation are known in the gastric pathogen Helicobacter pylori. An unanticipated case was suggested, however, upon finding two types of metronidazole...

Detection of qnr in Clinical Isolates of Escherichia coli from Korea

Jeong, Jin-Yong, Yoon, Hyun Jung, Kim, Eun Sil, Lee, Yoola, Choi, Sang-Ho, Kim, Nam Joong, ...

qnr was detected in 2 of 260 Escherichia coli clinical isolates collected from a Korean hospital during the period 2001 to 2003. The two strains were not clonally related. qnr was located in In4...

Emergence of Antibiotic Resistance during Therapy for Infections Caused by Enterobacteriaceae Producing AmpC β-Lactamase: Implications for Antibiotic Use▿

Choi, Sang-Ho, Lee, Jung Eun, Park, Su Jin, Choi, Seong-Ho, Lee, Sang-Oh, Jeong, Jin-Yong, ...

Enterobacter spp., Serratia marcescens, Citrobacter freundii, and Morganella morganii are characterized by chromosomally encoded AmpC β-lactamases and possess the ability to develop resistance upon...