Scientific Commons: Jin-Yong Jeong

A Study on Smoke Movement in Room Fires with Various Pool Fire Location (2008)

In order to investigate the fire-induced smoke movement in a three-dimensional room with an open door, numerical and experimental study was performed. The center, wall, and corner fire plumes for...

Analysis of the SHP-2 Binding Site of Helicobacter pylori CagA Protein in Korean (2008)

Jo, Ji-Yun, Jeong, Jin-Yong, Kang, Ho Young, Kim, Gun-Do, Byeon, Jeong-Sik, Myung, Seung-Jae, ...

Recently the pathological actions of CagA of Helicobacter pylori (H. pylori) on gastric epithelial cells have been reported. CagA is directly injected into the host cytoplasm and undergoes tyrosine...

Biological Effect of Metronidazole Resistance in Helicobacter Pylori (2008)

Lee, Gin Hyug, Lee, Sun-Mi, Nam, Won-Hee, Kim, Eun Sil, Kim, Jin Ho, Kang, Ho Young, ...

Resistance to metronidazole, a key component of therapies against Helicobacter pylori, is common in clinical isolates. Resistance generally requires inactivation of rdxA (HP0954), and sometimes also...

Mechanism of Metronidazole Resistance Regulated by the fdxA Gene in Helicobacter pylori. (2008)

Nam, Won-Hee, Lee, Sun-Mi, Kim, Eun-Sil, Kim, Jin-Ho, Jeong, Jin-Yong

Resistance to metronidazole in Helicobacter pylori results from inactivation of rdxA and frxA, the chromosomal genes for a nitroreductase that normally converts metronidazole from prodrug to...

Increasing incidence of quinolone resistance in human non-typhoid Salmonella enterica isolates in Korea and mechanisms involved in quinolone resistance (2005)

Choi, Sang-Ho, Woo, Jun Hee, Lee, Jung Eun, Park, Su Jin, Choo, Eun Ju, Kwak, Yee Gyung, ...

Objectives: We investigated the trends of nalidixic acid resistance in human non-typhoid Salmonella enterica in a Korean population, and examined some possible mechanisms involved in this resistance....

Increasing incidence of quinolone resistance in human non-typhoid Salmonella enterica isolates in Korea and mechanisms involved in quinolone resistance (2005)

Choi, Sang-Ho, Woo, Jun Hee, Lee, Jung Eun, Park, Su Jin, Choo, Eun Ju, Kwak, Yee Gyung, ...

Objectives: We investigated the trends of nalidixic acid resistance in human non-typhoid Salmonella enterica in a Korean population, and examined some possible mechanisms involved in this resistance....

Distinctiveness of Genotypes of Helicobacter pylori in Calcutta, India

Mukhopadhyay, Asish K., Kersulyte, Dangeruta, Jeong, Jin-Yong, Datta, Simanti, Ito, Yoshiyuki, Chowdhury, Abhijit, ...

The genotypes of 78 strains of Helicobacter pylori from Calcutta, India (55 from ulcer patients and 23 from more-benign infections), were studied, with a focus on putative virulence genes and neutral...

Sequential Inactivation of rdxA (HP0954) and frxA (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in Helicobacter pylori

Jeong, Jin-Yong, Mukhopadhyay, Asish K., Dailidiene, Daiva, Wang, Yipeng, Velapatiño, Billie, Gilman, Robert H., ...

Helicobacter pylori is a human-pathogenic bacterial species that is subdivided geographically, with different genotypes predominating in different parts of the world. Here we test and extend an...

Metronidazole Activation Is Mutagenic and Causes DNA Fragmentation in Helicobacter pylori and in Escherichia coli Containing a Cloned H. pylori rdxA+ (Nitroreductase) Gene

Sisson, Gary, Jeong, Jin-Yong, Goodwin, Avery, Bryden, Louis, Rossler, Norma, Lim-Morrison, Sabrina, ...

Much of the normal high sensitivity of wild-type Helicobacter pylori to metronidazole (Mtz) depends on rdxA (HP0954), a gene encoding a novel nitroreductase that catalyzes the conversion of Mtz from...

Roles of FrxA and RdxA Nitroreductases of Helicobacter pylori in Susceptibility and Resistance to Metronidazole

Jeong, Jin-Yong, Mukhopadhyay, Asish K., Akada, Junko K., Dailidiene, Daiva, Hoffman, Paul S., Berg, Douglas E.

The relative importance of the frxA and rdxA nitroreductase genes of Helicobacter pylori in metronidazole (MTZ) susceptibility and resistance has been controversial. Jeong et al. (J. Bacteriol....

Mouse-Colonizing Helicobacter pylori SS1 Is Unusually Susceptible to Metronidazole Due to Two Complementary Reductase Activities

Jeong, Jin-Yong, Berg, Douglas E.

In most strains of Helicobacter pylori, mutational inactivation of the rdxA (HP0954) gene, which encodes a nitroreductase that converts metronidazole (MTZ) from a harmless prodrug to a mutagenic and...

The fdxA Ferredoxin Gene Can Down-Regulate frxA Nitroreductase Gene Expression and Is Essential in Many Strains of Helicobacter pylori

Mukhopadhyay, Asish K., Jeong, Jin-Yong, Dailidiene, Daiva, Hoffman, Paul S., Berg, Douglas E.

Very few examples of metabolic regulation are known in the gastric pathogen Helicobacter pylori. An unanticipated case was suggested, however, upon finding two types of metronidazole...

Detection of qnr in Clinical Isolates of Escherichia coli from Korea

Jeong, Jin-Yong, Yoon, Hyun Jung, Kim, Eun Sil, Lee, Yoola, Choi, Sang-Ho, Kim, Nam Joong, ...

qnr was detected in 2 of 260 Escherichia coli clinical isolates collected from a Korean hospital during the period 2001 to 2003. The two strains were not clonally related. qnr was located in In4...